Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases

Inflammasomes are Differentially Expressed in Cardiovascular and other Tissues

(2017) Y. Yin et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy

(2016) J. Julie Wu et al.   Aging-US

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

ER stress activates the NLRP3 inflammasome via an UPR-independent pathway

(2012) P Menu et al.   Cell Death & Disease

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

(2012) Yun-Hee Youm et al.   Cell Reports

Amino-Functionalized Polystyrene Nanoparticles Activate the NLRP3 Inflammasome in Human Macrophages

(2011) Oleg Lunov et al.   ACS Nano

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

Lipopolysaccharide-Induced Mitochondrial DNA Depletion

(2011) Amal Choumar et al.   ANTIOXIDANTS & REDOX SIGNALING

Phagocytosis of cells dying through autophagy induces inflammasome activation and IL-1β release in human macrophages

(2011) Goran Petrovski et al.   Autophagy

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

NOD-like receptors and the innate immune system: Coping with danger, damage and death

(2011) Kristof Kersse et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Hyperglycemia Activates Caspase-1 and TXNIP-Mediated IL-1  Transcription in Human Adipose Tissue

(2011) T. B. Koenen et al.   DIABETES

Mitochondria in innate immunity

(2011) Damien Arnoult et al.   EMBO REPORTS

Mitochondria: Sovereign of inflammation?

(2011) Jürg Tschopp   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

The role of lysosomes in iron metabolism and recycling

(2011) Tino Kurz et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hemorrhagic Shock Activation of NLRP3 Inflammasome in Lung Endothelial Cells

(2011) M. Xiang et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Cyclic Polypeptide and Aminoglycoside Antibiotics Trigger IL-1  Secretion by Activating the NLRP3 Inflammasome

(2011) R. Allam et al.   JOURNAL OF IMMUNOLOGY

Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway

(2011) K. Niemi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome

(2011) F. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Adenovirus Type 5 Rupture of Lysosomes Leads to Cathepsin B-Dependent Mitochondrial Stress and Production of Reactive Oxygen Species

(2011) K. A. McGuire et al.   JOURNAL OF VIROLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome-Independent Modulation of Cytokine Response by Autophagy in Human Cells

(2011) Tania O. Crişan et al.   PLoS One

Cytosolic DNA Triggers Inflammasome Activation in Keratinocytes in Psoriatic Lesions

(2011) Y. Dombrowski et al.   Science Translational Medicine

Interplay between redox status and inflammasome activation

(2011) Anna Rubartelli et al.   TRENDS IN IMMUNOLOGY

Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation

(2011) Dmitri V. Krysko et al.   TRENDS IN IMMUNOLOGY

Inflammatory markers in population studies of aging

(2010) Tushar Singh et al.   AGEING RESEARCH REVIEWS

Oxidative stress caused by mitochondrial calcium overload

(2010) Tsung-I Peng et al.   Annals of the New York Academy of Sciences

Autophagy Shapes Inflammation

(2010) László Fésüs et al.   ANTIOXIDANTS & REDOX SIGNALING

Human NLRP3 inflammasome activation is Nox1-4 independent

(2010) R. van Bruggen et al.   BLOOD

The Inflammasomes

(2010) Kate Schroder et al.   CELL

NLRC5 Negatively Regulates the NF-κB and Type I Interferon Signaling Pathways

(2010) Jun Cui et al.   CELL

High-mobility group box 1 (HMGB1) as a master regulator of innate immunity

(2010) Alessandra Castiglioni et al.   CELL AND TISSUE RESEARCH

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The role of autophagy in β-cell lipotoxicity and type 2 diabetes

(2010) G. Las et al.   DIABETES OBESITY & METABOLISM

Impaired quality control of mitochondria: Aging from a new perspective

(2010) Tobias A. Weber et al.   EXPERIMENTAL GERONTOLOGY

Uncoupling protein UCP2: When mitochondrial activity meets immunity

(2010) Yalin Emre et al.   FEBS LETTERS

A Novel Pathway for Inducible Nitric-oxide Synthase Activation through Inflammasomes

(2010) Carina L. Buzzo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Does autophagy take a front seat in lifespan extension?

(2010) Goran Petrovski et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deletion of Mitochondrial Uncoupling Protein-2 Increases Ischemic Brain Damage after Transient Focal Ischemia by Altering Gene Expression Patterns and Enhancing Inflammatory Cytokines

(2010) Bryan A Haines et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tripartite-Motif Protein 30 Negatively Regulates NLRP3 Inflammasome Activation by Modulating Reactive Oxygen Species Production

(2010) Y. Hu et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial dysfunction as a cause of ageing

(2010) A. Trifunovic et al.   JOURNAL OF INTERNAL MEDICINE

Caspase-5 Expression Is Upregulated in Lesional Psoriatic Skin

(2010) Maria L. Salskov-Iversen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mitochondria and aging in the vascular system

(2010) Zoltan Ungvari et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease

(2010) Jun Ren et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Interleukin 18 in the CNS

(2010) Silvia Alboni et al.   Journal of Neuroinflammation

The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

(2010) S. Jha et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of Vascular Aging: New Perspectives

(2010) Z. Ungvari et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function

(2010) eMalick G. Njie et al.   NEUROBIOLOGY OF AGING

Anti-oxidative, anti-cancer and anti-inflammatory actions by thioredoxin 1 and thioredoxin-binding protein-2

(2010) Rie Watanabe et al.   PHARMACOLOGY & THERAPEUTICS

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

Inflammation, oxidative stress and lipids: the risk triad for atherosclerosis in gout

(2010) E. Krishnan   RHEUMATOLOGY

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

(2010) B. McDonald et al.   SCIENCE

Mitochondrial Peptides Are Potent Immune Activators That Activate Human Neutrophils Via FPR-1

(2010) Mustafa Raoof et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Multiple interleukin-1β–converting enzymes contribute to inflammatory arthritis

(2009) Christian Stehlik   ARTHRITIS AND RHEUMATISM

Caspase 1–independent activation of interleukin-1β in neutrophil-predominant inflammation

(2009) Monica Guma et al.   ARTHRITIS AND RHEUMATISM

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin-1β

(2009) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging

(2009) Hiroshi Nakanishi et al.   BEHAVIOURAL BRAIN RESEARCH

Meta-analysis of age-related gene expression profiles identifies common signatures of aging

(2009) João Pedro de Magalhães et al.   BIOINFORMATICS

Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

(2009) William R Swindell   BMC GENOMICS

Mitochondrial control of autophagic lysosomal pathway in Alzheimer's disease

(2009) S.M. Cardoso et al.   EXPERIMENTAL NEUROLOGY

Mitochondria and reactive oxygen species

(2009) Alicia J. Kowaltowski et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structural and functional link between the mitochondrial network and the endoplasmic reticulum

(2009) Carlotta Giorgi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cutting Edge: Necrosis Activates the NLRP3 Inflammasome

(2009) H. Li et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Pathogen-Induced Interleukin-1  Processing and Secretion Is Regulated by a Biphasic Redox Response

(2009) S. Tassi et al.   JOURNAL OF IMMUNOLOGY

DAMPs and inflammatory processes: the role of redox in the different outcomes

(2009) Sonia Carta et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Oxidative stress and metabolic syndrome

(2009) Christian K. Roberts et al.   LIFE SCIENCES

T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes

(2009) Greta Guarda et al.   NATURE

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Mechanism of Bcl-2 and Bcl-XL inhibition of NLRP1 inflammasome: Loop domain-dependent suppression of ATP binding and oligomerization

(2009) B. Faustin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLR-mediated control of inflammasome assembly in the host response against bacterial pathogens

(2009) Igor E. Brodsky et al.   SEMINARS IN IMMUNOLOGY

The aging of the immune system

(2009) Daniela Weiskopf et al.   TRANSPLANT INTERNATIONAL

Molecular mechanisms involved in inflammasome activation

(2009) Clare Bryant et al.   TRENDS IN CELL BIOLOGY

Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors

(2009) Elizabeth J. Kovacs et al.   TRENDS IN IMMUNOLOGY

Regulation of the aging process by autophagy

(2009) Antero Salminen et al.   TRENDS IN MOLECULAR MEDICINE

Radical-free biology of oxidative stress

(2008) Dean P. Jones   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

(2008) C.-L. Chen et al.   BLOOD

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

(2008) Martin Keller et al.   CELL

Critical Role of Bone Marrow Apoptosis-Associated Speck-Like Protein, an Inflammasome Adaptor Molecule, in Neointimal Formation After Vascular Injury in Mice

(2008) Noriyuki Yajima et al.   CIRCULATION

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

(2008) Ivan Tattoli et al.   EMBO REPORTS

Regulation of thioredoxin by ceramide in retinal pigment epithelial cells

(2008) Parameswaran G. Sreekumar et al.   EXPERIMENTAL EYE RESEARCH

The mitochondrial free radical theory of ageing - Where do we stand?

(2008) Jan Gruber   Frontiers in Bioscience-Landmark

Systematic expression profiling of innate immune genes defines a complex pattern of immunosenescence in peripheral and intestinal leukocytes

(2008) P Rosenstiel et al.   GENES AND IMMUNITY

Inflammasomes: guardians of cytosolic sanctity

(2008) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology

(2008) Antero Salminen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

(2008) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Aging of the Immune System as a Prognostic Factor for Human Longevity

(2008) Anis Larbi et al.   PHYSIOLOGY

Glucose sensing by MondoA:Mlx complexes: A role for hexokinases and direct regulation of thioredoxin-interacting protein expression

(2008) C. A. Stoltzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

(2007) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

(2007) Johanna Ojala et al.   NEUROBIOLOGY OF AGING