Facing glycosphingolipid–Shiga toxin interaction: dire straits for endothelial cells of the human vasculature

Specific Targeting of Tumor Endothelial Cells by a Shiga-like Toxin-Vascular Endothelial Growth Factor Fusion Protein as a Novel Treatment Strategy for Pancreatic Cancer

(2015) Birgit Hotz et al.   NEOPLASIA

Fractalkine and CX3CR1 Mediate Leukocyte Capture by Endothelium in Response to Shiga Toxin

(2014) C. Zanchi et al.   JOURNAL OF IMMUNOLOGY

Uncommon membrane distribution of Shiga toxin glycosphingolipid receptors in toxin-sensitive human glomerular microvascular endothelial cells

(2012) Josefine Betz et al.   BIOLOGICAL CHEMISTRY

Risk Factors for the Hemolytic Uremic Syndrome in Children Infected With Escherichia coli O157:H7: A Multivariable Analysis

(2012) C. S. Wong et al.   CLINICAL INFECTIOUS DISEASES

Promiscuous Shiga toxin 2e and its intimate relationship to Forssman

(2012) Johannes Müthing et al.   GLYCOBIOLOGY

Charged and Hydrophobic Surfaces on the A Chain of Shiga-Like Toxin 1 Recognize the C-Terminal Domain of Ribosomal Stalk Proteins

(2012) Andrew J. McCluskey et al.   PLoS One

Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis

(2012) S. Mukhopadhyay et al.   SCIENCE

Protein palmitoylation and subcellular trafficking

(2011) Clara Aicart-Ramos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Thin-layer chromatography, overlay technique and mass spectrometry: A versatile triad advancing glycosphingolipidomics

(2011) Iris Meisen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Shiga toxin (Stx)1B and Stx2B induce von Willebrand factor secretion from human umbilical vein endothelial cells through different signaling pathways

(2011) F. Liu et al.   BLOOD

Activation of cell stress response pathways by Shiga toxins

(2011) Vernon L. Tesh   CELLULAR MICROBIOLOGY

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

(2011) Alfred H. Merrill   CHEMICAL REVIEWS

Innate immunity in the vasculature: interactions with pathogenic bacteria

(2011) Mark Harding et al.   CURRENT OPINION IN MICROBIOLOGY

Inhibition of terminal complement activation in severe Shiga toxin-associated HUS - perfect example for a fast track from bench to bedside

(2011) Dorothea Orth-Höller et al.   EMBO Molecular Medicine

Enterohaemorrhagic Escherichia coli haemolysin is cleaved and inactivated by serine protease EspPα

(2011) Jens Brockmeyer et al.   ENVIRONMENTAL MICROBIOLOGY

Unique ganglioside binding by botulinum neurotoxins C and D-SA

(2011) Abby R. Kroken et al.   FEBS Journal

Bacteriophages carrying Shiga toxin genes: genomic variations, detection and potential treatment of pathogenic bacteria

(2011) Joanna M Łoś et al.   Future Microbiology

Differential Response of the Human Renal Proximal Tubular Epithelial Cell Line HK-2 to Shiga Toxin Types 1 and 2

(2011) Erin K. Lentz et al.   INFECTION AND IMMUNITY

Molecular Mechanisms That Mediate Colonization of Shiga Toxin-Producing Escherichia coli Strains

(2011) Mauricio J. Farfan et al.   INFECTION AND IMMUNITY

From simple to complex: investigating the effects of lipid composition and phase on the membrane interactions of biomolecules using in situ atomic force microscopy

(2011) Jian Zhong   Integrative Biology

Change in Conformation with Reduction of α-Helix Content Causes Loss of Neutrophil Binding Activity in Fully Cytotoxic Shiga Toxin 1

(2011) Maurizio Brigotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of Multilocus Variable-Number Tandem-Repeat Analysis and Multilocus Sequence Typing for Differentiation of Hemolytic-Uremic Syndrome-Associated Escherichia coli (HUSEC) Collection Strains

(2011) C. Jenke et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Intracellular Lipid Flux and Membrane Microdomains as Organizing Principles in Inflammatory Cell Signaling

(2011) M. B. Fessler et al.   JOURNAL OF IMMUNOLOGY

Encephalopathy, disseminated intravascular coagulation, and hemolytic–uremic syndrome after infection with enterohemorrhagic Escherichia coli O111

(2011) Sadaya Matano et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Shiga toxin glycosphingolipid receptors in microvascular and macrovascular endothelial cells: differential association with membrane lipid raft microdomains

(2011) Josefine Betz et al.   JOURNAL OF LIPID RESEARCH

Recent outbreak of hemolytic uremic syndrome in Germany

(2011) Ulrich Kunzendorf et al.   KIDNEY INTERNATIONAL

Treatment of severe neurological deficits with IgG depletion through immunoadsorption in patients with Escherichia coli O104:H4-associated haemolytic uraemic syndrome: a prospective trial

(2011) Andreas Greinacher et al.   LANCET

Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study

(2011) Martina Bielaszewska et al.   LANCET INFECTIOUS DISEASES

Fatal hemorrhage induced by subtilase cytotoxin from Shiga-toxigenic Escherichia coli

(2011) Takeshi Furukawa et al.   MICROBIAL PATHOGENESIS

Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages

(2011) R. N. Jinadasa et al.   MICROBIOLOGY-SGM

Tumor-Specific Targeting of Pancreatic Cancer with Shiga Toxin B-Subunit

(2011) M. Maak et al.   MOLECULAR CANCER THERAPEUTICS

Cholesterol modulates glycolipid conformation and receptor activity

(2011) Daniel Lingwood et al.   Nature Chemical Biology

Eculizumab in Severe Shiga-Toxin–Associated HUS

(2011) Anne-Laure Lapeyraque et al.   NEW ENGLAND JOURNAL OF MEDICINE

Epidemic Profile of Shiga-Toxin–ProducingEscherichia coliO104:H4 Outbreak in Germany

(2011) Christina Frank et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prospective Genomic Characterization of the German Enterohemorrhagic Escherichia coli O104:H4 Outbreak by Rapid Next Generation Sequencing Technology

(2011) Alexander Mellmann et al.   PLoS One

Structural remodeling, trafficking and functions of glycosylphosphatidylinositol-anchored proteins

(2011) Yusuke Maeda et al.   PROGRESS IN LIPID RESEARCH

Lipid-Mediated Endocytosis

(2011) H. Ewers et al.   Cold Spring Harbor Perspectives in Biology

Membrane Organization and Lipid Rafts

(2011) K. Simons et al.   Cold Spring Harbor Perspectives in Biology

Shiga Toxin Interaction with Human Intestinal Epithelium

(2011) Stephanie Schüller   Toxins

Shiga Toxin: Expression, Distribution, and Its Role in the Environment

(2011) Steven A. Mauro et al.   Toxins

Molecular make-up of the glomerular filtration barrier

(2010) Jaakko Patrakka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor

(2010) Valentina Arfilli et al.   BIOCHEMICAL JOURNAL

Host-cell lipid rafts: a safe door for micro-organisms?

(2010) Flávia Sarmento Vieira et al.   BIOLOGY OF THE CELL

Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice

(2010) J. Huang et al.   BLOOD

Lipid rafts: Keys to neurodegeneration

(2010) Cara-Lynne Schengrund   BRAIN RESEARCH BULLETIN

Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches

(2010) Filipa Lourenço Cardoso et al.   BRAIN RESEARCH REVIEWS

Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation

(2010) J. H. Chidlow et al.   CARDIOVASCULAR RESEARCH

LEEways: tales of EPEC, ATEC and EHEC

(2010) M. Alexander Schmidt   CELLULAR MICROBIOLOGY

Shiga Toxin–Producing Escherichia coli (STEC)

(2010) John M. Hunt   CLINICS IN LABORATORY MEDICINE

Ceramide-rich platforms in transmembrane signaling

(2010) Branka Stancevic et al.   FEBS LETTERS

Protein toxins from plants and bacteria: Probes for intracellular transport and tools in medicine

(2010) Kirsten Sandvig et al.   FEBS LETTERS

Toll-like receptor 4 facilitates binding of Shiga toxin to colon carcinoma and primary umbilical vein endothelial cells

(2010) Maria L. Torgersen et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Escherichia coli O157:H7: Animal Reservoir and Sources of Human Infection

(2010) Witold A. Ferens et al.   Foodborne Pathogens and Disease

Induction of apoptosis by Shiga toxins

(2010) Vernon L Tesh   Future Microbiology

Structural characterization and dynamics of globotetraosylceramide in vascular endothelial cells under TNF-α stimulation

(2010) Tetsuya Okuda et al.   GLYCOCONJUGATE JOURNAL

A Major Fraction of Glycosphingolipids in Model and Cellular Cholesterol-containing Membranes Is Undetectable by Their Binding Proteins

(2010) Radhia Mahfoud et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Label-free quantitative cell division monitoring of endothelial cells by digital holographic microscopy

(2010) Björn Kemper et al.   JOURNAL OF BIOMEDICAL OPTICS

Shiga Toxin 2–Specific but Not Shiga Toxin 1–Specific Human Monoclonal Antibody Protects Piglets Challenged with EnterohemorrhagicEscherichia coliProducing Shiga Toxin 1 and Shiga Toxin 2

(2010) Kwang‐il Jeong et al.   JOURNAL OF INFECTIOUS DISEASES

Tissue Factor–Dependent Procoagulant Activity of Subtilase Cytotoxin, a Potent AB5Toxin Produced by Shiga ToxigenicEscherichia coli

(2010) Hui Wang et al.   JOURNAL OF INFECTIOUS DISEASES

Endothelial damage induced by Shiga toxins delivered by neutrophils during transmigration

(2010) Maurizio Brigotti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutral glycosphingolipids in human blood: a precise mass spectrometry analysis with special reference to lipoprotein-associated Shiga toxin receptors

(2010) Christian H. Schweppe et al.   JOURNAL OF LIPID RESEARCH

Escherichia coli O157

(2010) Hugh Pennington   LANCET

Enhanced expression of ATP-binding cassette transporter A1 in non-rafts decreases the sensitivity of vascular endothelial cells to Shiga toxin

(2010) Nobutaka Higashi et al.   MICROBIAL PATHOGENESIS

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glomerular diseases: genetic causes and future therapeutics

(2010) Chih-Kang Chiang et al.   Nature Reviews Nephrology

Shiga toxin-associated hemolytic uremic syndrome: pathophysiology of endothelial dysfunction

(2010) Carla Zoja et al.   PEDIATRIC NEPHROLOGY

Interplay between Toxin Transport and Flotillin Localization

(2010) Sascha Pust et al.   PLoS One

A lipid matrix model of membrane raft structure

(2010) Peter J. Quinn   PROGRESS IN LIPID RESEARCH

On the structural diversity of Shiga toxin glycosphingolipid receptors in lymphoid and myeloid cells determined by nanoelectrospray ionization tandem mass spectrometry

(2010) Petra Hoffmann et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Pathophysiology of Typical Hemolytic Uremic Syndrome

(2010) Diana Karpman et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Treatment of Typical (Enteropathic) Hemolytic Uremic Syndrome

(2010) Martin Bitzan et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

EnterohemorrhagicEscherichia coliO26:H11–Associated Hemolytic Uremic Syndrome: Bacteriology and Clinical Presentation

(2010) Lothar-Bernd Zimmerhackl et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Complement in Typical Hemolytic Uremic Syndrome

(2010) Dorothea Orth et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells

(2010) Andreas Bauwens et al.   THROMBOSIS AND HAEMOSTASIS

Lipid Cosorting Mediated by Shiga Toxin Induced Tubulation

(2010) Mahassine Safouane et al.   TRAFFIC

Structure, biological functions and applications of the AB5 toxins

(2010) Travis Beddoe et al.   TRENDS IN BIOCHEMICAL SCIENCES

Exploring the caves: cavins, caveolins and caveolae

(2010) Carsten G. Hansen et al.   TRENDS IN CELL BIOLOGY

Escherichia coli Shiga Toxin Mechanisms of Action in Renal Disease

(2010) Tom G. Obrig   Toxins

Escherichia coli Subtilase Cytotoxin

(2010) Adrienne W. Paton et al.   Toxins

Shiga toxin and its use in targeted cancer therapy and imaging

(2010) Nikolai Engedal et al.   Microbial Biotechnology

Safety and Pharmacokinetics of Chimeric Anti-Shiga Toxin 1 and Anti-Shiga Toxin 2 Monoclonal Antibodies in Healthy Volunteers

(2009) M. Bitzan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

FLIM-FRET and FRAP reveal association of influenza virus haemagglutinin with membrane rafts

(2009) Stephanie Engel et al.   BIOCHEMICAL JOURNAL

New aspects of the regulation of glycosphingolipid receptor function

(2009) Clifford A. Lingwood et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Pathogenesis and treatment of Shiga toxin-producing Escherichia coli infections

(2009) Antonio Serna et al.   CURRENT OPINION IN GASTROENTEROLOGY

Gangliosides in cell recognition and membrane protein regulation

(2009) Pablo HH Lopez et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Sphingolipids and membrane environments for caveolin

(2009) Sandro Sonnino et al.   FEBS LETTERS

Membrane glycolipids in stem cells

(2009) Robert K. Yu et al.   FEBS LETTERS

Significance of glycosphingolipid fatty acid chain length on membrane microdomain-mediated signal transduction

(2009) Kazuhisa Iwabuchi et al.   FEBS LETTERS

Glycosphingolipids in microdomain formation and their spatial organization

(2009) Garima Gupta et al.   FEBS LETTERS

Globotriaosyl ceramide receptor function - Where membrane structure and pathology intersect

(2009) C.A. Lingwood et al.   FEBS LETTERS

Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motility

(2009) Sen-itiroh Hakomori   FEBS LETTERS

Intrahost Genome Alterations in Enterohemorrhagic Escherichia coli

(2009) Alexander Mellmann et al.   GASTROENTEROLOGY

Automated three-dimensional tracking of living cells by digital holographic microscopy

(2009) Patrik Langehanenberg et al.   JOURNAL OF BIOMEDICAL OPTICS

Molecular mechanisms of clathrin-independent endocytosis

(2009) C. G. Hansen et al.   JOURNAL OF CELL SCIENCE

Shiga Toxin, Cytolethal Distending Toxin, and Hemolysin Repertoires in Clinical Escherichia coli O91 Isolates

(2009) M. Bielaszewska et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Shiga Toxin Activates Complement and Binds Factor H: Evidence for an Active Role of Complement in Hemolytic Uremic Syndrome

(2009) Dorothea Orth et al.   JOURNAL OF IMMUNOLOGY

Cell entry strategy of clostridial neurotoxins

(2009) Thomas Binz et al.   JOURNAL OF NEUROCHEMISTRY

Treatment options for HUS secondary to Escherichia coli O157:H7

(2009) Martin Bitzan   KIDNEY INTERNATIONAL

A dietary non-human sialic acid may facilitate hemolytic-uremic syndrome

(2009) Jonas C. Löfling et al.   KIDNEY INTERNATIONAL

Detergent-resistant globotriaosyl ceramide may define verotoxin/glomeruli-restricted hemolytic uremic syndrome pathology

(2009) Fahima Khan et al.   KIDNEY INTERNATIONAL

Pathogenomics of the Virulence Plasmids of Escherichia coli

(2009) T. J. Johnson et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Vesicular stabilization and activity augmentation of enterohaemorrhagicEscherichia colihaemolysin

(2009) Thomas Aldick et al.   MOLECULAR MICROBIOLOGY

Shiga Toxin Receptor Gb3Cer/CD77: Tumor-Association and Promising Therapeutic Target in Pancreas and Colon Cancer

(2009) Ute Distler et al.   PLoS One

Receptor and substrate interactions of clostridial neurotoxins

(2009) Axel T. Brunger et al.   TOXICON

Endocytosis and retrograde transport of Shiga toxin

(2009) Kirsten Sandvig et al.   TOXICON

Glycosphingolipid Requirements for Endosome-to-Golgi Transport of Shiga Toxin

(2009) Hilde Raa et al.   TRAFFIC

Verocytotoxin-producing Escherichia coli (VTEC)

(2009) Mohamed A. Karmali et al.   VETERINARY MICROBIOLOGY

Mechanisms of Endothelial Dysfunction, Injury, and Death

(2008) Jordan S. Pober et al.   Annual Review of Pathology-Mechanisms of Disease

Glycosphingolipid behaviour in complex membranes

(2008) Alessandro Prinetti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

How the molecular features of glycosphingolipids affect domain formation in fluid membranes

(2008) Bodil Westerlund et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Shiga toxin 1 induces apoptosis through the endoplasmic reticulum stress response in human monocytic cells

(2008) Sang-Yun Lee et al.   CELLULAR MICROBIOLOGY

Biophysical approaches to protein-induced membrane deformations in trafficking

(2008) Pierre Sens et al.   CURRENT OPINION IN CELL BIOLOGY

Role of very long fatty acid-containing glycosphingolipids in membrane organization and cell signaling: the model of lactosylceramide in neutrophils

(2008) Sandro Sonnino et al.   GLYCOCONJUGATE JOURNAL

Glycosphingolipids in vascular endothelial cells: relationship of heterogeneity in Gb3Cer/CD77 receptor expression with differential Shiga toxin 1 cytotoxicity

(2008) Christian H. Schweppe et al.   GLYCOCONJUGATE JOURNAL

Clathrin-independent endocytosis: from nonexisting to an extreme degree of complexity

(2008) Kirsten Sandvig et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Shiga Toxin 2 Causes Apoptosis in Human Brain Microvascular Endothelial Cells via C/EBP Homologous Protein

(2008) J. Fujii et al.   INFECTION AND IMMUNITY

Differential intracellular transport and binding of verotoxin 1 and verotoxin 2 to globotriaosylceramide‐containing lipid assemblies

(2008) Patty Tam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Shiga Toxin 2 Affects the Central Nervous System through Receptor Globotriaosylceramide Localized to Neurons

(2008) Fumiko Obata et al.   JOURNAL OF INFECTIOUS DISEASES

Interactions between Shiga toxins and human polymorphonuclear leukocytes

(2008) Maurizio Brigotti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fatty acid-dependent globotriaosyl ceramide receptor function in detergent resistant model membranes

(2008) Radhia Mahfoud et al.   JOURNAL OF LIPID RESEARCH

The challenge of lipid rafts

(2008) Linda J. Pike   JOURNAL OF LIPID RESEARCH

Effect of Gb3 in lipid rafts in resistance to Shiga-like toxin of mutant Vero cells

(2008) Tatsuo Hanashima et al.   MICROBIAL PATHOGENESIS

Human colorectal tumors and metastases express Gb3 and can be targeted by an intestinal pathogen-based delivery tool

(2008) T. Falguieres et al.   MOLECULAR CANCER THERAPEUTICS

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE

Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin

(2008) Emma Byres et al.   NATURE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Shiga-toxin-induced firm adhesion of human leukocytes to endothelium is in part mediated by heparan sulfate

(2008) J. Geelen et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Inhibition of water absorption in human proximal tubular epithelial cells in response to Shiga toxin-2

(2008) Claudia Silberstein et al.   PEDIATRIC NEPHROLOGY

Treatment and outcome of Shiga-toxin-associated hemolytic uremic syndrome (HUS)

(2008) Johanna Scheiring et al.   PEDIATRIC NEPHROLOGY

Role of glycosphingolipid-enriched microdomains in innate immunity: Microdomain-dependent phagocytic cell functions

(2007) Fumiko Yoshizaki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structure and function of glycosphingolipids and sphingolipids: Recollections and future trends

(2007) Sen-itiroh Hakomori   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Functional role of glycosphingolipids and gangliosides in control of cell adhesion, motility, and growth, through glycosynaptic microdomains

(2007) Adriane Regina Todeschini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS