Article
Neurosciences
Aaron W. Beger, Kathleen A. Hauther, Beatrix Dudzik, Randall L. Woltjer, Paul L. Wood
Summary: Human brain lipidomics studies have revealed the structural lipids and lipid signal transduction pathways in neurological diseases. The potential of formalin-fixed whole body donors as supplemental tissue sources for lipid analysis, particularly in neurologic diseases, has been demonstrated through comparing lipid profiles of fresh and fixed brain tissue.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Microbiology
Wouter J. C. Feitz, Romy Bouwmeester, Thea J. A. M. van der Velden, Susan Goorden, Christoph Licht, Lambert P. J. W. van den Heuvel, Nicole C. A. J. van de Kar
Summary: This study suggests that inhibiting the synthesis of Gb3 could be a potential therapeutic target for protecting against (further) endothelial damage caused by Stx in the future.
Review
Chemistry, Organic
Cecilia Romano, Mads H. Clausen
Summary: Invariant natural killer T (iNKT) cells are a subpopulation of T lymphocytes stimulated by synthetic glycolipid alpha-galactosylceramide (alpha-GalCer) in complex with the CD1d receptor. Through cytokine production and co-stimulation of other lymphocytes, iNKT cells play a central role in directing immune responses in various physiological processes. Synthetic chemistry has advanced the field of iNKT cell stimulation, leading to the development of more efficient approaches and analogs for therapeutic applications.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Safoura Reza, Maciej Ugorski, Jaroslaw Suchanski
Summary: GlcCer and GalCer are involved in various physiological and pathological processes, playing important roles in maintaining myelin stability and differentiation of oligodendrocytes. Enzyme studies indirectly reveal the biological significance of these monohexosylcermides.
Review
Microbiology
Chunmiao Jiang, Jinxin Ge, Bin He, Bin Zeng
Summary: Filamentous fungi are economically important fungi used in various productions such as fermented foods and industrial enzymes. Glycosphingolipids (GSLs) play crucial roles in growth, differentiation, and stress response in filamentous fungi. GSLs found in filamentous fungi can be classified into neutral GSLs and acidic GSLs, with glycosylceramides playing important roles in skin-barrier function and potential dietary benefits.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Organic
Daniela Imperio, Laura Morelli, Federica Compostella, Luigi Panza
Summary: A concise and stereoselective synthesis of alpha-GalCer was achieved by utilizing carefully designed protecting groups on both the donor and the acceptor to control the stereochemistry of the glycosylation reaction. This synthetic strategy proved to be efficient, giving good yields of alpha-GalCer in a small number of steps.
Article
Microbiology
Jannatul F. Shoma, Ben Ernan, Griffin Keiser, Christian Heiss, Parastoo Azadi, Stephen J. Free
Summary: Through mutant phenotypic study, it was found that the acidic glycosphingolipid (GSL) biosynthetic pathway is essential for the viability of Neurospora crassa, while the neutral GSL biosynthetic pathway is essential for the normal growth and development of N. crassa.
Article
Chemistry, Medicinal
Xi-Feng Wang, Meng-Jia Zhang, Na He, Ya-Cong Wang, Cheng Yan, Xiang-Zhao Chen, Xiao-Fei Gao, Jun Guo, Rui Luo, Zheng Liu
Summary: The use of adjuvants can enhance the immunogenicity of COVID-19 vaccines and save on antigens. Experiments have shown that using the Th2-biasing agonist C20:2 at a low dose can generate higher titers of neutralizing antibodies.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Marc Caballe, Magda Faijes, Antoni Planas
Summary: Glycolipids, a type of complex molecule involved in important cellular processes, have attracted attention in biomedicine due to the immunostimulatory capabilities of a glycosphingolipid called alpha-galactosylceramide. Researchers have identified an enzyme, called ceramide glycosyltransferase, capable of synthesizing this glycolipid under specific conditions. Further protein engineering may enhance the stability and activity of this enzyme for the enzymatic synthesis of alpha-GalCer in biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Jahangir Iqbal, Abeer Al Otaibi, Sindiyan Alshaikh Mubarak, Ali Alqarni, Ahmed Bakillah
Summary: ABCC10 is involved in the synthesis and efflux of GlcCer, with its inhibition affecting both processes.
Article
Biochemistry & Molecular Biology
Remi Planes, Elmostafa Bahraoui
Summary: The study demonstrates that HIV-1, HIV-2, and SIV envelope glycoproteins interact not only with galactosylceramide (GalCer), but also with glucosylceramide (GlcCer), lactosylceramide (LacCer), and ceramide. These interactions were confirmed through molecular binding and physicochemical assays. The results showed specific interactions between iodinated radiolabeled HIV glycoproteins and the glycolipids/lipids, as demonstrated by dose-dependent inhibition and the absence of interaction with unrelated control proteins. The interactions were further confirmed through a physicochemical assay, which showed an increase in surface pressure of the glycolipid/lipid films upon addition of HIV envelope glycoproteins. Overall, these interactions may play a role in facilitating infection or activating signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
David Szamosvari, Munhyung Bae, Sunghee Bang, Betsabeh Khoramian Tusi, Chelsi D. Cassilly, Sung-Moo Park, Daniel B. Graham, Ramnik J. Xavier, Jon Clardy
Summary: This article explains what the immunogens for Lyme disease are, and points out the importance of making headgroup structural changes to the immunogens for the diagnosis, prevention, and treatment of the disease.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Urology & Nephrology
Behzad Najafian, Aurelio Silvestroni, Alexey Sokolovskiy, Camilla Tondel, Einar Svarstad, Bogdan Obrisca, Gener Ismail, Myrl D. Holida, Michael Mauer
Summary: A novel method was developed to quantify substance volume in affected podocytes of females with Fabry disease, leading to important new observations. The study found that the condition of F+ podocytes in females with Fabry disease is similar to males and worsens with age.
KIDNEY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Shannon J. McKie, Alex S. Nicholson, Emily Smith, Stuart Fawke, Eve R. Caroe, James C. Williamson, Benjamin G. Butt, Denisa Kolarova, Ondrej Peterka, Michal Holcapek, Paul J. Lehner, Stephen C. Graham, Janet E. Deane
Summary: Myelin is a multilayered membrane that tightly wraps neuronal axons, enabling efficient, high-speed signal propagation. This study reveals that altered lipid metabolism affects the abundance of specific plasma membrane proteins, which play important roles in cell adhesion and signaling, and are implicated in neurological diseases. The study also demonstrates the direct interaction between the adhesion molecule neurofascin (NFASC) and the sphingolipid sulfatide, providing insights into the pathogenesis of demyelinating diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Multidisciplinary
Taishi Miura, Makoto Yoritate, Go Hirai
Summary: In this study, a protection-group-free and photoredox-catalyzed C-glycosylation method using glycosyl sulfinates and Michael acceptors via the Giese radical addition is reported. This method provides a useful tool for synthesizing C-glycoside analogs of naturally occurring glycoconjugates in chemical biology studies.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Dominika M. Zacharski, Simone Brandt, Stefan Esch, Simone Koenig, Michael Mormann, Gudrun Ulrich-Merzenich, Andreas Hensel
Article
Nanoscience & Nanotechnology
Camila F. Borgognoni, Michael Mormann, Ying Qu, Marcus Schaefer, Klaus Langer, Cengiz Oeztuerk, Sylvia Wagner, Chunying Chen, Yuliang Zhao, Harald Fuchs, Kristina Riehemann
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2015)
Article
Biochemistry & Molecular Biology
Debparna Datta, Gottfried Pohlentz, Mona Schulte, Mathias Kaiser, Francisco M. Goycoolea, Johannes Muething, Michael Mormann, Musti J. Swamy
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2016)
Article
Cell Biology
Josefine Betz, Isabel Dorn, Ivan U. Kouzel, Andreas Bauwens, Iris Meisen, Bjoern Kemper, Martina Bielaszewska, Michael Mormann, Lena Weymann, Walter Sibrowski, Helge Karch, Peter Schlenke, Johannes Muething
CELLULAR MICROBIOLOGY
(2016)
Article
Chemistry, Analytical
Daniel Steil, Gottfried Pohlentz, Nadine Legros, Michael Mormann, Alexander Mellmann, Helge Karch, Johannes Muething
ANALYTICAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Dominika M. Zacharski, Stefan Esch, Simone Koenig, Michael Mormann, Simone Brandt, Gudrun Ulrich-Merzenich, Andreas Hensel
Article
Biochemistry & Molecular Biology
Kishore Babu Bobbili, Gottfried Pohlentz, Akkaladevi Narahari, Kaushal Sharma, Avadhesha Surolia, Michael Mormann, Musti J. Swamy
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Biochemistry & Molecular Biology
Kishore Babu Bobbili, Debparna Datta, Saradamoni Mondal, Sirilatha Polepalli, Gottfried Pohlentz, Michael Mormann, Musti J. Swamy
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Biochemistry & Molecular Biology
Kaur Manjeet, Jogi Madhuprakash, Michael Mormann, Bruno M. Moerschbacher, Appa Rao Podile
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Biology
Debparna Datta, Gottfried Pohlentz, Saradamoni Mondal, M. Bala Divya, Lalitha Guruprasad, Michael Mormann, Musti J. Swamy
JOURNAL OF BIOSCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Zalilawati Mat Rashid, Michael Mormann, Katja Steckhan, Alena Peters, Stefan Esch, Andreas Hensel
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Biochemical Research Methods
Stefan Schulze, Anne Oltmanns, Christian Fufezan, Julia Kraegenbring, Michael Mormann, Mechthild Pohlschroeder, Michael Hippler
Article
Chemistry, Applied
Roberta Paulert, Fabrice Brunel, Rebecca L. J. Melcher, Stefan Cord-Landwehr, Anna Niehues, Michael Mormann, Bruno M. Moerschbacher
Summary: Ulvans from green algae exhibit elicitor activity in plants, with desulfated ulvan dimers identified as the smallest active units. This discovery provides a promising biologic for sustainable agriculture.
CARBOHYDRATE POLYMERS
(2021)
Article
Immunology
Felix Kuhne, Lea Bonnington, Sebastian Malik, Marco Thomann, Cecile Avenal, Florian Cymer, Harald Wegele, Dietmar Reusch, Michael Mormann, Patrick Bulau
Article
Chemistry, Analytical
Stefan Cord-Landwehr, Phillip Ihmor, Anna Niehues, Heinrich Luftmann, Bruno M. Moerschbacher, Michael Mormann
ANALYTICAL CHEMISTRY
(2017)