Article
Biochemistry & Molecular Biology
Jie Wang, Yi Wu, Yecheng Wang, Yajun Shuai, Zongpu Xu, Quan Wan, Yuyin Chen, Mingying Yang
Summary: A composite matrix based on silk fibroin and graphene oxide was designed to improve the cell adhesion and direct the differentiation of MSCs into cardiac myocytes. The results showed that the composite matrix significantly enhanced the cardiomyogenic differentiation of MSCs, suggesting its potential application in myocardial repair tissue engineering.
Article
Cell Biology
Hao Zhang, Chengling Zhao, Guojun Jiang, Bei Hu, Huifeng Zheng, Yimei Hong, Zhen Cui, Linli Shi, Xin Li, Fang Lin, Yue Ding, Lu Wei, Mimi Li, Xiaoting Liang, Yuelin Zhang
Summary: The study found that Apelin rejuvenated AMSCs by activating AMPK, promoting autophagy, and enhancing cardiac protection following myocardial infarction in mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Min Ah Han, Jeong Hwa Jeon, Ji Young Shin, Hee Jung Kim, Ji Soo Lee, Chae Won Seo, Ye Jin Yun, Mi Yun Yoon, Jong Tae Kim, Young Il Yang, Seung Jin Lee
Summary: Strategies for stem cell-based cardiac regeneration and repair, specifically cardiac stem cells (CSCs) and the use of cellular spheroids, have shown promising therapeutic potential for ischemic heart disease. The optimized spheroid culture conditions enhance the expression levels of factors related to cardiac regeneration, leading to improved retention rates and significant cardiac regeneration effects in animal models. Intramyocardial administration of CSC spheroids could serve as an advanced therapeutic modality for enhanced cell engraftment and regenerative abilities in cardiac repair post-myocardial infarction.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Medicine, Research & Experimental
Deguan Lv, Xuling Luo, Zhe Chen, Jiaqi Liu, Meiqing Liu, Yao Li, Shifang Huang, Mingzhu Tang, Li Yang, Liqun Lu, Jinyong Jiang, Qionglin Zhou, Feng Xie, Cuiqing Zhong, Lanfang Li, Linxi Chen
Summary: This study reveals that apelin induces autophagy activation in lung adenocarcinoma cells, promoting cell migration through regulating BECN1 transcription via HIF1A. The findings suggest a potential therapeutic target for lung adenocarcinoma through targeting apelin-induced autophagy.
Article
Multidisciplinary Sciences
Liuying Hu, Yumiko Hayashi, Hiroyasu Kidoya, Nobuyuki Takakura
Summary: The Apelin/APJ signaling pathway plays a role in regulating tumor growth by inducing vascular maturation and enhancing anti-tumor immunity. Lack of Apelin leads to increased tumor growth, while treatment with [Pyr(1)]Apelin-13 inhibits tumor growth.EC-derived Apelin may regulate tumor formation in an autocrine manner by expressing APJ, and Apelin induces chemokine CCL8 expression in ECs. These findings suggest that Apelin acts as a tumor suppressor by enhancing the infiltration of CD8(+) T cells into tumors and inhibiting tumor growth.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Yunqian Guan, Ren Wang, Xiaobo Li, Haiqiang Zou, Wenxiu Yu, Zhaohui Liang, Lei Li, Ling Chen, Liping Zhou, Zhiguo Chen
Summary: The study found that astrocytes, not microglia, were the main source of TNF-alpha expression in the infarct area of rats after ischemia. MSC transplantation was shown to suppress TNF-alpha expression by astrocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Multidisciplinary Sciences
Mark M. Zaki, Emal Lesha, Khaled Said, Kiavash Kiaee, Lindsey Robinson-McCarthy, Haydy George, Angy Hanna, Evan Appleton, Songlei Liu, Alex H. M. Ng, Parastoo Khoshakhlagh, George M. Church
Summary: COVID-19 continues to burden society worldwide, with severe presentations lacking specific treatments. Cell therapies, with their customizability and regenerative function, offer great potential in treating severe COVID-19 cases beyond lung issues. There are currently 89 cell therapy trials ongoing in the field of COVID-19.
Article
Biochemistry & Molecular Biology
Lingyu Ye, Yujia Huang, Xueqing Liu, Xinyu Zhang, Yang Cao, Xiangju Kong, Xiaolei Yuan, Jie Xu, Hui Zhu
Summary: The study revealed that women with preeclampsia had increased maternal apelin concentration but reduced APJ expression in the placenta. Treatment with apelin-13 could attenuate oxidative stress injury in placental trophoblasts through the activation of the PI3K/AKT signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoting Liang, Yuelin Zhang, Fang Lin, Mimi Li, Xin Li, Yu Chen, Jing Liu, Qingshu Meng, Xiaoxue Ma, Enhao Wang, Lu Wei, Zhiying He, Huimin Fan, Xiaohui Zhou, Yue Ding, Zhongmin Liu
Summary: Direct transplantation of mitochondria derived from mesenchymal stem cells (MSC-mt) can enhance blood vessel density, inhibit cardiac remodeling and apoptosis, thus improving heart function. MSC-mt also has protective effects on endothelial cells.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Engineering, Biomedical
Ravi K. Ghanta, Aarthi Pugazenthi, Yunge Zhao, Christopher Sylvester, Mathew J. Wall, Rachel A. Mazur, Lauren N. Russell, Kyle J. Lampe
Summary: Injectable intramyocardial biomaterials have the potential to limit adverse ventricular remodeling through mechanical and biologic mechanisms. This study investigates the impact of biomaterial stiffness on ventricular mechanics in myocardial infarcts and demonstrates that high stiffness biomaterials can improve post-infarct ventricular mechanics and prevent negative tissue remodeling.
ACTA BIOMATERIALIA
(2022)
Review
Cell Biology
Natalia Respekta, Karolina Pich, Monika Dawid, Ewa Mlyczynska, Patrycja Kurowska, Agnieszka Rak
Summary: The apelinergic system, consisting of apelin, ELABELA, and the apelin receptor APJ, plays a multifaceted role in various biological functions. This review focuses on the role of the apelinergic system in cell apoptosis and highlights the signaling pathways involved, such as PI3K, ERK1/2, AKT, AMPK, and PKA. Dysregulation of apoptosis can lead to pathological conditions, and the apelinergic system shows potential as a therapeutic target in various diseases.
Article
Oncology
Xia-Qiu Tian, Xiao-Song Qian, Hong Wang, Yue-Jin Yang
Summary: This study found that adiponectin (APN) can promote the survival of transplanted mesenchymal stem cells (MSCs) after acute myocardial infarction (AMI) by activating the adenosine monophosphate-activated protein kinase (AMPK) signaling pathway. APN treatment improved cardiac function, reduced infarct size, suppressed inflammation, inhibited cardiomyocyte apoptosis, and increased arteriogenesis and angiogenesis in the peri-infarct myocardium. These effects were associated with AMPK phosphorylation and partially reversed by AMPK pathway inhibitors.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Cell Biology
Hui Wang, Linjing Cong, Xianghong Yin, Nan Zhang, Min Zhu, Tingting Sun, Junming Fan, Feng Xue, Xiaofang Fan, Yongsheng Gong
Summary: Activation of the Apelin-APJ axis can alleviate LPS-induced pulmonary fibrosis by activating ACE2, and ubiquitination may contribute to pulmonary fibrosis.
CELLULAR SIGNALLING
(2022)
Article
Medicine, General & Internal
Yu Ning, Peisen Huang, Guihao Chen, Yuyan Xiong, Zhaoting Gong, Chunxiao Wu, Junyan Xu, Wenyang Jiang, Xiaosong Li, Ruijie Tang, Lili Zhang, Mengjin Hu, Jing Xu, Jun Xu, Haiyan Qian, Chen Jin, Yuejin Yang
Summary: This study found that MSCATV-EV, derived from ATV-treated MSCs, has a good cardiac repair effect on acute myocardial infarction. The results showed that MSCATV-EV alleviated inflammation in the infarct region by regulating macrophage polarization. Additionally, the study identified the miR-139-3p/Stat1 pathway as the mechanism underlying the promotion of macrophage polarization by MSCATV-EV.
Article
Biochemistry & Molecular Biology
Beschan Ahmad, Anna Skorska, Markus Wolfien, Haval Sadraddin, Heiko Lemcke, Praveen Vasudevan, Olaf Wolkenhauer, Gustav Steinhoff, Robert David, Ralf Gaebel
Summary: This study investigated the effects of mesenchymal stem cell (MSC) injection on post-infarction arrhythmias. The results showed that MSC therapy after double infarction significantly reduced simple and complex arrhythmias. RNA sequencing analysis also revealed a decline in arrhythmias and reduced inflammatory pathways. Additionally, the study identified highly expressed genes linked to lowering the risk of heart failure, cardiomyopathy, and sudden cardiac death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Ying Zhang, Lihua Sun, Lina Xuan, Zhenwei Pan, Kang Li, Shuangshuang Liu, Yuechao Huang, Xuyun Zhao, Lihua Huang, Zhiguo Wang, Yan Hou, Junnan Li, Ye Tian, Jiahui Yu, Hui Han, Yanhong Liu, Fei Gao, Yong Zhang, Shu Wang, Zhimin Du, Yanjie Lu, Baofeng Yang
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Lina Xuan, Lihua Sun, Ying Zhang, Yuechao Huang, Yan Hou, Qingqi Li, Ying Guo, Bingbing Feng, Lina Cui, Xiaoxue Wang, Zhiguo Wang, Ye Tian, Bo Yu, Shu Wang, Chaoqian Xu, Mingyu Zhang, Zhimin Du, Yanjie Lu, Bao Feng Yang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2017)
Article
Oncology
Jiaqi Liu, Fei Sun, Yuying Wang, Wanqi Yang, Hongwen Xiao, Yue Zhang, Renzhong Lu, Haixia Zhu, Yuting Zhuang, Zhenwei Pan, Zhiguo Wang, Zhimin Du, Yanjie Lu
Article
Cell Biology
Yanan Jiang, Weijie Du, Qun Chu, Ying Qin, Gulnara Tuguzbaeva, Hui Wang, Anqi Li, Guiyang Li, Yanyao Li, Lu Chai, Er Yue, Xi Sun, Zhiguo Wang, Valentin Pavlov, Baofeng Yang, Yunlong Bai
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Gege Yan, Lai Zhang, Chao Feng, Rui Gong, Elina Idiiatullina, Qihe Huang, Mingyu He, Shuyuan Guo, Fan Yang, Yuan Li, Fengzhi Ding, Wenya Ma, Valentin Pavlov, Zhenbo Han, Zhiguo Wang, Chaoqian Xu, Benzhi Cai, Ye Yuan, Lei Yang
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Xuefeng Qu, Yue Du, You Shu, Ming Gao, Fei Sun, Shenjian Luo, Ti Yang, Linfeng Zhan, Yin Yuan, Wenfeng Chu, Zhenwei Pan, Zhiguo Wang, Baofeng Yang, Yanjie Lu
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Yong Zhang, Lihua Sun, Lina Xuan, Zhenwei Pan, Xueling Hu, Hongyu Liu, Yunlong Bai, Lei Jiao, Zhange Li, Lina Cui, Xiaoxue Wang, Siqi Wang, Tingting Yu, Bingbing Feng, Ying Guo, Zonghong Liu, Weixin Meng, Hequn Ren, Jiyuan Zhu, Xuyun Zhao, Chao Yang, Ying Zhang, Chaoqian Xu, Zhiguo Wang, Yanjie Lu, Hongli Shan, Baofeng Yang
NATURE COMMUNICATIONS
(2018)
Article
Pharmacology & Pharmacy
Xuexin Jin, Yuan Jiang, Genlong Xue, Yin Yuan, Haixia Zhu, Linfeng Zhan, Yining Zhuang, Qihe Huang, Ling Shi, Yue Zhao, Penghui Li, Yilin Sun, Wanzhen Su, Yang Zhang, Baofeng Yang, Yanjie Lu, Zhiguo Wang, Zhenwei Pan
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Genetics & Heredity
Hui Wang, Yuan Lv, Cao Wang, Dongjing Leng, Yan Yan, Moyondafoluwa Blessing Fasae, Syeda Madiha Zahra, Yanan Jiang, Zhiguo Wang, Baofeng Yang, Yunlong Bai
FRONTIERS IN GENETICS
(2019)
Article
Cardiac & Cardiovascular Systems
Jiamin Li, Chaoqian Xu, Yining Liu, Yuanshi Li, Sijia Du, Ruijie Zhang, Yuehang Sun, Ronghao Zhang, Ying Wang, Hongru Xue, Sha Ni, Mavlikhanova Asiya, Genlong Xue, Yanyao Li, Ling Shi, Desheng Li, Zhenwei Pan, Yong Zhang, Zhiguo Wang, Benzhi Cai, Ning Wang, Baofeng Yang
BASIC RESEARCH IN CARDIOLOGY
(2020)
Article
Immunology
Hui Wang, Yuan Lu, Yan Yan, Shanshan Tian, Dongjie Zheng, Dongjing Leng, Cao Wang, Jingfeng Jiao, Zhiguo Wang, Yunlong Bai
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Qingqi Li, Lei Jiao, Yingchun Shao, Mengmeng Li, Manyu Gong, Yuanyuan Zhang, Zhongyue Tan, Yanying Wang, Xuewen Yang, Zhiguo Wang, Ying Zhang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Pharmacology & Pharmacy
Hui Wang, Cao Wang, Yuan Lu, Yan Yan, Dongjing Leng, Shanshan Tian, Dongjie Zheng, Zhiguo Wang, Yunlong Bai
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Jin Ju, Dan Xiao, Nannan Shen, Tong Zhou, Hui Che, Xia Li, Shuqian Zhang, Justine Nyakango Mokembo, Nabanit Kumar Jha, Seth Mikaye Monayo, Zhiguo Wang, Yong Zhang
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2020)
Editorial Material
Engineering, Multidisciplinary
Zhiguo Wang