☆ 4.8 Editorial Material

Hot stuff: thyroid hormones and AMPK

CELL RESEARCH (2010)

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INST BIOCHEMISTRY & CELL BIOLOGY

DOI: 10.1038/cr.2010.153

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Cell Biology

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Summary: Plasmonic heating by nanoparticles has been utilized to enhance various chemical reactions. Now, thermoplasmonic activation has been extended to latent ruthenium catalysts for olefin metathesis triggered by visible and infrared light.

NATURE CHEMISTRY (2023)

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Article Physiology

Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis

Eva Rial-Pensado, Veronica Rivas-Limeres, Carmen Grijota-Martinez, Amanda Rodriguez-Diaz, Valentina Capelli, Olga Barca-Mayo, Ruben Nogueiras, Jens Mittag, Carlos Dieguez, Miguel Lopez

Summary: Thyroid hormones play a major role in regulating energy balance and BAT thermogenesis, and these actions are influenced by environmental temperature.

FRONTIERS IN PHYSIOLOGY (2022)

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Article Environmental Sciences

Bisphenol A promotes autophagy in ovarian granulosa cells by inducing AMPK/mTOR/ULK1 signalling pathway

Miaoling Lin, Rui Hua, Jing Ma, Yao Zhou, Pei Li, Xiya Xu, Zhiqiang Yu, Song Quan

Summary: This study demonstrated that BPA exposure could significantly decrease human ovarian functions and lead to abnormal folliculogenesis by activating autophagy in GCs through the AMPK/mTOR/ULK1 pathway.

ENVIRONMENT INTERNATIONAL (2021)

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Article Biochemistry & Molecular Biology

Metformin Attenuates Inflammation and Fibrosis in Thyroid-Associated Ophthalmopathy

Zhihui Xu, Huijing Ye, Wei Xiao, Anqi Sun, Shenglan Yang, Te Zhang, Xiaotong Sha, Huasheng Yang

Summary: The low activity of AMPK in periorbital tissue of TAO patients may be closely related to the occurrence and development of inflammation and fibrosis. Metformin exerts its anti-inflammatory and antifibrotic effects in TAO by activating AMPK, suggesting that AMPK may be a potential target for TAO therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels

Mirjana Babic Leko, Ivana Gunjaca, Nikolina Pleic, Tatijana Zemunik

Summary: Lifestyle factors like smoking, BMI, and iodine have a significant impact on TSH and thyroid hormone levels. However, there are inconsistencies in studies regarding how environmental factors influence thyroid function, indicating a need for further research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Environmental Sciences

Urinary phthalate metabolite concentrations, oxidative stress and thyroid function biomarkers among patients with thyroid nodules

Min Zhang, Yan-Ling Deng, Chong Liu, Pan-Pan Chen, Qiong Luo, Yu Miao, Fei-Peng Cui, Long-Qiang Wang, Ming Jiang, Qiang Zeng

Summary: This study examined the associations between phthalate exposures and thyroid function, as well as the potential mediating role of oxidative stress, among patients with thyroid nodules. The results showed that certain phthalate metabolites were linked to altered thyroid function and increased oxidative stress biomarkers. Additionally, lipid peroxidation may serve as an intermediate mechanism in the effects of phthalate exposures on thyroid function among patients with benign thyroid nodules.

ENVIRONMENTAL POLLUTION (2021)

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Article Endocrinology & Metabolism

The influence of thyroid state on hypothalamic AMP-activated protein kinase pathways in broilers

C. Lamberigts, Y. Wang, T. Dierckx, N. Buys, N. Everaert, J. Buyse

Summary: Our study revealed that thyroid hormones can affect appetite and body weight in broilers, with potential regulatory mechanisms through the AMPK pathways. In hyperthyroid conditions, AMPK alpha 1 subunit expression increased, whereas in hypothyroid conditions, active phosphorylated AMPK levels in the hypothalamus decreased, but gene expression of the AMPK alpha 1 and alpha 2 subunit increased.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2021)

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Article Biochemistry & Molecular Biology

A New Perspective on Thyroid Hormones: Crosstalk with Reproductive Hormones in Females

Bingtao Ren, Yan Zhu

Summary: Thyroid hormones play a vital role in regulating the female reproductive system through genomic and nongenomic mechanisms, interacting with other reproductive hormones in a complex signaling network. Understanding the interactions among these hormones is crucial for elucidating the etiology of female reproductive diseases and exploring new treatments for gynecological disorders.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Reproductive Biology

Thyroid hormones in canine pregnancy and lactation

Janna Hinderer, Julia Luedeke, Lisa Riege, Alexander Bartel, Barbara Kohn, Elisabeth Mueller, Sebastian P. Arlt

Summary: This study aimed to assess the influence of the cycle stage and pregnancy on hormone concentrations in female dogs by measuring TSH, fT4, tT4, and P4 levels. The results showed significant differences in hormone concentrations between sampling times, but no differences between pregnant and non-pregnant animals. The observed patterns of hormone concentration changes during pregnancy are similar to findings in humans, indicating potential effects on fetal thyroid function. The peak TSH concentrations during lactation suggest a higher demand for thyroid hormones during this phase. Therefore, the cycle stage should be considered when evaluating thyroid function in bitches.

THERIOGENOLOGY (2023)

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Article Biology

Modulatory effects of lycopene and vitamin E on cloacal temperature, thyroid hormonal and reproductive performance responses in laying hens during the hot-dry season

Joseph Olusegun Ayo, Joseph Ayodele Obidi, Peter Ibrahim Rekwot, Barth Izuchukwu Onyeanusi

Summary: The effects of lycopene and vitamin E on laying hens during the hot-dry season were evaluated. The study found that lycopene and vitamin E can decrease cloacal temperature, increase thyroid hormone concentrations, and improve ovarian and follicular activities.

JOURNAL OF THERMAL BIOLOGY (2022)

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Article Nutrition & Dietetics

Orally Induced Hyperthyroidism Regulates Hypothalamic AMP-Activated Protein Kinase

Valentina Capelli, Carmen Grijota-Martinez, Nathalia R. V. Dragano, Eval Rial-Pensado, Johan Ferno, Ruben Nogueiras, Jens Mittag, Carlos Dieguez, Miguel Lopez

Summary: This study used two different models of peripherally induced hyperthyroidism to assess the metabolic effects of peripheral TH treatment. The results showed that peripheral TH treatment affected various aspects of metabolism and induced changes in TH concentrations within the hypothalamus, indicating a central regulatory role in energy balance. Additionally, there was a shift in lipid metabolism from white adipose tissue accumulation to brown adipose tissue fueling, suggesting a complex interplay between central and peripheral effects of TH in the context of hyperthyroidism.

NUTRIENTS (2021)

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Review Endocrinology & Metabolism

Thyroid hormones and minerals in immunocorrection of disorders in autoimmune thyroid diseases

Viktor Kravchenko, Tamara Zakharchenko

Summary: Thyroid hormones and essential elements such as iodine, selenium, iron, copper, zinc, calcium, and magnesium play important roles in various organs and systems of the body, including the immune system and the thyroid gland, and disruptions in their supply can cause pathological changes. This review examines the immunomodulatory role of thyroid hormones and minerals, their properties, and their involvement in the pathogenesis of autoimmune thyroid diseases. It also discusses the imbalance between oxidants and antioxidants and the potential use of immunocorrection with dietary supplements in the treatment and prevention of autoimmune thyroid diseases.

FRONTIERS IN ENDOCRINOLOGY (2023)

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Review Radiology, Nuclear Medicine & Medical Imaging

Higher thyroid hormone levels and cancer

Petra Petranovic Ovcaricek, Frederik A. Verburg, Martha Hoffmann, Ioannis Iakovou, Jasna Mihailovic, Alexis Vrachimis, Markus Luster, Luca Giovanella

Summary: Numerous studies suggest a stimulating effect of triiodothyronine and thyroxin on cancer. The majority of evidence indicates an association between hyperthyroidism and the risk of developing cancer, as well as a poorer cancer prognosis. The rapid establishment of euthyroidism through radioiodine therapy is crucial in the management of hyperthyroidism in cancer patients.

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING (2021)

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Review Cell Biology

Thyroid and Corticosteroid Signaling in Amphibian Metamorphosis

Bidisha Paul, Zachary R. Sterner, Daniel R. Buchholz, Yun-Bo Shi, Laurent M. Sachs

Summary: Development in multicellular organisms relies on the integration of communication systems, particularly the neuroendocrine axes. The hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal/interrenal axes play central roles in coordinating body morphogenesis. Thyroid hormones and corticosteroids have critical functions in metamorphosis of anuran amphibians and are involved in the developmental transition seen in vertebrates.

CELLS (2022)

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Article Biochemistry & Molecular Biology

Chronic Exposure to Chlorpyrifos Damages Thyroid Activity and Imbalances Hepatic Thyroid Hormones Signaling and Glucose Metabolism: Dependency of T3-FOXO1 Axis by Hyperglycemia

Teresa Peluso, Valeria Nittoli, Carla Reale, Immacolata Porreca, Filomena Russo, Luca Roberto, Antonia Giacco, Elena Silvestri, Massimo Mallardo, Mario De Felice, Concetta Ambrosino

Summary: Early life exposure to Endocrine Disruptor Chemicals (EDCs), such as the pesticide Chlorpyrifos (CPF), has been found to affect thyroid activity, glucose metabolism, and lipid metabolism. In this study, the researchers investigated the effects of CPF exposure on the metabolism and signaling of thyroid hormones (THs) and lipid/glucose metabolism in mice. They found that these processes were altered in males that were exposed to CPF, leading to hypothyroidism and systemic hyperglycemia. Additionally, the researchers discovered that CPF affected glucose metabolism and TH levels through the modulation of FOXO1 activity in liver cells. These findings highlight the importance of considering the intergenerational and sex-specific effects of CPF exposure on metabolic homeostasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Cell Biology

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

D. Grahame Hardie

CURRENT OPINION IN CELL BIOLOGY (2015)

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Review Multidisciplinary Sciences

Keeping the home fires burning: AMP-activated protein kinase

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JOURNAL OF THE ROYAL SOCIETY INTERFACE (2018)

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Review Biology

LKB1 and AMPK and the cancer-metabolism link - ten years after

D. Grahame Hardie, Dario R. Alessi

BMC BIOLOGY (2013)

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Editorial Material Oncology

The LKB1-AMPK Pathway-Friend or Foe in Cancer?

D. Grahame Hardie

CANCER CELL (2013)

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Article Biochemistry & Molecular Biology

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin

Morgan D. Fullerton, Sandra Galic, Katarina Marcinko, Sarah Sikkema, Thomas Pulinilkunnil, Zhi-Ping Chen, Hayley M. O'Neill, Rebecca J. Ford, Rengasamy Palanivel, Matthew O'Brien, D. Grahame Hardie, S. Lance Macaulay, Jonathan D. Schertzer, Jason R. B. Dyck, Bryce J. van Denderen, Bruce E. Kemp, Gregory R. Steinberg

NATURE MEDICINE (2013)

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Article Multidisciplinary Sciences

Glycogen Content Regulates Peroxisome Proliferator Activated Receptor-partial derivative (PPAR-partial derivative) Activity in Rat Skeletal Muscle

Andrew Philp, Matthew G. MacKenzie, Micah Y. Belew, Mhairi C. Towler, Alan Corstorphine, Angela Papalamprou, D. Grahame Hardie, Keith Baar

PLOS ONE (2013)

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Article Biochemistry & Molecular Biology

The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria

Javier Moral-Sanz, Sophronia A. Lewis, Sandy Macmillan, Fiona A. Ross, Adrian Thomson, Benoit Viollet, Marc Foretz, Carmel Moran, D. Grahame Hardie, A. Mark Evans

SCIENCE SIGNALING (2018)

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Review Biochemistry & Molecular Biology

The strange case of AMPK and cancer: Dr Jekyll or Mr Hyde?

Diana Vara-Ciruelos, Fiona M. Russell, D. Grahame Hardie

OPEN BIOLOGY (2019)

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Review Biochemistry & Molecular Biology

AMPK and the Need to Breathe and Feed: What's the Matter with Oxygen?

A. Mark Evans, D. Grahame Hardie

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

AMP-Activated Protein Kinase: Do We Need Activators or Inhibitors to Treat or Prevent Cancer?

Fiona M. Russell, David Grahame Hardie

Summary: AMP-activated protein kinase (AMPK) plays a crucial role in regulating cellular energy balance by promoting ATP production and inhibiting cell growth. It may restrain aberrant growth before tumorigenesis, but support the survival of cancer cells once cancer has arisen.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Correction Biology

LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response (vol 5, 642, 2022)

Sandy MacMillan, Andrew P. Holmes, Mark L. Dallas, Amira D. Mahmoud, Michael J. Shipston, Chris Peers, D. Grahame Hardie, Prem Kumar, A. Mark Evans

COMMUNICATIONS BIOLOGY (2022)

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Article Biology

LKB1 is the gatekeeper of carotid body chemosensing and the hypoxic ventilatory response

Sandy MacMillan, Andrew P. Holmes, Mark L. Dallas, Amira D. Mahmoud, Michael J. Shipston, Chris Peers, D. Grahame Hardie, Prem Kumar, A. Mark Evans

Summary: This study reveals that LBK1 is a critical regulator of carotid body chemosensing, highlighting a difference in dependency on LKB1 and AMPK between the carotid body and the hypoxic ventilatory response.

COMMUNICATIONS BIOLOGY (2022)

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Review Cell Biology

New insights into activation and function of the AMPK

Gregory R. Steinberg, D. Grahame Hardie

Summary: AMP-activated protein kinase (AMPK) is a cellular energy sensor that is activated by increases in AMP/ADP to ATP ratios. Recent studies have discovered non-canonical pathways for AMPK activation, involving calcium, nutrients, metabolites, DNA and lysosome damage. AMPK has been found to regulate carbohydrate and lipid metabolism, mitochondrial and lysosomal homeostasis, and DNA repair. Its role in cancer, obesity, diabetes, nonalcoholic steatohepatitis (NASH), and other disorders has been explored, suggesting potential therapeutic targets.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2023)

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Review Biochemistry & Molecular Biology

AMP-activated protein kinase - a journey from 1 to 100 downstream targets

D. Grahame Hardie

Summary: This article reflects on the author's personal research journey, focusing on the early stages of defining AMPK and developing related tools, the exciting period of identifying upstream kinases in the late 1990s and early 2000s, and recent research on the complex role of AMPK in cancer.

BIOCHEMICAL JOURNAL (2022)

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Review Oncology

100 years of the Warburg effect: a historical perspective

D. Grahame Hardie

Summary: Otto Warburg published the first paper on the Warburg effect in 1923, revealing the difference in lactate production between tumor tissues and normal tissues in glucose metabolism. However, the mechanisms underlying the Warburg effect are still not fully understood to this day.

ENDOCRINE-RELATED CANCER (2022)

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Hot stuff: thyroid hormones and AMPK

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INST BIOCHEMISTRY & CELL BIOLOGY

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