Review
Cell Biology
Jirong Lv, Xue Xiao, Mingxia Bi, Tingting Tang, Deao Kong, Meining Diao, Qian Jiao, Xi Chen, Chunling Yan, Xixun Du, Hong Jiang
Summary: ATP-sensitive potassium channels (KATP channels) play a crucial role in linking the electrical activity of the cell membrane with cell metabolism. They have been found to be expressed in various cells and play important roles in neurodegenerative diseases. The KATP channel openers and inhibitors have protective effects on neurons by regulating neuronal excitability and neurotransmitter release, reducing abnormal protein aggregation and Ca2+ overload, and decreasing reactive oxygen species (ROS) production and microglia activation. However, KATP channels also exhibit dual effects in some cases.
AGEING RESEARCH REVIEWS
(2022)
Article
Neurosciences
Paulo S. Strazza, Daniela V. F. de Siqueira, Ricardo M. Leao
Summary: Cartwheel neurons in the dorsal cochlear nucleus are glycinergic interneurons that provide inhibition to fusiform neurons. Most of these neurons exhibit spontaneous firing, while a small fraction are quiet neurons. The quiet neurons have an outward conductance sensitive to tolbutamide, while active neurons can be affected by the K-ATP agonist diazoxide. The role of K-ATP channels in controlling the spontaneous firing of these neurons is revealed.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Cardiac & Cardiovascular Systems
Mark J. Specterman, Qadeer Aziz, Yiwen Li, Naomi A. Anderson, Leona Ojake, Keat-Eng Ng, Alison M. Thomas, Malcolm C. Finlay, Richard J. Schilling, Pier D. Lambiase, Andrew Tinker
Summary: This study investigated the effects of hypoxia on atrial electrophysiology in mice with global deletion of the K-ATP pore-forming subunits. The results showed that K-ATP blockade or absence resulted in atrial electrophysiological modifications at the cellular and tissue level. Furthermore, the global knockout of Kir6.2 prevented hypoxia-induced atrial path length shortening and arrhythmogenicity, suggesting a potential translational approach for treating ischemically driven atrial arrhythmia.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Iskra Cruz-Cruz, German Bernate-Obando, Carlos Larque, Rene Escalona, Rodolfo Pinto-Almazan, Myrian Velasco
Summary: Metabolic syndrome (MS) is a cluster of metabolic signs that increases the risk of developing type 2 diabetes and cardiovascular diseases. In the early stage of MS, a high-sugar diet can affect the pharmacological properties of K-ATP channels involved in insulin secretion.
Article
Pharmacology & Pharmacy
Abidullahl, Shujaat Ahmadi, Niaz Ali, Feras Almarshad, Muhammad Nabi, Shafiq Ur Rahman, Shakir Ullah, Jahangir Khan, Haya Hussain, Syeda Hajira Bukhari
Summary: The study found that Moxifloxacin and Gemifloxacin exert their relaxant effects on isolated rabbits' jejunal preparations possibly through activation of ATP-sensitive potassium channels (K-ATP). They relaxed low potassium-induced contractions and had EC50 values of 2.83 and 1.11 µg/mL for spontaneous contractions.
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Meng-Ting Wang, Hsueh-Yi Pan, Ya-Ling Huang, Li-Wei Wu, Pin-Chun Wang, Yu-Juei Hsu, Tzu-Chieh Lin, Chenwei Lin, Jyun-Heng Lai, Chien-Hsing Lee
Summary: In patients with type 2 diabetes receiving metformin, the use of high-affinity sulfonylureas for blocking mitoKATP channels is associated with an increased risk of major adverse cardiovascular events, myocardial infarction, all-cause mortality, and severe hypoglycemia compared to low-affinity sulfonylureas.
Review
Pharmacology & Pharmacy
Zhicheng Wang, Weikang Bian, Yufeng Yan, Dai-Min Zhang
Summary: ATP-sensitive potassium channels (K-ATP channels) play important roles in cellular excitability and metabolism. Activation of K-ATP channels can repolarize the membrane potential and reduce the occurrence of arrhythmias. Under severe and prolonged anoxia, K-ATP channels open to decrease cellular excitability and prevent action potential generation. Small active molecules can enhance the opening of K-ATP channels, leading to membrane repolarization and decreased malignant arrhythmias. Mutations in K-ATP channels worsen the regulatory roles in mutation-related diseases. However, efficient treatments for patients with K-ATP channel mutations are still lacking.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Mohammad Al-Mahdi Al-Karagholi
Summary: Migraine is a complex headache disorder involving various signaling pathways, with potassium channels playing a crucial role. Activation of potassium channels activates and sensitizes trigeminovascular neurons, leading to migraine attacks. Clinical trials have shown that potassium channel openers cause headache and migraine attacks associated with arterial dilation. Understanding the molecular structure and physiological function of potassium channels can provide insights into migraine pathophysiology and the development of potential treatments.
Article
Biochemistry & Molecular Biology
Michela Pecoraro, Stefania Marzocco, Ada Popolo
Summary: This study demonstrates a cooperative relationship between mCx43 and K-ATP channels in inducing cytoprotection in cardiomyocytes under hypoxic conditions. The presence of mCx43 is essential for the protective effects of diazoxide, an opener of K-ATP channels, against CoCl2-induced mitochondrial damage. These findings highlight the close functional link between mCx43 and K-ATP channels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Lidiia Mys, Yulia Goshovska, Nataliia Strutynska, Raisa Fedichkina, Yuliia Korkach, Ruslan Strutynskyi, Vadim Sagach
Summary: In old rats, administration of PLP increased the expression levels of CSE, 3-MST, UCP3, SUR2, and Kir6.1 genes, leading to higher H2S content, reduced oxidative stress, and prevented reperfusion dysfunction of the heart after ischemia.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Razan Orfali, Nora Albanyan
Summary: The Ca2+ ion is widely used as an intracellular signaling molecule, and Ca2+-activated potassium channels have evolved to receive and propagate Ca2+ signals. These channels are activated by increases in cytosolic calcium, which can be caused by Ca2+ influx via permeable channels or Ca2+ release from the endoplasmic reticulum. The Ca2+ sensitivity of these channels allows internal Ca2+ to regulate cell membrane activity. This review discusses the Ca2+ sensitivity of two well-studied groups of Ca2+-sensitive potassium channels: large-conductance Ca2+-activated K+ channels, K(Ca)1.1, and small/intermediate-conductance Ca2+-activated K+ channels, K(Ca)2.x/K(Ca)3.1.
Article
Cell Biology
Dae Hoon Kim, Jin Young Choi, Su Mi Kim, Seung-Myoung Son, Song-Yi Choi, Beommo Koo, Cheong-Sil Rah, Ji Hyun Nam, Moon Jin Ju, Jong Sung Lee, Ra Young You, Seung Hwa Hong, Junyoung Lee, Jang-Whan Bae, Chan Hyung Kim, Woong Choi, Hun Sik Kim, Wen-Xie Xu, Sang Jin Lee, Young Chul Kim, Hyo-Yung Yun
Summary: This study aimed to elucidate the underlying mechanisms and physiological function of vasomotion in human arteries. The results showed that vasomotion is sensitive to Ca2+-activated Cl- channels and metabolic changes, and may play an important role in the regulation of microcirculation dynamics.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Asser F. Bedair, Ahmed Wahid, Nesrine S. El-Mezayen, Amira F. El-Yazbi, Hadeel A. Khalil, Nayera W. Hassan, Elham A. Afify
Summary: Previous studies showed that nicorandil enhances morphine's antinociceptive effect and attenuates liver injury in rats with liver fibrosis. In this study, the underlying mechanisms of the nicorandil/morphine interaction were investigated, revealing that the combined therapy provides potent antinociception and hepatoprotection by modulating opioid receptors and cGMP signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Bilal Singh, Firas Khattab, Patrick Gilon
Summary: The study reveals that glucose controls alpha-cell [Ca2+](c) and glucagon secretion through multiple mechanisms. Increasing glucose concentration modestly decreases [Ca2+](c) in alpha-cells independently of their K-ATP channels and partly via somatostatin (SST). The changes in [Ca2+](c) parallel changes in glucagon release. Glucose also attenuates the efficacy of Ca2+ on exocytosis.
MOLECULAR METABOLISM
(2022)
Review
Cell Biology
Amalie Clement, Song Guo, Inger Jansen-Olesen, Sarah Louise Christensen
Summary: Migraine is a leading cause of disability globally, significantly impacting the lives of those affected. ATP-sensitive potassium (K-ATP) channels have been found to play a role in migraine pathophysiology. However, the development of better treatment options has faced challenges due to species differences in the efficacy and specificity of pharmacological tools targeting K-ATP channel subtypes.
Article
Biology
Hua-Qian Yang, Marta Perez-Hernandez, Jose Sanchez-Alonso, Andriy Shevchuk, Julia Gorelik, Eli Rothenberg, Mario Delmar, William A. Coetzee
Meeting Abstract
Biochemistry & Molecular Biology
Jordan Fuqua, Julia Hughes, Dylan Kuennen, Matthew Harris, Kristen Turner, Ana Kronemberger, Scott Ebert, Jason Dierdorff, Zhiyong Zhu, Leonid Zingman, Christopher Adams, Vitor Lira
Article
Multidisciplinary Sciences
Hua-Qian Yang, Wilnelly Martinez-Ortiz, JongIn Hwang, Xuexin Fan, Timothy J. Cardozo, William A. Coetzee
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Cardiac & Cardiovascular Systems
Ivan Gando, Chiara Campana, Reina Bianca Tan, Frank Cecchin, Eric A. Sobie, William A. Coetzee
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2020)
Article
Multidisciplinary Sciences
Francoise A. Gourronc, Kathleen R. Markan, Katarina Kulhankova, Zhiyong Zhu, Ryan Sheehy, Dawn E. Quelle, Leonid Zingman, Zoya B. Kurago, James A. Ankrum, Aloysius J. Klingelhutz
Article
Immunology
Berk Aykut, Ruonan Chen, Jacqueline Kim, Dongling Wu, Sorin A. A. Shadaloey, Raquel Abengozar, Pamela Preiss, Anjana Saxena, Smruti Pushalkar, Joshua Leinwand, Brian Diskin, Wei Wang, Gregor Werba, Matthew Berman, Steve Ki Buom Lee, Alireza Khodadadi-Jamayran, Deepak Saxena, William A. Coetzee, George Miller
SCIENCE IMMUNOLOGY
(2020)
Article
Endocrinology & Metabolism
Mohamed Rouabhi, Deng-Fu Guo, Donald A. Morgan, Zhiyong Zhu, Miguel Lopez, Leonid Zingman, Justin L. Grobe, Kamal Rahmouni
Summary: The study revealed that the SF1 neuron BBSome is crucial for regulating energy homeostasis by modulating sympathetic nervous system activity, affecting body weight, fat content, and energy expenditure. Additionally, the SF1 neuron BBSome plays a key role in the development of obesity-related comorbidities.
MOLECULAR METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Zhiyong Zhu, Zhan Gao, Biyi Chen, Duane D. Hall, Rachel Minerath, Olha Koval, Ana Sierra, Ekaterina Subbotina, Xiaoyi Zhu, Young-Rae Kim, Jun Yang, Isabella Grumbach, Kaikobad Irani, Chad Grueter, Long-Sheng Song, Denice M. Hodgson-Zingman, Leonid Zingman
Summary: The study demonstrates that delivering a exercise-similar heart rate pattern through atrial pacing while maintaining intracardiac synchrony can induce cardiac conditioning and enhance resistance to ischemic stress. This suggests that the heart rate pattern serves as a conditioning signal and has the potential to be repurposed for cardioprotection.
Article
Cell Biology
Sara C. Sebag, Zeyuan Zhang, Qingwen Qian, Mark Li, Zhiyong Zhu, Mikako Harata, Wenxian Li, Leonid V. Zingman, Limin Liu, Vitor A. Lira, Matthew J. Potthoff, Alexander Bartelt, Ling Yang
Summary: Brown adipose tissue thermogenic activity is regulated by protein S-nitrosylation, mediated by GSNOR. Loss of ADH5 impairs thermogenesis in BAT and worsens obesity-associated metabolic dysfunction. The study suggests that ADH5 controls BAT nitroso-redox homeostasis to regulate adipose thermogenesis.
Article
Endocrinology & Metabolism
Uday Singh, Jingwei Jiang, Kenji Saito, Brandon A. Toth, Jacob E. Dickey, Samuel R. Rodeghiero, Yue Deng, Guorui Deng, Baojian Xue, Zhiyong Zhu, Leonid V. Zingman, Joel C. Geerling, Huxing Cui
Summary: The PVNMC4R+ neurons project broadly to brain regions involved in feeding, neuroendocrine, and autonomic control, while receiving monosynaptic input mainly from other hypothalamic nuclei and circumventricular organs. Activation of PVNMC4R+ neurons leads to suppression of feeding and physiological changes in cardiovascular and thermoregulatory functions, accompanied by acute transient hyperactivity and rest-like behavior.
MOLECULAR METABOLISM
(2022)
Review
Cell Biology
Hua-Qian Yang, Fabio A. Echeverry, Assmaa ElSheikh, Ivan Gando, Sophia Anez Arredondo, Natalie Samper, Timothy Cardozo, Mario Delmar, Show-Ling Shyng, William A. Coetzee
Summary: Sarcolemmal/plasmalemmal ATP-sensitive K+ (K-ATP) channels play crucial roles in various cell types and tissues. Recent studies have highlighted that the surface expression of K-ATP channels is tightly regulated and has significant implications in both health and disease.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Andrew I. Sullivan, Meghan C. Naber, Kyle H. Flippo, Donald A. Morgan, Tate J. Neff, Sharon O. Jensen -Cody, Zhiyong Zhu, Leonid V. Zingman, Kamal Rahmouni, Matthew J. Potthoff
Summary: This study reveals the importance of the endocrine crosstalk between liver-and adipose-derived signals in the central nervous system for the regulation of energy homeostasis and body weight. FGF21 signaling to glutamatergic neurons and leptin receptor-expressing cells is necessary for FGF21 to modulate energy expenditure and promote weight loss. Co-administration of FGF21 and leptin synergistically leads to robust weight loss.
MOLECULAR METABOLISM
(2022)
Article
Cell Biology
Erkan Tuncay, Ivan Gando, Jian-Yi Huo, Gautham Yepuri, Natalie Sampler, Belma Turan, Hua-Qian Yang, Ravichandran Ramasamy, William A. Coetzee
Summary: Sirtuins are beneficial NAD+-dependent deacetylases that play roles in various human health conditions. In this study, researchers investigated the regulation of ATP-sensitive K+ (KATP) channels by sirtuins. They found that increasing NAD+ levels and activating sirtuins led to an increase in KATP channel current and surface expression. This finding has implications for cardiac protection against ischemic damage.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Uday Singh, Kenji Saito, Brandon Toth, Jacob Dickey, Zhiyong Zhu, Baojian Xue, Leonid Zingman, Huxing Cui