ARHI (DIRAS3) induces autophagy in ovarian cancer cells by downregulating the epidermal growth factor receptor, inhibiting PI3K and Ras/MAP signaling and activating the FOXo3a-mediated induction of Rab7

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

The PI3K/AKT/mTOR Signaling Pathway Is Overactivated in Primary Aldosteronism

(2013) Hengchuan Su et al.   PLoS One

Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis

(2012) Jiezhong Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The expression and prognosis of FOXO3a and Skp2 in human ovarian cancer

(2012) Mudan Lu et al.   MEDICAL ONCOLOGY

Effect of ARHI on lung cancer cell proliferation, apoptosis and invasion in vitro

(2012) Xiaohong Wu et al.   MOLECULAR BIOLOGY REPORTS

Class IA Phosphatidylinositol 3-Kinase p110α Regulates Phagosome Maturation

(2012) Emily P. Thi et al.   PLoS One

Effects of ARHI on cell cycle progression and apoptosis levels of breast cancer cells

(2012) Ying Li et al.   TUMOR BIOLOGY

Study of the PDK1/AKT signaling pathway using selective PDK1 inhibitors, HCS, and enhanced biochemical assays

(2011) Alexandra Hofler et al.   ANALYTICAL BIOCHEMISTRY

Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy

(2011) Min-Yu Chen et al.   CANCER

Deciphering the Role of Forkhead Transcription Factors in Cancer Therapy

(2011) Jer-Yen Yang et al.   CURRENT DRUG TARGETS

Inhibition of mTOR Kinase by AZD8055 Can Antagonize Chemotherapy-induced Cell Death through Autophagy Induction and Down-regulation of p62/Sequestosome 1

(2011) Shengbing Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest

(2011) Ian G. Ganley et al.   MOLECULAR CELL

The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways

(2011) D B Badgwell et al.   ONCOGENE

Met Receptor: A Moving Target

(2011) M. J. Clague   Science Signaling

Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action

(2010) Subhendu Mukherjee et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

MicroRNAs 221/222 and Genistein-Mediated Regulation of ARHI Tumor Suppressor Gene in Prostate Cancer

(2010) Y. Chen et al.   Cancer Prevention Research

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

Akt-FOXO3a signaling axis dysregulation in human oral squamous cell carcinoma and potent efficacy of FOXO3a-targeted gene therapy

(2010) Liang Fang et al.   ORAL ONCOLOGY

Constitutively Nuclear FOXO3a Localization Predicts Poor Survival and Promotes Akt Phosphorylation in Breast Cancer

(2010) Jie Chen et al.   PLoS One

Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation

(2009) Lothar Gremer et al.   HUMAN MOLECULAR GENETICS

FoxO Transcription Factors Promote Autophagy in Cardiomyocytes

(2009) Arunima Sengupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Altered mechanosensitive properties of vagal afferent fibers innervating the stomach following gastric surgery in rats

(2009) A. Miranda et al.   NEUROSCIENCE

The Role of Autophagy in Mammalian Development: Cell Makeover Rather than Cell Death

(2008) Francesco Cecconi et al.   DEVELOPMENTAL CELL

OncogenicHRASmutations cause prolonged PI3K signaling in response to epidermal growth factor in fibroblasts of patients with Costello syndrome

(2008) Georg Rosenberger et al.   HUMAN MUTATION

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

(2008) Jer-Yen Yang et al.   NATURE CELL BIOLOGY