Article
Environmental Sciences
Li Zhou, Chaoqin Zhang, Yu Qiang, Min Huang, Xiangmei Ren, Yuanhong Li, Jihong Shao, Lichun Xu
Summary: The study demonstrated that APSP can protect against lead-induced reproductive toxicity in male mice by attenuating testicular injury, improving sperm count and motility, reducing sperm abnormality rate, restoring antioxidant levels, inhibiting lipid peroxidation, and modulating the JNK signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Biochemistry & Molecular Biology
Guy Nadel, Galia Maik-Rachline, Rony Seger
Summary: The response of cells to extracellular signals is mediated by intracellular signaling pathways, one of which is the cJun-N-terminal Kinase (JNK) cascade. Proper regulation of this cascade, involving phosphorylations, dephosphorylation, scaffold proteins, subcellular localization changes, and degradation, is crucial for determining cell fate. This review focuses on these regulatory mechanisms, including the newly discovered PP2A switch, and emphasizes the transmission of apoptotic signals by the JNK cascade. Understanding the regulation of the JNK cascade may lead to new therapeutic approaches for JNK-dependent pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Qing Xia, Shuo Gao, Samuel Rajendran Rapael Gnanamuthu, Kaiyan Zhuang, Zhenzhen Song, Yun Zhang, Xue Wang, Pengfei Tu, Jianheng Li, Kechun Liu
Summary: Aconitine (AC) exerts severe toxic effects on zebrafish embryo development, including cardiac, liver, and neurodevelopment impairment, as well as ROS-mediated mitochondrial apoptosis. High-concentration AC exposure results in deficient cardiovascular system and cell apoptosis in the heart and brain regions.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Tiantian Lou, Jin Ma, Yanzheng Xie, Gengzhen Yao, Ye Fan, Shiyu Ma, Xu Zou
Summary: The study demonstrated that Nuanxin capsule effectively improved cardiac function in heart failure by reducing oxidative stress-induced mitochondrial dependent apoptosis through activating the AMPK/JNK signaling pathway, both in vivo and in vitro experiments.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Jing Zhao, Meini Le, Jie Li, Qiong Huang, Haocong Chen, Wenyi Zhang, Huiwen Mao, Qing Sun, Aiguo Li, Yingmin Zhao, Lingling Yu, Mingjiang Yi, Jie Wang, Xinyuan Li, Guangming Zhang, Jun Ma, Xiaohua Dong
Summary: LINC00938 acts as a neuroprotective factor to inhibit oxidative stress and cell apoptosis in the central nervous system under hypoxic-ischemic encephalopathy (HIE) conditions.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Pharmacology & Pharmacy
Chengzhi Zhang, Yanmei Yang, Yanhui Gao, Dianjun Sun
Summary: Excessive fluoride exposure can lead to neuronal apoptosis and cognitive dysfunction, with chronic fluoride-induced microglia activation and up-regulation of IL-1 beta playing important roles.
Article
Biochemistry & Molecular Biology
Jinxi Zhang, Yue Zhang, Xue Qi, Yuan Cui, Xiaoming Chen, Hongjin Lin
Summary: Cadmium exposure induces lung cell apoptosis and oxidative stress in swine, activating the mitochondrial apoptosis pathway via the TRAF2/ASK1/JNK signaling pathway.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yu Chen, Ping Li, Yueting Peng, Xiaoxue Xie, Yixi Zhang, Ying Jiang, Tingting Li, Xiang Qin, Shun Li, Hong Yang, Chunhui Wu, Chuan Zheng, Jie Zhu, Fengming You, Yiyao Liu
Summary: The study demonstrates that the soft substrate-induced ROS/JNK signaling increases cell apoptosis and protective autophagy by promoting the interaction of Bcl-2 and Beclin-1 and suppressing the interaction of Bcl-2 and Beclin-1, respectively, in human breast cancer cells.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Mahitab M. Nageeb, Aliaa Talaat, Samar M. Reda, Ghada A. Elsammak
Summary: Chronic kidney disease (CKD) is a leading cause of death globally. This study investigated the effect of infliximab, an anti-TNF-α drug, on adenine-induced CKD. The results showed that infliximab treatment reduced plasma levels of urea, creatinine, NGAL, and MDA, while increasing total antioxidant capacity (TAC). It also decreased the expression of inflammatory mediators such as IL-6 and NF-κB, along with the down-regulation of the ASK1/MAPK/JNK pathway. Histological and immunohistochemical changes in the kidney were improved with infliximab treatment. Overall, infliximab exhibited an ameliorative and curative effect on adenine-induced CKD by reducing oxidative stress, inflammation, and apoptosis.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Food Science & Technology
Linlin Qu, Rongzhan Fu, Xiaoxuan Ma, Daidi Fan
Summary: The study demonstrated that protopanaxatriol-type saponin (PTS) effectively protected against acetaminophen (APAP)-induced liver injury by reducing inflammation, oxidative stress, and hepatic apoptosis, and reversing histological changes. Additionally, PTS showed potential as a novel therapeutic agent for APAP-induced liver injury through the ROS-mediated JNK pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Bhuvaneshwari R. Gehi, Kundlik Gadhave, Vladimir N. Uversky, Rajanish Giri
Summary: This study investigated the presence of intrinsic disorder in proteins of the oxidative stress-induced JNK signaling cascade. It was found that most proteins in this pathway contain disordered regions, with scaffold proteins and transcription factors having the highest levels of intrinsic disorder. Additionally, the study characterized the molecular recognition features, posttranslational modification sites, and short linear motifs associated with the predicted disordered regions in these proteins.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Huan Li, Qin Yang, Zhen Huang, Cui Liang, Dian-Hong Zhang, Hui-Ting Shi, Jia-Qi Du, Bin-Bin Du, Yan-Zhou Zhang
Summary: Diabetic cardiomyopathy (DCM) is a heart dysfunction that occurs in patients with diabetes mellitus (DM). This study found that dual-specificity phosphatase 12 (DUSP12) plays an important role in DCM. Overexpression of DUSP12 worsens cardiac dysfunction and increases oxidative stress and apoptosis, while DUSP12 deficiency exacerbates these effects. The study also found that DUSP12 interacts with a specific signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Xinyu Deng, Yubing Li, Xing Li, Zhenpeng Zhang, Shu Dai, Hefei Wu, Fangling Zhang, Qichao Hu, Yuan Chen, Jinhao Zeng, Xiao Ma
Summary: Paeoniflorin (PF) acts as a protective agent against acetaminophen (APAP)-induced hepatotoxicity by inhibiting JNK-related signals.
Article
Immunology
Shanfu Zhang, Beibei Fu, Yan Xiong, Qingting Zhao, Shiyao Xu, Xiaoyuan Lin, Haibo Wu
Summary: The study revealed a protective role of Tgm2 in sepsis, showing that it can suppress apoptosis by inhibiting the JNK/BCL-2 signaling pathway and regulating mitochondria-mediated apoptosis. This highlights Tgm2 as a potential target for the development of novel anti-infective drugs.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Fang-fang Ren, Lin Zhao, Xian-yun Jiang, Jing-jing Zhang, Jia-min Gou, Xiao-yu Yu, Shu-jin Wu, Lei Li
Summary: Apoptosis, or programmed cell death, plays a critical role in the development of heart failure. Sphingosylphosphorylcholine (SPC), a bioactive sphingolipid, has been shown to inhibit apoptosis in myofibroblasts, non-muscle cells in the heart. In this study, the researchers investigated the role of the SPC receptor, calmodulin (CaM), in cardiomyocyte apoptosis and the associated signaling pathways. They found that SPC administration improved survival rate, cardiac hypertrophy, and cardiac fibrosis in mice with pressure overload-induced heart failure. In cardiomyocytes, SPC treatment inhibited cardiomyocyte hypertrophy, fibroblast-to-myofibroblast transition, and cell apoptosis. This was accompanied by reduced levels of pro-apoptotic proteins and phosphorylation of CaM, JNK, and p38, as well as increased levels of a cardiomyocyte-protective protein. The protective effect of SPC was annulled by a compound that increased CaM function. The researchers also demonstrated that SPC-mediated inhibition of cardiomyocyte apoptosis involved the regulation of p38 and JNK phosphorylation, which was downstream of CaM. These findings provide new evidence for SPC regulation of cardiomyocyte apoptosis and suggest it as a potential therapeutic target for cardiac remodeling following stress overload.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Hiroaki Kajiho, Yuko Kajiho, Emanuela Frittoli, Stefano Confalonieri, Giovanni Bertalot, Giuseppe Viale, Pier Paolo Di Fiore, Amanda Oldani, Massimiliano Garre, Galina V. Beznoussenko, Andrea Palamidessi, Manuela Vecchi, Philippe Chavrier, Frank Perez, Giorgio Scita
Article
Biochemistry & Molecular Biology
Tetsuo Kobayashi, Yuji Hori, Nami Ueda, Hiroaki Kajiho, Shin Muraoka, Fumi Shima, Tohru Kataoka, Kenji Kontani, Toshiaki Katada
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2009)
Article
Biochemistry & Molecular Biology
Ryota Saito, Tokiwa Yamasaki, Yoko Nagai, Jinzhan Wu, Hiroaki Kajiho, Tadashi Yokoi, Eiichiro Noda, Sachiko Nishina, Hitoshi Niwa, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2009)
Article
Biochemistry & Molecular Biology
Kentaro Nakagawa, Misato Sugahara, Tokiwa Yamasaki, Hiroaki Kajiho, Shinya Takahashi, Jun Hirayama, Yasuhiro Minami, Yasutaka Ohta, Toshio Watanabe, Yutaka Hata, Toshiaki Katada, Hiroshi Nishina
BIOCHEMICAL JOURNAL
(2010)
Article
Biochemistry & Molecular Biology
Andrea Palamidessi, Emanuela Frittoli, Nadia Ducano, Nina Offenhauser, Sara Sigismund, Hiroaki Kajiho, Dario Parazzoli, Amanda Oldani, Marco Gobbi, Guido Serini, Paolo Di Fiore, Giorgio Scita, Letizia Lanzetti
Article
Cell Biology
Yanneve Rolland, Paola Marighetti, Chiara Malinverno, Stefano Confalonieri, Chiara Luise, Nadia Ducano, Andrea Palamidessi, Sara Bisi, Hiroaki Kajiho, Flavia Troglio, Olga G. Shcherbakova, Alexander R. Dunn, Amanda Oldani, Letizia Lanzetti, Pier Paolo Di Fiore, Andrea Disanza, Giorgio Scita
DEVELOPMENTAL CELL
(2014)
Article
Biochemistry & Molecular Biology
Shuhei Tanemura, Haruka Momose, Nao Shimizu, Daiju Kitagawa, Jungwon Seo, Tokiwa Yamasaki, Kentaro Nakagawa, Hiroaki Kajiho, Josef M. Penninger, Toshiaki Katada, Hiroshi Nishina
JOURNAL OF BIOCHEMISTRY
(2009)
Article
Biochemistry & Molecular Biology
Hiroaki Kajiho, Kyoko Sakurai, Tomohiro Minoda, Manabu Yoshikawa, Satoshi Nakagawa, Shinichi Fukushima, Kenji Kontani, Toshiaki Katada
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Shoji Hata, Jun Hirayama, Hiroaki Kajiho, Kentaro Nakagawa, Yutaka Hata, Toshiaki Katada, Makoto Furutani-Seiki, Hiroshi Nishina
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Shinya Takahashi, Kyoko Sakurai, Arisa Ebihara, Hiroaki Kajiho, Kota Saito, Kenji Kontani, Hiroshi Nishina, Toshiaki Katada
NUCLEIC ACIDS RESEARCH
(2011)
Article
Multidisciplinary Sciences
Hiroaki Kajiho, Shinichi Fukushima, Kenji Kontani, Toshiaki Katada
Article
Cell & Tissue Engineering
Jinzhan Wu, Junko Kubota, Jun Hirayama, Yoko Nagai, Sachiko Nishina, Tadashi Yokoi, Yoichi Asaoka, Jungwon Seo, Nao Shimizu, Hiroaki Kajiho, Takashi Watanabe, Noriyuki Azuma, Toshiaki Katada, Hiroshi Nishina
STEM CELLS AND DEVELOPMENT
(2010)
Article
Biology
Masamitsu Fukuyama, Kensuke Sakuma, Riyong Park, Hidefumi Kasuga, Ryotaro Nagaya, Yuriko Atsumi, Yumi Shimomura, Shinya Takahashi, Hiroaki Kajiho, Ann Rougvie, Kenji Kontani, Toshiaki Katada
Article
Multidisciplinary Sciences
Hiroaki Kajiho, Yasunori Yamamoto, Toshiaki Sakisaka
SCIENTIFIC REPORTS
(2019)