Article
Chemistry, Medicinal
Theresa Kircher, Tatu Pantsar, Andreas Oder, Jens Peter von Kries, Michael Juchum, Bent Pfaffenrot, Philip Kloevekorn, Wolfgang Albrecht, Roland Selig, Stefan Laufer
Summary: MKK4 plays a key role in liver regeneration, making new small molecules inhibiting MKK4 potential candidates for treating acute and chronic liver diseases. Optimization of compound design led to the selection of fluorescent compounds with high binding affinities, with compound 45 identified as a suitable tool for studying new small-molecule inhibitors of MKK4.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
T. G. Sahana, Ke Zhang
Summary: Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease with multiple genetic and non-genetic risk factors. Cellular stress plays a significant role in ALS conditions, with the MAPK pathway being implicated in the disease pathogenesis and potential drug targeting.
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Oncology
Guifang Zhang, Dan Zheng, Xiaoqing Chen, Li Li, Jingrong Yu
Summary: MYCNOS is upregulated in ovarian adenocarcinoma and is associated with poor prognosis. The study suggests that MYCNOS may sponge miR-152 to upregulate MKK7 expression, promoting cell proliferation in ovarian cancer.
Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Yoshitoshi Kasuya, Jun-Dal Kim, Masahiko Hatano, Koichiro Tatsumi, Shuichi Matsuda
Summary: Idiopathic pulmonary fibrosis (IPF) is a severe progressive fibrotic lung disease with a poor prognosis, necessitating a deep understanding of molecular mechanisms for potential therapeutic advancements. Various cell types and stress-activated protein kinases (SAPKs) play crucial roles in the pathogenesis of pulmonary fibrosis, with potential therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Zhigang Fang, Hyeong-Geug Kim, Menghao Huang, Kushan Chowdhury, Ming O. Li, Suthat Liangpunsakul, X. Charlie Dong
Summary: This study demonstrates the protective role of Sesn1/2/3 in hepatic lipotoxicity-induced oxidative stress by reducing JNK phosphorylation and activity, leading to decreased lipotoxicity and oxidative stress in liver cells.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chuwei Lin, Aneirin Alan Lott, Wei Zhu, Craig P. Dufresne, Sixue Chen
Summary: This study used metabolomics and proteomics to investigate the metabolites and protein profiles of the mpk4 mutant and the wild type plants. It revealed the involvement of MPK4 in polyamine synthesis and photosynthesis, providing insights into the metabolic networks potentially regulated by MPK4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Teng Fu, Jong-Hwan Shin, Noh-Hyun Lee, Kwang Ho Lee, Kyoung Su Kim
Summary: This study reveals the importance of CsPMK1 in the development and pathogenicity of the chili pepper anthracnose fungus. The CsPMK1 mutant, Delta Cspmk1, showed normal mycelial growth and conidiation, but abnormal conidial morphology and delayed germination. Additionally, Delta Cspmk1 exhibited defects in appressorium formation, infectious growth, nuclear division, and lipid mobilization.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemical Research Methods
Sananda Mondal
Summary: In recent years, environmental stresses have increased due to human activities. Plants use signal transduction, particularly through the mitogen-activated protein kinase (MAPK) cascade, to interpret and respond to these stresses. MAPK signaling in plants can be regulated by different phytohormones and plays a crucial role in cell division, differentiation, and antioxidative mechanisms. However, soil pollution caused by heavy metals from industrialization and agrochemical use poses a threat to both human and plant survival.
PLANT MOLECULAR BIOLOGY REPORTER
(2023)
Article
Chemistry, Medicinal
Paul Gehrtz, Shir Marom, Mike Buehrmann, Julia Hardick, Silke Kleinboelting, Amit Shraga, Christian Dubiella, Ronen Gabizon, Jan N. Wiese, Matthias P. Mueller, Galit Cohen, Ilana Babaev, Khriesto Shurrush, Liat Avram, Efrat Resnick, Haim Barr, Daniel Rauh, Nir London
Summary: High-throughput nanomole-scale synthesis allows for efficient and economical late-stage functionalization of compounds. Copper-catalyzed azide-alkyne cycloaddition has been demonstrated to be capable of nanoscale late-stage functionalization of covalent kinase inhibitors, enabling the synthesis of hundreds of compounds that do not require purification for biological assay screening. This study presents a promising approach to improving the properties of lead chemical matter through high-throughput late-stage functionalization of covalent inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Article
Cell Biology
Chang-Ning Fu, Jia-Wen Song, Zhi-Peng Song, Qian-Wen Wang, Wen-Wu Bai, Tao Guo, Peng Li, Chao Liu, Shuang-Xi Wang, Bo Dong
Summary: Statin-induced skeletal injury is mediated by the excessive expression of miR-1a, leading to decreased MAP3K1 gene expression and subsequent apoptosis of skeletal muscle cells.
Review
Biochemistry & Molecular Biology
Mengmeng Zhang, Shuqun Zhang
Summary: This review provides a historic and recent understanding of the role of mitogen-activated protein kinase (MAPK) cascades in plant immunity, response to environmental stresses, and normal growth and development. The signaling specificity of MAPKs in plants is an interesting topic of research and is influenced by factors such as activation kinetics, spatial and temporal expression patterns, and functional characterization of MAPK substrates.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Vikram Jeet Singh, Bharti Sharma, Pooja A. Chawla
Summary: The article focuses on the MAPK signaling pathway and the role of different heterocyclic compounds with nitrogen, sulfur, and oxygen in blocking the MAPK signaling pathway. Heterocyclic compounds are important due to their high potency and selectivity against various targets involved in the MAPK signaling pathway for cancer management. The potential of these compounds in inhibiting MAPK cascade and recent advancements in developing MAPK signaling pathway inhibitors are discussed in detail.
BIOORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Jun Hirayama, Yikelamu Alifu, Rin Hamabe, Sho Yamaguchi, Jun Tomita, Yusuke Maruyama, Yoichi Asaoka, Ken-ichi Nakahama, Teruya Tamaru, Ken Takamatsu, Nobuhiko Takamatsu, Atsuhiko Hattori, Sachiko Nishina, Noriyuki Azuma, Atsuo Kawahara, Kazuhiko Kume, Hiroshi Nishina
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Mika Ikegame, Atsuhiko Hattori, Makoto J. Tabata, Kei-ichiro Kitamura, Yoshiaki Tabuchi, Yukihiro Furusawa, Yusuke Maruyama, Tatsuki Yamamoto, Toshio Sekiguchi, Risa Matsuoka, Taizo Hanmoto, Takahiro Ikari, Masato Endo, Katsunori Omori, Masaki Nakano, Sayaka Yashima, Sadakazu Ejiri, Toshiki Taya, Hiroshi Nakashima, Nobuaki Shimizu, Masahisa Nakamura, Takashi Kondo, Kazuichi Hayakawa, Ichiro Takasaki, Atsushi Kaminishi, Ryosuke Akatsuka, Yuichi Sasayama, Takumi Nishiuchi, Masayuki Nara, Hachiro Iseki, Vishwajit S. Chowdhury, Shigehito Wada, Kenichi Ijiri, Toshio Takeuchi, Tohru Suzuki, Hironori Ando, Kouhei Matsuda, Masanori Somei, Hiroyuki Mishima, Yuko Mikuni-Takagaki, Hisayuki Funahashi, Akihisa Takahashi, Yoshinari Watanabe, Masahiro Maeda, Hideaki Uchida, Akio Hayashi, Akira Kambegawa, Azusa Seki, Sachiko Yano, Toru Shimazu, Hiromi Suzuki, Jun Hirayama, Nobuo Suzuki
JOURNAL OF PINEAL RESEARCH
(2019)
Review
Pharmacology & Pharmacy
Yoshimi Okamoto-Uchida, Akari Nishimura, Junko Izawa, Atsuhiko Hattori, Nobuo Suzuki, Jun Hirayama
CURRENT DRUG TARGETS
(2020)
Article
Multidisciplinary Sciences
Hiroaki Kajiho, Yasunori Yamamoto, Toshiaki Sakisaka
SCIENTIFIC REPORTS
(2019)
Review
Biochemistry & Molecular Biology
Yoshimi Okamoto-Uchida, Junko Izawa, Akari Nishimura, Atsuhiko Hattori, Nobuo Suzuki, Jun Hirayama
Article
Oncology
Yukihiro Furusawa, Tatsuki Yamamoto, Atsuhiko Hattori, Nobuo Suzuki, Jun Hirayama, Toshio Sekiguchi, Yoshiaki Tabuchi
MOLECULAR MEDICINE REPORTS
(2020)
Article
Cell Biology
Junko Igarashi-Migitaka, Azusa Seki, Mika Ikegame, Masato Honda, Toshio Sekiguchi, Hiroyuki Mishima, Nobuaki Shimizu, Hajime Matsubara, Ajai K. Srivastav, Jun Hirayama, Yusuke Maruyama, Atsuko Kamijo-Ikemori, Kazuaki Hirata, Atsuhiko Hattori, Nobuo Suzuki
Article
Medicine, Research & Experimental
Tatsuki Yamamoto, Mika Ikegame, Jun Hirayama, Kei-Ichiro Kitamura, Yoshiaki Tabuchi, Yukihiro Furusawa, Toshio Sekiguchi, Masato Endo, Hiroyuki Mishima, Azusa Seki, Sachiko Yano, Hajime Matsubara, Atsuhiko Hattori, Nobuo Suzuki
BIOMEDICAL RESEARCH-TOKYO
(2020)
Article
Oncology
Yoshiaki Tabuchi, Hideyuki Hasegawa, Nobuo Suzuki, Yukihiro Furusawa, Tetsushi Hirano, Ryo Nagaoka, Jun Hirayama, Nobuhiko Hoshi, Takashi Mochizuki
Summary: The study demonstrated that low-intensity ultrasound (LIUS) can induce changes in gene expression in bone marrow stromal cells, leading to upregulation of certain genes associated with bone physiology and protein folding. This provides a basis for further understanding the detailed molecular mechanisms underlying the cellular effects of LIUS.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Endocrinology & Metabolism
Kei-ichiro Kitamura, Jun Hirayama, Yoshiaki Tabuchi, Takao Minami, Hajime Matsubara, Atsuhiko Hattori, Nobuo Suzuki
Summary: High plasma glucose induced by glucose metabolism disorders leads to the glycation of type 1 collagen, resulting in the formation of advanced glycation end-products which affect the characteristics of type 1 collagen.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Pharmacology & Pharmacy
Yikelamu Alifu, Satoshi Kofuji, Sachi Sunaga, Mizuki Kusaba, Jun Hirayama, Hiroshi Nishina
Summary: The light-inducible clock genes zPer2, zCry1a, and zCry2a are involved in regulating the oxidative status of zebrafish, indicating an important role in the metabolism of fish. The genotypedependent alteration of metabolomic profiles, including changes in cysteine/methionine metabolism and glutathione metabolism, further supports the relationship between light-inducible clock genes and metabolism in zebrafish.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Multidisciplinary Sciences
Yoshinori Sato, Hayato Horiuchi, Shinji Fukasawa, Shingo Takesawa, Jun Hirayama
Summary: The influences of priming process, saline circulation conditions, and saline incubation on the in vitro elution of substances from different types of membrane dialyzers were evaluated. The elution of substances varied among different dialyzers, and the information provided could be used for identifying non-PVP substances eluted from dialyzers.
Article
Fisheries
Aika Sekimoto, Tsuyoshi Ohira, Atsushi Shigematsu, Takuji Okumura, Miyuki Mekuchi, Kenji Toyota, Hiroyuki Mishima, Ryoya Kawamura, Kaito Hatano, Umi Kawago, Yoichiro Kitani, Toshio Sekiguchi, Thumronk Amornsakun, Jun Hirayama, Atsuhiko Hattori, Hajime Matsubara, Nobuo Suzuki
Summary: This study investigates the calcification mechanism of the exoskeleton of kuruma prawns and identifies CAP-1 as a peptide involved in chitin-binding and anti-calcification activities. CAP-1 mRNA expression in the prawns changes during molting, indicating its important role in exoskeleton calcification.
Article
Environmental Sciences
Nobuo Suzuki, Masato Honda, Masayuki Sato, Shuhei Yoshitake, Kimi Kawabe, Yoshiaki Tabuchi, Toshiki Omote, Toshio Sekiguchi, Yukihiro Furusawa, Akira Toriba, Ning Tang, Yohei Shimasaki, Edward G. Nagato, Lulu Zhang, Ajai K. Srivastav, Thumronk Amornsakun, Yoichiro Kitani, Hajime Matsubara, Takashi Yazawa, Jun Hirayama, Atsuhiko Hattori, Yuji Oshima, Kazuichi Hayakawa
Summary: This study investigated the toxicity and mechanism of action of 3-hydroxybenzo[c]phenanthrene (3-OHBcP) on bone metabolism in fish. The results showed that 3-OHBcP was over 1900 times more toxic than its parent compound and inhibited scale regeneration and osteoblastic activity in fish. In addition, 3-OHBcP induced apoptosis in fish scales.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Yoshinori Sato, Hayato Horiuchi, Shinji Fukasawa, Shingo Takesawa, Jun Hirayama
Summary: The duration of incubation of PSu membrane in saline is found to be a determinant of the level of PVP elution, as longer circulation results in greater PVP release from the dialyzer membranes. The flow rate does not impact PVP elution, while immersion of dialyzer membranes in saline for 24 hours significantly facilitates PVP release.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2021)