Article
Fisheries
Xiaotong Sun, Hongtao Nie, Xiwu Yan
Summary: This study identified and investigated three novel glycogen metabolism-related proteins in Manila clam, suggesting their potential involvement in innate immunity and important role in immune defense.
Article
Chemistry, Multidisciplinary
Husam Nassar, Wolfgang Sippl, Rana Abu Dahab, Mutasem Taha
Summary: Recent studies have suggested the potential inhibition of GSK3 beta by cephalosporin antibiotics, specifically cefixime and ceftriaxone. Docking experiments showed that these antibiotics exhibited the best binding scores to GSK3 beta, with exclusive hydrogen bonding. Molecular dynamics simulations and covalent docking supported the possibility of covalent bond formation between the antibiotics and GSK3 beta. In vitro inhibitory activity assays confirmed the inhibitory effects of cefixime and ceftriaxone on GSK3 beta, with lower IC50 values observed after preincubation.
Article
Biochemistry & Molecular Biology
Laura Vainio, Saija Taponen, Sini M. Kinnunen, Eveliina Halmetoja, Zoltan Szabo, Tarja Alakoski, Johanna Ulvila, Juhani Junttila, Paivi Lakkisto, Johanna Magga, Risto Kerkela
Summary: Phosphorylation of GSK3 beta at S389 enhances cardiomyocyte survival and protects from cardiomyocyte hypertrophy. The GSK3 beta S389A mutation promotes cardiomyocyte growth by activating the mTOR complex 1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Plant Sciences
Yun Song, Ying Wang, Qianqian Yu, Yueying Sun, Jianling Zhang, Jiasui Zhan, Maozhi Ren
Summary: Glycogen synthase kinase 3 (GSK3) family members are highly conserved protein kinases in mammals and plants, playing a pivotal role in the perception and transduction of diverse signals involved in plant development and stress responses. Recent research has shown that GSK3s are involved in plant adaptation to various stresses and their crosstalk with hormones. Understanding the molecular mechanisms of GSK3s in plant stress responses provides opportunities for developing stress-resilient crops using genetic engineering technology.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Multidisciplinary Sciences
Long He, Jennifer Endress, Sungyun Cho, Zhongchi Li, Yuxiang Zheng, John M. Asara, John Blenis
Summary: Serine/one-carbon metabolism plays a critical role in cancer cell growth, but the regulatory mechanisms are not well understood. This study reveals that glycogen synthase kinase 3 (GSK3) plays a key role in regulating the expression of serine/one-carbon metabolic enzymes. Inhibition of nuclear GSK3 signaling enhances the efficacy of serine/one-carbon metabolism inhibitors in suppressing cancer cell proliferation.
Article
Oncology
Xiaona Wei, Jianping Wu, Jiajia Li, Qiongqiong Yang
Summary: Cisplatin-induced acute kidney injury (AKI) is a complex critical illness with no effective treatment. In this study, the researchers identified PLK2 as a significantly up-regulated gene in AKI renal tissues and demonstrated its protective role in cisplatin-induced AKI. They also discovered that PLK2 may regulate AKI through the phosphorylation of GSK3β.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Lingjuan Wang, Sijin Ouyang, Bin Li, Hao Wu, Fengli Wang
Summary: Ferroptosis is a newly characterized form of non-apoptotic-programmed cell death that has implications in human diseases and potential therapeutic applications for cancer. GSK-3 beta acts as a positive modulator of ferroptosis by influencing cellular iron metabolism, indicating its potential as a target for cancer chemotherapy.
CELL DEATH DISCOVERY
(2021)
Review
Cell Biology
Ryan T. McCallum, Melissa L. Perreault
Summary: This study discussed the widespread multi-system involvement of GSK-3 in contributing to the neuropathology of MDD, emphasizing the feed-forward mechanistic links between all major neuronal signaling pathways.
Article
Biochemistry & Molecular Biology
Yuko Nagao, Kikuko Amo-Shiinoki, Hiroko Nakabayashi, Masayuki Hatanaka, Manabu Kondo, Kimie Matsunaga, Masahiro Emoto, Shigeru Okuya, Yukio Tanizawa, Katsuya Tanabe
Summary: Endoplasmic reticulum stress is a key pathogenic factor in type 1 and 2 diabetes. Gsk-3 inhibition prevents proteasomal degradation of ATF4 and alleviates apoptosis by regulating phosphorylation of ATF4-S214. Mechanistically, Gsk-3 inhibition modulates transcription targets of ATF4 and facilitates dephosphorylation of eIF2 alpha under ER stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Divya M. Teli, Anuradha K. Gajjar
Summary: Elevated glucose level due to β-cell dysfunction is a key marker of Type-II diabetes. GSK-3, an enzyme involved in glycogen metabolism control, has been explored for its potential as a target for diabetes treatment. This review article examines the structural analysis and molecular modeling of GSK-3, as well as advancements in the development of GSK-3 inhibitors as potential therapeutics for Type II diabetes.
BIOORGANIC & MEDICINAL CHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Ying Yang, Xiaoxiao Fan, Yun Ji, Ju Li, Zhaolai Dai, Zhenlong Wu
Summary: Glycine alleviates ER stress-induced apoptosis and dysfunction in intestinal barrier in a mTORC1-dependent manner. This study provides mechanistic insights into the protective effect of glycine on intestinal barrier integrity disrupted by ER stress.
Article
Neurosciences
Jiasi Yu, Dan Wu, Yanan Zhao, Linli Guo, Ping Liu
Summary: Glycogen synthase kinase-3 (GSK-3) plays a key role in the pathogenesis of Alzheimer's disease (AD), affecting beta-amyloid (Aβ) formation, tau protein phosphorylation, and apoptosis. Excessive presence of copper (Cu) promotes Aβ aggregation and increases AD risk. A metal-chelating imine GSK-3 inhibitor PIMPC was designed and synthesized to target GSK-3 and metal elements in AD. The results showed that PIMPC can down-regulate Aβ, tau, and p-tau protein expression, chelate Cu and aluminum (Al) elements in the brain, and alleviate cognitive impairments in AD rats induced by Aβ/Cu2+.
Article
Biochemistry & Molecular Biology
Yuxin Huang, Xiyuan Ping, Yilei Cui, Hao Yang, Jing Bao, Qichuan Yin, Hailaiti Ailifeire, Xingchao Shentu
Summary: This study investigates how lens epithelial cells adapt and maintain normal growth and metabolic activity under hypoxic conditions. The findings show that the glycolysis pathway is upregulated, enabling the cells to maintain energy metabolism and resist cell apoptosis caused by ER stress and ROS production. The study also provides insights into possible cellular damage repair mechanisms.
Article
Biochemistry & Molecular Biology
Jinsheng Liu, Li Li, Ping Xie, Xiaoyan Zhao, Dongjing Shi, Yan Zhang, Chuxiong Pan, Tianzuo Li
Summary: Mitochondria damage and apoptosis are associated with sevoflurane induced neurotoxicity. This study found that sevoflurane induces neurotoxicity by activating a GSK3 beta/Drp1 dependent pathway, leading to mitochondrial fission and apoptosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Maria Heloisa Massola Shimizu, Rildo Aparecido Volpini, Ana Carolina de Braganca, Mariana Moura Nascimento, Desiree Rita Denelle Bernardo, Antonio Carlos Seguro, Daniele Canale
Summary: Studies have shown that inhibition of glycogen synthase kinase 3 beta (GSK3 beta) with lithium can improve acute kidney injury (AKI) caused by rhabdomyolysis and promote renal function recovery. The administration of lithium can reduce kidney damage, inflammation, and oxidative stress associated with rhabdomyolysis-induced AKI. This study provides a new approach for the treatment of rhabdomyolysis-associated AKI using lithium.
Review
Biochemistry & Molecular Biology
Hartmut Kuhn, Swathi Banthiya, Klaus van Leyen
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2015)
Editorial Material
Neurosciences
Klaus van Leyen, Ken Arai, Xiaoying Wang, Eng H. Lo
Article
Endocrinology & Metabolism
Kazuhide Hayakawa, Loc-Duyen D. Pham, Ji Hae Seo, Nobukazu Miyamoto, Takakuni Maki, Yasukazu Terasaki, Sava Sakadzic, David Boas, Klaus van Leyen, Christian Waeber, Kyu-Won Kim, Ken Arai, Eng H. Lo
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2016)
Article
Endocrinology & Metabolism
Joo Eun Jung, Hulya Karatas, Yu Liu, Ayfer Yalcin, Joan Montaner, Eng H. Lo, Klaus van Leyen
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2015)
Article
Biochemistry & Molecular Biology
Michelle M. Armstrong, Cody J. Freedman, Joo Eun Jung, Yi Zheng, Chakrapani Kalyanaraman, Matthew P. Jacobson, Anton Simeonov, David J. Maloney, Klaus van Leyen, Ajit Jadhav, Theodore R. Holman
BIOORGANIC & MEDICINAL CHEMISTRY
(2016)
Article
Clinical Neurology
Kazim Yigitkanli, Yi Zheng, Anton Pekcec, Eng H. Lo, Klaus van Leyen
TRANSLATIONAL STROKE RESEARCH
(2017)
Article
Geriatrics & Gerontology
Natalya A. Smirnova, Navneet Ammal Kaidery, Dmitry M. Hushpulian, Ilay I. Rakhman, Natalya A. Smirnova, Navneet Ammal Kaidery, Dmitry M. Hushpulian, Ilay I. Rakhman, Andrey A. Poloznikov, Vladimir I. Tishkov, Saravanan S. Karuppagounder, Irina N. Gaisina, Anton Pekcec, Klaus Van Leyen, Sergey V. Kazakov, Lichuan Yang, Bobby Thomas, Rajiv R. Ratan, Irina G. Gazaryan
Meeting Abstract
Clinical Neurology
C. Cakir-Aktas, M. Yemisci, E. Bodur, E. Eren-Kocak, K. van Leyen, T. Dalkara, H. Karatas Kursun
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2017)
Article
Neurosciences
Song Zhao, Zhanyang Yu, Yu Liu, Yang Bai, Yinghua Jiang, Klaus van Leyen, Yong-Guang Yang, Josephine M. Lok, Michael J. Whalen, Eng H. Lo, Xiaoying Wang
NEUROSCIENCE LETTERS
(2017)
Article
Clinical Neurology
Yu Liu, Yi Zheng, Hulya Karatas, Xiaoying Wang, Christian Foerch, Eng H. Lo, Klaus van Leyen
Article
Clinical Neurology
Xiang Fan, Yinghua Jiang, Zhanyang Yu, Qi Liu, Shuzhen Guo, Xiaochuan Sun, Klaus van Leyen, MingMing Ning, Xiumei Gao, Eng H. Lo, Xiaoying Wang
TRANSLATIONAL STROKE RESEARCH
(2017)
Article
Neurosciences
H. Karatas, Joo Eun Jung, E. H. Lo, K. van Leyen
Review
Cell Biology
Pamela Maher, Klaus van Leyen, Partha Narayan Dey, Birgit Honrath, Amalia Dolga, Axel Methner
Meeting Abstract
Endocrinology & Metabolism
Y. Zheng, Y. Liu, K. Yigitkanli, H. Karatas, J. E. Jung, J. Carr, O. Bruns, M. Bawendi, K. van Leyen
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Meeting Abstract
Clinical Neurology
Yu Liu, Yi Zheng, Hulya Karatas, Christian Foerch, Eng H. Lo, Klaus Van Leyen