Why genes extending lifespan in model organisms have not been consistently associated with human longevity and what it means to translation research

Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity

(2014) Sofiya Milman et al.   AGING CELL

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age

(2014) Joris Deelen et al.   HUMAN MOLECULAR GENETICS

LongevityMap: a database of human genetic variants associated with longevity

(2013) Arie Budovsky et al.   TRENDS IN GENETICS

Whole transcriptome sequencing of the aging rat brain reveals dynamic RNA changes in the dark matter of the genome

(2012) Shona H. Wood et al.   AGE

Aging, Synaptic Dysfunction, and Insulin-Like Growth Factor (IGF)-1

(2012) F. Deak et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Rare and common variants: twenty arguments

(2012) Greg Gibson   NATURE REVIEWS GENETICS

Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing

(2012) Robi Tacutu et al.   NUCLEIC ACIDS RESEARCH

Genetic Signatures of Exceptional Longevity in Humans

(2012) Paola Sebastiani et al.   PLoS One

Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans

(2011) J. Guevara-Aguirre et al.   Science Translational Medicine

The GH/IGF1 axis and signaling pathways in the muscle and bone: mechanisms underlying age-related skeletal muscle wasting and osteoporosis

(2010) Sebastio Perrini et al.   JOURNAL OF ENDOCRINOLOGY

Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

(2009) Chen-Yu Liao et al.   AGING CELL

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Design of aging intervention studies: the NIA interventions testing program

(2008) N. L. Nadon et al.   AGE

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functionally significant insulin-like growth factor I receptor mutations in centenarians

(2008) Y. Suh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA