The role of S6K1 in ER-positive breast cancer

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy

(2015) Melissa L. Sokolosky et al.   Oncotarget

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health

(2015) William H. Chappell et al.   Oncotarget

Phase II trial of temsirolimus in patients with metastatic breast cancer

(2012) Gini F. Fleming et al.   BREAST CANCER RESEARCH AND TREATMENT

Estrogenic regulation of S6K1 expression creates a positive regulatory loop in control of breast cancer cell proliferation

(2012) D M Maruani et al.   ONCOGENE

A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer

(2011) E. M. Fox et al.   CANCER RESEARCH

mTOR inhibition in breast cancer: unraveling the complex mechanisms of mTOR signal transduction and its clinical implications in therapy

(2011) Ruth O'Regan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Transcriptional consequences of genomic structural aberrations in breast cancer

(2011) K. Inaki et al.   GENOME RESEARCH

Phosphatidylinositol 3-Kinase and Antiestrogen Resistance in Breast Cancer

(2011) Todd W. Miller et al.   JOURNAL OF CLINICAL ONCOLOGY

The IGF Pathway Regulates ERα through a S6K1-Dependent Mechanism in Breast Cancer Cells

(2011) Marc A. Becker et al.   MOLECULAR ENDOCRINOLOGY

Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer

(2011) José Baselga et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation

(2011) S. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene expression profiling of response to mTOR inhibitor everolimus in pre-operatively treated post-menopausal women with oestrogen receptor-positive breast cancer

(2010) Vicky S. Sabine et al.   BREAST CANCER RESEARCH AND TREATMENT

Phosphorylated S6K1 is a possible marker for endocrine therapy resistance in hormone receptor-positive breast cancer

(2010) Eun-Kyu Kim et al.   BREAST CANCER RESEARCH AND TREATMENT

Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer

(2010) Todd W. Miller et al.   JOURNAL OF CLINICAL INVESTIGATION

Phosphorylation of the mutant K303R estrogen receptor α at serine 305 affects aromatase inhibitor sensitivity

(2010) I Barone et al.   ONCOGENE

Copy Number Alterations that Predict Metastatic Capability of Human Breast Cancer

(2009) Y. Zhang et al.   CANCER RESEARCH

mTOR/S6K1 and MAPK/RSK signaling pathways coordinately regulate estrogen receptor α serine 167 phosphorylation

(2009) Rachel L. Yamnik et al.   FEBS LETTERS

Targeting the mTOR Signaling Network for Cancer Therapy

(2009) Funda Meric-Bernstam et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase II Randomized Study of Neoadjuvant Everolimus Plus Letrozole Compared With Placebo Plus Letrozole in Patients With Estrogen Receptor–Positive Breast Cancer

(2009) José Baselga et al.   JOURNAL OF CLINICAL ONCOLOGY

Genetic Alterations and Oncogenic Pathways Associated with Breast Cancer Subtypes

(2009) X. Hu et al.   MOLECULAR CANCER RESEARCH

Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells

(2009) Nalinie S. Wickramasinghe et al.   NUCLEIC ACIDS RESEARCH

Estradiol-regulated microRNAs control estradiol response in breast cancer cells

(2009) Poornima Bhat-Nakshatri et al.   NUCLEIC ACIDS RESEARCH

SKAR Links Pre-mRNA Splicing to mTOR/S6K1-Mediated Enhanced Translation Efficiency of Spliced mRNAs

(2008) Xiaoju Max Ma et al.   CELL

Down-Regulation of Phosphatidylinositol 3'-Kinase/AKT/Molecular Target of Rapamycin Metabolic Pathway by Primary Letrozole-Based Therapy in Human Breast Cancer

(2008) D. Generali et al.   CLINICAL CANCER RESEARCH

S6 Kinase 1 Regulates Estrogen Receptor α in Control of Breast Cancer Cell Proliferation

(2008) Rachel L. Yamnik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparative effects of estradiol, methyl-piperidino-pyrazole, raloxifene, and ICI 182 780 on gene expression in the murine uterus

(2008) Angela M Davis et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Phosphorylation at serines 104 and 106 by Erk1/2 MAPK is important for estrogen receptor-α activity

(2008) Ross S Thomas et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progression

(2008) Sujun Hua et al.   Molecular Systems Biology