Article
Multidisciplinary Sciences
Takahiro Masaki, Makoto Habara, Yuki Sato, Takahiro Goshima, Keisuke Maeda, Shunsuke Hanaki, Midori Shimada
Summary: The study reveals that calcineurin regulates the stability and activity of ER-alpha in breast cancer cells by modulating its phosphorylation at Ser 294 and Ser 118 positions. The expression of the calcineurin A-alpha gene (PPP3CA) is associated with poor prognosis in ER-alpha-positive breast cancer patients, suggesting calcineurin as a promising target for therapies in ER-alpha-positive breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Candice B. Herber, Chaoshen Yuan, Anthony Chang, Jen-Chywan Wang, Isaac Cohen, Dale C. Leitman
Summary: This study suggests that 2',3',4'-THC may act as a new class of ERα modulators that are not direct agonists or antagonists. By altering the activity of ERα on gene regulation and cell proliferation, 2',3',4'-THC has a reprogramming effect, unlike antagonists that compete with E2 for binding to ERα. Adding a reprogramming drug to MHT may offer a new strategy to overcome the adverse proliferative effects of estrogen in MHT.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aoi Ikedo, Yuuki Imai
Summary: Estrogen deficiency impairs fracture healing by affecting the expression ratio of estrogen receptors, especially ERα, in callus during the process. The study clarified the significance of ERs during fracture healing using osteoblast-specific ER knockout mice, showing that ERα in osteocalcin-positive osteoblasts may contribute to the late stage of bone regeneration.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Iva Busic-Pavlek, Ivo Dumic-Cule, Lucija Kovacevic, Milan Milosevic, Petra Delimar, Lea Korsa, Zlatko Marusic, Maja Prutki
Summary: The calcium-sensing receptor (CaSR) is important in maintaining calcium balance and altered signaling through CaSR is associated with the development of various tumors including colorectal and breast tumors. A retrospective study involving 79 patients with invasive breast carcinoma explored the expression of CaSR in breast cancer. The study found that higher CaSR expression was correlated with larger tumor size, presence of HER2 receptors, lymph node involvement, distant metastasis, and increased Ki-67 proliferation index. This suggests that higher CaSR expression may indicate a poor prognosis and treatment outcome in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Marco Fiocchetti, Giovanna Bastari, Manuela Cipolletti, Stefano Leone, Filippo Acconcia, Maria Marino
Summary: Phthalates, including diethyl phthalate (DEP), are synthetic chemicals widely used as plasticizers and additives in personal care products, posing potential health risks such as increased breast cancer risk. The estrogen disrupting activities of DEP are controversial, but it interacts with estrogen receptor alpha (ER alpha) signaling, emphasizing the need for further research on its mechanisms.
Article
Medicine, Research & Experimental
Yumiao Shi, Yiqi Zhang, Suyang Yu, Jiamei Luo, Zhiying Pan, Xiaoqiang Wang, Jie Tian
Summary: This study found that KOR was the only opioid receptor significantly decreased in breast cancer tumor tissues compared to normal tissues. Decreased expression of KOR was associated with poor clinical outcomes in estrogen receptor positive breast cancer. In vitro studies confirmed the anti-tumor effects of KOR agonists in ER-positive breast cancer cells, and identified KOR-ER-XBP1 as a potential downstream signaling pathway mediating these effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Yu-Chen S. H. Yang, Zi-Lin Li, Tung-Yung Huang, Kuan-Wei Su, Chi-Yu Lin, Chi-Hung Huang, Han-Yu Chen, Mei-Chin Lu, Haw-Ming Huang, Sheng-Yang Lee, Jaqueline Whang-Peng, Hung-Yun Lin, Paul J. Davis, Kuan Wang
Summary: Heteronemin can suppress proliferation of both ER-positive and ER-negative breast cancer cells by inhibiting the activation of ERK1/2 and STAT3. It can also counteract E-2-induced proliferation in breast cancer cells and affect mitochondrial reactive oxygen species, leading to G(0)/G(1) phase arrest.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dahae Lee, Young-Mi Kim, Young-Won Chin, Ki Sung Kang
Summary: This study demonstrated that schisandrol A has estrogen-like effects by inducing the expression of ER alpha through the PI3K/AKT and ERK signaling pathways, promoting the proliferation of MCF-7 cells. The effects of schisandrol A were more significant compared to E2 and could be mitigated by the ER antagonist ICI.
Article
Biochemistry & Molecular Biology
Alexander M. Scherbakov, Danila V. Sorokin, Olga A. Omelchuk, Andrey E. Shchekotikhin, Mikhail A. Krasil'nikov
Summary: The study showed that glucose starvation can enhance the antiproliferative and antiestrogenic potency of oligomycin A in hormone-dependent breast cancer cells, particularly in MCF-7 cells. This suggests that glucose starvation and inhibition of glycolysis could be potential strategies to explore the antitumor effects of oligomycin A against hormone-dependent breast cancers.
Article
Oncology
Zhi-Feng Guo, Fan-Long Kong
Summary: This study investigated the relationship between Akt and H2A.X in human breast cancer cells. It found that Akt negatively regulated the phosphorylation of H2A.X, promoting cellular survival and migration. The findings shed light on the pathogenesis and treatment mechanisms of breast cancer.
Article
Cell Biology
Zhiguo Niu, Jianing Fan, Fengzhe Chen, Huijie Yang, Xin Li, Ting Zhuang, Chunlei Guo, Qi Cao, Jian Zhu, Hui Wang, Qingsong Huang
Summary: Breast cancer is the most common malignancy in women globally. Abnormal expression of RBCK1 protein in breast tumors makes it a valuable diagnostic marker and drug target. Hypoxic regions in breast cancer activate the HIF1 pathway, influencing tumor recurrence and metastasis. Targeting RBCK1 could be a promising treatment strategy for ER-positive breast cancer.
CELL DEATH & DISEASE
(2022)
Article
Biology
Natalia Vydra, Patryk Janus, Pawel Kus, Tomasz Stokowy, Katarzyna Mrowiec, Agnieszka Toma-Jonik, Aleksandra Krzywon, Alexander Jorge Cortez, Bartosz Wojtas, Bartlomiej Gielniewski, Roman Jaksik, Marek Kimmel, Wieslawa Widlak
Summary: Heat shock factor 1 (HSF1) is linked to estrogen (E2) signaling through estrogen receptor alpha (ER alpha), and its deficiency in ER-positive breast cancer cells may decrease ER alpha level, attenuate the mitogenic action of E2, reduce cell motility, and increase sensitivity to hormonal therapy and CDK4/6 inhibitors. Additionally, HSF1 enhances the genomic action of ER alpha in ER-positive breast cancer, and an elevated HSF1 level is associated with metastatic disease.
Article
Cell Biology
Xiaoqing Wan, Jiaxin Hou, Shurong Liu, Yanli Zhang, Wenqing Li, Yanru Zhang, Yi Ding
Summary: Resistance to anthracyclines, such as doxorubicin, is commonly observed in ER alpha-positive breast cancer patients. EMT plays a role in chemotherapy-induced drug resistance, with ER alpha-positive cells showing lower sensitivity to doxorubicin compared to ER alpha-negative cells. The regulation of E-cadherin expression in response to doxorubicin treatment varies depending on ER alpha status, with potential implications for treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ya-Shuan Chou, Shu-Chun Chuang, Chung-Hwan Chen, Mei-Ling Ho, Je-Ken Chang
Summary: Estrogen enhances long bone growth during early puberty, with GPER-1 playing a crucial role in regulating growth plate chondrocyte function. Knocking out GPER-1 in chondrocytes led to decreased body length and bone growth, demonstrating GPER-1's positive regulation on chondrocyte proliferation and longitudinal bone growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Xiao Ma, Juhong Wang, Guifen Hu, Yinggang Chen, Xiaoling Hu, Yijia Zhu, Linchao Ding, Shilong Ning
Summary: Sesamol induces ER alpha re-expression in ER alpha-negative breast carcinoma, making the cancer responsive to endocrine treatment drugs by downregulating DNMT3A and DNMT3B expression.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
