The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells

HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2

(2016) Philippos Peidis et al.   Aging-US

Chronic myeloid leukemia stem cells in the era of targeted therapies: resistance, persistence and long-term dormancy

(2015) Jean-Claude Chomel et al.   Oncotarget

Mechanisms of AXL overexpression and function in Imatinib-resistant chronic myeloid leukemia cells

(2015) Maeva Dufies et al.   Oncotarget

BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia

(2012) Oliver Hantschel et al.   Nature Chemical Biology

Akt Determines Cell Fate Through Inhibition of the PERK-eIF2  Phosphorylation Pathway

(2011) Z. Mounir et al.   Science Signaling

eIF2  Kinase PKR Modulates the Hypoxic Response by Stat3-Dependent Transcriptional Suppression of HIF-1 

(2010) A. I. Papadakis et al.   CANCER RESEARCH

Hedgehog pathway activation in chronic myeloid leukemia: A promise for a novel combination therapeutic approach?

(2010) Zainab Jagani et al.   CELL CYCLE

Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death

(2010) P Peidis et al.   CELL DEATH AND DIFFERENTIATION

Critical molecular pathways in cancer stem cells of chronic myeloid leukemia

(2010) Y Chen et al.   LEUKEMIA

Phosphorylation of eIF2α at Serine 51 Is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency

(2010) Hala Muaddi et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis

(2010) B J Altman et al.   ONCOGENE

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

(2010) E Bobrovnikova-Marjon et al.   ONCOGENE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data

(2009) V. G. Oehler et al.   BLOOD

Contribution of BCR–ABL-independent activation of ERK1/2 to acquired imatinib resistance in K562 chronic myeloid leukemia cells

(2009) Takeru Nambu et al.   CANCER SCIENCE

Targeting autophagy potentiates tyrosine kinase inhibitor–induced cell death in Philadelphia chromosome–positive cells, including primary CML stem cells

(2009) Cristian Bellodi et al.   JOURNAL OF CLINICAL INVESTIGATION

The anti-apoptotic role of the unfolded protein response in Bcr-Abl-positive leukemia cells

(2009) Atsuko Tanimura et al.   LEUKEMIA RESEARCH

Endoplasmic reticulum stress and autophagy as targets for cancer therapy

(2008) Axel H. Schönthal   CANCER LETTERS

BCR/ABL and Other Kinases from Chronic Myeloproliferative Disorders Stimulate Single-Strand Annealing, an Unfaithful DNA Double-Strand Break Repair

(2008) K. Cramer et al.   CANCER RESEARCH

PERK-dependent regulation of IAP translation during ER stress

(2008) R B Hamanaka et al.   ONCOGENE