YAP oncogene overexpression supercharges colon cancer proliferation

The Class I Hdac Inhibitor Mgcd0103 Induces Cell Cycle Arrest and Apoptosis in Colon Cancer Initiating Cells by Upregulating Dickkopf-1 and Non-Canonical Wnt Signaling

(2015)   Oncotarget

Molecular identification and targeting of colorectal cancer stem cells

(2015)   Oncotarget

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation

(2011) Karin Schlegelmilch et al.   CELL

Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab

(2011) Lori S. Hart et al.   CELL CYCLE

Hippo signaling inDrosophila: Recent advances and insights

(2011) Binnaz Kucuk Staley et al.   DEVELOPMENTAL DYNAMICS

Facultative stem cells in liver and pancreas: Fact and fancy

(2011) Kilangsungla Yanger et al.   DEVELOPMENTAL DYNAMICS

The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma

(2011) K. P. L. Bhat et al.   GENES & DEVELOPMENT

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

Connective tissue growth factor autocriny in human hepatocellular carcinoma: Oncogenic role and regulation by epidermal growth factor receptor/yes-associated protein-mediated activation

(2011) Raquel Urtasun et al.   HEPATOLOGY

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

(2011) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering tumor-suppressor signaling in flies: Genetic link between Scribble/Dlg/Lgl and the Hippo pathways

(2011) Masato Enomoto et al.   Journal of Genetics and Genomics

Hippo signaling: A hub of growth control, tumor suppression and pluripotency maintenance

(2011) Mengxin Yin et al.   Journal of Genetics and Genomics

Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor

(2011) Murugan Paramasivam et al.   MOLECULAR BIOLOGY OF THE CELL

Differences in Yes-associated protein and mRNA levels in regenerating liver and hepatocellular carcinoma

(2011) Jiahong Dong   Molecular Medicine Reports

Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP

(2011) T Oka et al.   ONCOGENE

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene

(2011) X Zhang et al.   ONCOGENE

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

(2011) D. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components

(2011) N.-G. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size

(2011) T. Heallen et al.   SCIENCE

 -Catenin Is a Tumor Suppressor That Controls Cell Accumulation by Regulating the Localization and Activity of the Transcriptional Coactivator Yap1

(2011) M. R. Silvis et al.   Science Signaling

Zyxin Links Fat Signaling to the Hippo Pathway

(2011) Cordelia Rauskolb et al.   PLOS BIOLOGY

Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development

(2010) J Avruch et al.   BRITISH JOURNAL OF CANCER

YAP is a candidate oncogene for esophageal squamous cell carcinoma

(2010) Tomoki Muramatsu et al.   CARCINOGENESIS

Tissue-Resident Adult Stem Cell Populations of Rapidly Self-Renewing Organs

(2010) Nick Barker et al.   Cell Stem Cell

Upstream Regulation of the Hippo Size Control Pathway

(2010) Felix A. Grusche et al.   CURRENT BIOLOGY

Ajuba LIM Proteins Are Negative Regulators of the Hippo Signaling Pathway

(2010) Meghna Das Thakur et al.   CURRENT BIOLOGY

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded

(2010) Jianzhong Yu et al.   DEVELOPMENTAL CELL

Kibra Is a Regulator of the Salvador/Warts/Hippo Signaling Network

(2010) Alice Genevet et al.   DEVELOPMENTAL CELL

The Lats2 tumor suppressor augments p53-mediated apoptosis by promoting the nuclear proapoptotic function of ASPP1

(2010) Y. Aylon et al.   GENES & DEVELOPMENT

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

(2010) J. Cai et al.   GENES & DEVELOPMENT

Cytoplasmic ASPP1 inhibits apoptosis through the control of YAP

(2010) A. M. Vigneron et al.   GENES & DEVELOPMENT

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

(2010) I. Lian et al.   GENES & DEVELOPMENT

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF -TRCP

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

(2010) H. Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

(2010) L. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RASSF proteins in cancer; from epigenetic silencing to functional characterization

(2009) Antje M. Richter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

(2009) Michelle Z. Xu et al.   CANCER

Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene

(2009) Dawang Zhou et al.   CANCER CELL

Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling

(2009) Hyangyee Oh et al.   DEVELOPMENTAL BIOLOGY

The FERM-Domain Protein Expanded Regulates Hippo Pathway Activity via Direct Interactions with the Transcriptional Activator Yorkie

(2009) Caroline Badouel et al.   DEVELOPMENTAL CELL

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

(2009) A. Fernandez-L et al.   GENES & DEVELOPMENT

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

(2009) Jianmin Zhang et al.   NATURE CELL BIOLOGY

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium

(2008) Laurens G. van der Flier et al.   Annual Review of Physiology

Yes-associated protein (YAP) functions as a tumor suppressor in breast

(2008) M Yuan et al.   CELL DEATH AND DIFFERENTIATION

SCALLOPED Interacts with YORKIE, the Nuclear Effector of the Hippo Tumor-Suppressor Pathway in Drosophila

(2008) Youlian Goulev et al.   CURRENT BIOLOGY

In vivo regulation of Yorkie phosphorylation and localization

(2008) H. Oh et al.   DEVELOPMENT

The TEAD/TEF Family Protein Scalloped Mediates Transcriptional Output of the Hippo Growth-Regulatory Pathway

(2008) Shian Wu et al.   DEVELOPMENTAL CELL

The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control

(2008) Lei Zhang et al.   DEVELOPMENTAL CELL

YAP regulates neural progenitor cell number via the TEA domain transcription factor

(2008) X. Cao et al.   GENES & DEVELOPMENT

TEAD mediates YAP-dependent gene induction and growth control

(2008) B. Zhao et al.   GENES & DEVELOPMENT

Expression of Yes-associated protein in common solid tumors

(2008) Angela A. Steinhardt et al.   HUMAN PATHOLOGY

Rassf Family of Tumor Suppressor Polypeptides

(2008) Joseph Avruch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway

(2008) Q.-Y. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

(2008) Dan Levy et al.   MOLECULAR CELL

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL