Article
Biochemistry & Molecular Biology
Sixian Qi, Zhenxing Zhong, Yuwen Zhu, Yebin Wang, Mingyue Ma, Yu Wang, Xincheng Liu, Ruxin Jin, Zhihan Jiao, Rui Zhu, Zhao Sha, Kyvan Dang, Ying Liu, Dae-Sik Lim, Junhao Mao, Lei Zhang, Fa-Xing Yu
Summary: This study reveals that the HPO1 and HPO2 modules together regulate the activity of LATS1/2 kinases and YAP/TAZ transcriptional co-activators in the Hippo pathway. Inactivation of either HPO1 or HPO2 module leads to partial activation of YAP/TAZ, bile duct hyperplasia, and hepatocellular carcinoma (HCC) in mice livers. On the other hand, inactivation of both HPO1 and HPO2 modules results in full activation of YAP/TAZ, rapid development of intrahepatic cholangiocarcinoma (iCCA), and early lethality.
Correction
Biochemistry & Molecular Biology
Dae-Wook Yang, Kwang-Wook Choi
Summary: A revised version of this paper has been published and can be accessed through a link at the top of the paper.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Rui-Hua Li, Tian Tian, Qi-Wei Ge, Xin-Yu He, Cheng-Yu Shi, Jun-Hong Li, Zhen Zhang, Fang-Zhou Liu, Ling-Jie Sang, Zuo-Zhen Yang, Ya-Zhuo Liu, Yan Xiong, Qingfeng Yan, Xu Li, Huai-Qiang Ju, Jian Liu, Liang-Jing Wang, Jian-Zhong Shao, Wenqi Wang, Tianhua Zhou, Aifu Lin
Summary: The lipid-associated lncRNA SNHG9 promotes breast cancer development by driving the liquid droplet formation of the signaling kinase LATS1 and inhibiting the Hippo pathway, affecting YAP activity.
Review
Oncology
Jing Xu, Xin-Yuan Liu, Qi Zhang, Hua Liu, Peng Zhang, Zi-Bin Tian, Cui-Ping Zhang, Xiao-Yu Li
Summary: This article summarizes recent studies, clarifying the close association between long non-coding RNAs, tumor-associated macrophages, and Yes-associated protein and tumorigenesis, and analyzes the prospects of tumor immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yan Meng, Yan Sang, Jianping Liao, Qiudong Zhao, Shuping Qu, Rong Li, Jinghua Jiang, Meifeng Wang, Jiahong Wang, Dong Wu, Chun Cheng, Lixin Wei
Summary: Liver cancer patients exhibit transcriptional diversity in tumor cells, which is associated with stemness and potentially driven by tumor-associated fibroblasts (TAF). Specifically, TAF interacts with heterogeneous tumor cells via COL1A1-ITGA2, and COL1A1-mediated YAP activation is mechanistically linked to increased transcriptional diversity. The levels of COL1A1, ITGA2, and YAP are also correlated with morphological heterogeneity and poor overall survival of liver cancer patients.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Xu Li, Shu Zhuo, Ting Zhuang, Yong Suk Cho, Guojin Wu, Yuchen Liu, Kun Mu, Kai Zhang, Peng Su, Yingzi Yang, Cheng Cheng Zhang, Jian Zhu, Jin Jiang
Summary: Hippo signaling restricts tissue growth by inhibiting YAP, which also functions as a tumor suppressor in ER+ breast cancer by interfering with the TEAD-ERα signaling axis.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Fabin Dang, Li Nie, Wenyi Wei
Summary: Cell cycle progression relies on the activation of cyclin-dependent kinases, regulated in part by ubiquitin-mediated proteolysis. Dysregulated proteolytic control can lead to uncontrolled cell proliferation and tumorigenesis. Targeting E3 ubiquitin ligases involved in cell cycle regulation may offer novel therapeutic strategies for cancer treatment.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Xianping Wang, Hui Liang, Wenyan Xu, Xianjue Ma
Summary: Both Hippo signaling pathways and cell polarity regulation are vital for cell proliferation and tissue homeostasis. This study uncovers the Wnd-Nmo axis as a crucial molecular link between loss-of-cell polarity-triggered Hippo inactivation and overgrowth in Drosophila, providing new insights into how cell polarity loss contributes to overgrowth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Stefania Pagliari, Vladimir Vinarsky, Fabiana Martino, Ana Rubina Perestrelo, Jorge Oliver De La Cruz, Guido Caluori, Jan Vrbsky, Pamela Mozetic, Antonio Pompeiano, Andrea Zancla, Sri Ganji Ranjani, Petr Skladal, Dan Kytyr, Zbynek Zdrahal, Gabriele Grassi, Maurilio Sampaolesi, Alberto Rainer, Giancarlo Forte
Summary: The YAP-TEAD complex plays a crucial role in cellular processes such as migration, division, and differentiation. PSCs exhibit sustained YAP-driven transcriptional activity despite growing in dense colonies, which can be restored by tampering with the Tankyrase enzyme.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Yu Wang, Yuwen Zhu, Yuan Gu, Mingyue Ma, Yebin Wang, Sixian Qi, Yan Zeng, Rui Zhu, Xueying Wang, Pengcheng Yu, Jianhui Xu, Yilai Shu, Fa-Xing Yu
Summary: Mutations in the NF2 gene result in neurofibromatosis type 2, impacting the Hippo signaling pathway and leading to increased YAP/TAZ activity, promoting tumorigenesis.
Article
Biochemistry & Molecular Biology
Rina Nagata, Nanami Akai, Shu Kondo, Kuniaki Saito, Shizue Ohsawa, Tatsushi Igaki
Summary: Mutations in the tumor-suppressor Hippo pathway activate the transcriptional coactivator Yorkie, leading to autonomous cell proliferation and non-autonomous cell death. This study reveals that Yki-induced supercompetition is crucial for tumorigenesis and is driven by non-autonomous induction of autophagy.
Article
Chemistry, Multidisciplinary
Hui Zhang, Moubin Lin, Chao Dong, Yang Tang, Liwei An, Junyi Ju, Fuping Wen, Fan Chen, Meng Wang, Wenjia Wang, Min Chen, Yun Zhao, Jixi Li, Steven X. Hou, Xinhua Lin, Lulu Hu, Wenbo Bu, Dianqing Wu, Lin Li, Shi Jiao, Zhaocai Zhou
Summary: The MST4-p beta-catenin(Thr40) signaling axis is essential for intestinal stem cell homeostasis and CRC development, preventing beta-catenin degradation and leading to its accumulation and activation. Enhanced MST4 activity exacerbates CRC progression, suggesting potential for targeted therapy.
Article
Developmental Biology
Chhavi Sood, Virginia T. Justis, Susan E. Doyle, Sarah E. Siegrist
Summary: Notch signaling coordinates neuroblast intrinsic temporal programs with extrinsic nutrient cues to regulate quiescence in fruit flies. Reduction in Notch activity delays or bypasses quiescence, resulting in continuous neuroblast division. Notch and its ligand Delta are expressed in neuroblasts before entering quiescence, and Delta transactivates Notch in adjacent GMC daughters. Over time and with increasing Delta-expressing daughters, neuroblast Notch activity increases, leading to cell cycle exit and attenuation of Notch pathway activity in quiescent neuroblasts.
Article
Biochemistry & Molecular Biology
Mengzhu Lv, Ying Gong, Xuesong Liu, Yan Wang, Qingnan Wu, Jie Chen, Qingjie Min, Dongyu Zhao, Xianfeng Li, Dongshao Chen, Di Yang, Danna Yeerken, Rui Liu, Jinting Li, Weimin Zhang, Qimin Zhan
Summary: We discovered that mitochondrial D-lactate catabolism is a necessary oncogenic event in the development of esophageal squamous cell carcinoma (ESCC). We found that cyclin-dependent kinase 7 (CDK7) phosphorylates nuclear Yes-associated protein 1 (YAP) and enhances its transcription function, promoting the expression of D-lactate dehydrogenase (LDHD). The CDK7-YAP-LDHD axis helps ESCC cancer stem cells (CSCs) escape ferroptosis and generate pyruvate to support their self-renewal potential.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Oncology
Xuehui Wang, Changle Ji, Jiashu Hu, Xiaochong Deng, Wenfang Zheng, Yunhe Yu, Kaiyao Hua, Xiqian Zhou, Lin Fang
Summary: Hsa_circ_0005273 is overexpressed in breast cancer tissues and cell lines, promoting BC progression by regulating the miR-200a-3p/YAP1 axis and inactivating the Hippo signaling pathway.
Depletion of hsa_circ_0005273 inhibits tumor cell proliferation, migration, and cell cycle progression, suggesting it as a potential therapeutic target for breast cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)