Accelerated aging in the tumor microenvironment

Aging: past, present and future

(2016) Mikhail V. Blagosklonny et al.   Aging-US

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

(2016) Stephanos Pavlides et al.   Aging-US

Mitochondrial targeted catalase suppresses invasive breast cancer in mice

(2011) Jorming Goh et al.   BMC CANCER

Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?

(2011) Federica Sotgia et al.   BMC Medicine

Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment

(2011) Casey Trimmer et al.   CANCER BIOLOGY & THERAPY

Vitamin Supplement Use During Breast Cancer Treatment and Survival: A Prospective Cohort Study

(2011) S. Nechuta et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

An absence of stromal caveolin-1 is associated with advanced prostate cancer, metastatic disease spread and epithelial Akt activation

(2011) Dolores Di Vizio et al.   CELL CYCLE

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Increasing healthy lifespan by suppressing aging in our lifetime: Preliminary proposal 

(2011) Mikhail V Blagosklonny   CELL CYCLE

Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers

(2011) Agnieszka K. Witkiewicz et al.   CELL CYCLE

Cytokine production and inflammation drive autophagy in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Evidence for a stromal-epithelial “lactate shuttle” in human tumors

(2011) Diana Whitaker-Menezes et al.   CELL CYCLE

Stromal–epithelial metabolic coupling in cancer: Integrating autophagy and metabolism in the tumor microenvironment

(2011) Ubaldo E. Martinez-Outschoorn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Flies selected for longevity retain a young gene expression profile

(2010) Pernille Sarup et al.   AGE

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

(2010) Agnieszka K. Witkiewicz et al.   CANCER BIOLOGY & THERAPY

Understanding the "lethal" drivers of tumor-stroma co-evolution

(2010) Michael P. Lisanti et al.   CANCER BIOLOGY & THERAPY

The autophagic tumor stroma model of cancer

(2010) Stephanos Pavlides et al.   CELL CYCLE

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

The autophagic tumor stroma model of cancer or “battery-operated tumor growth”

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the “reverse Warburg effect”: A transcriptional informatics analysis with validation

(2010) Stephanos Pavlides et al.   CELL CYCLE

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: Implications for breast cancer and DCIS therapy with autophagy inhibitors

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Conditional β-catenin loss in mice promotes chemical hepatocarcinogenesis: Role of oxidative stress and platelet-derived growth factor receptor α/phosphoinositide 3-kinase signaling

(2010) Xu-Feng Zhang et al.   HEPATOLOGY

Life Extension by Diet Restriction and N-Acetyl-L-Cysteine in Genetically Heterogeneous Mice

(2010) K. Flurkey et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Murine models of premature ageing for the study of diet-induced immune changes: improvement of leucocyte functions in two strains of old prematurely ageing mice by dietary supplementation with sulphur-containing antioxidants

(2010) Mónica De la Fuente   PROCEEDINGS OF THE NUTRITION SOCIETY

Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis

(2009) Makiya Nishikawa et al.   ADVANCED DRUG DELIVERY REVIEWS

Vegetarian diets: what do we know of their effects on common chronic diseases?

(2009) Gary E Fraser   AMERICAN JOURNAL OF CLINICAL NUTRITION

Stromal Cell Expression of Caveolin-1 Predicts Outcome in Breast Cancer

(2009) Erica K. Sloan et al.   AMERICAN JOURNAL OF PATHOLOGY

An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers

(2009) Agnieszka K. Witkiewicz et al.   AMERICAN JOURNAL OF PATHOLOGY

Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

(2009) William R Swindell   BMC GENOMICS

Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase

(2009) Kenji Hyoudou et al.   JOURNAL OF CONTROLLED RELEASE

Reactive oxygen species in tumor metastasis

(2008) Makiya Nishikawa   CANCER LETTERS