Article
Biochemistry & Molecular Biology
Wenjuan Yu, Ramesh Singh, Zhao Wang, Bert W. O'Malley, Ping Yi
Summary: TRAF4-mediated ubiquitination of IRS-1 is physiologically relevant and crucial for IGF signal transduction, as it promotes an atypical K29-linked ubiquitination at the C-terminal end of IRS-1, affecting downstream AKT and ERK phosphorylation and breast cancer cell proliferation. The nonproteolytic ubiquitination of IRS-1 is a key step in conveying IGF-1 stimulation from IGFR to IRS-1.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Cell Biology
Yusuke Nishimura, Jitpisute Chunthorng-Orn, Samuel Lord, Ibrahim Musa, Peter Dawson, Lars Holm, Yu-Chiang Lai
Summary: In this study, the researchers showed that Atrogin-1 and MuRF1 protein contents are regulated by different mechanisms, specifically the downstream of Akt, and that Atrogin-1 protein content can be regulated by the rapamycin-sensitive mTOR-S6K1-dependent signaling pathway.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Laith M. Haj-Ahmad, Muhannad M. Mahmoud, Nabil W. G. Sweis, Isam Bsisu, Ahmad M. Alghrabli, Alaa M. Ibrahim, Ayman A. Zayed
Summary: The serum IGF-1/IGFBP-3 ratio is a useful marker for the diagnosis of growth hormone deficiency in children. Combining serum IGF-1, IGFBP-3, and the IGF-1/IGFBP-3 ratio can improve the specificity of the diagnosis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Anna Fedorczak, Andrzej Lewinski, Renata Stawerska
Summary: The regulation of growth processes in children depends on the synthesis of growth hormone and insulin-like growth factor 1. Recently, SIRT1 has been found to be one of the factors regulating growth hormone secretion and its effects. SIRT1 is involved in GH signal transduction in hepatocytes and the synthesis of GH and GHRH in other cells. It is also implicated in various cellular processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xuan Li, Kai-Bin Yang, Wei Chen, Jia Mai, Xiao-Qi Wu, Ting Sun, Rui-Yan Wu, Lin Jiao, Dan-Dan Li, Jiao Ji, Hai-Liang Zhang, Yan Yu, Yu-Hong Chen, Gong-Kan Feng, Rong Deng, Jun-Dong Li, Xiao-Feng Zhu
Summary: The E3 ubiquitin ligase CUL3 interacts with BECN1 to promote its ubiquitination and degradation, leading to a decrease in autophagic activity and promoting tumor cell proliferation. Additionally, KLHL38 acts as a substrate adaptor for the CUL3 E3 ligase complex-mediated degradation of BECN1.
Article
Medicine, General & Internal
Marzena Kolasa-Kicinska, Renata Stawerska, Pawel Stawerski, Andrzej Kaluzynski, Elzbieta Czkwianianc, Andrzej Lewinski
Summary: This study found that short children infected with H. pylori have lower concentrations of ghrelin and IGF-1 compared to children without infection, which may contribute to their poorer growth rate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell & Tissue Engineering
Wen-Cheng Lo, Chi-Sheng Chiou, Feng-Chou Tsai, Chun-Hao Chan, Samantha Mao, Yue-Hua Deng, Chia-Yu Wu, Bou-Yue Peng, Win-Ping Deng
Summary: Nicotine may induce intervertebral disc degeneration, and platelet-derived biomaterials (PDB) can inhibit this process by modulating the IGF-1/AKT/IRS-1 signaling axis.
CELL TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Vivek Reddy Palicharla, Devanshi Gupta, Debjani Bhattacharya, Subbareddy Maddika
Summary: The study reveals a new role of the HECT-E3 ligase HACE1 as a molecular adaptor independent of its ligase activity. By promoting Spindlin-1 degradation, HACE1 regulates cell-cell adhesion. These findings suggest HACE1 plays an important noncatalytic role in presenting selected substrates for proteasomal degradation.
Article
Oncology
Gregoire Quinet, Wendy Xolalpa, Diana Reyes-Garau, Nuria Profitos-Peleja, Mikel Azkargorta, Laurie Ceccato, Maria Gonzalez-Santamarta, Maria Marsal, Jordi Andilla, Fabienne Aillet, Francesc Bosch, Felix Elortza, Pablo Loza-Alvarez, Brigitte Sola, Olivier Coux, Rune Matthiesen, Gael Roue, Manuel S. Rodriguez
Summary: The research identified an enrichment of autophagy-lysosome system (ALS) components in bortezomib (BTZ)-resistant cells in mantle cell lymphoma (MCL) patients. By blocking proteaphagy, the normal proteasomal activity was reactivated and the BTZ antitumor effect was restored in vitro and in vivo models of BTZ resistance. These findings suggest a proteolytic switch from the ubiquitin-proteasome system (UPS) to ALS in B-cell lymphoma refractory to proteasome inhibition, opening up new therapeutic avenues for treatment-resistant tumors.
Review
Oncology
Jinlong Tang, Yuan Li, Shuli Xia, Jinfan Li, Qi Yang, Kefeng Ding, Honghe Zhang
Summary: SQSTM1/p62 is a versatile protein involved in regulating various processes in tumor cells, such as genetic stability, autophagy, and cell death, impacting tumor occurrence, development, as well as patient treatment and prognosis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Guangzhi Yang, Qing Yang, Yanying Li, Yanhong Zhang, Shuxiong Chen, Dongye He, Mei Zhang, Bo Ban, Fupeng Liu
Summary: This study aims to evaluate the association between the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis and muscle density in children and adolescents of short stature. The results showed that a chest CT scan is a credible method of evaluating body composition in these individuals. Peak GH and IGF-1 SDS are independent predictors of muscle density.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemical Research Methods
Tanya R. Porras-Yakushi, Justin M. Reitsma, Michael J. Sweredoski, Raymond J. Deshaies, Sonja Hess
Summary: The study conducted a large-scale ubiquitylome analysis of proteasome inhibitors and identified numerous unique ubiquitylation sites in protein groups. It also highlighted candidate proteins for further study, indicating potential targets for the ubiquitin proteasome system. Additionally, the research observed a decrease in ubiquitylation of the tumor suppressor protein MORF4L1 upon proteasome inhibition, suggesting a potential anti-tumor effect of certain proteasome inhibitors.
JOURNAL OF PROTEOMICS
(2021)
Article
Microbiology
Yu Pang, Mao Li, Yanrong Zhou, Wei Liu, Ran Tao, Hejin Zhang, Shaobo Xiao, Liurong Fang
Summary: The study reveals that UPS plays a crucial role in the proliferation of PRRSV by affecting viral attachment and replication during the middle stage of infection.
VETERINARY MICROBIOLOGY
(2021)
Review
Virology
Benjamin Stupfler, Cedric Verriez, Sarah Gallois-Montbrun, Roland Marquet, Jean-Christophe Paillart
Summary: The ubiquitin-proteasome system plays a crucial role in normal cell physiology and during viral infections. HIV-1 viral infectivity factor (Vif) has been shown to counteract cellular deaminases by recruiting E3-ubiquitin ligase complex, leading to their polyubiquitination and degradation. Research on the degradation-independent inhibition of A3s by Vif remains limited, but it has been shown to impede A3s through other processes.
Article
Nanoscience & Nanotechnology
Longbin Zhang, Liyong Zou, Xuejun Jiang, Shuqun Cheng, Jun Zhang, Xia Qin, Zhexue Qin, Chengzhi Chen, Zhen Zou
Summary: This study reveals that activated Nrf2 and HO-1 play a negative regulatory role in endothelial cells under zinc oxide nanoparticles (ZnONPs) treatment, and the Nrf2-HO-1 axis is the crucial regulatory mechanism for antioxidative response.