In-depth proteomic analysis of proteasome inhibitors bortezomib, carfilzomib and MG132 reveals that mortality factor 4-like 1 (MORF4L1) protein ubiquitylation is negatively impacted

Carfilzomib-dexamethasone versus bortezomib-dexamethasone in relapsed or refractory multiple myeloma: updated overall survival, safety, and subgroups

(2019) Robert Z. Orlowski et al.   Clinical Lymphoma Myeloma & Leukemia

Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study

(2016) Meletios A Dimopoulos et al.   LANCET ONCOLOGY

Specificity of Protein Covalent Modification by the Electrophilic Proteasome Inhibitor Carfilzomib in Human Cells

(2016) Joel D. Federspiel et al.   MOLECULAR & CELLULAR PROTEOMICS

Using the Ubiquitin-modified Proteome to Monitor Distinct and Spatially Restricted Protein Homeostasis Dysfunction

(2016) Joshua M. Gendron et al.   MOLECULAR & CELLULAR PROTEOMICS

Plug-and-play analysis of the human phosphoproteome by targeted high-resolution mass spectrometry

(2016) Robert T Lawrence et al.   NATURE METHODS

Carfilzomib: A second-generation proteasome inhibitor for the treatment of multiple myeloma

(2015) A. McBride et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

High Resolution Parallel Reaction Monitoring with Electron Transfer Dissociation for Middle-Down Proteomics

(2015) Michael J. Sweredoski et al.   ANALYTICAL CHEMISTRY

Cyclin D1 sensitizes myeloma cells to endoplasmic reticulum stress-mediated apoptosis by activating the unfolded protein response pathway

(2015) Sophie Bustany et al.   BMC CANCER

Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line

(2015) P. Gupta et al.   DEVELOPMENT

ETD Outperforms CID and HCD in the Analysis of the Ubiquitylated Proteome

(2015) Tanya R. Porras-Yakushi et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Deep, Quantitative Coverage of the Lysine Acetylome Using Novel Anti-acetyl-lysine Antibodies and an Optimized Proteomic Workflow

(2015) Tanya Svinkina et al.   MOLECULAR & CELLULAR PROTEOMICS

Mortality factor 4 like 1 protein mediates epithelial cell death in a mouse model of pneumonia

(2015) Chunbin Zou et al.   Science Translational Medicine

Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy

(2014) Raymond J Deshaies   BMC BIOLOGY

Carfilzomib in multiple myeloma

(2014) Claudia Andreu-Vieyra et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Histone Deacetylase 2 (HDAC2) Protein-dependent Deacetylation of Mortality Factor 4-like 1 (MORF4L1) Protein Enhances Its Homodimerization

(2014) Yan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulated protein turnover: snapshots of the proteasome in action

(2014) Sucharita Bhattacharyya et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Perilous journey: a tour of the ubiquitin–proteasome system

(2014) Gary Kleiger et al.   TRENDS IN CELL BIOLOGY

Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies

(2013) Lindsey N. Micel et al.   JOURNAL OF CLINICAL ONCOLOGY

Evaluation and Optimization of Mass Spectrometric Settings during Data-dependent Acquisition Mode: Focus on LTQ-Orbitrap Mass Analyzers

(2013) Anastasia Kalli et al.   JOURNAL OF PROTEOME RESEARCH

Assessment and Improvement of Statistical Tools for Comparative Proteomics Analysis of Sparse Data Sets with Few Experimental Replicates

(2013) Veit Schwämmle et al.   JOURNAL OF PROTEOME RESEARCH

Peptide Level Immunoaffinity Enrichment Enhances Ubiquitination Site Identification on Individual Proteins

(2013) Veronica G. Anania et al.   MOLECULAR & CELLULAR PROTEOMICS

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Integrated proteomic analysis of post-translational modifications by serial enrichment

(2013) Philipp Mertins et al.   NATURE METHODS

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Wnt/beta-Catenin Signaling and Small Molecule Inhibitors

(2012) Andrey Voronkov et al.   CURRENT PHARMACEUTICAL DESIGN

Expert System for Computer-assisted Annotation of MS/MS Spectra

(2012) Nadin Neuhauser et al.   MOLECULAR & CELLULAR PROTEOMICS

Global Subcellular Characterization of Protein Degradation Using Quantitative Proteomics

(2012) Mark Larance et al.   MOLECULAR & CELLULAR PROTEOMICS

Methods for Quantification ofin vivoChanges in Protein Ubiquitination following Proteasome and Deubiquitinase Inhibition

(2012) Namrata D. Udeshi et al.   MOLECULAR & CELLULAR PROTEOMICS

Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments

(2012) Namrata D. Udeshi et al.   MOLECULAR & CELLULAR PROTEOMICS

Protein homeostasis and aging: Role of ubiquitin protein ligases

(2012) Nihar Ranjan Jana   NEUROCHEMISTRY INTERNATIONAL

Structure-Based Discovery of a Novel Inhibitor Targeting the β-Catenin/Tcf4 Interaction

(2011) Wang Tian et al.   BIOCHEMISTRY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response

(2011) Caterina Bendotti et al.   PROGRESS IN NEUROBIOLOGY

Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

(2010) Philip Cohen et al.   CELL

Improved Quantitative Mass Spectrometry Methods for Characterizing Complex Ubiquitin Signals

(2010) Lilian Phu et al.   MOLECULAR & CELLULAR PROTEOMICS

The ubiquitin proteasome system in neuropathology

(2009) Norman L. Lehman   ACTA NEUROPATHOLOGICA

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Linear polyubiquitination: a new regulator of NF-κB activation

(2009) Kazuhiro Iwai et al.   EMBO REPORTS

The ubiquitin system, disease, and drug discovery

(2008) Matthew D Petroski   BMC BIOCHEMISTRY

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Iodoacetamide-induced artifact mimics ubiquitination in mass spectrometry

(2008) Michael L Nielsen et al.   NATURE METHODS