Editorial Material
Biotechnology & Applied Microbiology
Joao Pedro de Magalhaes, Alejandro Ocampo
Summary: Cells can be rejuvenated and biological clocks reset through cellular reprogramming, and many companies are now developing therapies using this technique to rejuvenate human beings. However, the current research in rejuvenation is mostly based on in vitro studies, and it remains to be seen if it can be translated into clinical applications.
TRENDS IN BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Anastasia Buyalskaya, Marcos Gallo, Colin F. Camerer
Summary: Social science is entering a golden age with explosive growth in new data and analytic methods, interdisciplinary approaches, and a recognition of their importance in solving challenging global problems. Developing a lingua franca can encourage more interdisciplinary research, as demonstrated through case studies in social networks and behavioral economics. Challenges such as career incentives and the search for unifying frameworks need to be addressed with best practices in response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Daniel J. Simpson, Nelly N. Olova, Tamir Chandra
Summary: Ageing is inevitable, but recent research has shown that slowing down and reversing the ageing process may be possible through induced pluripotent stem cells and epigenetic rejuvenation. Reprogramming-induced rejuvenation strategies offer promising candidates for safely reducing biological age.
CLINICAL EPIGENETICS
(2021)
Article
Developmental Biology
Prim B. Singh, Assem Zhakupova
Summary: 'Age reprogramming' is a process that rejuvenates the molecular and cellular pathways of a cell without going through an embryonic stage. It helps to understand how to reverse aging while retaining cellular identity and function, which is beneficial for regenerative medicine.
Review
Mechanics
Stephane Moreau
Summary: This review covers the latest developments in computational aeroacoustics, focusing on noise generated by fluid flows and its propagation. It highlights the use of high-order schemes and the lattice Boltzmann method as effective methods to tackle noise problems in complex geometries. The review presents examples of applying these methods to jet noise and installed airfoil noise, as well as discussing simulations of airframe noise and turbomachinery noise.
Review
Developmental Biology
Sydney Leaman, Nicolas Marichal, Benedikt Berninger
Summary: Cellular identity can be reprogrammed through gene regulatory networks, and recent research suggests that this reprogramming can mitigate disease phenotypes.
Review
Gastroenterology & Hepatology
James R. Goldenring, Jason C. Mills
Summary: The mucosa of the body of the stomach uses depth-dependent mechanisms to respond to injury, leading to various histopathological changes and potential progression to dysplasia and cancer. This metaplasia process is broadly conserved across tissues and species, involving specific cytokines in facilitating the reprogramming of cells into different types, with implications for diagnostic and clinical purposes.
Article
Chemistry, Physical
Keisuke Takahashi, Lauren Takahashi
Summary: Materials informatics is at a turning point, transitioning from its early stages to its golden age. The ability to manipulate synthesis, properties, and characterization data is crucial for material design and understanding. This article discusses the ultimate goal of materials informatics and potential key components.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Veronika M. Shoba, Dhanushka N. P. Munkanatta Godage, Santosh K. Chaudhary, Arghya Deb, Sachini U. Siriwardena, Amit Choudhary
Summary: Phosphorylation-inducing chimeric small molecules (PHICS) can enable protein kinase C (PKC) to have new activities, such as inducing inhibitory neo-phosphorylations on a variant and phosphorylating cytosol-based neo-substrates. PKC with PHICS can also induce death of chronic myeloid leukemia cells. Synthetic chemistry has the power to expand the chemical and functional diversity of proteins in cells using bifunctional molecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Cell Biology
Huarong Chen, Yifei Wang, Hao Su, Xiaoting Zhang, Hongyan Chen, Jun Yu
Summary: N-6-Methyladenosine (m(6)A) is a common modification on eukaryote messenger RNA, playing a crucial role in posttranscriptional regulation. Recent studies have shown that perturbation of m(6)A regulators can greatly affect cell fate transitions and is associated with various diseases, including cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ying Hua Su, Li Ping Tang, Xiang Yu Zhao, Xian Sheng Zhang
Summary: Plant cells have a strong capacity for reproduction, as a single plant cell can give rise to a whole plant via somatic embryogenesis without fertilization. Reprogramming somatic cells into totipotent cells is a critical step in somatic embryogenesis, inducible by stimuli such as plant hormones, transcriptional regulators and stress. Key molecular regulators and associated networks that control cell fate transition from somatic to totipotent cells are highlighted, with several outstanding questions proposed for further understanding of plant cell totipotency mechanisms.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2021)
Article
Cell Biology
Tomoaki Hishida, Mako Yamamoto, Yuriko Hishida-Nozaki, Changwei Shao, Ling Huang, Chao Wang, Kensaku Shojima, Yuan Xue, Yuqing Hang, Maxim Shokhirev, Sebastian Memczak, Sanjeeb Kumar Sahu, Fumiyuki Hatanaka, Ruben Rabadan Ros, Matthew B. Maxwell, Jasmine Chavez, Yanjiao Shao, Hsin-Kai Liao, Paloma Martinez-Redondo, Isabel Guillen-Guillen, Reyna Hernandez-Benitez, Concepcion Rodriguez Esteban, Jing Qu, Michael C. Holmes, Fei Yi, Raymond D. Hickey, Pedro Guillen Garcia, Estrella Nunez Delicado, Antoni Castells, Josep M. Campistol, Yang Yu, Diana C. Hargreaves, Akihiro Asai, Pradeep Reddy, Guang-Hui Liu, Juan Carlos Izpisua Belmonte
Summary: Mammals have limited regenerative capacity, but inducing specific factor expression can enhance liver regeneration. This study provides a new avenue for tissue regeneration.
Editorial Material
Plant Sciences
Ralf Welsch, Alisher Touraev, Klaus Palme
Summary: The fertilized egg is the starting point for multicellular organism development, plant cells have the ability to regenerate, and the fate of regenerating tissues is regulated by plant hormones.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Review
Crystallography
Marco Minissale, Eric Salomon, Federica Pappalardo, Celine Martin, Matthias Muntwiler, Thierry Angot, Guy Le Lay
Summary: Germanene, an artificial graphene-like material, shows topological insulator properties at room temperature and is compatible with silicon technology, making it a promising candidate for nanoelectronics. Researchers prepared germanene using dry epitaxy on metal surfaces and studied its predicted electronic properties. They also investigated the growth of germanene using a bottom-up synthesis strategy on a gold thin film supported by germanium, resulting in monolayer germanene with Dirac fermions.
Review
Microbiology
Anil Pant, Lara Dsouza, Zhilong Yang
Summary: This article summarizes how viruses alter major cellular metabolic pathways to support their replication needs, emphasizing the utilization of cellular signaling cascades and the changes in cellular nutrition and metabolism during viral infections. Studying these changes enhances understanding of fundamental metabolic regulation processes and offers potential for combatting viral diseases, metabolic disorders, and cancer.
