Editorial Material
Biology
Avraham N. Bayer, Fred L. Homa
Summary: An interferon-induced restrictive factor blocks the replication of herpesviruses by disassembling the capsid proteins surrounding their genome.
Editorial Material
Biochemistry & Molecular Biology
Patricia M. Di Lorenzo
Summary: In vivo two photon calcium imaging in the gustatory cortex of alert mice shows that taste-responsive cells can vary in their breadth of tuning across taste qualities and are sparse and spatially distributed across the cortex.
Review
Cardiac & Cardiovascular Systems
Jordana Borges, Krysten E. Ferraino, Natalie Cora, Deepika Nagliya, Malka S. Suster, Alexandra M. Carbone, Anastasios Lymperopoulos
Summary: Systolic heart failure is a global disease with the highest mortality rate, characterized by reduced cardiac function. Neurohormonal imbalances play a crucial role in chronic heart failure, and the adrenal glands are important in modulating cardiac neurohormonal stress. Adrenergic receptors and AngII receptors are the two most extensively studied types of adrenal GPCRs in this context.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Environmental Studies
Daniela Giudici, Paolo Boccagni
Summary: By studying the association between refugees' intimate lives and private relationships with their access to public space, this article explores their conditional access. The research reveals that asylum seekers negotiate for the right to stay by providing private life details to state institutions. Their access to the hosting community increasingly relies on cultivating domestic activities and intimate relations in public spaces. However, exposing the intimate self in the public does not guarantee recognition but rather normalizes the refugees' conditional belonging in the national space.
ENVIRONMENT AND PLANNING D-SOCIETY & SPACE
(2022)
Article
Biochemistry & Molecular Biology
Han Liao, Anushri Gaur, Hunter McConie, Amirtha Shekar, Karen Wang, Jeffrey T. Chang, Ghislain Breton, Catherine Denicourt
Summary: NOP2/NSUN1 catalyzes the deposition of m(5)C at position 4447 on the 28S rRNA, and regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs. Additionally, NOP2/NSUN1 facilitates the recruitment and stable assembly of U3 and U8 snoRNAs into snoRNP complexes.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Medicine, Research & Experimental
Mu Yang, Shujin Li, Li Huang, Rulian Zhao, Erkuan Dai, Xiaoyan Jiang, Yunqi He, Jinglin Lu, Li Peng, Wenjing Liu, Zhaotian Zhang, Dan Jiang, Yi Zhang, Zhilin Jiang, Yeming Yang, Peiquan Zhao, Xianjun Zhu, Xiaoyan Ding, Zhenglin Yang
Summary: Familial exudative vitreoretinopathy (FEVR) is a hereditary disorder that causes vision loss. In this study, genetic analysis identified variants in the CTNND1 gene that are associated with FEVR. Further experiments revealed that these variants affect cell adhesion and Wnt signaling activity, leading to the development of FEVR.
Article
Biochemistry & Molecular Biology
Alessio Malacrida, Guido Cavaletti, Mariarosaria Miloso
Summary: This study investigated the mechanism of action of Rigosertib on cholangiocarcinoma cells EGI-1 using Western blotting technique. The results showed an increase in EMI1 and Cyclin B protein levels and a significant reduction in CDK1 phosphorylation after Rigosertib treatment. The expression of PLK1 increased after 24 hours of treatment and decreased after 48 hours. Additionally, p53 levels increased and its activity was found to be necessary for the effects of Rigosertib on cell viability in EGI-1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Oncology
Dragomir B. Krastev, Andrew J. Wicks, Christopher J. Lord
Summary: The study found that PARP inhibitors not only inhibit the catalytic activity of PARP1, but also trap it on DNA, leading to cytotoxicity in tumor cells. This discovery not only changed our understanding of how PARP inhibitors work, but also prompted further research on how PARP1 carries out its normal function in the absence of inhibitors.
Article
Medical Laboratory Technology
Andres M. Acosta, Justine Barletta, Guru Sonpavde, Stuart Schnitt, Michelle S. Hirsch
Summary: E-cadherin, B-Cat, and p-120 exhibit membranous staining in conventional and micropapillary UC, while abnormal staining of E-Cad and p-120 in PC-UC and SUC aids in diagnosis.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Endocrinology & Metabolism
George A. Brooks, Adam D. Osmond, Robert G. Leija, Casey C. Curl, Jose A. Arevalo, Justin J. Duong, Michael A. Horning
Summary: The Lactate Shuttle hypothesis is supported by various techniques, but there has been controversy over whether lactate tracers measure lactate or pyruvate turnover. In this review, the authors discuss the analytical errors, inappropriate models and methods, as well as the roles of heart and lung parenchyma in lactate-pyruvate interactions. With support from magnetic resonance spectroscopy and immunocytochemistry, the authors conclude that carbon-labeled lactate tracers can be used to measure lactate fluxes.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Astronomy & Astrophysics
Zeno Capatti
Summary: In this paper, the authors investigate the infrared behavior of amplitudes and show that energy conservation imposes strong constraints on the threshold singularity structure of Feynman diagrams. They develop an algorithmic procedure using Fourier transforms and graph-theoretic notions, which enables closed-form Fourier integrations and introduces a novel three-dimensional representation of loop integrals. These results have implications for studying cancellation mechanisms, evaluating loop integrals numerically, and simplifying threshold regularization procedures.
Article
Physiology
Paulraj Kanmani, Hoda El-Hossiny Elkafas, Muhammed Ghazal, Richard D. Minshall, Guochang Hu
Summary: Inflammasome activation plays a crucial role in the development of inflammatory response and sepsis. The molecular mechanism controlling inflammasome activation is not well understood. This study found that p120-catenin expression in macrophages contributes to the regulation of NLRP3 inflammasome activation by maintaining mitochondrial homeostasis and reducing mitochondrial reactive oxygen species production. The stabilization of p120-catenin expression in macrophages may serve as a novel strategy to prevent uncontrolled inflammatory response in sepsis.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Editorial Material
Hematology
Juerg Schwaller
Summary: The study found that the MLL-AF4 fusion protein is an effector of infant acute lymphoblastic leukemia and has the opportunity to immortalize hematopoietic stem and progenitor cells during development.
Review
Microbiology
Jorge E. Galan
Summary: Microbial infections are controlled by host inflammatory responses initiated by innate immune receptors recognizing microbial products. The enteric pathogen Salmonella Typhimurium triggers inflammation in the intestinal tract using effector proteins without engaging innate immune receptors, while also employing other effectors to restrict the inflammatory response and preserve host homeostasis. The interaction between S. Typhimurium and its host represents a unique balance achieved through co-evolution, with mechanisms aimed at recovering host homeostasis after the inflammatory response.
NATURE REVIEWS MICROBIOLOGY
(2021)
Article
Business, Finance
Nilesh B. Sah, Anandi Banerjee, James Malm, Deepak G. More
Summary: This study highlights the risk management activities of dual class firms, specifically focusing on their use of foreign exchange derivatives. Compared to single class firms, dual class firms engage in lower levels of FX hedging activities due to their long-term orientation and insulation from short-term market pressures. Additionally, the research finds that these firms are more reluctant to use futures contracts for FX hedging, preferring opacity and hesitating to divert resources from their long-term goals.
FINANCE RESEARCH LETTERS
(2022)