CTNND1 variants cause familial exudative vitreoretinopathy through the Wnt/cadherin axis

Novel truncating variants in CTNNB1 cause familial exudative vitreoretinopathy

(2022) Yunqi He et al.   JOURNAL OF MEDICAL GENETICS

Endothelium-derived semaphorin 3G attenuates ischemic retinopathy by coordinating β-catenin–dependent vascular remodeling

(2021) Dan-Yang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Whole-Exome Sequencing Identified DLG1 as a Candidate Gene for Familial Exudative Vitreoretinopathy

(2021) Shanshan Zhang et al.   Genetic Testing and Molecular Biomarkers

Catenin α 1 mutations cause familial exudative vitreoretinopathy by overactivating Norrin/β-catenin signaling

(2021) Xianjun Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

The ER membrane protein complex subunit Emc3 controls angiogenesis via the FZD4/WNT signaling axis

(2021) Mu Yang et al.   Science China-Life Sciences

Variants in the Wnt co-receptor LRP6 are associated with familial exudative vitreoretinopathy

(2021) Shujin Li et al.   Journal of Genetics and Genomics

Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors

(2020) Philip Allan Seymour et al.   DEVELOPMENTAL CELL

A mouse model for Kinesin Family Member 11 (Kif11)-associated familial exudative vitreoretinopathy

(2020) Yanshu Wang et al.   HUMAN MOLECULAR GENETICS

Role of the GLUT1 Glucose Transporter in Postnatal CNS Angiogenesis and Blood-Brain Barrier Integrity

(2020) Koen Veys et al.   CIRCULATION RESEARCH

Novel truncating mutations in CTNND1 cause a dominant craniofacial and cardiac syndrome

(2020) Reham Alharatani et al.   HUMAN MOLECULAR GENETICS

VE-cadherin endocytosis controls vascular integrity and patterning during development

(2020) Cynthia M. Grimsley-Myers et al.   JOURNAL OF CELL BIOLOGY

p120-catenin regulates WNT signaling and EMT in the mouse embryo

(2019) Rocío Hernández-Martínez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin-linked kinase controls retinal angiogenesis and is linked to Wnt signaling and exudative vitreoretinopathy

(2019) Hongryeol Park et al.   Nature Communications

Mutations in the Epithelial Cadherin-p120-Catenin Complex Cause Mendelian Non-Syndromic Cleft Lip with or without Cleft Palate

(2018) Liza L. Cox et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Variants in members of the cadherin–catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome

(2018) Anneke Kievit et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Knockdown of P120 catenin aggravates endothelial injury under an impinging flow by inducing breakdown of adherens junctions

(2018) Jian‑Lan Zhao et al.   Molecular Medicine Reports

Wnt Signaling in vascular eye diseases

(2018) Zhongxiao Wang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions

(2018) Noboru Ishiyama et al.   Nature Communications

Therapeutic targeting of angiogenesis molecular pathways in angiogenesis-dependent diseases

(2018) Asghar Fallah et al.   BIOMEDICINE & PHARMACOTHERAPY

Blepharocheilodontic syndrome is a CDH1 pathway–related disorder due to mutations in CDH1 and CTNND1

(2017) Jamal Ghoumid et al.   GENETICS IN MEDICINE

The VE-cadherin cytoplasmic domain undergoes proteolytic processing during endocytosis

(2017) Wenji Su et al.   MOLECULAR BIOLOGY OF THE CELL

p120-catenin regulates VE-cadherin endocytosis and degradation induced by the Kaposi sarcoma–associated ubiquitin ligase K5

(2017) Benjamin A. Nanes et al.   MOLECULAR BIOLOGY OF THE CELL

The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels

(2017) Jenna Mazzoni et al.   NEURON

Microglia Polarization with M1/M2 Phenotype Changes in rd1 Mouse Model of Retinal Degeneration

(2017) Tian Zhou et al.   Frontiers in Neuroanatomy

The front and rear of collective cell migration

(2016) Roberto Mayor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CTNNB1 mutation associated with familial exudative vitreoretinopathy (FEVR) phenotype

(2016) Maxwell W. Dixon et al.   OPHTHALMIC GENETICS

δ-Catenin interacts with LEF-1 and negatively regulates its transcriptional activity

(2015) Yongfeng He et al.   CELL BIOLOGY INTERNATIONAL

Mechanisms of Vessel Pruning and Regression

(2015) Claudia Korn et al.   DEVELOPMENTAL CELL

The Endothelial Transcription Factor ERG Promotes Vascular Stability and Growth through Wnt/β-Catenin Signaling

(2015) Graeme M. Birdsey et al.   DEVELOPMENTAL CELL

Norrin/Frizzled4 Signaling in Retinal Vascular Development and Blood Brain Barrier Plasticity

(2012) Yanshu Wang et al.   CELL

p120-catenin is essential for terminal end bud function and mammary morphogenesis

(2012) S. J. Kurley et al.   DEVELOPMENT

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

p120-catenin binding masks an endocytic signal conserved in classical cadherins

(2012) Benjamin A. Nanes et al.   JOURNAL OF CELL BIOLOGY

Nuclear p120 catenin unlocks mitotic block of contact-inhibited human corneal endothelial monolayers without disrupting adherent junctions

(2012) Y.-T. Zhu et al.   JOURNAL OF CELL SCIENCE

p120 catenin is required for normal renal tubulogenesis and glomerulogenesis

(2011) D. K. Marciano et al.   DEVELOPMENT

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

A Computational Tool for Quantitative Analysis of Vascular Networks

(2011) Enrique Zudaire et al.   PLoS One

Next-Generation Sequencing of a 40 Mb Linkage Interval Reveals TSPAN12 Mutations in Patients with Familial Exudative Vitreoretinopathy

(2010) Konstantinos Nikopoulos et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in TSPAN12 Cause Autosomal-Dominant Familial Exudative Vitreoretinopathy

(2010) James A. Poulter et al.   AMERICAN JOURNAL OF HUMAN GENETICS

p120 regulates endothelial permeability independently of its NH2 terminus and Rho binding

(2010) Crystal R. Herron et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Dynamic and Static Interactions between p120 Catenin and E-Cadherin Regulate the Stability of Cell-Cell Adhesion

(2010) Noboru Ishiyama et al.   CELL

p120-Catenin Is Required for Mouse Vascular Development

(2010) Rebecca G. Oas et al.   CIRCULATION RESEARCH

The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling

(2010) Monica Corada et al.   DEVELOPMENTAL CELL

A p120-catenin-CK1  complex regulates Wnt signaling

(2010) D. Casagolda et al.   JOURNAL OF CELL SCIENCE

Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice

(2010) Mara E Pitulescu et al.   Nature Protocols

TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling

(2009) Harald J. Junge et al.   CELL

Norrin, Frizzled-4, and Lrp5 Signaling in Endothelial Cells Controls a Genetic Program for Retinal Vascularization

(2009) Xin Ye et al.   CELL

Nrarp Coordinates Endothelial Notch and Wnt Signaling to Control Vessel Density in Angiogenesis

(2009) Li-Kun Phng et al.   DEVELOPMENTAL CELL

p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation

(2008) P. Alcaide et al.   BLOOD