Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo

The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent

(2015) Chen Li et al.   CANCER BIOLOGY & THERAPY

ABC294640, a sphingosine kinase 2 inhibitor, enhances the antitumor effects of TRAIL in non-small cell lung cancer

(2015) Jie Yang et al.   CANCER BIOLOGY & THERAPY

Short hairpin RNA- mediated gene knockdown of FOXM1 inhibits the proliferation and metastasis of human colon cancer cells through reversal of epithelial-to-mesenchymal transformation

(2015) KanKan Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

CELLFOOD™ induces apoptosis in human mesothelioma and colorectal cancer cells by modulating p53, c-myc and pAkt signaling pathways

(2014) Barbara Nuvoli et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

KRAS mutations in tumor tissue and plasma by different assays predict survival of patients with metastatic colorectal cancer

(2014) Jian-Ming Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Towards improved drugs, combinations and patient selection

(2014) Hans-Joachim Schmoll et al.   Nature Reviews Clinical Oncology

Adjuvant chemotherapy for rectal cancer—an unresolved issue

(2014) Manisha Palta et al.   Nature Reviews Clinical Oncology

Inhibition of sphingosine kinase-2 ablates androgen resistant prostate cancer proliferation and survival

(2014) Matthew M. Gestaut et al.   Pharmacological Reports

Bortezomib-induced apoptosis in cultured pancreatic cancer cells is associated with ceramide production

(2013) Lei Gong et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Rechallenge therapy and treatment holiday: different strategies in management of metastatic colorectal cancer

(2013) Giuseppe Tonini et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sphingolipids: regulators of crosstalk between apoptosis and autophagy

(2012) Megan M. Young et al.   JOURNAL OF LIPID RESEARCH

C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1

(2012) Chiranthani Sumanasekera et al.   NUCLEIC ACIDS RESEARCH

Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules

(2011) S. Pyne et al.   CANCER RESEARCH

Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D

(2011) Min Xiao et al.   EXPERIMENTAL CELL RESEARCH

Ablation of Sphingosine Kinase-2 Inhibits Tumor Cell Proliferation and Migration

(2011) P. Gao et al.   MOLECULAR CANCER RESEARCH

Ceramide in Chemotherapy of Tumors

(2011) Marie-Therese Dimanche-Boitrel et al.   Recent Patents on Anti-Cancer Drug Discovery

Sphingosine-1-phosphate signaling and its role in disease

(2011) Michael Maceyka et al.   TRENDS IN CELL BIOLOGY

Antiestrogenic Effects of the Novel Sphingosine Kinase-2 Inhibitor ABC294640

(2010) James W. Antoon et al.   ENDOCRINOLOGY

Pharmacology and Antitumor Activity of ABC294640, a Selective Inhibitor of Sphingosine Kinase-2

(2010) K. J. French et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

mTOR Signaling Pathway Is a Target for the Treatment of Colorectal Cancer

(2009) Yan-Jie Zhang et al.   ANNALS OF SURGICAL ONCOLOGY

Frequent alterations of the PI3K/AKT/mTOR pathways in hereditary nonpolyposis colorectal cancer

(2009) Anna Isinger Ekstrand et al.   Familial Cancer

Ceramide induces p38 MAPK and JNK activation through a mechanism involving a thioredoxin-interacting protein-mediated pathway

(2008) C.-L. Chen et al.   BLOOD

Targeting SphK1 as a New Strategy against Cancer

(2008) Dai Shida et al.   CURRENT DRUG TARGETS