Review
Pharmacology & Pharmacy
Gerardo Ramirez-Rico, Maria Elisa Drago-Serrano, Nidia Leon-Sicairos, Mireya de la Garza
Summary: This review focuses on the regulatory effects of orally administered bovine lactoferrin (Lf) on the inflammatory response associated with colorectal cancer (CRC). This approach suggests that bovine Lf, as a safe natural compound, may be used alone or as an adjunct agent to increase the effectiveness and reduce the side effects of anticancer chemotherapy for CRC, which is a frequently diagnosed cancer with clinical and epidemiologic relevance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Simon Bernard Iloki Assanga, Lidianys Maria Lewis Lujan, Mark F. McCarty
Summary: Progressive up-regulation of β-catenin signaling is common in CRC transformation. Measures like cGMP/PKG signaling and dietary factors can oppose this signaling and prevent or slow the transformation. Other strategies include selective activation of estrogen receptor β, inhibition of CK2, and assurance of adequate folate status to oppose β-catenin signaling in colorectal epithelium.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gabriella Serio, Federica Pezzuto, Francesco Fortarezza, Andrea Marzullo, Maria Celeste Delfino, Antonio d'Amati, Daniele Egidio Romano, Sonia Maniglio, Concetta Caporusso, Teresa Lettini, Domenica Cavone, Luigi Vimercati
Summary: There is evidence suggesting that asbestos may play a role in the carcinogenesis of digestive cancers, although the mechanism is still unclear. This study reports four unusual cases of colorectal cancers in patients with long-term asbestos exposure who also developed mesothelioma. The evaluation of certain proteins supports the hypothesis that they are tumor suppressor genes involved in disease progression in both digestive cancers and mesothelioma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Simona Serini, Roberta Cassano, Federica Curcio, Sonia Trombino, Gabriella Calviello
Summary: This article critically analyzes the results of recent studies investigating the effects of omega-3 PUFA-containing nanoformulations in breast cancer and ovarian cancer. The studies show that omega-3 PUFAs have anti-inflammatory, antiangiogenic, and antitumor effects, and can enhance drug delivery and minimize side effects. These findings provide a theoretical basis for further interventional clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Julia Hanevelt, Ivonne J. H. Schoenaker, Richard M. Brohet, Ruud W. M. Schrauwen, Frederique J. N. Baas, Pieter J. Tanis, Henderik L. van Westreenen, Wouter H. de Vos tot Nederveen Cappel
Summary: The VOC pattern of colorectal carcinoma (CRC) patients is altered by curative surgery, indicating a potential correlation between exhaled VOCs and the presence of CRC. However, further large-scale prospective research is needed to improve the performance of Aeonose (TM) as a potential diagnostic tool for the clinical follow-up of CRC patients.
Article
Oncology
Rebecca L. Siegel, Nikita Sandeep Wagle, Andrea Cercek, Robert A. Smith, Ahmedin Jemal
Summary: Colorectal cancer is the second leading cause of cancer death in the United States. The incidence of CRC has slowed down, but it is shifting to a younger age, advanced stage, and left colon/rectum. Mortality from CRC has declined overall, but increased in individuals younger than 50 years and Native Americans younger than 65 years. Uncovering the reasons for rising incidence and improving access to screening and treatment are crucial in combating CRC.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Surgery
Jeong Min Choo, Hyo Seon Ryu, Ji Seon Kim, Ju Yong Cheong, Se-Jin Baek, Jung Myun Kwak, Jin Kim
Summary: This study conducted a preliminary analysis of the chatGPT(TM)'s ability to formulate a management plan for patients with colorectal cancer. The results showed that the chatGPT(TM) was able to adhere to oncological principles and take into account the patient's overall health and functional status. The concordance rate of oncological management recommendations between chatGPT(TM) and the MDT was 86.7%.
ANZ JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Oxana Dmitrieva-Posocco, Andrea C. Wong, Patrick Lundgren, Aleksandra M. Golos, Helene C. Descamps, Lenka Dohnalova, Zvi Cramer, Yuhua Tian, Brian Yueh, Onur Eskiocak, Gabor Egervari, Yemin Lan, Jinping Liu, Jiaxin Fan, Jihee Kim, Bhoomi Madhu, Kai Markus Schneider, Svetlana Khoziainova, Natalia Andreeva, Qiaohong Wang, Ning Li, Emma E. Furth, Will Bailis, Judith R. Kelsen, Kathryn E. Hamilton, Klaus H. Kaestner, Shelley L. Berger, Jonathan A. Epstein, Rajan Jain, Mingyao Li, Semir Beyaz, Christopher J. Lengner, Bryson W. Katona, Sergei I. Grivennikov, Christoph A. Thaiss, Maayan Levy
Summary: The study identifies a metabolite signalling pathway that can be used as a strategy for preventing and treating colorectal cancer. Ketogenic diets and the ketone body BHB show a strong inhibitory effect on tumor growth by reducing cell proliferation. The findings suggest that BHB-triggered pathway could play a crucial role in regulating intestinal tumorigenesis.
Article
Multidisciplinary Sciences
Najma Tabussam, Rashid Mehmood Rana, Muhammad Kausar Nawaz Shah, Muhammad Sheeraz Ahmad, Muhammad Sajjad, Yongqiang Lu
Summary: This study evaluated the nutraceutical profile of elite onion germplasm and selected hybrids with improved nutraceutical quality. Fourier Transform Infrared Spectroscopy (FTIR) analysis and spectrophotometric/colorimetric quantification were used to screen the nutraceutical components. The onion genotypes were categorized based on common functional groups obtained from FTIR analysis and bulb color. The results showed that certain genotypes had higher concentrations of pyruvic acid, total flavonoids, and total phenolic content, while vitamin C content was weakly associated with color pigmentation. The study also identified specific hybrids with improved nutraceutical quality through line x tester analysis. The observed parameters were found to be genetically inherited, and could be significantly improved through appropriate breeding strategies.
Article
Medicine, Research & Experimental
Morvarid Farhang Ghahremani, Kelly Kai Yin Seto, Woohyun Cho, Michael Craig Miller, Paul Smith, David Frederick Englert
Summary: A new technology platform was evaluated for capturing and profiling circulating tumor cells (CTCs) from blood, enabling gene expression analysis for assessing disease status and treatment response. The platform allowed sensitive quantification of expression levels from as little as 20 pg of total RNA or a single cultured tumor cell. The results showed that the technology could effectively distinguish different types of breast and ovarian cancer cells, even in the presence of white blood cell RNA.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Bohan Chen, Yiping Ma, Jinfang Bi, Wenbin Wang, Anshun He, Guangsong Su, Zhongfang Zhao, Jiandang Shi, Lei Zhang
Summary: The study revealed the regulatory network of colorectal-cancer-specific enhancers, which are associated with changes in over 50% of the topological associated domains (TADs) and interact with 152 genes that are significantly highly expressed in colorectal cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Philip B. Paty, Julio Garcia-Aguilar
Summary: Although surgery has been the mainstay for treating colorectal cancer, advances in technology and clinical trials over the past 50 years have significantly expanded and improved the detection, staging, treatment, and understanding of this disease. This review highlights the contributions of surgeons, oncologists, gastroenterologists, engineers, and scientists in enhancing postsurgical survival, reducing treatment time and toxicity, and improving patients' quality of life over the past half-century.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Qingqing Pan, Xi Fan, Li Xie, Di Wu, Rong Liu, Wenxia Gao, Kui Luo, Bin He, Yuji Pu
Summary: This review provides a cutting-edge summary of nanomedicine-based treatment in colorectal cancer, including drug delivery systems, therapeutic strategies, and efforts to address therapy resistance, metastasis, and recurrence. The potential of gut microbiota regulation in preventing and treating colorectal cancer is also discussed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Oncology
Luigi Marongiu, Heike Allgayer
Summary: Evidence suggests that microorganisms, including specific viruses and bacteriophages, may play a significant role in the oncogenesis and progression of colorectal cancer. However, the mechanisms underlying these associations are not fully understood. Various viruses, such as EBV, HPV, JCV, and CMV, have been linked to CRC, along with bacteriophages. The complex interplay between different species within the microbiome and their impact on colorectal cells and the microenvironment may explain the challenges in establishing clear causal links between specific viral infections and CRC.
MOLECULAR ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ricardo Benjamin Maccioni, Camila Calfio, Andrea Gonzalez, Valentina Luettges
Summary: The incidence of Alzheimer's disease is increasing worldwide. Prevention efforts, such as adopting a healthy lifestyle, using disease-modifying agents, and focusing on nutrition, can help mitigate symptoms or even prevent AD.
Article
Chemistry, Organic
Giacomo Mari, Lucia De Crescentini, Serena Benedetti, Francesco Palma, Stefania Santeusanio, Fabio Mantellini
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Review
Pharmacology & Pharmacy
Francesca Luchetti, Rita Crinelli, Maria Gemma Nasoni, Serena Benedetti, Francesco Palma, Alessandra Fraternale, Luigi Iuliano
Summary: Oxidized LDLs and oxysterols play a crucial role in endothelial dysfunction and atherosclerosis, with caveolae and caveolin-1 emerging as important targets and mediators in this process. Their involvement in lipid transcytosis and signalling pathways highlights the complex interplay that contributes to endothelial cell dysfunction induced by oxLDLs.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Serena Benedetti, Maria Gemma Nasoni, Francesco Palma, Roberto Citarella, Francesca Luchetti
Summary: In this study, significant decrease of sTWEAK levels and increase of sCD163 levels were observed in the serum of ultramarathon athletes after the race. Positive relationships were found between IL-6 and sCD163 levels with cardiac damage markers, while sTWEAK showed an inverse correlation with IL-6 and NT-proBNP.
Article
Oncology
Barbara Nuvoli, Barbara Antoniani, Roberta Libener, Antonio Maconi, Andrea Sacconi, Mariantonia Carosi, Rossella Galati
Summary: This study revealed a novel COX-2/CYP19A1 axis in the pathogenesis of MPM that can be pharmacologically targeted, with synergistic effects observed in the combination of rofecoxib and exemestane inhibitors in MPM cell proliferation, and pAKT identified as an actionable mediator in the COX-2-CYP19A1 axis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Chemistry, Medicinal
Michele Verboni, Serena Benedetti, Raffaella Campana, Francesco Palma, Lucia Potenza, Maurizio Sisti, Andrea Duranti, Simone Lucarini
Summary: This study investigates a new glycolipid compound, URB1418, which exhibits antifungal and anti-inflammatory properties. It is also more stable and cost-effective to produce compared to reference compounds, making it a promising candidate for various applications.
Meeting Abstract
Oncology
C. Signorelli, M. Chilelli, P. Amodio, M. Schirripa, I. Sperduti, R. Santoro, T. Ranalli, G. Pessina, F. Natoni, A. Virtuoso, J. Giron Berrios, M. Mazzotta, F. Nelli, M. Fabbri, F. Primi, E. Marrucci, E. Ruggeri
ANNALS OF ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Valeria Purpura, Serena Benedetti, Elena Bondioli, Francesca Scarpellini, Agnese Giacometti, Maria Cristina Albertini, Davide Melandri
Summary: The human amniotic membrane (HAM) has biological properties that promote wound healing, making it an ideal biological dressing for treating clinical conditions such as burns and non-healing wounds. However, preservation methods are necessary to maintain the tissue properties of HAM during banking. Cryopreservation and freezing, commonly used methods, can cause oxidative stress-induced cell injury and affect tissue regenerative properties. This study explores the use of quercetin, a natural compound with antioxidant activity, to improve the antioxidant and regenerative properties of frozen or cryopreserved HAM tissues.
Correction
Oncology
Barbara Nuvoli, Raffaela Santoro, Simona Catalani, Serafina Battistelli, Serena Benedetti, Franco Canestrari, Rossella Galati
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Serena Benedetti, Simona Catalani, Silvia De Stefani, Mariangela Primiterra, Alessandra Fraternale, Francesco Palma, Simone Palini
Summary: This study aimed to develop an assay for reactive oxygen species detection in semen samples. The microplate-based 2',7'-dichlorofluorescein diacetate assay was successfully adapted and showed potential for evaluating oxidative stress in whole semen. It could be used for preliminary assessment of semen oxidation levels and for evaluating the effect of pro-glutathione molecules on semen oxidative status.
Correction
Oncology
Barbara Nuvoli, Barbara Antoniani, Roberta Libener, Antonio Maconi, Andrea Sacconi, Mariantonia Carosi, Rossella Galati
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Retraction
Biochemistry & Molecular Biology
Barbara Nuvoli, Sabrina Germoni, Carlotta Morosetti, Raffaela Santoro, Giancarlo Cortese, Serena Masi, Iole Cordone, Rossella Galati
Article
Chemistry, Medicinal
Michele Verboni, Maurizio Sisti, Raffaella Campana, Serena Benedetti, Francesco Palma, Lucia Potenza, Simone Lucarini, Andrea Duranti
Summary: A library of 6-O-sucrose monoester surfactants was synthesized and tested for their antimicrobial activities. The synthetic procedure, a modified Mitsunobu reaction, showed improved results compared to the literature. Most of these glycolipids exhibited satisfactory antifungal activities, with sucrose palmitoleate (URB1537) showing good activity against Candida albicans ATCC 10231, Fusarium spp., and Aspergillus fumigatus IDRAH01. URB1537 was further characterized for its radical scavenging, anti-inflammatory, and biocompatibility properties, demonstrating control of inflammatory response and safety.
Article
Nutrition & Dietetics
Mariastella Colomba, Serena Benedetti, Daniele Fraternale, Andrea Guidarelli, Sofia Coppari, Valerio Freschi, Rita Crinelli, George E. N. Kass, Andrea Gorassini, Giancarlo Verardo, Carla Roselli, Maria Assunta Meli, Barbara Di Giacomo, Maria Cristina Albertini
Summary: In this study, we used bioinformatics analysis and experimental validation to investigate the mechanism behind the antioxidant effects of Prunus spinosa fruit (PSF) extract during a pro-inflammatory TLR4 insult. The analysis suggested that the extract activates the biological process of cellular senescence and identified potential targets in ARE signaling, MMP, and p53 SR pathways. Experimental validation showed that the extract reduces oxidative stress through the modulation of Nrf2, but no significant effects were observed on p53 and MMP modulation.
Article
Pharmacology & Pharmacy
Shiva Khorshid, Rosita Goffi, Giorgia Maurizii, Serena Benedetti, Giovanna Sotgiu, Roberto Zamboni, Sara Buoso, Roberta Galuppi, Talita Bordoni, Mattia Tiboni, Annalisa Aluigi, Luca Casettari
Summary: Fungal infections of the skin, nails, and hair are a common health concern. The use of keratin nanoparticles can improve antifungal agent penetration and provide sustainable targeted drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biophysics
Mattia Tiboni, Paola Astolfi, Michele Verboni, Serena Benedetti, Elisabetta Giorgini, Valentina Notarstefano, Francesco Vita, Simone Ranieri, Andrea Duranti, Simone Lucarini, Luca Casettari, Michela Pisani
Summary: Lyotropic Liquid Crystalline (LLC) nanoparticles are a smart and biocompatible drug delivery system. Cubosomes with complex 3D structures can carry drugs of different nature effectively. The addition of mannose-based esters can modify the structural parameters and control drug release and targeting. The drug delivery potential and cytocompatibility of these nanoparticles have been evaluated through various experimental measurements.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
