The beneficial effect of Zinc(II) on low-dose chemotherapeutic sensitivity involves p53 activation in wild-type p53-carrying colorectal cancer cells

HIF-1α antagonizes p53-mediated apoptosis by triggering HIPK2 degradation

(2016) Lavinia Nardinocchi et al.   Aging-US

Genome-wide analysis discloses reversal of the hypoxia-induced changes of gene expression in colon cancer cells by zinc supplementation

(2015) Michal Sheffer et al.   Oncotarget

Small molecule compounds targeting the p53 pathway: are we finally making progress?

(2014) Xin Yu et al.   APOPTOSIS

The multiple facets of drug resistance: one history, different approaches

(2014) Evandro Niero et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Degradation of mutant p53H175 protein by Zn(II) through autophagy

(2014) A Garufi et al.   Cell Death & Disease

A fluorescent curcumin-based Zn(II)-complex reactivates mutant (R175H and R273H) p53 in cancer cells

(2013) Alessia Garufi et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells

(2013) Mara Cirone et al.   OncoImmunology

Restoring p53 active conformation by zinc increases the response of mutant p53 tumor cells to anticancer drugs

(2011) Rosa Puca et al.   CELL CYCLE

Zinc supplementation augments in vivo antitumor effect of chemotherapy by restoring p53 function

(2011) Ofer Margalit et al.   INTERNATIONAL JOURNAL OF CANCER

Counteracting MDM2-induced HIPK2 downregulation restores HIPK2/p53 apoptotic signaling in cancer cells

(2010) Lavinia Nardinocchi et al.   FEBS LETTERS

Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

(2010) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

The missing Zinc: p53 misfolding and cancer

(2010) Stewart N. Loh   Metallomics

Zinc Downregulates HIF-1α and Inhibits Its Activity in Tumor Cells In Vitro and In Vivo

(2010) Lavinia Nardinocchi et al.   PLoS One

Doxorubicin Cardiomyopathy

(2009) Kanu Chatterjee et al.   CARDIOLOGY

Targeting Hypoxia in Cancer Cells by Restoring Homeodomain Interacting Protein-Kinase 2 and p53 Activity and Suppressing HIF-1α

(2009) Lavinia Nardinocchi et al.   PLoS One

Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown

(2008) R. Puca et al.   CANCER RESEARCH

Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc

(2008) Rosa Puca et al.   EXPERIMENTAL CELL RESEARCH

Apoptosis-Inducing Factor and Colon Cancer

(2007) Alejandro Millan et al.   JOURNAL OF SURGICAL RESEARCH