Keep your heart in shape: molecular chaperone networks for treating heart disease

Cardiovascular autophagy

(2013) Sergio Lavandero et al.   Autophagy

Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction

(2013) Bernhard Unsöld et al.   CARDIOVASCULAR RESEARCH

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?

(2013) Monte S. Willis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects

(2012) Helen V. Edwards et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

A Thrombospondin-Dependent Pathway for a Protective ER Stress Response

(2012) Jeffrey M. Lynch et al.   CELL

HSF Transcription Factor Family, Heat Shock Response, and Protein Intrinsic Disorder

(2012) Sandy D. Westerheide et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Identification of a missense mutation in the melusin-encoding ITGB1BP2 gene in a patient with dilated cardiomyopathy

(2012) Volker Ruppert et al.   GENE

HSPBs: Small proteins with big implications in human disease

(2012) Harm H. Kampinga et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The small heat shock proteins family: The long forgotten chaperones

(2012) C. Garrido et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

New concepts of endoplasmic reticulum function in the heart: Programmed to conserve

(2012) Shirin Doroudgar et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Matricellular Proteins in Cardiac Adaptation and Disease

(2012) Nikolaos G. Frangogiannis   PHYSIOLOGICAL REVIEWS

Genome-wide Studies of Copy Number Variation and Exome Sequencing Identify Rare Variants in BAG3 as a Cause of Dilated Cardiomyopathy

(2011) Nadine Norton et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Desmin-related cardiomyopathy: an unfolding story

(2011) Patrick M. McLendon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

BAG3 and friends: Co-chaperones in selective autophagy during aging and disease

(2011) Christian Behl   Autophagy

Phosphorylation by cyclic AMP-dependent protein kinase inhibits chaperone-like activity of human HSP22 in vitro

(2011) A. A. Shemetov et al.   BIOCHEMISTRY-MOSCOW

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

IQGAP1 regulates ERK1/2 and AKT signalling in the heart and sustains functional remodelling upon pressure overload

(2011) Mauro Sbroggiò et al.   CARDIOVASCULAR RESEARCH

Morgana and melusin: Two fairies chaperoning signal transduction

(2011) Roberta Ferretti et al.   CELL CYCLE

The emerging role of HSP20 as a multifunctional protective agent

(2011) H.V. Edwards et al.   CELLULAR SIGNALLING

H11 Kinase/Heat Shock Protein 22 Deletion Impairs Both Nuclear and Mitochondrial Functions of STAT3 and Accelerates the Transition Into Heart Failure on Cardiac Overload

(2011) Hongyu Qiu et al.   CIRCULATION

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

Small Heat Shock Protein 20 Interacts With Protein Phosphatase-1 and Enhances Sarcoplasmic Reticulum Calcium Cycling

(2011) Jiang Qian et al.   CIRCULATION RESEARCH

A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy

(2011) Eric Villard et al.   EUROPEAN HEART JOURNAL

Molecular chaperones in targeting misfolded proteins for ubiquitin-dependent degradation

(2011) Franziska Kriegenburg et al.   FEBS Journal

Dilated cardiomyopathy-associatedBAG3mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes

(2011) Takuro Arimura et al.   HUMAN MUTATION

Phosphoinositide 3-Kinase (PI3K(p110α)) Directly Regulates Key Components of the Z-disc and Cardiac Structure

(2011) Ashley J. Waardenberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK1/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1

(2011) M. Sbroggio et al.   JOURNAL OF CELL SCIENCE

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

(2011) Y.Y. Sin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Small-molecule proteostasis regulators for protein conformational diseases

(2011) Barbara Calamini et al.   Nature Chemical Biology

The therapeutic potential of ischemic conditioning: an update

(2011) Derek J. Hausenloy et al.   Nature Reviews Cardiology

HSPB1, HSPB6, HSPB7 and HSPB8 Protect against RhoA GTPase-Induced Remodeling in Tachypaced Atrial Myocytes

(2011) Lei Ke et al.   PLoS One

BAG3: a multifaceted protein that regulates major cell pathways

(2011) A Rosati et al.   Cell Death & Disease

Small heat shock proteins, protein degradation and protein aggregation diseases

(2010) Michel J. Vos et al.   Autophagy

Ablation of C/EBP Homologous Protein Attenuates Endoplasmic Reticulum–Mediated Apoptosis and Cardiac Dysfunction Induced by Pressure Overload

(2010) Hai Ying Fu et al.   CIRCULATION

BAG3 and Hsc70 Interact With Actin Capping Protein CapZ to Maintain Myofibrillar Integrity Under Mechanical Stress

(2010) Akinori Hishiya et al.   CIRCULATION RESEARCH

Two Close, Too Close

(2010) Gerald W. Dorn et al.   CIRCULATION RESEARCH

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease

(2010) Tetsuo Minamino et al.   CIRCULATION RESEARCH

Biology of Endoplasmic Reticulum Stress in the Heart

(2010) Jody Groenendyk et al.   CIRCULATION RESEARCH

Common Variants in HSPB7 and FRMD4B Associated With Advanced Heart Failure

(2010) Thomas P. Cappola et al.   Circulation-Cardiovascular Genetics

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

Heat Shock Proteins: Therapeutic Drug Targets for Chronic Neurodegeneration?

(2010) M. Sajjad et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

ATF6 is important under both pathological and physiological states in the heart

(2010) Hauhiro Toko et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Small heat shock protein 20 (HspB6) in cardiac hypertrophy and failure

(2010) Guo-Chang Fan et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

New antiarrhythmic drugs for treatment of atrial fibrillation

(2010) Dobromir Dobrev et al.   LANCET

Mechanistic Evaluation of the Novel HSP90 Inhibitor NVP-AUY922 in Adult and Pediatric Glioblastoma

(2010) N. Gaspar et al.   MOLECULAR CANCER THERAPEUTICS

Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons

(2010) Valeria Specchia et al.   NATURE

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Understanding of the Hsp90 molecular chaperone reaches new heights

(2010) Cara K Vaughan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation

(2010) Zagaa Odgerel et al.   NEUROMUSCULAR DISORDERS

Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by  -crystallin-B

(2010) N. Bousette et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy

(2010) Klaus Stark et al.   PLoS Genetics

The stress-inducible HspB8-Bag3 complex induces the eIF2α kinase pathway: Implications for protein quality control and viral factory degradation?

(2009) Serena Carra   Autophagy

Melusin gene (ITGB1BP2) nucleotide variations study in hypertensive and cardiopathic patients

(2009) Valeria Palumbo et al.   BMC Medical Genetics

MicroRNA-320 Is Involved in the Regulation of Cardiac Ischemia/Reperfusion Injury by Targeting Heat-Shock Protein 20

(2009) Xiao-Ping Ren et al.   CIRCULATION

Activation of the Bone Morphogenetic Protein Receptor by H11Kinase/Hsp22 Promotes Cardiac Cell Growth and Survival

(2009) Xiangzhen Sui et al.   CIRCULATION RESEARCH

Blockade of Hsp20 Phosphorylation Exacerbates Cardiac Ischemia/Reperfusion Injury by Suppressed Autophagy and Increased Cell Death

(2009) Jiang Qian et al.   CIRCULATION RESEARCH

Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease

(2009) Scot J. Matkovich et al.   JOURNAL OF CLINICAL INVESTIGATION

Chaperonin overexpression promotes genetic variation and enzyme evolution

(2009) Nobuhiko Tokuriki et al.   NATURE

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity

(2009) M Brunet Simioni et al.   ONCOGENE

Protective Effect of Geranylgeranylacetone via Enhancement of HSPB8 Induction in Desmin-Related Cardiomyopathy

(2009) Atsushi Sanbe et al.   PLoS One

Mutation in BAG3 causes severe dominant childhood muscular dystrophy

(2008) Duygu Selcen et al.   ANNALS OF NEUROLOGY

Structural and Functional Diversities between Members of the Human HSPB, HSPH, HSPA, and DNAJ Chaperone Families†

(2008) Michel J. Vos et al.   BIOCHEMISTRY

Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia

(2008) M. Sakabe et al.   CARDIOVASCULAR RESEARCH

Heat shock proteins as molecular targets for intervention in atrial fibrillation

(2008) B. J.J.M. Brundel et al.   CARDIOVASCULAR RESEARCH

Build it up-Tear it down: protein quality control in the cardiac sarcomere

(2008) M. S. Willis et al.   CARDIOVASCULAR RESEARCH

Guidelines for the nomenclature of the human heat shock proteins

(2008) Harm H. Kampinga et al.   CELL STRESS & CHAPERONES

αB-Crystallin Suppresses Pressure Overload Cardiac Hypertrophy

(2008) Asangi R.K. Kumarapeli et al.   CIRCULATION RESEARCH

Heat Shock Protein 20 Interacting With Phosphorylated Akt Reduces Doxorubicin-Triggered Oxidative Stress and Cardiotoxicity

(2008) Guo-Chang Fan et al.   CIRCULATION RESEARCH

The mammalian CHORD-containing protein melusin is a stress response protein interacting with Hsp90 and Sgt1

(2008) Mauro Sbroggiò et al.   FEBS LETTERS

Human Mutation in the Anti-apoptotic Heat Shock Protein 20 Abrogates Its Cardioprotective Effects

(2008) Persoulla Nicolaou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Hsp90 Chaperone Machinery Regulates Signaling by Modulating Ligand Binding Clefts

(2008) William B. Pratt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY