Article
Medicine, Research & Experimental
Shi Hua Tan, Sze Jie Loo, Yu Gao, Zhong Hao Tao, Li Ping Su, Chen Xu Wang, Sophia L. Zhang, Yong Hui Mu, Ying Hua Cui, Desiree Abdurrachim, Wei Hsin Wang, Janise Lalic, Kheng Choon Lim, Jun Bu, Ru San Tan, Teck Hock Lee, Jianyi Zhang, Lei Ye
Summary: In a porcine model of myocardial infarction, co-treatment with Tb4-microspheres and hiPSC-CMs improved the engraftment and reparative potency of the transplanted hiPSC-CMs, induced vasculogenesis and proliferation of cardiomyocytes and endothelial cells, improved left ventricular systolic function, and reduced infarct size. HiPSC-CM implantation did not increase the incidence of ventricular arrhythmias and did not induce tumorigenesis in the immunosuppressed pigs.
Article
Nanoscience & Nanotechnology
Wenjie Guo, Weijing Feng, Jing Huang, Jianwu Zhang, Xianglin Fan, Shaodan Ma, Minghui Li, Jie Zhan, Yanbin Cai, Minsheng Chen
Summary: The activation of pro-HGF through self-assembled nanofibers can promote angiogenesis and prevent apoptosis, providing a new strategy for the treatment of acute myocardial infarction.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Cardiac & Cardiovascular Systems
Robert D. Hume, Tejas Deshmukh, Tram Doan, Woo Jun Shim, Shaan Kanagalingam, Vikram Tallapragada, Fairooj Rashid, Maria Marcuello, Daniel Blessing, Dinesh Selvakumar, Kalyan Raguram, Faraz Pathan, Dinny Graham, Samir Ounzain, Eddy Kizana, Richard P. Harvey, Nathan J. Palpant, James J. H. Chong
Summary: After myocardial infarction, platelet-derived growth factors (PDGFs) inhibit fibroblast differentiation into myofibroblasts, reducing fibrosis and improving heart function.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Rongrong Wu, Wangxing Hu, Huan Chen, Yingchao Wang, Qingju Li, Changchen Xiao, Lin Fan, Zhiwei Zhong, Xiaoying Chen, Kaiqi Lv, Shuhan Zhong, Yanna Shi, Jinghai Chen, Wei Zhu, Jianyi Zhang, Xinyang Hu, Jian'an Wang
Summary: Angiogenesis is essential for vascular development, and the role of regulatory long noncoding RNAs in this process is underexplored. This study identifies a novel lncRNA, SCDAL, enriched in human embryonic stem cell-derived mesenchymal stem cells, which plays a crucial role in angiogenesis by regulating the GDF6 pathway. Targeting the SCDAL-GDF6 pathway may hold potential as a therapy for ischemic heart diseases.
Article
Engineering, Environmental
Zhicun Wang, Cheng Hu, Wen Zhang, Wenqi Liu, Ruiqi Dong, Shuyi He, Dongdong Wu, Yunbing Wang, Li Yang
Summary: Injectable hydrogels have the potential to effectively treat myocardial infarction by modulating the microenvironment and function of the heart at different stages, providing therapeutic benefits such as promoting cell proliferation, inhibiting fibrosis, and improving heart function.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Endocrinology & Metabolism
Jiawen Li, Xingchang Zheng, Zuoming Guo, Ying Fan, Fang Tian, Teng Li, Qing Pan, Fengyu Liu, Xiao Liang
Summary: This study found that (-)-Epicatechin can improve pathological injury and myocardial fibrosis in acute myocardial infarction (AMI) patients by suppressing the TGF-beta 1 pathway. This discovery provides new insights into the treatment of AMI.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cardiac & Cardiovascular Systems
Nihar Masurkar, Marion Bouvet, Damien Logeart, Charlene Jouve, Fatou Drame, Olivier Claude, Maguelonne Roux, Clement Delacroix, Damien Bergerot, Jean-Jacques Mercadier, Marc Sirol, Barnabas Gellen, Marine Livrozet, Antoine Fayol, Estelle Robidel, David-Alexandre Tregouet, Giovanna Marazzi, David Sassoon, Mariana Valente, Jean-Sebastien Hulot
Summary: After myocardial infarction, the secretion of GDF3 by cardiac stromal cells promotes fibroblast proliferation, leading to adverse fibrotic remodeling.
Article
Pharmacology & Pharmacy
Meifang Wu, Yanguang Guo, Ying Wu, Kaizu Xu, Liming Lin
Summary: Sacubitril/valsartan has a significant improvement on cardiac function and fibrosis in rats after experimental myocardial infarction, by inhibiting collagen synthesis in myocardial fibroblasts through the suppression of the TGF/Smads signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gloria Abizanda, Leyre Lopez-Muneta, Javier Linares, Luis Ramos, Arantxa Baraibar-Churio, Miriam Bobadilla, Elena Iglesias, Giulia Coppiello, Purificacion Ripalda-Cemborain, Xabier L. Aranguren, Felipe Prosper, Ana Perez-Ruiz, Xonia Carvajal-Vergara
Summary: The study demonstrates for the first time that preconditioning the infarcted cardiac tissue with local irradiation can substantially enhance cell engraftment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Polymer Science
Wei Hu, Cui Yang, Xiaodan Guo, Yihong Wu, Xian Jun Loh, Zibiao Li, Yun-Long Wu, Caisheng Wu
Summary: Myocardial infarction is a serious disease and traditional treatment methods have limitations. Recent research has shown that injectable hydrogels can improve heart function and prognosis, providing new treatment strategies for MI.
Article
Cardiac & Cardiovascular Systems
Sunil Rao, Bodo Kirsch, Deepak L. Bhatt, Andrzej Budaj, Rosa Coppolecchia, John Eikelboom, Stefan K. James, W. Schuyler Jones, Bela Merkely, Lars Keller, Renicus S. Hermanides, Gianluca Campo, Jose Luis Ferreiro, Taro Shibasaki, Hardi Mundl, John H. Alexander
Summary: This study investigated the pharmacodynamics, safety, and efficacy of the oral FXIa inhibitor asundexian for secondary prevention after acute myocardial infarction (MI). The results showed that asundexian effectively inhibited coagulation activity without increasing the risk of bleeding or ischemic events.
Article
Engineering, Biomedical
Zhouguang Wang, Yan Huang, Yan He, Sinan Khor, Xingxing Zhong, Jian Xiao, Qingsong Ye, Xiaokun Li
Summary: The use of an injectable coacervate to protect growth factor FGF10 has shown to significantly improve heart condition in a mouse acute myocardial infarction model, with better outcomes compared to free FGF10 or heparin+FGF10 treatment, especially in the long term. The coacervate treatment effectively inhibited cardiac deterioration, reduced myocardial inflammation and fibrosis, improved arterioles and capillaries stabilization, and activated signaling pathways related to cardiac function and angiogenesis.
BIOACTIVE MATERIALS
(2021)
Article
Plant Sciences
Ke-feng Zeng, Hui-juan Wang, Bo Deng, Ting-fang Chen, Jun-bang Chen, Wen-jun Ding, Si Chen, Jun-di Xie, Si-min Lu, Guang-hong Chen, Ying Zhang, Zhang-bin Tan, Hong-bin Ou, Yong-zhen Tan, Shuang-wei Zhang, Ying-chun Zhou, Jing-zhi Zhang, Bin Liu
Summary: This study found that ethyl ferulate (EF) attenuated myocardial fibrosis post-MI by directly suppressing TGFBR1 and its downstream signaling pathway.
Article
Chemistry, Multidisciplinary
Marcelo Munoz, Cagla Eren Cimenci, Keshav Goel, Maxime Comtois-Bona, Mahir Hossain, Christopher McTiernan, Matias Zuniga-Bustos, Alex Ross, Brenda Truong, Darryl R. Davis, Wenbin Liang, Benjamin Rotstein, Marc Ruel, Horacio Poblete, Erik J. Suuronen, Emilio Alarcon
Summary: This article reports on the development and testing of a sprayable nanotherapeutic that can improve cardiac function and conductivity, reduce infarct size, and increase the number of blood vessels and cardiomyocytes in infarcted myocardium.
Article
Immunology
Rianne Nederlof, Sophia Reidel, Andre Spychala, Stefanie Goedecke, Andre Heinen, Tobias Lautwein, Patrick Petzsch, Karl Koehrer, Axel Goedecke
Summary: IGF1 treatment induces an anti-inflammatory phenotype in bone marrow derived neutrophils and attenuates inflammation after myocardial infarction (MI). The effect of IGF1 is mediated through the JAK2/STAT6 pathway rather than the canonical Ras/Raf/ERK or PI3K/AKT pathway. Single cell sequencing analysis shows that IGF1 treatment downregulates pro-inflammatory genes and upregulates anti-inflammatory genes in neutrophils and macrophages after MI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Noriyuki Kashiyama, Robert L. Kormos, Yasumoto Matsumura, Antonio D'Amore, Shigeru Miyagawa, Yoshiki Sawa, William R. Wagner
Summary: Combining ADSCs with a cardiac patch shows improved engraftment, cardiac function, and neovascularization in a rat ischemic cardiomyopathy model.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Masaro Nakae, Koichi Toda, Daisuke Yoshioka, Shigeru Miyagawa, Satoshi Kainuma, Takuji Kawamura, Ai Kawamura, Noriyuki Kashiyama, Yoshiki Sawa
Summary: This study describes a new repair technique for ventricular septal rupture after acute myocardial infarction, using two patches to exclude the infarcted myocardium and close the rupture site without the need for sutures. The technique showed promising clinical outcomes in preventing recurrent interventricular shunt after ventricular septal rupture.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Mikiko Senzai, Satoshi Kainuma, Koichi Toda, Shigeru Miyagawa, Daisuke Yoshioka, Takuji Kawamura, Ai Kawamura, Noriyuki Kashiyama, Yusuke Misumi, Takayoshi Ueno, Toru Kuratani, Tetsuhisa Kitamura, Sho Komukai, Kazuhiro Taniguchi, Yoshiki Sawa
Summary: This study aimed to investigate the incidence and determinants of postoperative adverse events in patients with ischemic cardiomyopathy who underwent long-term durable mitral valve repair. The results showed that approximately 50% of the patients died or were hospitalized for heart failure during the 5-year follow-up, even in the absence of recurrent mitral regurgitation. This finding suggests that durable mitral repair does not always lead to favorable clinical outcomes, and adverse events may be associated with volume overload due to impaired renal function and less favorable pulmonary hemodynamics.
ANNALS OF THORACIC SURGERY
(2022)
Article
Engineering, Biomedical
Hiroko Iseoka, Masao Sasai, Shigeru Miyagawa, Kazuhiro Takekita, Satoshi Date, Hirohito Ayame, Azusa Nishida, Sho Sanami, Takao Hayakawa, Yoshiki Sawa
Summary: Quality control is crucial in the manufacturing cost of cell products, with mycoplasma testing being an important biological test. A mycoplasma identification program using a convolutional neural network can reduce test time and improve sensitivity, leading to a low-cost and streamlined manufacturing process for cellular products.
JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Cardiac & Cardiovascular Systems
Junki Yokota, Toru Kuratani, Kazuo Shimamura, Takayuki Shijo, Kizuku Yamashita, Toru Ide, Ryota Matsumoto, Shigeru Miyagawa
Summary: The study found that the use of protection sheet can significantly reduce the risk of radiation exposure to the eye of surgeons during endocardiovascular surgery in the hybrid operating room.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Masato Nakamura, Hitoshi Yaku, Junya Ako, Hirokuni Arai, Tohru Asai, Taishiro Chikamori, Hiroyuki Daida, Kiyoshi Doi, Toshihiro Fukui, Toshiaki Ito, Kazushige Kadota, Junjiro Kobayashi, Tatsuhiko Komiya, Ken Kozuma, Yoshihisa Nakagawa, Koichi Nakao, Hiroshi Niinami, Takayuki Ohno, Yukio Ozaki, Masataka Sata, Shuichiro Takanashi, Hirofumi Takemura, Takafumi Ueno, Satoshi Yasuda, Hitoshi Yokoyama, Tomoyuki Fujita, Tokuo Kasai, Shun Kohsaka, Takashi Kubo, Susumu Manabe, Naoya Matsumoto, Shigeru Miyagawa, Tomohiro Mizuno, Noboru Motomura, Satoshi Numata, Hiroyuki Nakajima, Hirotaka Oda, Hiromasa Otake, Fumiyuki Otsuka, Ken-Ichiro Sasaki, Kazunori Shimada, Tomoki Shimokawa, Toshiro Shinke, Tomoaki Suzuki, Masao Takahashi, Nobuhiro Tanaka, Hiroshi Tsuneyoshi, Taiki Tojo, Dai Une, Satoru Wakasa, Koji Yamaguchi, Takashi Akasaka, Atsushi Hirayama, Kazuo Kimura, Takeshi Kimura, Yoshiro Matsui, Shunichi Miyazaki, Yoshitaka Okamura, Minoru Ono, Hiroki Shiomi, Kazuo Tanemoto
CIRCULATION JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Keisuke Miyake, Shigeru Miyagawa, Akima Harada, Yoshiki Sawa
Summary: This study developed a new method to enhance the efficacy of cell therapy in peripheral artery disease (PAD) using cell sheet technology. Administration of clustered cells (CCs) improved cell survival, blood perfusion, angiogenesis, muscle regeneration, and regulated inflammation status. These findings suggest the clinical potential of CCs in rescuing severely damaged limbs in PAD.
Article
Cell & Tissue Engineering
Hiroyuki Inoue, Satoki Nakamura, Shuichiro Higo, Mikio Shiba, Yasuaki Kohama, Takumi Kondo, Satoshi Kameda, Tomoka Tabata, Shota Okuno, Yoshihiko Ikeda, Junjun Li, Li Liu, Satoru Yamazaki, Maki Takeda, Emiko Ito, Seiji Takashima, Shigeru Miyagawa, Yoshiki Sawa, Shungo Hikoso, Yasushi Sakata
Summary: Isogenic induced pluripotent stem cell-derived cardiomyocytes with precisely adjusted expression of plakophilin-2 from a patient with arrhythmogenic cardiomyopathy were generated, successfully recapitulating the disease pathology and providing proof of concept for gene replacement therapy.
Article
Engineering, Biomedical
Tsubasa Mikami, Takuji Kawamura, Keita Inoguchi, Ai Kawamura, Kei Nakamoto, Daisuke Yoshioka, Koichi Toda, Yasushi Sakata, Shigeru Miyagawa
Summary: A pump infection is a fatal complication specific to left ventricular assist devices, and infection recurrence is a major concern during device exchange. In this case, we used the Impella 5.0 to maintain proper hemodynamics and treat the infection, effectively controlling the infection and minimizing organ dysfunction. This demonstrates that the Impella 5.0 can serve as an effective bridge for device exchange.
JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Engineering, Biomedical
Tsutomu Doita, Takuji Kawamura, Koichi Inoue, Ai Kawamura, Noriyuki Kashiyama, Ryohei Matsuura, Tetsuya Saito, Daisuke Yoshioka, Koichi Toda, Shigeru Miyagawa
Summary: Thrombus formation is a common and often life-threatening complication in patients with severe heart failure and LVAD support. Choosing the appropriate treatment for pump thrombosis, particularly in emergency cases with severe pump failure, is challenging.
JOURNAL OF ARTIFICIAL ORGANS
(2022)
Article
Cell Biology
Yusuke Kametani, Shota Tanaka, Yuriko Wada, Shota Suzuki, Ayaka Umeda, Kosuke Nishinaka, Yoshiaki Okada, Makiko Maeda, Shigeru Miyagawa, Yoshiki Sawa, Masanori Obana, Yasushi Fujio
Summary: Mammalian cardiomyocytes largely cease to proliferate immediately after birth, limiting the regenerative activity of the heart. Inhibition of GSK-3 promotes cardiomyocyte proliferation, and YAP is endogenously activated. This study addresses the importance of YAP activity in GSK-3 inhibitor-induced cardiomyocyte proliferation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Shohei Yoshida, Shigeru Miyagawa, Takashi Matsuzaki, Yasuyuki Ishii, Emi Fukuda-Kawaguchi, Takuji Kawamura, Ai Kawamura, Yuki Nakamura, Koichi Toda, Yoshiki Sawa
Summary: Mixed-chimera mice established using RGI-2001 showed prolonged graft survival after allogeneic iPSC-CM transplantation and reduced infiltration of immune cells.
Article
Cardiac & Cardiovascular Systems
Ai Kawamura, Koichi Maeda, Kizuku Yamashita, Kazuo Shimamura, Shigeru Miyagawa
Summary: This article reports the first experience of transfemoral (TF)-TAVR with the insertion of a filter device for two patients with severe aortic stenosis who were incidentally detected a grade 4 atheroma in the ascending aorta preoperatively. The patients had a favorable postoperative course without any cerebrovascular events or procedure-related complications.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Yuji Tominaga, Takayoshi Ueno, Masaki Taira, Shigeru Miyagawa, Yoshiki Sawa
Summary: The case study presented a 28-year-old male with multiple heart conditions and infective endocarditis, making surgical planning difficult due to the inability to accurately assess the cardiac condition. A staged approach was chosen, with pulmonary valve replacement performed first for source control, followed by a more definitive operation after recovery.
SAGE OPEN MEDICAL CASE REPORTS
(2022)
Article
Immunology
Satoko Motegi, Atsunori Tsuchiya, Takahiro Iwasawa, Takeki Sato, Masaru Kumagai, Kazuki Natsui, Shunsuke Nojiri, Masahiro Ogawa, Suguru Takeuchi, Yosiki Sakai, Shigeru Miyagawa, Yoshiki Sawa, Shuji Terai
Summary: ONO-1301 demonstrated therapeutic effects in ameliorating liver damage and fibrosis progression in a mouse model of NASH. It also suppressed liver tumor occurrence and showed anti-inflammatory properties in in vitro studies. Additionally, ONO-1301 can potentially be a new drug candidate against NASH due to its multidirectional effects on various pathways.
INFLAMMATION AND REGENERATION
(2022)