Systems biology of the functional and dysfunctional endothelium

A regulatory role of Kruppel-like factor 4 in endothelial argininosuccinate synthetase 1 expression in response to laminar shear stress

(2012) Gyeong In Mun et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Systems and synthetic biology of the vessel wall

(2012) Jennifer Frueh et al.   FEBS LETTERS

Atheroprotective mechanisms of shear stress-regulated microRNAs

(2012) Reinier A. Boon et al.   THROMBOSIS AND HAEMOSTASIS

The role of microRNAs in arterial remodelling

(2012) Maliheh Nazari-Jahantigh et al.   THROMBOSIS AND HAEMOSTASIS

Endothelial cells express a unique transcriptional profile under very high wall shear stress known to induce expansive arterial remodeling

(2011) Jennifer M. Dolan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

MicroRNA-663 upregulated by oscillatory shear stress plays a role in inflammatory response of endothelial cells

(2011) Chih-Wen Ni et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Differential endothelial cell gene expression by African Americans versusCaucasian Americans: a possible contribution to health disparity in vascular disease and cancer

(2011) P Wei et al.   BMC Medicine

Coronary Artery Endothelial Transcriptome In Vivo

(2011) Mete Civelek et al.   Circulation-Cardiovascular Genetics

Semi-supervised Nonnegative Matrix Factorization for gene expression deconvolution: A case study

(2011) Renaud Gaujoux et al.   INFECTION GENETICS AND EVOLUTION

Characterization of the differential response of endothelial cells exposed to normal and elevated laminar shear stress

(2011) Stephen J. White et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Gene expression deconvolution in linear space

(2011) Shai S Shen-Orr et al.   NATURE METHODS

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Stabilisation of atherosclerotic plaques

(2011) Jacob Fog Bentzon et al.   THROMBOSIS AND HAEMOSTASIS

Gene expression deconvolution in clinical samples

(2011) Yingdong Zhao et al.   Genome Medicine

Endothelial Gene Expression in Regions of Defined Shear Exposure in the Porcine Iliac Arteries

(2010) Jeffrey A. LaMack et al.   ANNALS OF BIOMEDICAL ENGINEERING

Role of hemodynamic shear stress in cardiovascular disease

(2010) Emanuele Cecchi et al.   ATHEROSCLEROSIS

Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow

(2010) C.-W. Ni et al.   BLOOD

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts

(2010) S. Xia et al.   DEVELOPMENT

Pathological Findings at Bifurcation Lesions

(2010) Gaku Nakazawa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

MEK5 is Activated by Shear Stress, Activates ERK5 and Induces KLF4 to Modulate TNF Responses in Human Dermal Microvascular Endothelial Cells

(2010) PAUL R. CLARK et al.   MICROCIRCULATION

Unraveling human complexity and disease with systems biology and personalized medicine

(2010) Stephen Naylor et al.   Personalized Medicine

OCT Assessment of Thin-Cap Fibroatheroma Distribution in Native Coronary Arteries

(2010) Kenichi Fujii et al.   JACC-Cardiovascular Imaging

Endothelial cell responses to atheroprone flow are driven by two separate flow components: low time-average shear stress and fluid flow reversal

(2009) Daniel E. Conway et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype

(2009) Caroline Cheng et al.   ATHEROSCLEROSIS

Defining the regulation of KLF4 expression and its downstream transcriptional targets in vascular endothelial cells

(2009) Guadalupe Villarreal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ERK5 and the regulation of endothelial cell function

(2009) Owain Llŷr Roberts et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium

(2009) R. A. Boon et al.   BLOOD

A framework for evolutionary systems biology

(2009) Laurence Loewe   BMC Systems Biology

Frequency and Spatial Distribution of Thin-Cap Fibroatheroma Assessed by 3-Vessel Intravascular Ultrasound and Optical Coherence Tomography

(2009) Teruyoshi Kume et al.   CIRCULATION JOURNAL

Chronic Endoplasmic Reticulum Stress Activates Unfolded Protein Response in Arterial Endothelium in Regions of Susceptibility to Atherosclerosis

(2009) Mete Civelek et al.   CIRCULATION RESEARCH

Differential gene expression in young and senescent endothelial cells under static and laminar shear stress conditions

(2009) Gyeong In Mun et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effect of fluid flow-induced shear stress on human mesenchymal stem cells: Differential gene expression of IL1B and MAP3K8 in MAPK signaling

(2009) John R. Glossop et al.   GENE EXPRESSION PATTERNS

The critical role of hemodynamics in the development of cerebral vascular disease

(2009) Alexander M. Nixon et al.   JOURNAL OF NEUROSURGERY

Comparative systems biology across an evolutionary gradient within the Shewanella genus

(2009) K. T. Konstantinidis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo Assessment of High-Risk Coronary Plaques at Bifurcations With Combined Intravascular Ultrasound and Optical Coherence Tomography

(2009) Nieves Gonzalo et al.   JACC-Cardiovascular Imaging

Distribution and Frequency of Thin-Capped Fibroatheromas and Ruptured Plaques in the Entire Culprit Coronary Artery in Patients With Acute Coronary Syndrome as Determined by Optical Coherence Tomography

(2008) Atsushi Tanaka et al.   AMERICAN JOURNAL OF CARDIOLOGY

In vivo differences between endothelial transcriptional profiles of coronary and iliac arteries revealed by microarray analysis

(2008) Ji Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Gene Expression of Endothelial Cells under Pulsatile Non-Reversing vs. Steady Shear Stress; Comparison of Nitric Oxide Production

(2008) Andrew Yee et al.   ANNALS OF BIOMEDICAL ENGINEERING

Vascular endothelial responses to altered shear stress: Pathologic implications for atherosclerosis

(2008) Jeng-Jiann Chiu et al.   ANNALS OF MEDICINE

Prediction of the Localization of High-Risk Coronary Atherosclerotic Plaques on the Basis of Low Endothelial Shear Stress

(2008) Yiannis S. Chatzizisis et al.   CIRCULATION

Microbial systems biology: New frontiers open to predictive microbiology

(2008) Stanley Brul et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

KLF2-dependent, Shear Stress-induced Expression of CD59

(2008) Anne R. Kinderlerer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology

(2008) Peter F Davies   Nature clinical practice. Cardiovascular medicine

A Three-Vessel Virtual Histology Intravascular Ultrasound Analysis of Frequency and Distribution of Thin-Cap Fibroatheromas in Patients With Acute Coronary Syndrome or Stable Angina Pectoris

(2007) Myeong-Ki Hong et al.   AMERICAN JOURNAL OF CARDIOLOGY