Article
Hematology
Giulia De Rossi, Maria Vahatupa, Enrico Cristante, Samantha Arokiasamy, Sidath E. Liyanage, Ulrike May, Laura Pellinen, Hannele Uusitalo-Jarvinen, James W. Bainbridge, Tero A. H. Jarvinen, James R. Whiteford
Summary: This study establishes the crucial role of SDC4 in pathological angiogenesis, particularly in eye diseases and tumor development. SDC4 is identified as a downstream mediator of VEGFA-induced vascular endothelial cadherin internalization, representing a potential target for antiangiogenic therapies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jessica Oyie Sousa Onyeisi, Carla Cristina Lopes, Martin Goette
Summary: Syndecan-4 plays crucial roles in cell behavior and interactions with growth factors, extracellular matrix molecules, and signaling proteins in various cancers. The expression level of syndecan-4 is important for understanding malignant transformation and it emerges as a target for cancer therapy and diagnosis.
Article
Biochemistry & Molecular Biology
Jisun Hwang, Bohee Jang, Ayoung Kim, Yejin Lee, Joonha Lee, Chungho Kim, Jinmahn Kim, Kyeong Min Moon, Kyuhyung Kim, Ram Wagle, Young-Han Song, Eok-Soo Oh
Summary: The transmembrane domain (TMD) of syndecan-2 specifically regulates receptor cytoplasmic domain function and downstream signaling events controlling cell behavior, as shown through in vivo invertebrate models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Emanuela Pessolano, Raffaella Belvedere, Nunzia Novizio, Amelia Filippelli, Mauro Perretti, James Whiteford, Antonello Petrella
Summary: This study demonstrated that Mesoglycan promotes cell motility and angiogenesis by acting on the key receptor Syndecan-4. The research revealed that Mesoglycan exerts its pro-angiogenic effects by activating three interconnected molecular axes.
Review
Biochemistry & Molecular Biology
Christina A. Daly, Eric T. Hall, Stacey K. Ogden
Summary: Cells communicate with their neighbors during development and tissue homeostasis to ensure coordinated responses to signals. One way this communication occurs is through specialized extensions called cytonemes. However, the molecular mechanisms of cytoneme initiation, growth, and signal delivery are still not fully understood.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Hematology
Israel Vlodavsky, Uri Barash, Hien M. Nguyen, Shi-Ming Yang, Neta Ilan
Summary: Cell surface proteoglycans play crucial roles in regulating various cellular functions, such as proliferation, survival, adhesion, migration, and differentiation, through interactions with the extracellular environment. Heparanase, as a key enzyme involved in this process, is responsible for modulating tissue hemostasis and diverse cellular activities, ultimately contributing to the pathogenesis of diseases.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Article
Biochemistry & Molecular Biology
Faheem Shaik, Michaela, J. M. Balderstone, Samantha Arokiasamy, James R. Whiteford
Summary: The purpose of this review is to explore the biological insights into the role of Syndecan-4 in both the injured heart and later during cardiac repair and remodeling.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Xu Xu, Yefei Shi, Peipei Luan, Wenxin Kou, Bo Li, Ming Zhai, Shuangjie You, Qing Yu, Jianhui Zhuang, Weixia Jian, Mark W. Feinberg, Wenhui Peng
Summary: NLRC5 plays a crucial role in angiogenesis in tissue repair by enhancing STAT3 transcriptional activity, which provides a new target for angiogenic therapy.
Article
Endocrinology & Metabolism
Panyun Wu, Tengteng Zhu, Yiyuan Huang, Zhenfei Fang, Fei Luo
Summary: Research in recent decades has revealed the presence and function of lactate in the body. Lactate, primarily produced through glycolysis, plays important roles in tissue and organ regulation, especially in the cardiovascular system. The heart, as both a net consumer and the organ with the highest lactate consumption, contributes to cardiovascular homeostasis through energy supply and signal regulation. Lactate also affects the occurrence, development, and prognosis of various cardiovascular diseases. This article aims to explore the regulation of the cardiovascular system by lactate under physiological and pathological conditions, provide a better understanding of the lactate-cardiovascular health relationship, and propose new ideas for preventing and treating cardiovascular diseases. Additionally, it summarizes the current progress in treatments targeting lactate metabolism, transport, and signaling in cardiovascular diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Leonardo A. Perez, Lisette Leyton, Alejandra Valdivia
Summary: This article reviews and discusses the essential regulatory roles of Thy-1, integrins, and syndecan 4 in skin wound healing. Their expression is tightly controlled during the healing process, and the lack of their expression leads to delayed wound healing.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Momoko Akiyama, Ryosuke Ueki, Masataka Yanagawa, Mitsuhiro Abe, Michio Hiroshima, Yasushi Sako, Shinsuke Sando
Summary: In this study, a synthetic receptor agonist was designed using a DNA aptamer as a building block to fine-tune agonism. The developed synthetic partial agonist can regulate therapeutically relevant cellular activities by eliciting finely-tuned receptor signaling.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Oncology
Jing Liu, Fang Zhang, Jie He, Shuyun Wang, Leirong Wang, Juan Li, Wenjing Shi, Yali Han, Aiqin Gao, Yuping Sun
Summary: Current anti-angiogenic therapies have changed the paradigm of treating colorectal cancer (CRC) patients with advanced diseases. However, the clinical response rate is still low at less than 10% due largely to complex angiogenic factors released by tumor cells. Exploring novel mechanisms of tumor angiogenesis and identifying alternative targets for combination therapies are therefore essential to effective inhibition of tumor vascularization and CRC development.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Edward Hartsough, Rajani R. J. Shelke, Razie Amraei, Zahra Aryan, Saran Lotfollahzadeh, Nader Rahimi
Summary: Activation and signal transduction of vascular endothelial growth factor receptor-2 (VEGFR-2) play crucial roles in vasculogenesis and pathological angiogenesis. The study reveals that protein arginine methyltransferase 4 (PRMT4) mediates methylation of a specific site on VEGFR-2, which affects VEGFR-2-induced angiogenic responses. This finding may have implications for the development of targeted VEGFR-2 inhibitors.
Article
Oncology
Masao Saitoh
Summary: The epithelial-mesenchymal transition (EMT) is a process where epithelial cells transform into mesenchymal cells, which is associated with invasion, metastasis, and resistance to therapy in cancer. Transcription factors, such as ZEB1/ZEB2, SNAIL, and TWIST, play important roles in driving the EMT process. This review focuses on understanding the molecular mechanisms that sustain high levels of these transcription factors in aggressive carcinomas and their upregulation by transforming growth factor-β during cancer progression.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Fanrui Meng, Yukai Cao, Han Su, Tianyan Liu, Limin Tian, Yu Zhang, Jiarui Yang, Wei Xiao, Deshan Li
Summary: This study demonstrates that rNDV-VEGF-Trap significantly inhibits the growth and migration of tumor cells through anti-angiogenesis and apoptosis. It also reduces tumor volume and weight, suggesting its potential as a candidate for carcinoma therapy, especially for colon cancer.
Article
Neurosciences
Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Lennart Schlaphoff, Constanze Depp, Tim Duking, Jan Winchenbach, Jonathan Neuber, David Ewers, Patricia Scholz, Franziska van der Meer, Ludovico Cantuti-Castelvetri, Andrew O. Sasmita, Martin Meschkat, Torben Ruhwedel, Wiebke Mobius, Roman Sankowski, Marco Prinz, Inge Huitinga, Michael W. Sereda, Francesca Odoardi, Till Ischebeck, Mikael Simons, Christine Stadelmann-Nessler, Julia M. Edgar, Klaus-Armin Nave, Gesine Saher
Summary: The study reveals that sterol synthesis in microglia/macrophages is crucial for resolving inflammation and inducing remyelination in the repair of demyelinated lesions in multiple sclerosis (MS), with desmosterol activating LXR signaling as a key mechanism.
NATURE NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jonathan Voeglein, Irena Kostova, Thomas Arzberger, Sigrun Roeber, Peer Schmitz, Mikael Simons, Viktoria Ruf, Otto Windl, Jochen Herms, Marianne Dieterich, Adrian Danek, Gunter U. Hoeglinger, Armin Giese, Johannes Levin
Summary: This study analyzed the prevalence and clinical implications of the first reported clinical symptoms in neuropathologically proven neurodegenerative diseases. Different diseases showed different first clinical symptoms, with cognitive symptoms predicting longer survival and motor symptoms predicting shorter survival. Assessing first clinical symptoms may improve accuracy of diagnosis and prognosis in neurodegenerative diseases.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Nicolas Ricard, Sabine Bailly, Christophe Guignabert, Michael Simons
Summary: Endothelial cells play a crucial role in controlling oxygen, nutrient exchange, and cellular trafficking between blood and organs. The quiescent state of endothelium is actively regulated and constantly receives important signalling inputs. Understanding organ-specific pathways and their disruption in vascular pathologies can lead to the development of preventive strategies and new therapeutic targets.
NATURE REVIEWS CARDIOLOGY
(2021)
Article
Neurosciences
Shima Safaiyan, Simon Besson-Girard, Tugberk Kaya, Ludovico Cantuti-Castelvetri, Lu Liu, Hao Ji, Martina Schifferer, Garyfallia Gouna, Fumere Usifo, Nirmal Kannaiyan, Dirk Fitzner, Xianyuan Xiang, Moritz J. Rossner, Matthias Brendel, Ozgun Gokce, Mikael Simons
Summary: Research has identified white matter-associated microglia (WAMs) as a protective response during aging, characterized by phagocytic activity and lipid metabolism gene activation. WAMs depend on triggering receptor expressed on myeloid cells 2 (TREM2) signaling and are independent of apolipoprotein E (APOE) in contrast to mouse models of Alzheimer's disease.
Article
Multidisciplinary Sciences
Alessio Colombo, Lina Dinkel, Stephan A. Mueller, Laura Sebastian Monasor, Martina Schifferer, Ludovico Cantuti-Castelvetri, Jasmin Koenig, Lea Vidatic, Tatiana Bremova-Ertl, Andrew P. Lieberman, Silva Hecimovic, Mikael Simons, Stefan F. Lichtenthaler, Michael Strupp, Susanne A. Schneider, Sabina Tahirovic
Summary: Niemann-Pick type C disease is primarily caused by mutations in NPC1, leading to abnormal lipid storage in late endosomes/lysosomes. Research shows that NPC1 disruption significantly impairs microglial function, potentially triggering abnormalities in phagocytosis and myelin turnover in microglia before neuronal death.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Heon-Woo Lee, Yanying Xu, Liqun He, Woosoung Choi, David Gonzalez, Suk-Won Jin, Michael Simons
Summary: Venous endothelial cells are identified as the primary subtype responsible for the expansion of angiogenic vascular networks, arteriovenous malformations formation, and pathological angiogenesis. They proliferate, migrate against the blood flow, and differentiate into different types of endothelial cells during both physiological and pathological angiogenesis processes. This highlights the crucial role of venous endothelium in both normal development and disease pathogenesis.
Article
Clinical Neurology
Jonathan Voeglein, Irena Kostova, Thomas Arzberger, Soheyl Noachtar, Marianne Dieterich, Jochen Herms, Peer Schmitz, Viktoria Ruf, Otto Windl, Sigrun Roeber, Mikael Simons, Gunter U. Hoeglinger, Adrian Danek, Armin Giese, Johannes Levin
Summary: In neurodegenerative diseases, seizure prevalence varies among different diseases, with cognitive symptoms increasing the risk of seizures and motor symptoms decreasing the risk.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Immunology
Garyfallia Gouna, Christian Klose, Mar Bosch-Queralt, Lu Liu, Ozgun Gokce, Martina Schifferer, Ludovico Cantuti-Castelvetri, Mikael Simons
Summary: Microglia play a key role in promoting myelin repair after demyelinating injury, with cholesterol esterification being essential for myelin debris clearance and lipid droplet generation. TREM2 is crucial for adapting to excess cholesterol exposure and regulating lipid droplet formation, ultimately impacting the innate immune response and remyelination.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Hanqiang Deng, Yanying Xu, Xiaoyue Hu, Zhen W. Zhuang, Yuzhou Chang, Yewei Wang, Aglaia Ntokou, Martin A. Schwartz, Bing Su, Michael Simons
Summary: Arterial inward remodeling plays a critical role in the progression of common diseases such as hypertension and atherosclerosis. This study revealed the unexpected involvement of endothelial MEKK3 in regulating TGF-beta R1-Smad2/3 signaling and arterial remodeling in artery diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Horst Penkert, Alix Bertrand, Vini Tiwari, Stephan Breimann, Stephan A. Mueller, Paul M. Jordan, Mathias J. Gerl, Christian Klose, Ludovico Cantuti-Castelvetri, Mar Bosch-Queralt, Ilya Levental, Stefan F. Lichtenthaler, Oliver Werz, Mikael Simons
Summary: The study reveals that n-3 fatty acids can promote the balance of inflammatory reactions, reduce phagocytic infiltrate, accelerate the decline of microglia/macrophages, enhance oligodendrocyte generation, and ultimately improve lesion recovery in demyelinating injuries of the central nervous system.
Article
Cell Biology
Lisa Rausch, Konstantin Lutz, Martina Schifferer, Elena Winheim, Rudi Gruber, Elina F. Oesterhaus, Linus Rinke, Johannes C. Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Christopher Mandel, Michael Bergwelt-Baildon, Mikael Simons, Tobias Straub, Anne B. Krug, Jan Kranich, Thomas Brocker
Summary: The study revealed an unexpectedly high amount of PS + PMP in the blood of COVID-19 patients, with a strong correlation to disease severity. PS may serve as a novel marker for disease severity, triggering blood coagulation, the complement system, and inflammation, leading to immune dysfunction in COVID-19.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Multidisciplinary Sciences
Nicolai Franzmeier, Matthias Brendel, Leonie Beyer, Luna Slemann, Gabor G. Kovacs, Thomas Arzberger, Carolin Kurz, Gesine Respondek, Milica J. Lukic, Davina Biel, Anna Rubinski, Lukas Frontzkowski, Selina Hummel, Andre Muller, Anika Finze, Carla Palleis, Emanuel Joseph, Endy Weidinger, Sabrina Katzdobler, Mengmeng Song, Gloria Biechele, Maike Kern, Maximilian Scheifele, Boris-Stephan Rauchmann, Robert Perneczky, Michael Rullman, Marianne Patt, Andreas Schildan, Henryk Barthel, Osama Sabri, Jost J. Rumpf, Matthias L. Schroeter, Joseph Classen, Victor Villemagne, John Seibyl, Andrew W. Stephens, Edward B. Lee, David G. Coughlin, Armin Giese, Murray Grossman, Corey T. McMillan, Ellen Gelpi, Laura Molina-Porcel, Yaroslau Compta, John C. van Swieten, Laura Donker Laat, Claire Troakes, Safa Al-Sarraj, John L. Robinson, Sharon X. Xie, David J. Irwin, Sigrun Roeber, Jochen Herms, Mikael Simons, Peter Bartenstein, Virginia M. Lee, John Q. Trojanowski, Johannes Levin, Gunter Hoeglinger, Michael Ewers
Summary: The present study combines tau-PET, resting-state fMRI, and histopathology data to demonstrate the association between brain connectivity and tau deposition patterns in 4-repeat tauopathies.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Yanyin Xu, Jiasheng Zhang, Heon-Woo Lee, Guogang Zhang, Yongping Bai, Michael Simons
Summary: Understanding the development of cerebral vasculature is crucial for CNS research and therapeutics. A new method called flattened cortex whole mount (FCWM) technique was developed for high-resolution imaging of pial cerebral vessels. FCWM offers advantages such as precise localization of blood vessels and compatibility with confocal imaging. Application of FCWM revealed type-specific maturation and remodeling of cerebral blood vessels linked to endothelial proliferation, during postnatal development and stroke settings.
Article
Physiology
Michael Simons
Summary: Endothelial-to-mesenchymal transition (EndMT) is a physiological process that plays important roles in both embryonic development and adult tissue pathology. Recent research has revealed a complex set of interactions underlying EndMT, which contributes to the pathophysiological basis of various deadly and intractable diseases. This mini review aims to summarize the recent advances and provide a comprehensive perspective on this complex field.
CURRENT OPINION IN PHYSIOLOGY
(2023)
Meeting Abstract
Neurosciences
M. Djannatian, U. Weikert, S. Safaiyan, C. Wrede, C. Deichsel, G. Kislinger, T. Ruhwedel, D. S. Campbell, T. van Ham, B. Schmid, J. Hegermann, W. Moebius, M. Schifferer, M. Simons