Article
Pharmacology & Pharmacy
Motonao Nakamura, Takao Shimizu
Summary: Leukotriene B4 (LTB4) is a lipid generated by the enzymatic oxidation of arachidonic acid and acts as a potent activator of leukocytes and other inflammatory cells. This review discusses the physiological and pathophysiological significance of LTB4 and its specific G protein-coupled receptors (GPCRs): BLT1 and BLT2, and the potential of targeting these receptors for the treatment of various inflammatory diseases. The structure and post-translational modifications of BLT1 and BLT2 are also explored.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Motonao Nakamura, Takao Shimizu
Summary: This review provides current knowledge on the biosynthesis and physiological roles of LTB4 through cognate receptors. It discusses the potential therapeutic targets for diseases such as rheumatoid arthritis and bronchial asthma by targeting LTB4 receptors.
Review
Immunology
Takehiko Yokomizo, Takao Shimizu
Summary: Leukotriene B-4 (LTB4) is a chemotactic factor for inflammatory cells derived from arachidonate, and an important drug target. The high-affinity LTB4 receptor, BLT1, is involved in the pathogenesis of various inflammatory and immune diseases. The low-affinity receptor, BLT2, is a receptor for 12-hydroxyheptadecatrienoic acid and is involved in maintaining barrier function and promoting wound healing. BLT1 antagonists and BLT2 agonists are potential candidates for treating inflammatory diseases.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Ryotaro Shioda, Airi Jo-Watanabe, Toshiaki Okuno, Kazuko Saeki, Maiko Nakayama, Yusuke Suzuki, Takehiko Yokomizo
Summary: Leukotriene B-4 (LTB4) and its receptor BLT1 are the key factors in the pathogenesis of crescentic glomerulonephritis, and targeting them may be a potential therapeutic strategy for this disease.
Article
Biochemistry & Molecular Biology
Donghwan Park, Dong-Wook Kwak, Jae-Hong Kim
Summary: This study found that levels of ligands for BLT1/2 were significantly increased in bronchoalveolar lavage fluid after house dust mites challenge, and blocking BLT1 or BLT2, as well as 5-lipoxygenase or 12-lipoxygenase, suppressed T(H)2 cytokines production and alleviated lung inflammation in a mouse model of eosinophilic airway inflammation induced by house dust mites. These results suggest that the 5-/12-LO-BLT1/2 cascade plays a role in mediating T(H)2 cytokine production in house dust mite-induced airway inflammation, indicating that BLT1/2 may be a potential therapeutic target for patients with house dust mite-induced allergic asthma.
Article
Multidisciplinary Sciences
Marie A. C. Depuydt, Femke D. Vlaswinkel, Esmeralda Hemme, Lucie Delfos, Mireia N. A. Bernabe Kleijn, Peter J. van Santbrink, Amanda C. Foks, Bram Slutter, Johan Kuiper, Ilze Bot
Summary: BLT1 antagonism does not affect mast cell accumulation or plaque size in advanced atherosclerosis, suggesting the involvement of other mechanisms in mast cell accumulation during atherosclerosis progression.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Dong-Wook Kwak, Donghwan Park, Jae-Hong Kim
Summary: The study demonstrated that blocking BLT1 or BLT2 signaling pathways significantly suppressed airway inflammation and IL-17 production, thereby alleviating neutrophil-dominant airway inflammation. The 5-/12-LO enzymes and the BLT1/BLT2-linked cascade play crucial roles in neutrophil-dominant airway inflammation and IL-17 synthesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Dong-Wook Kwak, Donghwan Park, Jae-Hong Kim
Summary: The study shows that BLT1 and BLT2 play a role in stimulating NLRP3 inflammasome and IL-1 beta synthesis, contributing significantly to neutrophil-dominant asthmatic airway inflammation.
Article
Integrative & Complementary Medicine
Yong Zhang, Zhengxia Zha, Wenhua Shen, Dan Li, Naixin Kang, Zhong Chen, Yanli Liu, Guoqiang Xu, Qiongming Xu
Summary: The study demonstrated that anemoside B4 ameliorated TNBS-induced colitis symptoms by inhibiting tissue damage, inflammatory cell infiltration, pro-inflammatory cytokine production, apoptosis, and slowed proliferation in colon. Quantitative proteomic analyses revealed that anemoside B4 significantly altered 56 proteins in TNBS-induced rats, with a focus on proteins related to TCA cycle and respiratory electron transport chain. S100A9, one of the most significantly down-regulated proteins, was associated with NF-kappa B and MAPK signaling pathways in UC pathogenesis.
Article
Peripheral Vascular Disease
Tamas Kriska, Anja Herrnreiter, Sandra L. Pfister, Adeniyi Adebesin, John R. Falck, William B. Campbell
Summary: The macrophage 12/15-LO pathway enhances the action of Ang II in hypertension development, mainly by promoting endothelial synthesis of a superoxide-derived TP agonist.
Article
Chemistry, Medicinal
Seokwon Shin, Jayeon Park, Ye Eun Lee, Hanbin Ko, Hyung-Sun Youn
Summary: Toll-like receptors (TLRs) play a crucial role in immune responses by activating signaling pathways that induce inflammation. Research has shown that isobavachalcone (IBC) can inhibit the activation of TLR signaling pathways, opening up new therapeutic options for inflammatory diseases involving TLRs.
ARCHIV DER PHARMAZIE
(2022)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeong-Min Hong, Ji-Hong Moon, Young Min Oh, Sang-Youel Park
Summary: The activation of calcineurin and autophagy induced by prion peptide leads to neuroinflammation driven by NF-kappa B, suggesting that calcineurin and autophagy may be potential therapeutic targets for neurodegenerative diseases, including prion disease.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Food Science & Technology
Luanying He, Hui Weng, Qing Li, Guojun Shi, Xiuping Liu, Yushi Du, Jiakun Zheng, Wenhua Ling, Dongliang Wang
Summary: Lactucopicrin inhibits NF-kappa B activation in inflammed macrophages, reduces atherosclerotic plaque area and macrophage accumulation in mice, and does not affect serum lipid levels. It suggests that dietary supplementation with lactucopicrin is a promising strategy to inhibit atherosclerotic cardiovascular disease.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Ana Devesa, Celia Rodriguez Olleros, Xhorxhi Kaci, Elham Askari, Andrea Camblor Blasco, Ana Maria Pello Lazaro, Sandra Gomez Talavera, Juan Gomez Octavio, Gregoria Lapena, Felipe Navarro, Jose Tunon, Borja Ibanez, Alvaro Acena
Summary: This study found a higher prevalence of MGUS in patients with HFpEF compared to the general population. The presence of MGUS did not significantly correlate with clinical outcomes, but beta-blockers and ACEIs/ARBs were associated with reduced mortality and readmission rates in HFpEF patients. Hyperpotassemia was related to worse prognosis.
CARDIOLOGY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Steven H. J. Hageman, Ailsa J. McKay, Peter Ueda, Laura H. Gunn, Tomas Jernberg, Emil Hagstrom, Deepak L. Bhatt, Ph Gabriel Steg, Kristi Lall, Reedik Magi, Mari Nordbo Gynnild, Hanne Ellekjaer, Ingvild Saltvedt, Jose Tunon, Ignacio Mahillo, Alvaro Acena, Karol Kaminski, Malgorzata Chlabicz, Emilia Sawicka, Taavi Tillman, John W. McEvoy, Emanuele Di Angelantonio, Ian Graham, Dirk De Bacquer, Kausik K. Ray, Jannick A. N. Dorresteijn, Frank L. J. Visseren
Summary: This study developed and validated a risk score tool, SMART2, for predicting recurrent ASCVD events in patients with established ASCVD. The tool was calibrated for different regions and demonstrated its clinical utility in treatment decision-making.
EUROPEAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Estefania Nunez, Valentin Fuster, Maria Gomez-Serrano, Jose Manuel Valdivielso, Juan Miguel Fernandez-Alvira, Diego Martinez-Lopez, Jose Manuel Rodriguez, Elena Bonzon-Kulichenko, Enrique Calvo, Alvaro Alfayate, Marcelino Bermudez-Lopez, Joan Carles Escola-Gil, Leticia Fernandez-Friera, Isabel Cerro-Pardo, Jose Maria Mendiguren, Fatima Sanchez-Cabo, Javier Sanz, Jose Maria Ordovas, Luis Miguel Blanco-Colio, Jose Manuel Garcia-Ruiz, Borja Ibanez, Enrique Lara-Pezzi, Antonio Fernandez-Ortiz, Jose Luis Martin-Ventura, Jesus Vazquez
Summary: This study identified circulating proteins that are associated with subclinical atherosclerosis and can predict the disease. These proteins offer potential for improving primary prevention strategies in areas where cardiovascular imaging is not available.
Review
Cell Biology
Jose Luis Martin-Ventura, Carmen Roncal, Josune Orbe, Luis Miguel Blanco-Colio
Summary: Cardiovascular diseases are the leading cause of death globally. In recent years, there has been significant interest in studying extracellular vesicles (EVs) as potential biomarkers for the diagnosis and prognosis of chronic cardiovascular diseases. EVs play a crucial role in the pathological processes of cardiovascular remodeling, especially in vascular and valvular calcification.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Peripheral Vascular Disease
Alvaro Acena, Ana Maria Pello-Lazaro, Juan Martinez-Milla, Oscar Gonzalez-Lorenzo, Nieves Tarin, Carmen Cristobal, Luis M. Blanco-Colio, Jose Luis Martin-Ventura, Ana Huelmos, Marta Lopez-Castillo, Joaquin Alonso, Carlos Gutierrez-Landaluce, Lorenzo Lopez Bescos, Luis Alonso-Pulpon, Emilio Gonzalez-Parra, Jesus Egido, Ignacio Mahillo-Fernandez, Oscar Lorenzo, Maria Luisa Gonzalez-Casaus, Jose Tunon
Summary: This study aimed to assess the influence of estimated glomerular filtration rate (eGFR) on the short-term prognosis of Mineral Metabolism (MM) markers in patients with stable coronary artery disease (SCAD). The results showed that parathormone (PTH) only had independent predictive value in patients with eGFR < 60 ml/min/1.73 m(2), while calcidiol and fibroblast growth factor-23 (FGF23) became the only components of MM that could predict prognosis for patients with eGFR >= 60 ml/min/1.73 m(2).
CLINICA E INVESTIGACION EN ARTERIOSCLEROSIS
(2022)
Article
Surgery
Isabel Cerro-Pardo, Jes S. Lindholt, Estefania Nunez, Raquel Roldan-Montero, Lucia Ortega-Villanueva, Cesar Vegas-Dominguez, Carmen Gomez-Guerrero, Jean-Baptiste Michel, Luis M. Blanco-Colio, Jesus Vazquez, Jose L. Martin-Ventura
Summary: Abdominal aortic aneurysm (AAA) is characterized by the presence of B cells and immunoglobulins in the aortic wall. Kappa and lambda free light chains (FLCs) produced by B cells were found to be increased in AAA patients. The study showed that elevated plasma cFLC levels are associated with the presence of AAA and can independently predict death, major adverse cardiovascular events (MACE), and major adverse lower limb events (MALE) in AAA patients.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Jose M. Rubio Campal, Alberto Sanchez Arjona, Camila S. Garcia Talavera, Loreto Bravo Calero, Carla Lazaro Rivera, Francisco Diaz Cortegana, Jose Tunon, Adrian M. Baranchuk
Summary: Atrial pacing (AP) is associated with the development of atrial high-rate episodes (AHRE), with paced P-wave duration being a strong predictor of AHRE in patients with dual-chamber cardiac implantable electronic devices (CIEDs).
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Raquel Roldan-Montero, Juan M. Perez-Saez, Isabel Cerro-Pardo, Jorge Oller, Diego Martinez-Lopez, Estefania Nunez, Sebastian M. Maller, Carmen Gutierrez-Munoz, Nerea Mendez-Barbero, Joan C. Escola-Gil, Jean-Baptiste Michel, Maria Mittelbrunn, Jesus Vazquez, Luis M. Blanco-Colio, Gabriel A. Rabinovich, Jose L. Martin-Ventura
Summary: Galectin-1 (Gal-1) plays a significant role as a therapeutic target for atherosclerosis and abdominal aortic aneurysm (AAA). Lack of Gal-1 leads to severe atherosclerosis and VSMC phenotypic switch, while treatment with recombinant Gal-1 prevents these effects and alleviates the conditions of atherosclerosis and AAA.
Article
Medicine, General & Internal
Juan Martinez-Milla, Alvaro Acena, Ana Pello, Marta Lopez-Castillo, Hans Paul Gaebelt, Oscar Gonzalez-Lorenzo, Nieves Tarin, Carmen Cristobal, Luis M. Blanco-Colio, Jose Luis Martin-Ventura, Ana Huelmos, Andrea Kallmeyer, Joaquin Alonso, Carlos Gutierrez-Landaluce, Lorenzo Lopez Bescos, Jesus Egido, Ignacio Mahillo-Fernandez, Oscar Lorenzo, Maria Luisa Gonzalez-Casaus, Jose Tunon
Summary: This study aims to assess the influence of NT-ProBNP on the prognostic role of MM markers in patients with stable coronary artery disease. It found that PTH and NT-ProBNP are predictors of poor outcome in patients with NT-ProBNP > 125 pg/mL, while calcidiol and non-HDL cholesterol are the independent predictors of poor outcome in the subgroup of patients with NT-ProBNP <= 125 pg/mL.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Andrea Kallmeyer, Ana Maria Pello Lazaro, Luis M. Blanco-Colio, Alvaro Acena, Oscar Gonzalez-Lorenzo, Nieves Tarin, Carmen Cristobal, Carlos Gutierrez-Landaluce, Ana Huelmos, Jairo Lumpuy-Castillo, Marta Lopez-Castillo, Juan Manuel Montalvo, Joaquin J. Alonso Martin, Lorenzo Lopez-Bescos, Jesus Egido, Oscar Lorenzo, Jose Tunon
Summary: This study found that the absence of high Lp(a) levels and high HDL-c levels were independent predictors of the absence of coronary artery disease in patients with myocardial infarction. High Lp(a) levels were also an independent predictor of ischemic events or death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Belen Picatoste, Isabel Cerro-Pardo, Luis M. Blanco-Colio, Jose L. Martin-Ventura
Summary: This review discusses the impact of diabetes mellitus (DM) on abdominal aortic aneurysms (AAA). It suggests that DM may have a protective role, potentially through factors such as hyperglycemia or insulin resistance, as well as through the effect of prescribed DM drugs. The review also summarizes the potential cellular and molecular pathways involved in the vascular effects of DM and provides an overview of current antidiabetic therapies that could be beneficial for AAA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Marcelino Cortes, Oscar Lorenzo, Jairo Lumpuy-Castillo, Sacramento Martinez-Albaladejo, Mikel Taibo-Urquia, Ana Maria Pello, Antonio Jose Bollas, Miguel Orejas, Miguel angel Navas, Ester Macia, Maria Esther Martinez, Andrea Rueda, Jose Tunon
Summary: This study analyzed the effect of dapagliflozin on cardiac structure and function in patients with normal ejection fraction. The results showed that the use of SGLT2i was associated with improvements in both structural and functional aspects of the heart in diabetic patients with normal ejection fraction.
JOURNAL OF CLINICAL MEDICINE
(2023)