Review
Cell Biology
Tiantian Li, Hongchi Yu, Demao Zhang, Tang Feng, Michael Miao, Jianwei Li, Xiaoheng Liu
Summary: Vascular calcification is associated with increased risk of heart disease, stroke, and atherosclerotic plaque rupture. Extracellular vesicles, particularly matrix vesicles, play a crucial role in the early stages of vascular calcification. However, the underlying mechanism by which matrix vesicles drive vascular smooth muscle cells phenotype switching and calcification remains unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Liu Ouyang, Changjiang Yu, Zhiyong Xie, Xiaoyan Su, Zengmei Xu, Ping Song, Jian Li, Hui Huang, Ye Ding, Ming-Hui Zou
Summary: Aberrant IDO1-regulated tryptophan metabolism may result in osteogenic reprogramming and calcification of VSMCs, while L-tryptophan can inhibit this process via an aryl hydrocarbon receptor-dependent pathway.
Article
Biophysics
Jia-yan Chen, You-xiang Wang, Ke-feng Ren, Yun-bing Wang, Guo-sheng Fu, Jian Ji
Summary: This study found that the osteogenesis of vascular SMCs is influenced by substrate stiffness, with cells on the intermediate substrate stiffness (0.909 MPa) showing the highest extent of osteogenesis. Transforming growth factor-beta 1 and autophagy were involved in this stiffness-dependent process.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Cardiac & Cardiovascular Systems
Sang-Ho Woo, Dongsoo Kyung, Seung Hyun Lee, Kyu Seong Park, Minkyu Kim, Kibyeong Kim, Hyo-Jung Kwon, Young-Suk Won, Inpyo Choi, Young-Jun Park, Du-Min Go, Jeong-Seop Oh, Won Kee Yoon, Seung Sam Paik, Ji Hyeon Kim, Yong-Hwan Kim, Jae-Hoon Choi, Dae-Yong Kim
Summary: This study reveals that TXNIP plays a regulatory role in the osteochondrogenic transition of vascular smooth muscle cells (VSMCs) and affects the occurrence of atherosclerotic calcification. The effects of TXNIP were analyzed through the phenotypes of Txnip(-/-) mice, Tagln-Cre; Txnip(flox/flox) mice, and mice transplanted with the bone marrow of Txnip(-/-) mice. The downregulation of TXNIP in human calcified atherosclerotic plaques was also confirmed through reanalysis of a public single-cell RNA-sequencing dataset. In vitro experiments showed that suppression of TXNIP promotes osteodifferentiation of VSMCs. These findings suggest that TXNIP regulates atherosclerotic calcification by suppressing bone morphogenetic protein signaling and inhibiting the transition of VSMCs toward an osteochondrogenic phenotype.
CIRCULATION RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Tong Li, Baofu Wang, Hao Ding, Shiqi Chen, Weiting Cheng, Yang Li, Xiaoxiao Wu, Lei Wang, Yangyang Jiang, Ziwen Lu, Yu Teng, Sha Su, Xiaowan Han, Mingjing Zhao
Summary: Atherosclerosis (AS)-related diseases are the leading cause of death in clinical patients. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, and intercellular communication through extracellular vesicles (EVs) is important in the pathophysiology of AS.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Yu-Xia Zhang, Ri-Ning Tang, Li-Ting Wang, Bi-Cheng Liu
Summary: Chronic kidney disease (CKD) is a significant health issue globally, with vascular calcification (VC) playing a major role in the cardiovascular morbidity and high mortality of CKD. Intercellular crosstalk between ECs and SMCs is crucial in the development of VC associated with CKD.
CELL PROLIFERATION
(2021)
Article
Cardiac & Cardiovascular Systems
Jaqueline Herrmann, Mengdi Xia, Manasa Reddy Gummi, Anna Greco, Annika Schacke, Markus van der Giet, Markus Toelle, Mirjam Schuchardt
Summary: Vessel wall calcification is a structural pathology of aged vessels associated with high cardiovascular mortality in elderly patients. Chronic inflammation and oxidative stress in aging lead to activation of PRRs in vascular cells, contributing to VSMC calcification. Inhibition of PRR activation may be a potential target for reducing vascular calcification and subsequent cardiovascular mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Maria Francesca Greco, Alessandra Stefania Rizzuto, Marta Zara, Marco Cafora, Chiara Favero, Giulia Solazzo, Ilaria Giusti, Maria Pia Adorni, Francesca Zimetti, Vincenza Dolo, Cristina Banfi, Nicola Ferri, Cesare R. Sirtori, Alberto Corsini, Silvia Stella Barbieri, Anna Pistocchi, Valentina Bollati, Chiara Macchi, Massimiliano Ruscica
Summary: This study reveals that PCSK9 plays an inflammatory role through EVs released by vascular smooth muscle cells, affecting the function and content of neighboring cells, and may have a significant role in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Cristina Mas-Bargues, Consuelo Borras, Matilde Alique
Summary: Vascular calcification is an irreversible pathological process associated with a loss of vascular wall function. It occurs due to aging and age-related diseases, and there are currently no early diagnostic tools available. Mediators such as oxidative stress, inflammation, and extracellular vesicles play a crucial role in the generation and progression of vascular calcification.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Jianing Gao, Yanghui Chen, Huiqing Wang, Xin Li, Ke Li, Yangkai Xu, Xianwei Xie, Yansong Guo, Nana Yang, Xinhua Zhang, Dong Ma, Hong S. Lu, Ying H. Shen, Yong Liu, Jifeng Zhang, Y. Eugene Chen, Alan Daugherty, Dao Wen Wang, Lemin Zheng
Summary: This study investigates the role of GSDMD in vascular smooth muscle cell phenotypic alteration and abdominal aortic aneurysm (AAA) formation. Gsdmd is found to be upregulated in aortic VSMCs in Ang II-induced AAA. VSMC-specific Gsdmd deletion ameliorates AAA formation. Untargeted metabolomic analysis reveals a significant reduction of putrescine in GSDMD-deficient mice.
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Hao-Yue Tang, Ai-Qun Chen, Huan Zhang, Xiao-Fei Gao, Xiang-Quan Kong, Jun-Jie Zhang
Summary: This article provides an updated summary of the recent studies and systematic knowledge of vascular smooth muscle cells (VSMCs) phenotypic switching in cardiovascular diseases such as atherosclerosis, in-stent restenosis, aortic aneurysms, and vascular calcification. It may guide future research and provide novel insights into the prevention and treatment of related diseases.
Review
Cardiac & Cardiovascular Systems
Haocheng Lu, Wa Du, Lu Ren, Milton H. Hamblin, Richard C. Becker, Y. Eugene Chen, Yanbo Fan
Summary: Aortic aneurysm, including thoracic and abdominal types, is a prevalent aortic disease and a major cause of death globally. Treatments include open surgery and endovascular procedures. Thoracic aneurysm is more genetically influenced, while both types share common features like loss of VSMCs and inflammation.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Genetics & Heredity
Meichun Wu, Min Xun, Yuping Chen
Summary: Circular RNAs control the phenotypic adaptation, proliferation, migration, apoptosis, and senescence of vascular smooth muscle cells under multiple stimuli, affecting the progression of cardiovascular diseases.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Cardiac & Cardiovascular Systems
Yan Zhong Liu, Zong Xiang Li, Lin Lin Zhang, Dan Wang, Yi Ping Liu
Summary: Vascular calcification is an important characteristic of cardiovascular disease, mainly caused by the phenotypic differentiation of vascular smooth muscle cells. Mitochondrial dysfunction may play a detrimental role in vascular smooth muscle cell calcification. This review summarizes existing studies on targeting mitochondria as a treatment for vascular calcification, focusing on the roles of mitochondrial processes in regulating the phenotypic transition of vascular smooth muscle cells.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Manuel Navarro-Oviedo, Juan Marta-Enguita, Carmen Roncal, Jose A. Rodriguez, Beatriz Zandio, Ramon Lecumberri, Jose Hermida, Julen Oyarzabal, Antonio Pineda-Lucena, Jose A. Paramo, Roberto Munoz, Josune Orbe
Summary: This study evaluated the effects of CM-352 in an experimental ICH model associated with oral anticoagulants and compared it with clinically used PCC. The results showed that CM-352 can reduce hemorrhage volume and improve functional outcome. Additionally, CM-352 can also reduce neutrophil infiltration by inhibiting MMP-10 and rivaroxaban-related fibrinolytic effects.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Estefania Nunez, Valentin Fuster, Maria Gomez-Serrano, Jose Manuel Valdivielso, Juan Miguel Fernandez-Alvira, Diego Martinez-Lopez, Jose Manuel Rodriguez, Elena Bonzon-Kulichenko, Enrique Calvo, Alvaro Alfayate, Marcelino Bermudez-Lopez, Joan Carles Escola-Gil, Leticia Fernandez-Friera, Isabel Cerro-Pardo, Jose Maria Mendiguren, Fatima Sanchez-Cabo, Javier Sanz, Jose Maria Ordovas, Luis Miguel Blanco-Colio, Jose Manuel Garcia-Ruiz, Borja Ibanez, Enrique Lara-Pezzi, Antonio Fernandez-Ortiz, Jose Luis Martin-Ventura, Jesus Vazquez
Summary: This study identified circulating proteins that are associated with subclinical atherosclerosis and can predict the disease. These proteins offer potential for improving primary prevention strategies in areas where cardiovascular imaging is not available.
Article
Surgery
Isabel Cerro-Pardo, Jes S. Lindholt, Estefania Nunez, Raquel Roldan-Montero, Lucia Ortega-Villanueva, Cesar Vegas-Dominguez, Carmen Gomez-Guerrero, Jean-Baptiste Michel, Luis M. Blanco-Colio, Jesus Vazquez, Jose L. Martin-Ventura
Summary: Abdominal aortic aneurysm (AAA) is characterized by the presence of B cells and immunoglobulins in the aortic wall. Kappa and lambda free light chains (FLCs) produced by B cells were found to be increased in AAA patients. The study showed that elevated plasma cFLC levels are associated with the presence of AAA and can independently predict death, major adverse cardiovascular events (MACE), and major adverse lower limb events (MALE) in AAA patients.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Surgery
Goren Saenz-Pipaon, Susana Ravassa, Katrine L. Larsen, Esther Martinez-Aguilar, Josune Orbe, Jose A. Rodriguez, Leopoldo Fernandez-Alonso, Arantxa Gonzalez, Jose L. Martin-Ventura, Jose A. Paramo, Jes S. Lindholt, Carmen Roncal
Summary: The study aimed to determine the prognostic value of LCN2 and calprotectin in cardiovascular risk assessment for PAD patients. The results confirmed the association of these two inflammatory biomarkers with increased risks of CV death and MALE through examination of their expression in human femoral plaques and measurement of their levels in serum and plasma of PAD patients.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Multidisciplinary Sciences
Raquel Roldan-Montero, Juan M. Perez-Saez, Isabel Cerro-Pardo, Jorge Oller, Diego Martinez-Lopez, Estefania Nunez, Sebastian M. Maller, Carmen Gutierrez-Munoz, Nerea Mendez-Barbero, Joan C. Escola-Gil, Jean-Baptiste Michel, Maria Mittelbrunn, Jesus Vazquez, Luis M. Blanco-Colio, Gabriel A. Rabinovich, Jose L. Martin-Ventura
Summary: Galectin-1 (Gal-1) plays a significant role as a therapeutic target for atherosclerosis and abdominal aortic aneurysm (AAA). Lack of Gal-1 leads to severe atherosclerosis and VSMC phenotypic switch, while treatment with recombinant Gal-1 prevents these effects and alleviates the conditions of atherosclerosis and AAA.
Article
Biology
Sebastian Fernandez-Alonso, Esther Martinez-Aguilar, Susana Ravassa, Josune Orbe, Jose A. Paramo, Leopoldo Fernandez-Alonso, Carmen Roncal
Summary: Predicting the progression of abdominal aortic aneurysm is a challenge. Plasma TAT complexes and D-dimer are associated with the severity of the disease and can be used to evaluate tumor growth and progression.
Article
Medicine, General & Internal
Juan Martinez-Milla, Alvaro Acena, Ana Pello, Marta Lopez-Castillo, Hans Paul Gaebelt, Oscar Gonzalez-Lorenzo, Nieves Tarin, Carmen Cristobal, Luis M. Blanco-Colio, Jose Luis Martin-Ventura, Ana Huelmos, Andrea Kallmeyer, Joaquin Alonso, Carlos Gutierrez-Landaluce, Lorenzo Lopez Bescos, Jesus Egido, Ignacio Mahillo-Fernandez, Oscar Lorenzo, Maria Luisa Gonzalez-Casaus, Jose Tunon
Summary: This study aims to assess the influence of NT-ProBNP on the prognostic role of MM markers in patients with stable coronary artery disease. It found that PTH and NT-ProBNP are predictors of poor outcome in patients with NT-ProBNP > 125 pg/mL, while calcidiol and non-HDL cholesterol are the independent predictors of poor outcome in the subgroup of patients with NT-ProBNP <= 125 pg/mL.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jorge Gonzalez-Zamora, Maria Hernandez, Sergio Recalde, Jaione Bezunartea, Ana Montoliu, Valentina Bilbao-Malave, Josune Orbe, Jose A. Rodriguez, Sara Llorente-Gonzalez, Patricia Fernandez-Robredo, Alfredo Garcia-Layana
Summary: Age-related macular degeneration is the leading cause of severe visual loss in older adults in developed countries. The role of oxidative stress and matrix metalloproteinases, particularly MMP10, in the pathophysiology of AMD is of great interest. This study aimed to clarify the involvement of MMP10 in choroidal neovascularization and found that it plays a significant role in its development, making it a potential therapeutic target.
Article
Nutrition & Dietetics
Daria Abasheva, Marta M. Dolcet-Negre, Maria A. Fernandez-Seara, Jose Maria Mora-Gutierrez, Josune Orbe, Francisco Javier Escalada, Nuria Garcia-Fernandez
Summary: This study indicates that vitamin D-3 levels are related to MMP-10 levels in patients with Type 2 diabetes. Deficiency in vitamin D-3 can lead to reduced MMP-10 expression, while higher 25(OH)D-3 values may help prevent vascular complications.
Article
Biochemistry & Molecular Biology
Javier Marques, Joaquin Fernandez-Irigoyen, Elena Ainzua, Maria Martinez-Azcona, Adriana Cortes, Carmen Roncal, Josune Orbe, Enrique Santamaria, Guillermo Zalba
Summary: NADPH oxidases (NOX) are the main source of reactive oxygen species (ROS) in blood vessels. NOX5, the latest member of the NOX family, plays a role in endothelial dysfunction and the onset of cardiovascular diseases. Overexpression of NOX5 inhibits cell proliferation, promotes apoptosis, alters metabolism, and increases cell migration in endothelial cells.
Article
Medicine, General & Internal
Andrea Kallmeyer, Ana Maria Pello Lazaro, Luis M. Blanco-Colio, Alvaro Acena, Oscar Gonzalez-Lorenzo, Nieves Tarin, Carmen Cristobal, Carlos Gutierrez-Landaluce, Ana Huelmos, Jairo Lumpuy-Castillo, Marta Lopez-Castillo, Juan Manuel Montalvo, Joaquin J. Alonso Martin, Lorenzo Lopez-Bescos, Jesus Egido, Oscar Lorenzo, Jose Tunon
Summary: This study found that the absence of high Lp(a) levels and high HDL-c levels were independent predictors of the absence of coronary artery disease in patients with myocardial infarction. High Lp(a) levels were also an independent predictor of ischemic events or death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Belen Picatoste, Isabel Cerro-Pardo, Luis M. Blanco-Colio, Jose L. Martin-Ventura
Summary: This review discusses the impact of diabetes mellitus (DM) on abdominal aortic aneurysms (AAA). It suggests that DM may have a protective role, potentially through factors such as hyperglycemia or insulin resistance, as well as through the effect of prescribed DM drugs. The review also summarizes the potential cellular and molecular pathways involved in the vascular effects of DM and provides an overview of current antidiabetic therapies that could be beneficial for AAA.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Operations Research & Management Science
Jesus Orbe, Jorge Virto
Summary: In this article, an extension of the penalized splines approach is considered for censored semiparametric modelling using Kaplan-Meier weights. The proposed estimation method and statistical inferences in the model are developed. Simulation studies show satisfactory performance of the method, while a real data set demonstrates its comparability to parametric approaches.
SORT-STATISTICS AND OPERATIONS RESEARCH TRANSACTIONS
(2022)
