Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
M. Viveka, Latha Chaturvedula, Amit Kumar Ram, Balasubramaniyan Vairappan
Summary: This study investigated the association between striatin and eNOS in regulating NO production in the placenta of women with and without pre-eclampsia. The results showed that striatin and peNOS protein expression were significantly reduced, while p65NF-kappa B and iNOS were upregulated in the placenta of pre-eclamptic women. These findings suggest that improving placental striatin expression may be a potential strategy for preventing and treating endothelial dysfunction in pre-eclampsia.
INDIAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Peripheral Vascular Disease
Sarah M. McCann Haworth, Zhengbing Zhuge, Carina Nihlen, Matilda Fornell Von Rosen, Eddie Weitzberg, Jon O. Lundberg, Rafael T. Krmar, Josefine Nasiell, Mattias Carlstrom
Summary: This study reveals that in patients with pre-eclampsia, red blood cells exhibit increased arginase activity and expression, which are correlated with disease severity. Red blood cells can mediate endothelial dysfunction in pre-eclampsia through arginase-dependent and oxidative stress-dependent mechanisms. Targeting red blood cell arginase may offer a novel treatment approach for pre-eclampsia.
JOURNAL OF HYPERTENSION
(2021)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Xiaowan Han, Tong Li, Tieshan Wang, Baofu Wang, Yang Li, Lei Wang, Ziwen Lu, Aiming Wu, Lisong Liu, Guozhong Pan, Mingjing Zhao
Summary: This study evaluated the correlation between different microparticle phenotypes and plaque burden, and investigated the role of microparticles in atherosclerosis. The results showed that CD11a(+) LMP and CD11a(+)/CD45(+) LMP may be potential biomarkers for predicting carotid atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn
Summary: This study found that lipid emulsion enhanced the vasoconstriction induced by dexmedetomidine by inhibiting nitric oxide synthesis, potentially through reducing dexmedetomidine concentration. Dexmedetomidine-induced nitric oxide synthesis may be caused by Src kinase-induced caveolin-1 phosphorylation leading to increased eNOS (Ser1177) phosphorylation and decreased eNOS (Thr495) phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Giorgia Marisi, Irene Azzali, Alessandro Passardi, Francesca Rebuzzi, Giulia Bartolini, Milena Urbini, Matteo Canale, Chiara Molinari, Laura Matteucci, Francesco Giulio Sullo, Silvia Angela Debonis, Chiara Gallio, Graziana Gallo, Giovanni Luca Frassineti, Paola Ulivi
Summary: This study aimed to validate the predictive impact of eNOS and VEGF polymorphisms on the response to Bev plus chemotherapy in mCRC patients. The results showed that these polymorphisms were not associated with PFS, OS, and ORR. Haplotype analysis also did not confirm the previous findings. Therefore, these polymorphisms failed to serve as predictive factors for treatment response in mCRC patients.
SCIENTIFIC REPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Yoon Kyung Choi, Young-Myeong Kim
Summary: The interaction between CO and NO plays a crucial role in maintaining vascular homeostasis and regeneration by improving endothelial function and promoting cell-cell communication, thus sustaining the health of cardiovascular and neurovascular systems.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: TMAO may be involved in impairing the endothelial-dependent vasodilatory mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Eric A. Shikatani, Tao Wang, Luke S. Dingwell, Colin White-Dzuro, Abdul Momen, Mansoor Husain
Summary: This study found that GDF5 deficiency can reduce the incidence of cardiac rupture after myocardial infarction and improve survival rates in mice. Additionally, GDF5 deficiency leads to increased myocardial fibrosis and decreased afterload. However, it also results in the occurrence of chronic adverse remodeling.
CARDIOVASCULAR PATHOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
Martin Kveton, Lukas Hudec, Ivan Vykopal, Matej Halinkovic, Miroslav Laco, Andrea Felsoova, Wanda Benesova, Ondrej Fabian
Summary: This comprehensive review explores the transformative role of digital pathology and computational pathology, especially through machine learning, in the field of heart transplantation. These methodologies have the potential to enhance diagnostic outcomes and reduce observer variability by extracting valuable information from large datasets beyond human perceptual capabilities. However, challenges such as limited sample sizes, diverse data sources, and the absence of standardized protocols hinder the widespread adoption of these techniques.
CARDIOVASCULAR PATHOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Abhinav Goyal, Andrew J. Layman, Melanie C. Bois, Joseph J. Maleszewski
Summary: This study examined the prevalence and characteristics of Lambl excrescences (LEs) in 403 healthy human hearts and found that the prevalence of LEs in healthy hearts is far lower than previously reported.
CARDIOVASCULAR PATHOLOGY
(2024)
