Article
Cardiac & Cardiovascular Systems
Eliot G. Peyster, Sara Arabyarmohammadi, Andrew Janowczyk, Sepideh Azarianpour-Esfahani, Miroslav Sekulic, Clarissa Cassol, Luke Blower, Anil Parwani, Priti Lal, Michael D. Feldman, Kenneth B. Margulies, Anant Madabhushi
Summary: The study aimed to demonstrate that cellular rejection grades generated via computational histological analysis are comparable to those provided by expert pathologists, showing that the computational method can provide expert-quality rejection grading within the range of inter-grader variability seen among human pathologists.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Eliot G. Peyster, Sara Arabyarmohammadi, Andrew Janowczyk, Sepideh Azarianpour-Esfahani, Miroslav Sekulic, Clarissa Cassol, Luke Blower, Anil Parwani, Priti Lal, Michael D. Feldman, Kenneth B. Margulies, Anant Madabhushi
Summary: The study demonstrates that a computational histological analysis tool, CACHE-Grader, can provide expert-quality rejection grading that is on par with human pathologists, showing nearly identical performance in both internal and external validation sets. The tool has the ability to accurately reproduce the clinical standard for cellular rejection diagnosis and has superior sensitivity for high-grade rejection.
EUROPEAN HEART JOURNAL
(2021)
Article
Health Care Sciences & Services
Estefania Tarazon, Lorena Perez-Carrillo, Manuel Portoles, Esther Rosello-Lleti
Summary: This study focuses on analyzing new ultrastructural findings in cardiac biopsy rejection through the observation of perinuclear clustering of mitochondria, which could complement and improve the diagnosis of rejection.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Guillaume Coutance, Maud Racape, Guillaume Baudry, Lucien Lecuyer, Francois Roubille, Katrien Blanchart, Eric Epailly, Emmanuelle Vermes, Sabine Pattier, Aude Boignard, Arnaud Gay, Patrick Bruneval, Xavier Jouven, Jean-Paul Duong Van Huyen, Alexandre Loupy
Summary: The study investigates the association between microRNAs and cardiac rejection, and validates the association between three identified microRNAs and rejection. The results contribute to the discovery of a noninvasive biomarker, offering a means to measure rejection.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Madeleine M. Hamilton, Michael Sciaudone, Patricia P. Chang, Natalie M. Bowman, Tessa M. Andermann, Luther A. Bartelt, Sudha P. Jaganathan, Lisa J. Rose-Jones, Megan E. Andrews, Bart Singer
Summary: This report describes a case of acute Chagas disease reactivation after heart transplantation, highlighting the importance of pre-transplant testing for Chagas in patients with epidemiologic risk factors.
CARDIOVASCULAR PATHOLOGY
(2022)
Review
Cell Biology
Alton B. Farris, Juan Vizcarra, Mohamed Amgad, Lee A. D. Cooper, David Gutman, Julien Hogan
Summary: Whole slide imaging (WSI) is an important technique in digital pathology, leading to increased interest in image analysis (IA) techniques, including artificial intelligence (AI) and hypothesis-driven algorithms. Renal pathology, particularly in renal transplant pathology, has seen a rise in research using AI/machine learning for identification of features such as glomeruli. Deep learning methods like artificial neural networks (ANNs)/ convolutional neural networks (CNNs) are commonly employed for analyzing 'big data' in pathology WSIs.
Article
Urology & Nephrology
Ivy A. Rosales, Grace K. Mahowald, Kristen Tomaszewski, Kiyohiko Hotta, Naoya Iwahara, Takuya Otsuka, Takahiro Tsuji, Yusuke Takada, Ellen Acheampong, Milagros Araujo-Medina, Amy Bruce, Andrea Rios, Anthony Benedict Cosimi, Nahel Elias, Tatsuo Kawai, Hannah Gilligan, Kassem Safa, Leonardo V. Riella, Nina E. Tolkoff-Rubin, Winfred W. Williams Jr, Rex Neal Smith, Robert B. Colvin
Summary: In this study, mRNA analysis was performed to gain insights into the pathogenesis of chronic active antibody-mediated rejection (CAMR). The results showed that peritubular capillary inflammation and donor-specific antibodies (DSA) are the primary drivers of elevation in AMR pathway scores. Transcripts revealed subpathological evidence of both AMR and TCMR, which have predictive value for graft loss.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Vidhya Nair, Eric C. Belanger, Mariana M. Lamacie, Ross A. Davies, John P. Veinot
Summary: A 75-year-old female post orthotopic heart transplantation presented with shortness of breath, hand tremor and delirium. The cause was found to be metastatic lobular breast carcinoma causing a paraneoplastic syndrome.
CARDIOVASCULAR PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
M. P. Humphries, P. Maxwell, M. Salto-Tellez
Summary: QuPath, created at Queen's University Belfast, is the most widely used image analysis software program globally, addressing various needs in tissue-based image analysis and serving as the system of choice for researchers in scientific research.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Oncology
Peter Bankhead
Summary: The potential of quantitative image analysis and artificial intelligence in digital pathology is highlighted. However, the lack of available software and the complexity of existing methods hinder widespread adoption. This review emphasizes the need for collaboration and multidisciplinary approaches in developing new algorithms and calls for greater attention to openness, implementation, and usability. The interaction between digital pathology and the bioimage analysis community is seen as beneficial in terms of data sharing and idea exchange.
JOURNAL OF PATHOLOGY
(2022)
Article
Medicine, General & Internal
M. Alvaro Berbis, David S. McClintock, Andrey Bychkov, Jeroen Van der Laak, Liron Pantanowitz, Jochen K. Lennerz, Jerome Y. Cheng, Brett Delahunt, Lars Egevad, Catarina Eloy, Alton B. Farris III, Filippo Fraggetta, Raimundo Garcia del Moral, Douglas J. Hartman, Markus D. Herrmann, Eva Hollemans, Kenneth A. Iczkowski, Aly Karsan, Mark Kriegsmann, Mohamed E. Salama, John H. Sinard, J. Mark Tuthill, Bethany Williams, Cesar Casado-Sanchez, Victor Sanchez-Turrion, Antonio Luna, Jose Aneiros-Fernandez, Jeanne Shen
Summary: AI is expected to be routinely and impactfully used in pathology practice by 2030, according to experts in the field. This consensus study highlights the anticipated short-to-mid-term impact of AI and raises important practical, ethical, and legal challenges that need to be addressed prior to its clinical implementation.
Review
Oncology
Vidya Sankar Viswanathan, Paula Toro, German Corredor, Sanjay Mukhopadhyay, Anant Madabhushi
Summary: The development of digital pathology and artificial intelligence has provided new opportunities for the diagnosis and treatment of lung diseases. Research has explored the application of AI methods and tools in lung diseases, including image analysis and the use of biomarkers. AI tools also have the potential to play a role in areas such as multimodal data analysis, 3D pathology, and transplant rejection in lung diseases.
JOURNAL OF PATHOLOGY
(2022)
Review
Pathology
Matthew G. Hanna, Edi Brogi
Summary: Digital and computational pathology plays an important role in breast pathology. By utilizing digital imaging and computational analysis, it has the potential to improve diagnostic accuracy, enhance collaboration and remote pathology, as well as contribute to the classification and management of breast diseases.
ADVANCES IN ANATOMIC PATHOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Eliot G. Peyster, Andrew Janowczyk, Abigail Swamidoss, Samhith Kethireddy, Michael D. Feldman, Kenneth B. Margulies
Summary: This study developed a precision medicine tool for predicting the development of cardiac allograft vasculopathy (CAV) in heart transplant recipients using computational analysis of digital pathology images. The incorporation of computationally extracted histological features greatly improved the prediction of future CAV development, enhancing the precision and personalization of treatment plans.
Article
Immunology
Zhe Yang, Fei Han, Tao Liao, Haofeng Zheng, Zihuan Luo, Maolin Ma, Jiannan He, Lei Li, Yongrong Ye, Rui Zhang, Zhengyu Huang, Yannan Zhang, Qiquan Sun
Summary: Artemisinin demonstrates significant immunosuppressive effects in rat cardiac transplantation model, attenuating rejection reactions and prolonging allograft survival. By targeting multiple effector cells, artemisinin effectively reduces T cell-mediated rejection and antibody-mediated rejection, showing potential for clinical use in transplant rejection prevention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zuzana Rabekova, Sona Frankova, Milan Jirsa, Magdalena Neroldova, Mariia Lunova, Ondrej Fabian, Martin Kveton, David Varys, Klara Chmelova, Vera Adamkova, Jaroslav A. Hubacek, Julius Spicak, Dusan Merta, Jan Sperl
Summary: The study found that patients with liver cirrhosis carrying the SERPINA1 MZ and MS genotypes have a significantly lower risk of hepatocellular carcinoma. MZ and MS heterozygotes have lower serum AAT levels. Multivariate analysis identified MZ or MS genotype carriage as a protective factor, while factors such as age, gender, BMI, and viral aetiology of cirrhosis increase the risk of HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Sona Frankova, Zuzana Rabekova, Magdalena Neroldova, Ondrej Fabian, Martin Kveton, Jaroslav A. Hubacek, Julius Spicak, Vera Adamkova, Milan Jirsa, Jan Sperl
JOURNAL OF HEPATOLOGY
(2022)
Article
Physiology
Monika Cahova, Martin Kveton, Vojtech Petr, David Funda, Helena Dankova, Ondrej Viklicky, Petra Hruba
Summary: The study showed that ACE inhibitors or angiotensin II receptor blockers do not affect ACE2 expression in kidney transplant recipients. Therefore, long-term RAAS treatment can still be continued for kidney transplant recipients, despite acute complications such as COVID-19 where ACE2 serves as the entry protein for infection.
KIDNEY & BLOOD PRESSURE RESEARCH
(2021)
Letter
Dermatology
Eva Sticova, Martin Kveton, Monika Dubska, Andrea Kubatova
INDIAN JOURNAL OF DERMATOLOGY VENEREOLOGY & LEPROLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Eric A. Shikatani, Tao Wang, Luke S. Dingwell, Colin White-Dzuro, Abdul Momen, Mansoor Husain
Summary: This study found that GDF5 deficiency can reduce the incidence of cardiac rupture after myocardial infarction and improve survival rates in mice. Additionally, GDF5 deficiency leads to increased myocardial fibrosis and decreased afterload. However, it also results in the occurrence of chronic adverse remodeling.
CARDIOVASCULAR PATHOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Abhinav Goyal, Andrew J. Layman, Melanie C. Bois, Joseph J. Maleszewski
Summary: This study examined the prevalence and characteristics of Lambl excrescences (LEs) in 403 healthy human hearts and found that the prevalence of LEs in healthy hearts is far lower than previously reported.
CARDIOVASCULAR PATHOLOGY
(2024)