Review
Cardiac & Cardiovascular Systems
Paola Gargiulo, Federica Marzano, Marco Salvatore, Christian Basile, Davide Buonocore, Antonio Luca Maria Parlati, Ermanno Nardi, Gaetano Asile, Vincenza Abbate, Angela Colella, Alfonsina Chirico, Caterina Marciano, Stefania Paolillo, Pasquale Perrone-Filardi
Summary: Heart failure is a significant health issue with a high burden on both society and the economy. Recent research has shown that microRNAs play an important role in the development and prognosis of heart failure, serving as biomarkers for diagnosis and prognosis. Exploration of microRNAs as potential therapeutic targets is also ongoing.
Article
Biochemistry & Molecular Biology
Matthew Reily-Bell, Andrew Bahn, Rajesh Katare
Summary: Research shows that ROS is one of the main causes of diabetic heart disease, and miRNAs play a crucial role in treating the disease. However, since miRNAs have multiple targets and exhibit different functions in different environments, a thorough understanding of their mechanisms is needed for successful application.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Endocrinology & Metabolism
Xinyu Wang, Han Wu, Guangyan Yang, Jiaqing Xiang, Lijiao Xiong, Li Zhao, Tingfeng Liao, Xinyue Zhao, Lin Kang, Shu Yang, Zhen Liang
Summary: REG1A and RUNX3 may serve as biomarkers for predicting the risk of developing DKD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Dhananjie Chandrasekera, Rajesh Katare
Summary: Diabetes is a metabolic disorder that affects many people, and microRNAs (miRNAs) have been found to play a significant role in the development and progression of Diabetic Heart Disease (DHD). Exosomes, extracellular nanovesicles, carry diverse cargos and play a role in cardiovascular disease and DHD.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiabing Zhan, Kunying Jin, Nan Ding, Yufei Zhou, Guo Hu, Shuai Yuan, Rong Xie, Zheng Wen, Chen Chen, Huaping Li, Dao Wen Wang
Summary: Intensive glycemic control is insufficient for reducing the risk of heart failure in patients with diabetes mellitus. MiR-320 and CD36 mutually enhance each other's expression, forming a positive feedback loop that sustains a hyperlipidemic state in the heart.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Biochemistry & Molecular Biology
Jelena Munjas, Miron Sopic, Aleksandra Stefanovic, Rok Kosir, Ana Ninic, Ivana Joksic, Tamara Antonic, Vesna Spasojevic-Kalimanovska, Ursula Prosenc Zmrzljak
Summary: Preeclampsia is a significant cause of maternal and neonatal morbidity and mortality worldwide, with abnormalities in lncRNAs and miRNAs in the placenta being associated with its pathophysiology. Currently, there is a lack of clinically available predictive biomarkers for Preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Jiao Li, Shanshan Zheng, Chaoqun Ma, Xuexun Chen, Xuan Li, Shengjie Li, Ping Wang, Ping Chen, Zunsong Wang, Wenbin Li, Yipeng Liu
Summary: Diabetic kidney disease (DKD) is a common end-stage renal disease caused by chronic diabetes. It is characterized by persistent proteinuria and a decline in the glomerular filtration rate. Recent studies have shown that podocyte injury is a central factor in the development of DKD, and research on exosomes in podocyte injury associated with DKD has made significant progress.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Manveen K. Gupta, Anita Sahu, Yu Sun, Maradumane L. Mohan, Avinash Kumar, Ajaykumar Zalavadia, Xi Wang, Elizabeth E. Martelli, Kate Stenson, Conner P. Witherow, Judy Drazba, Srinivasan Dasarathy, Sathyamangla V. Naga Prasad
Summary: The expression of miRNA-7 in cardiomyocytes results in cardiac dilation instead of adaptive hypertrophic response. miRNA-7 Tg mice showed cardiac dilation and increased fibrosis under TAC, bypassing the adaptive hypertrophic response. The findings suggest a role of miRNA-7 beyond regulation of EGFR/ERRB in mediating cardiac dilation.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Ying Zhao, Linlin Zhuang, Peilong Tian, Ming Ma, Guoqiu Wu, Yu Zhang
Summary: Acute myocardial infarction (AMI) is a serious cardiovascular disease with a high rate of morbidity and mortality. Early diagnosis of AMI is crucial, and miR-208 has potential as an early biomarker due to its specific expression in the heart and release by damaged myocardial cells soon after AMI. In this study, a denatured bubble-mediated RT-ASEA method was developed for rapid and efficient detection of miR-208a. The method showed good performance in terms of repeatability, determination limit, and linearity, and demonstrated strong correlation with the gold standard cTnI concentration for AMI diagnosis. The RT-ASEA method could effectively distinguish between AMI and healthy groups, with high sensitivity and specificity. This study provides important support for the development of miR-208a as an early biomarker for AMI.
ANALYTICAL METHODS
(2023)
Article
Medicine, Research & Experimental
M. Nasser, Muqaddas Masood, Salah Adlat, Deng Gang, Shuoji Zhu, Ge Li, Nanbo Li, Jimei Chen, Ping Zhu
Summary: This review discusses the molecular mechanisms of exosomes and internal microRNAs derived from mesenchymal stem cells in repairing cardiac ischemic injury. It highlights the potential advantages of exosomal miRNAs in disease diagnosis and predicting curative effects. Studies also show that mesenchymal stem cell-derived micro-exosomes can regulate cell proliferation, apoptosis, inflammation, and angiogenesis in ischemic tissue.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Medicine, General & Internal
Niamh Errington, James Iremonger, Josephine A. Pickworth, Sokratis Kariotis, Christopher J. Rhodes, Alexander Mk Rothman, Robin Condliffe, Charles A. Elliot, David G. Kiely, Luke S. Howard, John Wharton, A. A. Roger Thompson, Nicholas W. Morrell, Martin R. Wilkins, Dennis Wang, Allan Lawrie
Summary: This study identified two microRNAs using consensus machine learning approaches to distinguish PAH from both disease and healthy controls. These circulating microRNAs and their target genes may offer insights into PAH pathogenesis and reveal potential drug targets.
Article
Cell Biology
Xuefeng Lin, Liqin Zhang, Wei Zhang, Xinjun Lei, Qun Lu, Aiqun Ma
Summary: This study reveals that circRNA circ_0001006 exacerbates cardiac hypertrophy by suppressing miR-214-3p, leading to enhanced PAK6 levels.
Article
Immunology
Nikos Kyritsis, Abel Torres-Espin, Patrick G. Schupp, J. Russell Huie, Austin Chou, Xuan Duong-Fernandez, Leigh H. Thomas, Rachel E. Tsolinas, Debra D. Hemmerle, Lisa U. Pascual, Vineeta Singh, Jonathan Z. Pan, Jason F. Talbott, William D. Whetstone, John F. Burke, Anthony M. DiGiorgio, Philip R. Weinstein, Geoffrey T. Manley, Sanjay S. Dhall, Adam R. Ferguson, Michael C. Oldham, Jacqueline C. Bresnahan, Michael S. Beattie
Summary: By analyzing global gene expression in peripheral white blood cells, we identified genes that can predict the severity of spinal cord injury, particularly for complete SCIs and AIS D SCIs with high accuracy. This suggests that global transcriptomic changes in peripheral blood cells may have diagnostic and prognostic value for SCI severity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Sobuj Mia, Ravi Sonkar, Lamario Williams, Mary N. Latimer, Isabelle Frayne Robillard, Abhinav Diwan, Stuart J. Frank, Christine Des Rosiers, Martin E. Young
Summary: The study found that during obesity, there is a diurnal metabolic inflexibility in the heart specifically for nonoxidative lipid metabolism, but not for substrate oxidation. By restricting food intake to the active period, partial restoration of whole body metabolic flexibility and day-night differences in cardiac triglyceride synthesis and lipidome can be achieved.
Article
Biochemistry & Molecular Biology
Lara Aguilar-Iglesias, Ana Merino-Merino, Ester Sanchez-Corral, Maria-Jesus Garcia-Sanchez, Isabel Santos-Sanchez, Ruth Saez-Maleta, Jose-Angel Perez-Rivera
Summary: This study aims to compare the diagnostic performance of cardiac biomarkers in predicting frailty in different age groups. The results show that in the younger group, frailty is primarily determined by age and comorbidities, while in the elderly group, NT-proBNP is significantly associated with frailty. Adding NT-proBNP can improve the detection of frailty in elderly patients with acute heart failure.
Article
Multidisciplinary Sciences
Fenja Knoepp, Zoe Ashley, Daniel Barth, Jan-Peter Baldin, Michael Jennings, Marina Kazantseva, Eng Leng Saw, Rajesh Katare, Diego Alvarez de la Rosa, Norbert Weissmann, Martin Fronius
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Dhananjie N. K. Chandrasekera, Joshua P. H. Neale, Isabelle van Hout, Shruti Rawal, Sean Coffey, Gregory T. Jones, Richard Bunton, Ramanen Sugunesegran, Dominic Parry, Philip Davis, Patrick Manning, Michael J. A. Williams, Rajesh Katare
Article
Pharmacology & Pharmacy
Prakash Khadka, Philip C. Hill, Boya Zhang, Rajesh Katare, Jack Dummer, Shyamal C. Das
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Endocrinology & Metabolism
Lorna J. Daniels, Marco Annandale, Parisa Koutsifeli, Xun Li, Carol T. Bussey, Isabelle van Hout, Richard W. Bunton, Philip J. Davis, Sean Coffey, Rajesh Katare, Regis R. Lamberts, Lea M. D. Delbridge, Kimberley M. Mellor
Summary: This study indicates that elevated myocardial fructose and sorbitol levels in diabetic patients are associated with diastolic dysfunction. Experimental evidence suggests that fructose may promote the formation of cardiomyocyte cytosolic lipid inclusions, potentially contributing to lipotoxicity in the diabetic heart.
NUTRITION & DIABETES
(2021)
Article
Biochemistry & Molecular Biology
Matthew Reily-Bell, Andrew Bahn, Rajesh Katare
Summary: Research shows that ROS is one of the main causes of diabetic heart disease, and miRNAs play a crucial role in treating the disease. However, since miRNAs have multiple targets and exhibit different functions in different environments, a thorough understanding of their mechanisms is needed for successful application.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Hematology
Aranzazu Chamorro-Jorganes, Walid K. Sweaad, Rajesh Katare, Marie Besnier, Maryam Anwar, N. Beazley-Long, Graciela Sala-Newby, Inigo Ruiz-Polo, Dhananjie Chandrasekera, Alison A. Ritchie, Andrew Benest, Costanza Emanueli
Summary: The research revealed that METTL3 regulates m(6)A RNA methylation in endothelial cells and is essential for angiogenesis, potentially through influencing the processing of let-7e and miR-17-92 cluster.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Eng Leng Saw, James T. Pearson, Daryl O. Schwenke, Pujika Emani Munasinghe, Hirotsugu Tsuchimochi, Shruti Rawal, Sean Coffey, Philip Davis, Richard Bunton, Isabelle Van Hout, Yuko Kai, Michael J. A. Williams, Yoshihiko Kakinuma, Martin Fronius, Rajesh Katare
Summary: This study identified dysregulation of cardiac NNCS in diabetic heart disease (DHD) and demonstrated that increased cardiac ACh is beneficial for maintaining cardiac and vascular function in diabetic hearts. Activation of cardiac NNCS could potentially serve as a new therapeutic strategy to prevent or delay the development of DHD.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Jayanthi Bellae Papannarao, Daryl O. Schwenke, Patrick Manning, Rajesh Katare
Summary: The upregulation of miR-200c and miR-let-7b in individuals with obesity is associated with the downregulation of ACE2, potentially increasing susceptibility to COVID-19. Therefore, the level of miR-200c may serve as a potential early biomarker for identifying individuals at risk of severe COVID-19.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Cardiac & Cardiovascular Systems
Jingshu Chen, Rulin Zhuang, Henry S. Cheng, Anurag Jamaiyar, Carmel Assa, Michael McCoy, Shruti Rawal, Daniel Perez-Cremades, Mark W. Feinberg
Summary: A new method for isolating and culturing diverse cell types from the mouse aorta simultaneously has been developed, allowing for the extraction of highly pure cells for studying the function and mechanisms of various vascular diseases.
Article
Biochemistry & Molecular Biology
Anthony Soonseng Yee-Goh, Atsushi Yamauchi, Isabelle van Hout, Jayanthi Bellae Papannarao, Ramanen Sugunesegran, Dominic Parry, Philip Davis, Rajesh Katare
Summary: Cardiac progenitor cells (CPCs) and adipocyte stem cells (ASCs) have potential in treating heart diseases. A study found that CPCs and ASCs from the same patient have different characteristics, with CPCs showing slightly superior functional efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Ramakanth Satthenapalli, Scott Lee, Jayanthi Bellae Papannarao, Timothy A. Hore, Akash Chakraborty, Peter P. Jones, Regis R. Lamberts, Rajesh Katare
Summary: This study successfully differentiated pluripotent stem cells into ventricular-specific cardiomyocytes by regulating Wnt and retinoic acid signaling pathways.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Pharmacology & Pharmacy
Shruti Rawal, Shubham Khot, Vivek Bora, Bhoomika Patel, Mayur M. Patel
Summary: This study develops an orally administrable, folate-receptor-targeted Nanostructured lipid carriers (NLCs) of Docetaxel (DX) to overcome the bioavailability and toxicity issues of intravenous administration in lung cancer chemotherapy, showing promising antitumor efficacy and safety.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Oncology
Alan T. Yeo, Rushil Shah, Konstantinos Aliazis, Rinku Pal, Tuoye Xu, Piyan Zhang, Shruti Rawal, Christopher M. Rose, Frederick S. Varn, Vicky A. Appleman, Joon Yoon, Hemant Varma, Steven P. Gygi, Roel G. W. Verhaak, Vassiliki A. Boussiotis, Al Charest
Summary: The composition of the tumor immune microenvironment (TIME) is a key determinant of patients' response to immunotherapy. A study on glioblastoma (GBM) identified an immune landscape associated with cancer driver mutations and resistance to checkpoint blockade immunotherapy. The study also discovered an axis involving GBM-secreted CXCL1/2/3 and PMN-MDSC-expressed CXCR2 that regulates the output of PMN-MDSCs, leading to increased resistance to immunotherapy.
CANCER IMMUNOLOGY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Elisa Avolio, Rajesh Katare, Anita C. Thomas, Andrea Caporali, Daryl Schwenke, Michele Carrabba, Marco Meloni, Massimo Caputo, Paolo Madeddu
Summary: Pericytes in the heart can be pharmacologically modulated to promote neovascularization and repair of ischemic heart. These cells acquire characteristics similar to vascular smooth muscle cells after excluding EGF/bFGF or exposure to PD0325901 inhibitor, becoming more proangiogenic, responsive to vasoactive agents, and insensitive to chemoattractants.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell & Tissue Engineering
Ryan McQuaig, Parul Dixit, Atsushi Yamauchi, Isabelle Van Hout, Jayanthi Bellae Papannarao, Richard Bunton, Dominic Parry, Philip Davis, Rajesh Katare
CELL TRANSPLANTATION
(2020)