标题
The paradigm of mutant p53-expressing cancer stem cells and drug resistance
作者
关键词
-
出版物
CARCINOGENESIS
Volume 35, Issue 6, Pages 1196-1208
出版商
Oxford University Press (OUP)
发表日期
2014-03-22
DOI
10.1093/carcin/bgu073
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- P53 and aging: A fresh look at an old paradigm
- (2016) Masha V. Poyurovsky et al. Aging-US
- Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness
- (2015) Helge Siemens et al. Oncotarget
- Loss of p53 Induces Tumorigenesis in p21-Deficient Mesenchymal Stem Cells
- (2015) Rene Rodriguez et al. NEOPLASIA
- Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?
- (2014) Anthony J. Mutsaers et al. BONE
- Caught in the cross fire: p53 in inflammation
- (2014) Tomer Cooks et al. CARCINOGENESIS
- The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele
- (2014) Y Shetzer et al. CELL DEATH AND DIFFERENTIATION
- p53: The barrier to cancer stem cell formation
- (2014) Ronit Aloni-Grinstein et al. FEBS LETTERS
- TP53 Mutants in the Tower of Babel of Cancer Progression
- (2014) Alessandra Bisio et al. HUMAN MUTATION
- Autophagy of cancer stem cells is involved with chemoresistance of colon cancer cells
- (2013) Shaobin Wu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer
- (2013) Tomer Cooks et al. CANCER CELL
- Cancer Stem–like Cell Marker CD44 Promotes Bone Metastases by Enhancing Tumorigenicity, Cell Motility, and Hyaluronan Production
- (2013) Toru Hiraga et al. CANCER RESEARCH
- The Hallmarks of Aging
- (2013) Carlos López-Otín et al. CELL
- Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9
- (2013) Jacqueline L.Y. Chee et al. CELL CYCLE
- p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity
- (2013) A Molchadsky et al. CELL DEATH AND DIFFERENTIATION
- Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis
- (2013) W Hanel et al. CELL DEATH AND DIFFERENTIATION
- Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation
- (2013) Yao-An Shen et al. Evidence-based Complementary and Alternative Medicine
- p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes
- (2013) Abdul M. Mondal et al. JOURNAL OF CLINICAL INVESTIGATION
- Serine substitution of proline at codon 151 ofTP53confers gain of function activity leading to anoikis resistance and tumor progression of head and neck cancer cells
- (2013) Tong-Xin Xie et al. LARYNGOSCOPE
- Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche
- (2013) Andrea Flesken-Nikitin et al. NATURE
- Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells
- (2013) S Masciarelli et al. ONCOGENE
- Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta
- (2013) Shalom Madar et al. PLoS One
- Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells
- (2013) Atsushi Sato et al. Stem Cell Research
- Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression
- (2013) W Wang et al. Cell Death & Disease
- Tumour-associated mutant p53 drives the Warburg effect
- (2013) Cen Zhang et al. Nature Communications
- Cell-type, Dose, and Mutation-type Specificity Dictate Mutant p53 Functions In Vivo
- (2012) Ming Kei Lee et al. CANCER CELL
- miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
- (2012) Helge Siemens et al. CELL CYCLE
- p53 Counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition
- (2012) R Brosh et al. CELL DEATH AND DIFFERENTIATION
- Mutant p53: one name, many proteins
- (2012) W. A. Freed-Pastor et al. GENES & DEVELOPMENT
- Cellular reprogramming and cancer development
- (2012) Katsunori Semi et al. INTERNATIONAL JOURNAL OF CANCER
- Complexity of cancer stem cells
- (2012) Eiji Sugihara et al. INTERNATIONAL JOURNAL OF CANCER
- Various p53 mutant proteins differently regulate the Ras circuit to induce a cancer-related gene signature
- (2012) Hilla Solomon et al. JOURNAL OF CELL SCIENCE
- The gain of function of p53 cancer mutant in promoting mammary tumorigenesis
- (2012) X Lu et al. ONCOGENE
- The differentiation stage of p53-Rb-deficient bone marrow mesenchymal stem cells imposes the phenotype of in vivo sarcoma development
- (2012) R Rubio et al. ONCOGENE
- Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis
- (2012) P Dong et al. ONCOGENE
- Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44+ human breast cancer cells
- (2011) Alysha K. Croker et al. BREAST CANCER RESEARCH AND TREATMENT
- Gain-of-function mutant p53 upregulates CXC chemokines and enhances cell migration
- (2011) W.Andrew Yeudall et al. CARCINOGENESIS
- Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
- (2011) Philip J. Stephens et al. CELL
- Strategies for Homeostatic Stem Cell Self-Renewal in Adult Tissues
- (2011) Benjamin D. Simons et al. CELL
- Cell Fate Plug and Play: Direct Reprogramming and Induced Pluripotency
- (2011) Stuart M. Chambers et al. CELL
- Mosaic Analysis with Double Markers Reveals Tumor Cell of Origin in Glioma
- (2011) Chong Liu et al. CELL
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance
- (2011) Ayesha B. Alvero et al. CELL CYCLE
- MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function
- (2011) S Donzelli et al. CELL DEATH AND DIFFERENTIATION
- Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy
- (2011) M Bartucci et al. CELL DEATH AND DIFFERENTIATION
- Modeling sarcomagenesis using multipotent mesenchymal stem cells
- (2011) Rene Rodriguez et al. CELL RESEARCH
- p53 coordinates cranial neural crest cell growth and epithelial-mesenchymal transition/delamination processes
- (2011) A. Rinon et al. DEVELOPMENT
- SPATA18, a Spermatogenesis-Associated Gene, Is a Novel Transcriptional Target of p53 and p63
- (2011) C. Bornstein et al. MOLECULAR AND CELLULAR BIOLOGY
- The transcriptional and signalling networks of pluripotency
- (2011) Huck-Hui Ng et al. NATURE CELL BIOLOGY
- p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs
- (2011) Chun-Ju Chang et al. NATURE CELL BIOLOGY
- The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
- (2011) Can Liu et al. NATURE MEDICINE
- DNA damage response in adult stem cells: pathways and consequences
- (2011) Pankaj K. Mandal et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- The p53 family: guardians of maternal reproduction
- (2011) Arnold J. Levine et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation
- (2011) C R Jeter et al. ONCOGENE
- Inhibition of Ataxia Telangiectasia- and Rad3 -Related Function Abrogates the In Vitro and In Vivo Tumorigenicity of Human Colon Cancer Cells Through Depletion of the CD133+ Tumor-Initiating Cell Fraction
- (2011) Eike Gallmeier et al. STEM CELLS
- Colon Cancer Stem Cells: Bench-to-Bedside—New Therapeutical Approaches in Clinical Oncology for Disease Breakdown
- (2011) Simone Di Franco et al. Cancers
- Local Mesenchymal Stem/Progenitor Cells Are a Preferential Target for Initiation of Adult Soft Tissue Sarcomas Associated with p53 and Rb Deficiency
- (2010) Jinhyang Choi et al. AMERICAN JOURNAL OF PATHOLOGY
- Phenotypic Heterogeneity among Tumorigenic Melanoma Cells from Patients that Is Reversible and Not Hierarchically Organized
- (2010) Elsa Quintana et al. CANCER CELL
- Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53
- (2010) Perry Stambolsky et al. CANCER CELL
- CD117 and Stro-1 Identify Osteosarcoma Tumor-Initiating Cells Associated with Metastasis and Drug Resistance
- (2010) Amit S. Adhikari et al. CANCER RESEARCH
- Deficiency in p53 but not Retinoblastoma Induces the Transformation of Mesenchymal Stem Cells In vitro and Initiates Leiomyosarcoma In vivo
- (2010) R. Rubio et al. CANCER RESEARCH
- p53 Regulates the Ras Circuit to Inhibit the Expression of a Cancer-Related Gene Signature by Various Molecular Pathways
- (2010) Y. Buganim et al. CANCER RESEARCH
- Coexpression of Oct4 and Nanog Enhances Malignancy in Lung Adenocarcinoma by Inducing Cancer Stem Cell-Like Properties and Epithelial-Mesenchymal Transdifferentiation
- (2010) S.-H. Chiou et al. CANCER RESEARCH
- p53 is balancing development, differentiation and de-differentiation to assure cancer prevention
- (2010) A. Molchadsky et al. CARCINOGENESIS
- Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy
- (2010) Gianluca Bossi et al. CELL CYCLE
- Mutant p53R175H upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells
- (2010) I Kogan-Sakin et al. CELL DEATH AND DIFFERENTIATION
- NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53
- (2010) Marie Zbinden et al. EMBO JOURNAL
- Regulation of p53 in embryonic stem cells
- (2010) Valeriya Solozobova et al. EXPERIMENTAL CELL RESEARCH
- Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells
- (2010) Rachel Sarig et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Translating p53 into the clinic
- (2010) Chit Fang Cheok et al. Nature Reviews Clinical Oncology
- Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers
- (2010) Shan Deng et al. PLoS One
- Inactivation of p53 in breast cancers correlates with stem cell transcriptional signatures
- (2010) H. Mizuno et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cancer stem cells in solid tumors
- (2010) Patrick C. Hermann et al. SEMINARS IN CANCER BIOLOGY
- The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells
- (2010) Irene Ma et al. Stem Cell Reviews and Reports
- p53 Research: The Past Thirty Years and the Next Thirty Years
- (2010) D. Lane et al. Cold Spring Harbor Perspectives in Biology
- Expression of Mutant p53 Proteins Implicates a Lineage Relationship between Neural Stem Cells and Malignant Astrocytic Glioma in a Murine Model
- (2009) Yuan Wang et al. CANCER CELL
- Role of the Murine Reprogramming Factors in the Induction of Pluripotency
- (2009) Rupa Sridharan et al. CELL
- The Tumor Suppressor p53 Regulates Polarity of Self-Renewing Divisions in Mammary Stem Cells
- (2009) Angelo Cicalese et al. CELL
- Mutant p53 Drives Invasion by Promoting Integrin Recycling
- (2009) Patricia A.J. Muller et al. CELL
- Association of Breast Cancer Stem Cells Identified by Aldehyde Dehydrogenase 1 Expression with Resistance to Sequential Paclitaxel and Epirubicin-Based Chemotherapy for Breast Cancers
- (2009) T. Tanei et al. CLINICAL CANCER RESEARCH
- p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells
- (2009) Alejandro Armesilla-Diaz et al. EXPERIMENTAL CELL RESEARCH
- Effective generation of iPS cells from CD34+ cord blood cells by inhibition of p53
- (2009) Chiemi Takenaka et al. EXPERIMENTAL HEMATOLOGY
- The tumor suppressors pRB and p53 as regulators of adipocyte differentiation and function
- (2009) Philip Hallenborg et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Senescence impairs successful reprogramming to pluripotent stem cells
- (2009) A. Banito et al. GENES & DEVELOPMENT
- Beyond Li Fraumeni Syndrome: Clinical Characteristics of Families Withp53Germline Mutations
- (2009) Kelly D. Gonzalez et al. JOURNAL OF CLINICAL ONCOLOGY
- ABC Transporters, Drug Resistance, and Cancer Stem Cells
- (2009) Michael Dean JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
- Transcriptional control of the proliferation cluster by the tumor suppressor p53
- (2009) Ran Brosh et al. Molecular BioSystems
- Association of reactive oxygen species levels and radioresistance in cancer stem cells
- (2009) Maximilian Diehn et al. NATURE
- The promises and perils of p53
- (2009) Valery Krizhanovsky et al. NATURE
- Linking the p53 tumour suppressor pathway to somatic cell reprogramming
- (2009) Teruhisa Kawamura et al. NATURE
- A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
- (2009) Rosa M. Marión et al. NATURE
- Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
- (2009) Hyenjong Hong et al. NATURE
- Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
- (2009) Jochen Utikal et al. NATURE
- Forcing cells to change lineages
- (2009) Thomas Graf et al. NATURE
- The Ink4/Arf locus is a barrier for iPS cell reprogramming
- (2009) Han Li et al. NATURE
- Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
- (2009) Dunyaporn Trachootham et al. NATURE REVIEWS DRUG DISCOVERY
- The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis
- (2009) Giulia Fontemaggi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Mutant p53 Gain-of-Function in Cancer
- (2009) M. Oren et al. Cold Spring Harbor Perspectives in Biology
- Stem cell concepts renew cancer research
- (2008) J. E. Dick BLOOD
- Potential identity of multi-potential cancer stem-like subpopulation after radiation of cultured brain glioma
- (2008) Mi K Kang et al. BMC NEUROSCIENCE
- p53 hot-spot mutants increase tumor vascularization via ROS-mediated activation of the HIF1/VEGF-A pathway
- (2008) N.V. Khromova et al. CANCER LETTERS
- Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors
- (2008) S. Zhang et al. CANCER RESEARCH
- Growth-Inhibitory and Tumor- Suppressive Functions of p53 Depend on Its Repression of CD44 Expression
- (2008) Samuel Godar et al. CELL
- The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
- (2008) Sendurai A. Mani et al. CELL
- Cancer stem cells – old concepts, new insights
- (2008) L Vermeulen et al. CELL DEATH AND DIFFERENTIATION
- Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation
- (2008) Yang Zhao et al. Cell Stem Cell
- Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma
- (2008) J. N. Sarkaria et al. CLINICAL CANCER RESEARCH
- The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss
- (2008) T. Terzian et al. GENES & DEVELOPMENT
- The miR-200 Family Inhibits Epithelial-Mesenchymal Transition and Cancer Cell Migration by Direct Targeting of E-cadherin Transcriptional RepressorsZEB1andZEB2
- (2008) Manav Korpal et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- p53 family in development
- (2008) Nadia Danilova et al. MECHANISMS OF DEVELOPMENT
- Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype
- (2008) Helene R. McMurray et al. NATURE
- Identification of cells initiating human melanomas
- (2008) Tobias Schatton et al. NATURE
- An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors
- (2008) Ittai Ben-Porath et al. NATURE GENETICS
- Cancer Genes Hypermethylated in Human Embryonic Stem Cells
- (2008) Vincenzo Calvanese et al. PLoS One
- p53 Plays a Role in Mesenchymal Differentiation Programs, in a Cell Fate Dependent Manner
- (2008) Alina Molchadsky et al. PLoS One
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now