Article
Pathology
Sujani Madhurika Kodagoda Gamage, Tracie Cheng, Katherine Ting-Wei Lee, Lakal Dissabandara, Alfred King-Yin Lam, Vinod Gopalan
Summary: The study found that hemin can be cytotoxic to normal colonic cells, but cancer cells are more resistant. Additionally, hemin also impedes cell migration and induces upregulation of P53 and beta-catenin genes and proteins, leading to G1 and G2/M cell cycle arrests in both normal colonic epithelial cells and colon carcinoma cells.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Nutrition & Dietetics
D. Thivel, L. Metz, V. Julian, L. Isacco, J. Verney, G. Ennequin, K. Charlot, K. Beaulieu, G. Finlayson, J. A. King
Summary: Physical exercise and dietary restriction can both induce energy deficits, but they may lead to different compensatory responses in appetite. Current research provides an overview of the effects of iso-energetic deficits induced by exercise compared to dietary restriction on subsequent energy intake, appetite sensations, and potentially involved hedonic and physiological mechanisms.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Arti Nile, Jisoo Shin, Juhyun Shin, Gyun Seok Park, Suhyun Lee, Ji-Ho Lee, Kyung-Woo Lee, Beob Gyun Kim, Sung Gu Han, Ramesh Kumar Saini, Jae-Wook Oh
Summary: This study investigated the effects of cinnamaldehyde-rich cinnamon extract (CRCE) on colorectal cancer cell lines HCT 116 and HT-29. The results showed that CRCE inhibited cell proliferation and migration, induced cell apoptosis, and activated apoptotic proteins. In addition, CRCE also induced mitochondrial stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Agata Borkowska, Aleksandra Olszewska, Weronika Skarzynska, Marta Marciniak, Maciej Skrzeszewski, Claudine Kieda, Halina Was
Summary: High consumption of red meat and bleeding or bruising can promote oxidative stress and cancer development. Study suggests that oxidative stress can trigger escape from therapy-induced senescence (TIS) and contribute to tumor re-growth. Therapy-induced senescence could be a potential target in cancer therapy.
Article
Chemistry, Applied
Luis Miguel Guaman-Ortiz, Natalia Bailon-Moscoso, Vladimir Morocho, Daisy Vega-Ojeda, Fernando Gordillo, Alirica I. Suarez
Summary: Onoseriolide exhibits cytotoxic and cytostatic effects on human colon cancer cells by upregulating p53 and p21 expression to induce cell cycle arrest, activating autophagy as a protective mechanism and inducing apoptosis as the cell death pathway.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Medicinal
Giovana Bicudo Gomes, Claudia Stutz Zubieta, Jhefferson dos Santos Guilhermi, Monica Cristina Toffoli-Kadri, Adilson Beatriz, Jamal Rafique, Eduardo Benedetti Parisotto, Sumbal Saba, Renata Trentin Perdomo
Summary: Incidence rates of colon cancer are increasing annually due to genetic and epigenetic alterations that lead to drug resistance. Recent studies have found that novel synthetic selenium compounds, such as MRK-107, are more effective and less toxic than conventional drugs, exhibiting biocompatibility and pro-oxidant effects on tumor cells. MRK-107 inhibits cell proliferation, prevents cell regeneration and metastatic transition, and induces apoptosis in colon cancer cells through oxidative stress and activation of apoptotic pathways.
Article
Multidisciplinary Sciences
Erin J. Stephenson, Amanda S. Stayton, Aarti Sethuraman, Prahlad K. Rao, Charles Klazer Gomes, Molly C. Mulcahy, Liam McAllan, Michelle A. Puchowicz, Joseph F. Pierre, Dave Bridges, Joan C. Han
Summary: This study found that sucrose intake induces sexually dimorphic effects and influences the severity of fatty liver disease and the contribution of fatty acid synthesis to hepatic triglycerides in a sex-dependent manner. These findings demonstrate the role of sex in sucrose-induced fatty liver and highlight the importance of extrahepatic metabolism in the pathogenesis of diet-induced fatty liver and NAFLD.
NATURE COMMUNICATIONS
(2022)
Article
Nutrition & Dietetics
C. Breuillard, C. Moinard, A. Goron, N. Neveux, A. De Reviers, V. C. Mazurak, L. Cynober, V. E. Baracos
Summary: The study found that dietary citrulline supplementation did not alter the tumor response to chemotherapy and had no effect on nutritional status. This lack of effect may be due to anorexia and the low amount of citrulline and protein ingested.
CLINICAL NUTRITION
(2021)
Article
Agriculture, Multidisciplinary
Precious Adedayo Adesina, Kana Isayama, Gertrude Cynthia Sitolo, Yoshinari Yamamoto, Takuya Suzuki
Summary: This study investigated the regulation of intestinal HSP70 by propionate in human intestinal Caco-2 cells as well as the impact of fermentable dietary fiber on colonic HSP70 expression in mice. The findings suggest that propionate may play a role in maintaining intestinal homeostasis by inducing HSP70 expression, while fermentable dietary fiber can increase SCFAs and HSP70 expression in the colon.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Behavioral Sciences
Alicia Fillon, Lena Pelissier, Kristine Beaulieu, Keyne Charlot, Julie Siroux, Sarah Bagot, Melina Bailly, Audrey Boscaro, Graham Finlayson, Yves Boirie, Martine Duclos, Laurie Isacco, Bruno Pereira, Valerie Julian, David Thivel
Summary: This study compared the effects of exercise and energy restriction on energy intake, appetite sensations, and food reward in adolescents with obesity. The results showed that energy intake was higher in the energy restriction group compared to the exercise and control groups. Protein and lipid intake were also higher in the energy restriction group. Hunger, desire to eat, and prospective food consumption were higher in the energy restriction group, while fullness was lower. Impulse wanting for sweet food was lower in the exercise group compared to the control group.
Article
Pharmacology & Pharmacy
Hae Dong Kim, Eun Jung Park, Eun Kyoung Choi, Seuk Young Song, Kwang-Lae Hoe, Dong-Uk Kim
Summary: G-749, a potential TAM receptor tyrosine kinase inhibitor, effectively inhibits tumorigenesis by degrading TYRO3 and inhibiting cell proliferation signaling pathway in colon cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Sujin Lee, Ji Sun Lim, Hyun Seok Yun, Yoonsu Kim, Soojung Jeong, Seong Deok Hwang, Jong Won Kim, Jisun Oh, Jong-Sang Kim
Summary: The study shows that Ceriporia lacerata (CL) has a beneficial effect on scopolamine-induced memory impairment in mice by enhancing the antioxidant levels in HT22 mouse hippocampal neuronal cells to protect them from oxidative stress-induced damage.
FOOD SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Xue Tang, Fanhang Zeng, Jun Wang, Yipin Lyu, Renqiang Yu, Naiyan Lu, Zhou Zhou, Ailing Chen
Summary: This study aims to investigate the mechanisms underlying the effects of dityrosine (DT) on disrupted hepatic energy metabolism. The results showed that DT mainly acted via miR-144-3p, which decreased the fumaric acid level in the tricarboxylic acid (TCA) cycle, thereby reducing nuclear factor erythroid 2-related factor 2 (Nrf2) expression and antioxidant activity. Administration of the antioxidant lycopene alleviated DT-induced damage, confirming the involvement of the Nrf2 pathway in abnormal hepatic lipid metabolism and energy homeostasis induced by DT.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Environmental Sciences
Beatrice De Felice, Roberto Ambrosini, Renato Bacchetta, Marco Aldo Ortenzi, Marco Parolini
Summary: Polyethylene terephthalate (PET) is a major plastic polymer contaminating natural ecosystems, with PET microplastics (PET-MPs) found in aquatic and terrestrial ecosystems. This study investigated the ingestion and potential adverse effects of irregularly shaped PET-MPs on giant snails, showing that the snails efficiently ingested and egested the PET-MPs without experiencing oxidative stress, but significant changes were observed in their growth trajectories. These results suggest that PET-MPs may pose a risk to terrestrial organisms during early-life stages.
Article
Biochemistry & Molecular Biology
Stephanie A. Eid, Phillipe D. O'Brien, Katharina H. Kretzler, Dae-Gyu Jang, Faye E. Mendelson, John M. Hayes, Andrew Carter, Hongyu Zhang, Subramaniam Pennathur, Frank C. Brosius, Emily J. Koubek, Eva L. Feldman
Summary: Patients with type 2 diabetes often experience complications such as diabetic kidney disease and diabetic peripheral neuropathy, which lower their quality of life and increase mortality. This study examined the therapeutic efficacy of three dietary interventions in a type 2 diabetes mouse model. The interventions improved weight and glycemic status and alleviated diabetic kidney disease, but did not affect diabetic peripheral neuropathy.
Article
Gastroenterology & Hepatology
Antje Mohs, Tobias Otto, Kai Markus Schneider, Mona Peltzer, Mark Boekschoten, Christian H. Holland, Christian A. Hudert, Laura Kalveram, Susanna Wiegand, Julio Saez-Rodriguez, Thomas Longerich, Jan G. Hengstler, Christian Trautwein
Summary: In chronic liver diseases, NRF2 activation may protect the liver by ameliorating fibrosis and preventing the progression of hepatocellular carcinoma.
JOURNAL OF HEPATOLOGY
(2021)
Review
Neurosciences
Matthew G. Pontifex, Mohammad M. A. H. Malik, Emily Connell, Michael Mueller, David Vauzour
Summary: Citrus fruits are a rich source of non-essential bioactive compounds, particularly flavanones, which have been shown to have neuroprotective potential. Both preclinical and human studies support the benefits of citrus fruits in improving cognitive performance and reducing disease risk, highlighting the need for further exploration of citrus polyphenols for therapeutic efficacy.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Ian de Bus, Sandra van Krimpen, Guido J. Hooiveld, Mark Boekschoten, Mieke Poland, Renger F. Witkamp, Bauke Albada, Michiel G. J. Balvers
Summary: The oxygenated metabolites 13- and 16-HDHEA showed weaker immunomodulating effects on RAW264.7 macrophages compared to their parent molecule DHEA. COX-2 metabolism of DHEA may act as a regulatory mechanism to limit the anti-inflammatory properties of DHEA.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Biochemistry & Molecular Biology
David Vauzour, Catarina Rendeiro, Alfonsina D'Amato, Pierre Waffo-Teguo, Tristan Richard, Jean Michel Merillon, Matthew G. Pontifex, Emily Connell, Michael Muller, Laurie T. Butler, Claire M. Williams, Jeremy P. E. Spencer
Summary: The study shows that six weeks of supplementation with pure anthocyanins improved spatial memory and psychomotor performance in aged rats, along with changes in the expression profile of key proteins integral to synaptic function/maintenance. This suggests that purified anthocyanin consumption enhances spatial learning and motor coordination in aged animals through modulation of key synaptic proteins.
Article
Nutrition & Dietetics
Matthew G. Pontifex, Aleena Mushtaq, Gwenaelle Le Gall, Ildefonso Rodriguez-Ramiro, Britt Anne Blokker, Mara E. M. Hoogteijling, Matthew Ricci, Michael Pellizzon, David Vauzour, Michael Muller
Summary: The addition of inulin and psyllium individually resulted in distinct changes in gut microbiota, with psyllium also leading to reductions in blood sugar and diabetes-associated metabolites. A combination diet benefitted from both inulin and psyllium related microbial changes.
Article
Microbiology
Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodriguez-Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L. Carvalho, Simon R. Carding, Michael Muller, Robert C. Glen, David Vauzour, Simon McArthur
Summary: The study shows that methylamine substances can directly affect the integrity of the blood-brain barrier in mammals by improving its function through regulation of tight junction proteins. Long-term exposure to trimethylamine N-oxide helps protect cognitive function, reducing astrocyte and microglial reactivity in specific brain regions.
Article
Nutrition & Dietetics
Matthew G. Pontifex, Anneloes Martinsen, Rasha N. M. Saleh, Glenn Harden, Chris Fox, Michael Muller, David Vauzour, Anne-Marie Minihane
Summary: Female carriers of the APOE4 gene mutation are more likely to develop Alzheimer's disease compared to their male counterparts, and menopause may contribute to this. This study found that supplementing with DHA-enriched fish oil can mitigate the detrimental effects of menopause and the APOE4 gene mutation on cognitive function.
Article
Nutrition & Dietetics
Emma Flanagan, Donnie Cameron, Rashed Sobhan, Chloe Wong, Matthew G. Pontifex, Nicole Tosi, Pedro Mena, Daniele Del Rio, Saber Sami, Arjan Narbad, Michael Mueller, Michael Hornberger, David Vauzour
Summary: This study suggests that daily cranberry supplementation can improve episodic memory performance and neural functioning in older adults, while also reducing LDL cholesterol levels.
FRONTIERS IN NUTRITION
(2022)
Review
Neurosciences
Emily Connell, Gwenaelle Le Gall, Matthew G. Pontifex, Saber Sami, John F. Cryan, Gerard Clarke, Michael Mueller, David Vauzour
Summary: The increasing prevalence of age-related cognitive decline and dementia is a consequence of our ageing global population. The microbiota-gut-brain axis, a dynamic bidirectional communication system between the gut, its microbiome, and the central nervous system, may play a role in cognitive health and disease. Microbial-derived metabolites have been identified as potential risk factors for cognitive decline, impacting cognition through cytotoxic metabolite production, neuroinflammation, and other mechanisms.
MOLECULAR NEURODEGENERATION
(2022)
Article
Engineering, Biomedical
Rei Kuwabara, Tian Qin, L. Alberto Llacua, Shuxian Hu, Mark Boekschoten, Bart J. de Haan, Alexandra M. Smink, Paul de Vos
Summary: The immunoisolation of pancreatic islets in alginate microcapsules is a method used to treat diabetes, but the long-term function of the islets is limited. This study investigated the effects of collagen IV combined with laminin sequences on the survival of microencapsulated islets. Collagen IV with RGD had the most significant effect, enhancing the bioluminescence, oxygen consumption rate, and glucose-induced insulin release of allogeneic islets. Transcriptomics analysis showed that the inclusion of ECM promoted insulin secretion and suppressed inflammation and hypoxic stress pathways.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Jiye Kang, Ziwei Wang, Eleonora Cremonini, Gwenaelle Le Gall, Matthew G. Pontifex, Michael Muller, David Vauzour, Patricia I. Oteiza
Summary: Mounting evidence shows that consuming a high-fat diet (HFD) and developing obesity can lead to changes in cognition and mood. However, certain dietary bioactives, such as (-)-epicatechin (EC), may help prevent obesity-related cognitive decline. This study investigated the effects of EC supplementation on HFD-induced obesity-associated alterations in memory and mood. The results demonstrate that EC can mitigate anxiety-related behaviors and impact BDNF and glucocorticoids-mediated signaling.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Matthew G. Pontifex, David Vauzour, Michael Muller
Summary: Diets and dietary constituents have an impact on disease risk, and this impact may be modulated by sex. Current evidence suggests that sex differences in disease risk are disease-specific, highlighting the importance of sex stratification in nutritional research.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2023)
Article
Food Science & Technology
Shangxin Song, Yulin Gao, Tianlan Xia, Yefei Zhou, Guido J. E. J. Hooiveld, Michael Muller, Chunbao Li
Summary: This study investigated the impact of high or normal dietary chicken protein levels on obesity development in rats fed high-fat diets. The high chicken protein diet significantly reduced body weight gain, adipose tissue mass, and adipocyte size in comparison to the normal diet, without affecting food intake. It also reduced blood insulin and glycosylated serum protein, but had no effect on OGTT and HOMA-IR results. Additionally, the high chicken protein diet downregulated EAT transcriptomics related to lipid biosynthesis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Oncology
Natalia E. Cortez, Cecilia Rodriguez Lanzi, Brian Hong, Jihao Xu, Fangyi Wang, Shuai Chen, Jon J. Ramsey, Matthew G. Pontifex, Michael Muller, David Vauzour, Payam Vahmani, Chang-il Hwang, Karen Matsukuma, Gerardo G. Mackenzie
CANCER RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Matthew G. Pontifex, Emily Connell, Gwenaelle Le Gall, Line Pourtau, David Gaudout, Cristina Angeloni, Lorenzo Zallocco, Maurizio Ronci, Laura Giusti, Michael Muller, David Vauzour
Summary: The supplementation of saffron extract has been found to improve anxiety-related behavior and induce changes in gut microbiota. The increased abundance of specific microbial species, such as Akkermansia, Muribaculaceae, Christensenellacae, and Alloprevotella, was correlated with improvements in anxiety symptoms. These changes were also associated with alterations in brain metabolism and protein expression, suggesting a novel gut-brain axis interaction in anxiety disorders.