Article
Biochemistry & Molecular Biology
Joan Sala-Gaston, Leonardo Pedrazza, Juanma Ramirez, Arturo Martinez-Martinez, Lettie E. Rawlins, Emma L. Baple, Andrew H. Crosby, Ugo Mayor, Francesc Ventura, Jose Luis Rosa
Summary: Pathogenic variants in the HERC2 gene are associated with HERC2 Angelman-like syndrome. These variants affect intracellular signaling, leading to the activation of the C-RAF/MKK3/p38 pathway and an enhanced antioxidant response.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Clement Solie, Alessandro Contestabile, Pedro Espinosa, Stefano Musardo, Sebastiano Bariselli, Chieko Huber, Alan Carleton, Camilla Bellone
Summary: This study shows that the pathway from superior colliculus to ventral tegmental area (VTA) plays a key role in encoding orienting behavior and modulating social interaction. The researchers found that this pathway affects VTA dopamine neurons projecting onto dorsolateral striatum, and the stimulation or inhibition of this pathway can influence social interaction in mice.
NATURE COMMUNICATIONS
(2022)
Review
Pharmacology & Pharmacy
Chao Dong, Jiao Wu, Yin Chen, Jianyun Nie, Ceshi Chen
Summary: Hyperactivation of the PI3K/AKT/mTOR pathway is associated with drug resistance and cancer progression in breast cancer patients. Current research is focusing on developing drugs targeting this pathway to overcome acquired resistance to standard therapies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Dermatology
Liqun Wang, Wentao Zhang, Ruiyan Cen, Chenda Yue, Tianzhen Xiao, Yumeng Deng, Lingfei Li, Kedai Sun, Xia Lei
Summary: This study found that 5-aminolevulinic acid (ALA)-PDT can promote early inflammatory responses by regulating macrophage M1 polarization and activating the ERK/MAPK-NLRP3 pathway, thereby enhancing macrophage phagocytosis.
LASERS IN SURGERY AND MEDICINE
(2022)
Article
Oncology
Dan Moldoveanu, Tanya L. Hoskin, Courtney N. Day, Amy K. Schulze, Matthew P. Goetz, Judy C. Boughey
Summary: This study compares ER-low with ER-negative and ER-positive breast cancer, and investigates the significance of PR expression within ER-low disease. The study finds that ER-low/PR- and ER-low/PR+ have similar pathological complete response rates after neoadjuvant chemotherapy, and both are more similar to the ER- group than the ER+ group.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Environmental Sciences
Joseph M. Braun, George D. Papandonatos, Nan Li, Clara G. Sears, Jessie P. Buckley, Kim M. Cecil, Aimin Chen, Charles B. Eaton, Heidi J. Kalkwarf, Karl T. Kelsey, Bruce P. Lanphear, Kimberly Yolton
Summary: In this cohort, physical activity during adolescence modified the association between prenatal serum PFOA concentrations and cardiometabolic risk in children, suggesting that lifestyle interventions may alleviate the adverse effects of PFOA exposure. However, diet did not modify any associations.
ENVIRONMENTAL RESEARCH
(2022)
Review
Pathology
Debora Salles, Samara F. Santino, Daniel Araki Ribeiro, Andrea C. M. Malinverni, Joao N. Stavale
Summary: Pilocytic astrocytomas are the most common primary tumors in the first two decades of life, and research has shown that alterations in the MAPK pathway play a significant role in the formation and development of these tumors. These alterations can be used as auxiliary markers for diagnosis and potential therapeutic targets.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Chemistry, Medicinal
Claudia Korzeniecki, Ronny Priefer
Summary: KRAS genes are commonly mutated in cancer, and targeting KRAS mutant cancers has proven difficult due to lack of success with direct inhibitors. Researchers are now focusing on targeting other areas of the MAPK signaling pathway to inhibit KRAS function.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Editorial Material
Oncology
Hannah F. Wingate, Khandan Keyomarsi
Summary: Cyclin-dependent kinase (CDK) 4/6 inhibitors have revolutionized the treatment landscape of hormone receptor-positive breast cancers. However, a significant portion of patients develop resistance to these inhibitors, making it challenging for clinicians to choose the next treatment option. Recent studies have used transcriptomic analysis to identify biomarkers that could potentially guide the selection of subsequent therapies.
Article
Biochemistry & Molecular Biology
Anh Thu Ha, Jae Youl Cho, Daewon Kim
Summary: This study found that MLK3 plays a key role in regulating AP-1-mediated inflammatory responses in macrophages and can serve as a target molecule for treating AP-1-mediated inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Guoqiang Li, Lei Duan, Fengbiao Yang, Liang Yang, Yajun Deng, Yue Yu, Yanlong Xu, Yinian Zhang
Summary: This study demonstrates the protective effect of curcumin on traumatic brain injury (TBI) and its molecular mechanisms involving the p38/MAPK signaling pathway. Curcumin ameliorates secondary brain injury and inflammation associated with TBI, indicating its potential as a therapeutic approach for TBI-related inflammation.
PHYTOTHERAPY RESEARCH
(2022)
Article
Oncology
Olivia Pagani, Barbara A. Walley, Gini F. Fleming, Marco Colleoni, Istvan Lang, Henry L. Gomez, Carlo Tondini, Harold J. Burstein, Matthew P. Goetz, Eva M. Ciruelos, Vered Stearns, Herve R. Bonnefoi, Silvana Martino, Charles E. Geyer, Claudio Chini, Fabio Puglisi, Simon Spazzapan, Thomas Ruhstaller, Eric P. Winer, Barbara Ruepp, Sherene Loi, Alan S. Coates, Richard D. Gelber, Aron Goldhirsch, Meredith M. Regan, Prudence A. Francis
Summary: The combined analysis of SOFT-TEXT compared the outcomes of 4,690 premenopausal women with ER/PgR+ early breast cancer randomly assigned to exemestane + OFS or tamoxifen + OFS. Exemestane + OFS showed significant improvement in DFS and DRFI, but not overall survival, compared to tamoxifen + OFS. This study provides guidance for selecting patients who may benefit from exemestane over tamoxifen in the setting of OFS.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Oncology
Jing Chen, Runlan Wan, Qinqin Li, Zhenghuan Rao, Yanlin Wang, Lei Zhang, Alexander Tobias Teichmann
Summary: Dysregulation of the Hippo pathway is related to tumorigenesis, and targeting this pathway can improve specific antitumor effects and reduce drug resistance in breast cancer.
CANCER CELL INTERNATIONAL
(2021)
Article
Chemistry, Multidisciplinary
Shanshi Tong, Zhilong Yu, Fang Yin, Qilin Yang, Juhang Chu, Luyao Huang, Wenxue Gao, Mingping Qian
Summary: The synthesized MnPB NPs in this study are nanoparticles with high drug-loading capacity and excellent CDT/PTT effect. The safety of MnPB NPs has been verified by in vitro and in vivo experiments, and it has been shown to inhibit migration and induce tumor elimination in pancreatic cancer cells.
FRONTIERS IN CHEMISTRY
(2022)
Article
Oncology
Caitriona Cahir, Kathleen Bennett, Stephan U. Dombrowski, Catherine M. Kelly, Mary Wells, Eila Watson, Linda Sharp
Summary: To develop intervention for endocrine therapy (ET) non-adherence in women with breast cancer, this study measured modifiable determinants using Theoretical Domains Framework (TDF) and examined their relationships using Perceptions and Practicalities Approach (PAPA). The final model explained 59% of non-adherence variance and had an acceptable fit. Knowledge mediated non-adherence through beliefs about consequences and capabilities. Illness intrusiveness mediated non-adherence through beliefs about consequences. Beliefs about consequences mediated non-adherence through memory, attention, decision processes, and environment.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Biochemistry & Molecular Biology
Bernhard Luscher, Ivan Ahel, Matthias Altmeyer, Alan Ashworth, Peter Bai, Paul Chang, Michael Cohen, Daniela Corda, Francoise Dantzer, Matthew D. Daugherty, Ted M. Dawson, Valina L. Dawson, Sebastian Deindl, Anthony R. Fehr, Karla L. H. Feijs, Dmitri V. Filippov, Jean-Philippe Gagne, Giovanna Grimaldi, Sebastian Guettler, Nicolas C. Hoch, Michael O. Hottiger, Patricia Korn, W. Lee Kraus, Andreas Ladurner, Lari Lehtio, Anthony K. L. Leung, Christopher J. Lord, Aswin Mangerich, Ivan Matic, Jason Matthews, George-Lucian Moldovan, Joel Moss, Gioacchino Natoli, Michael L. Nielsen, Mario Niepel, Friedrich Nolte, John Pascal, Bryce M. Paschal, Krzysztof Pawlowski, Guy G. Poirier, Susan Smith, Gyula Timinszky, Zhao-Qi Wang, Jose Yelamos, Xiaochun Yu, Roko Zaja, Mathias Ziegler
Summary: ADP-ribosylation, a post-translational modification of proteins, nucleic acids, and metabolites, plays diverse roles in cellular processes such as stress responses, signaling, and transcriptional regulation. Recent advances in research have identified a wide range of cellular pathways regulated by ADP-ribosylation, highlighting the importance of understanding this mechanism in cell biology.
Article
Cell Biology
Dragomir B. Krastev, Shudong Li, Yilun Sun, Andrew Wicks, Gwendoline Hoslett, Daniel Weekes, Luned M. Badder, Eleanor G. Knight, Rebecca Marlow, Mercedes Pardo Calvo, Lu Yu, Tanaji T. Talele, Jiri Bartek, Jyoti Choudhary, Yves Pommier, Stephen J. Pettitt, Andrew Tutt, Kristijan Ramadan, Christopher J. Lord
Summary: The study reveals the regulatory mechanism of trapped PARP1, which is undergoes SUMOylation and ubiquitylation, leading to the recruitment of p97 ATPase for the removal of trapped PARP1 from chromatin and prevention of PARP inhibitor-induced cytotoxicity. Inhibitors targeting p97-complex prolong the trapping of PARP1, enhancing the cytotoxicity of PARP inhibitors in certain types of tumor cells.
NATURE CELL BIOLOGY
(2022)
Review
Oncology
K. Van Baelen, T. Geukens, M. Maetens, V Tjan-Heijnen, C. J. Lord, S. Linn, F-C Bidard, F. Richard, W. W. Yang, R. E. Steele, S. J. Pettitt, C. Van Ongeval, M. De Schepper, E. Isnaldi, I Nevelsteen, A. Smeets, K. Punie, L. Voorwerk, H. Wildiers, G. Floris, A. Vincent-Salomon, P. W. B. Derksen, P. Neven, E. Senkus, E. Sawyer, M. Kok, C. Desmedt
Summary: ILC is a unique type of breast cancer with distinct pathological and biological features, leading to differences in diagnosis, treatment response, resistance, and targets compared to NST.
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
I Vergote, A. Gonzalez-Martin, I Ray-Coquard, P. Harter, N. Colombo, P. Pujol, D. Lorusso, M. R. Mirza, B. Brasiuniene, R. Madry, J. D. Brenton, M. G. E. M. Ausems, R. Buettner, D. Lambrechts
Summary: This study aimed to establish a European-wide consensus on genetic testing and clinical management for patients with newly diagnosed advanced ovarian cancer, as well as biomarkers for predicting the effectiveness of PARPi in first-line treatment. The consensus recommendations, based on input from experts across Europe, provide clear guidance on BRCA and HRR deficiency testing for these patients.
ANNALS OF ONCOLOGY
(2022)
Review
Oncology
Joseph S. Baxter, Diana Zatreanu, Stephen J. Pettitt, Christopher J. Lord
Summary: The DNA damage response is a complex protein network that detects and repairs DNA damage, preventing cancer. PARP inhibitors are effective in treating cancer, and new DDR targets are being investigated. Drug resistance is a problem in cancer treatment, and there is some understanding of PARPi resistance.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Violeta Serra, Anderson T. Wang, Marta Castroviejo-Bermejo, Urszula M. Polanska, Marta Palafox, Andrea Herencia-Ropero, Gemma N. Jones, Zhongwu Lai, Joshua Armenia, Filippos Michopoulos, Alba Llop-Guevara, Rachel Brough, Aditi Gulati, Stephen J. Pettitt, Krishna C. Bulusu, Jenni Nikkila, Zena Wilson, Adina Hughes, Paul W. G. Wijnhoven, Ambar Ahmed, Alejandra Bruna, Albert Gris-Oliver, Marta Guzman, Olga Rodriguez, Judit Grueso, Joaquin Arribas, Javier Cortes, Cristina Saura, Alan Lau, Susan Critchlow, Brian Dougherty, Carlos Caldas, Gordon B. Mills, J. Carl Barrett, Josep V. Forment, Elaine Cadogan, Christopher J. Lord, Cristina Cruz, Judith Balmana, Mark J. O'Connor
Summary: Targeting the replication stress response is a valid therapeutic option to overcome PARPi resistance, providing new strategies for treating tumors such as breast and ovarian cancer.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Elise Rouleau-Turcotte, Dragomir B. Krastev, Stephen J. Pettitt, Christopher J. Lord, John M. Pascal
Summary: PARP1 can rapidly detect DNA strand break damage and activate the production of poly(ADP-ribose) by signaling break detection to its catalytic domain. This study provides insights into the contributions of the regulatory helical domain (HD) to PARP1 allostery and the interaction with DNA damage, as well as the mechanisms of PARP1 catalytic activation and retention on DNA damage.
Article
Oncology
Marta J. Llorca-Cardenosa, Lauren I. Aronson, Dragomir B. Krastev, Jadwiga Nieminuszczy, John Alexander, Feifei Song, Malgorzata Dylewska, Ronan Broderick, Rachel Brough, Astrid Zimmermann, Frank T. Zenke, Bora Gurel, Ruth Riisnaes, Ana Ferreira, Theodoros Roumeliotis, Jyoti Choudhary, Stephen J. Pettitt, Johann de Bono, Andres Cervantes, Syed Haider, Wojciech Niedzwiedz, Christopher J. Lord, Irene Y. Chong
Summary: The study highlights the potential issue of drug resistance in using ATR inhibitors in gastric cancer, particularly with loss-of-function mutations in SMG8 and SMG9, and suggests that targeting these pathways may enhance the overall effectiveness of ATRi.
Article
Oncology
Sanne R. Martens-de Kemp, Malgorzata A. Komor, Rosa Hegi, Anne S. Bolijn, Marianne Tijssen, Florence L. M. de Groen, Annekatrien Depla, Monique van Leerdam, Gerrit A. Meijer, Remond J. A. Fijneman, Beatriz Carvalho
Summary: Gain of chromosome arm 13q and overexpression of miR-17-92 cluster are associated with colorectal adenoma-to-carcinoma progression. However, overexpression of miR-17-92 alone is insufficient to cause malignancy.
Correction
Oncology
K. Van Baelen, T. Geukens, M. Maetens, V. Tjan-Heijnen, C. J. Lord, S. Linn, F. -C. Bidard, F. Richard, W. W. Yang, R. E. Steele, S. J. Pettitt, C. Van Ongeval, M. De Schepper, E. Isnaldi, I. Nevelsteen, A. Smeets, K. Punie, L. Voorwerk, H. Wildiers, G. Floris, A. Vincent Salomon, P. W. B. Derksen, P. Neven, E. Senkus, E. Sawyer, M. Kok, C. Desmedt
ANNALS OF ONCOLOGY
(2023)
Article
Dermatology
Jenny Giang, Antien L. L. Mooyaart, Sanne R. R. Martens-de Kemp, Lies Jaspars, Marlies Wakkee, Erik Eijken, Walter Voogt, Winand N. M. Dinjens, Jeffrey Damman
Summary: We present two cases of plaque-type trichoblastoma with atypical foci, which are characterized by poor circumscription and locally infiltrative growth pattern. These lesions mostly require multiple stages of Mohs micrographic surgery. In this report, we describe two cases of plaque-type trichoblastoma with atypical foci, which harbored somatic mutations in the Hedgehog pathway, thus should be acknowledged as intermediate malignancies.
JOURNAL OF CUTANEOUS PATHOLOGY
(2023)
Meeting Abstract
Oncology
Diana Zatreanu, Helen Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luted Badder, Daniela Novo, Eleanor Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Andre Nussenzweig, Marcel Tijsterman, Andrew N. Tutt, Simon Boulton, Geoff Higgins, Stephen J. Pettitt, Graeme C. Smith, Christopher J. Lord
Meeting Abstract
Oncology
Diana Zatreanu, Helen Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luted Badder, Daniela Novo, Eleanor Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Andre Nussenzweig, Marcel Tijsterman, Andrew N. Tutt, Simon Boulton, Geoff Higgins, Stephen J. Pettitt, Graeme C. Smith, Christopher J. Lord
Meeting Abstract
Oncology
R. Ferro, A. Carroll, A. Mendes-Pereira, V. Reen, I. Roxanis, S. Annunziato, J. Jonkers, N. Liv, J. Alexander, J. Quist, M. Pardo, T. I. Roumeliotis, J. S. Choudhary, D. Weekes, P. Marra, R. Natrajan, A. Grigoriadis, S. Haider, C. J. Lord, A. J. Tutt
EUROPEAN JOURNAL OF CANCER
(2022)
Meeting Abstract
Oncology
Asuka Kawai-Kawachi, Madison Lenormand, Clemence Henon, Thomas Eychenne, Leo Colmet-Daage, Nicolas Dorvault, Marlene Garrido, Clemence Astier, Carine Ngo, Helen Pemberton, Aditi Gulati, Stephen Pettitt, Roman Chabanon, Christopher J. Lord, Sophie Postel-Vinay