标题
The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin
作者
关键词
-
出版物
NATURE CELL BIOLOGY
Volume 24, Issue 1, Pages 62-73
出版商
Springer Science and Business Media LLC
发表日期
2022-01-11
DOI
10.1038/s41556-021-00807-6
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Poly(ADP-ribosyl)ation temporally confines SUMO-dependent ataxin-3 recruitment to control DNA double-strand break repair
- (2021) Annika Pfeiffer et al. JOURNAL OF CELL SCIENCE
- Structural basis for allosteric PARP-1 retention on DNA breaks
- (2020) Levani Zandarashvili et al. SCIENCE
- TEX264 coordinates p97- and SPRTN-mediated resolution of topoisomerase 1-DNA adducts
- (2020) John Fielden et al. Nature Communications
- The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
- (2020) Marco Gatti et al. Cell Reports
- Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer
- (2020) Zhong Y. Yeow et al. NATURE
- Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo
- (2020) Zhengping Shao et al. NUCLEIC ACIDS RESEARCH
- Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer
- (2019) Stefano Annunziato et al. Nature Communications
- Targeting Topoisomerase I in the Era of Precision Medicine
- (2019) Anish Thomas et al. CLINICAL CANCER RESEARCH
- Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality
- (2018) Ewa Gogola et al. CANCER CELL
- Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function
- (2018) Jan B Heidelberger et al. EMBO REPORTS
- AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation
- (2018) Julia Hülsmann et al. MOLECULAR & CELLULAR PROTEOMICS
- A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates
- (2018) Edmond Y. Huang et al. MOLECULAR BIOLOGY OF THE CELL
- VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling
- (2018) Johannes van den Boom et al. MOLECULAR CELL
- SLFN11 Blocks Stressed Replication Forks Independently of ATR
- (2018) Junko Murai et al. MOLECULAR CELL
- A quantitative mass spectrometry-based approach to monitor the dynamics of endogenous chromatin-associated protein complexes
- (2018) Evangelia K. Papachristou et al. Nature Communications
- Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets
- (2018) Dragomir B. Krastev et al. Nature Communications
- Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance
- (2018) Stephen J. Pettitt et al. Nature Communications
- Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
- (2018) Jone Michelena et al. Nature Communications
- PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow
- (2018) Todd A. Hopkins et al. MOLECULAR CANCER RESEARCH
- Structural Basis of p97 Inhibition by the Site-Selective Anti-Cancer Compound CB-5083
- (2018) Wai Kwan Tang et al. MOLECULAR PHARMACOLOGY
- The PRIDE database and related tools and resources in 2019: improving support for quantification data
- (2018) Yasset Perez-Riverol et al. NUCLEIC ACIDS RESEARCH
- Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
- (2017) Zdenek Skrott et al. NATURE
- BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance
- (2017) Alexandra A Duarte et al. NATURE METHODS
- PARP inhibitors: Synthetic lethality in the clinic
- (2017) Christopher J. Lord et al. SCIENCE
- Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells
- (2017) Stephen J. Pettitt et al. Scientific Data
- HPF1/C4orf27 Is a PARP-1-Interacting Protein that Regulates PARP-1 ADP-Ribosylation Activity
- (2016) Ian Gibbs-Seymour et al. MOLECULAR CELL
- Rapid immunoprecipitation mass spectrometry of endogenous proteins (RIME) for analysis of chromatin complexes
- (2016) Hisham Mohammed et al. Nature Protocols
- ADPriboDB: The database of ADP-ribosylated proteins
- (2016) Christina A. Vivelo et al. NUCLEIC ACIDS RESEARCH
- System-wide identification of wild-type SUMO-2 conjugation sites
- (2015) Ivo A. Hendriks et al. Nature Communications
- Ubiquitin Signals Proteolysis-Independent Stripping of Transcription Factors
- (2014) Ada Ndoja et al. MOLECULAR CELL
- Directed evolution of APEX2 for electron microscopy and proximity labeling
- (2014) Stephanie S Lam et al. NATURE METHODS
- Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication
- (2014) Marija Maric et al. SCIENCE
- Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
- (2012) J. Murai et al. CANCER RESEARCH
- Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage
- (2012) Pavel Moudry et al. CELL CYCLE
- Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
- (2012) Hemmo Meyer et al. NATURE CELL BIOLOGY
- A Genome-wide Screen Identifies p97 as an Essential Regulator of DNA Damage-Dependent CDT1 Destruction
- (2011) Malavika Raman et al. MOLECULAR CELL
- Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations
- (2011) Danilo Ritz et al. NATURE CELL BIOLOGY
- The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
- (2011) Mayura Meerang et al. NATURE CELL BIOLOGY
- A hyperactive piggyBac transposase for mammalian applications
- (2011) K. Yusa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PIASy Mediates SUMO-2/3 Conjugation of Poly(ADP-ribose) Polymerase 1 (PARP1) on Mitotic Chromosomes
- (2010) Hyunju Ryu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PARP-1 transcriptional activity is regulated by sumoylation upon heat shock
- (2009) Nadine Martin et al. EMBO JOURNAL
- Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
- (2009) Yaron Galanty et al. NATURE
- A ubiquitin-selective AAA-ATPase mediates transcriptional switching by remodelling a repressor–promoter DNA complex
- (2009) Alexander J. Wilcox et al. NATURE CELL BIOLOGY
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