Article
Biochemistry & Molecular Biology
Jeroen Dobbelaere, Tiffany Y. Su, Balazs Erdi, Alexander Schleiffer, Alexander Dammermann
Summary: Cilia are cellular projections that perform sensory and motile functions in eukaryotic cells. In this study, a set of 386 human genes associated with cilium assembly or motility were identified by analyzing the presence and absence pattern in the genomes of diverse eukaryotes. The novel genes were further characterized and found to be related to cilium defects in fruit flies and nematodes. This dataset defines the core set of genes required for cilium assembly and motility across eukaryotes and provides a valuable resource for future studies.
Article
Multidisciplinary Sciences
Suhayl Mulla, Adele R. Ludlam, Aiman Elragig, Cathy Slack, Zita Balklava, Michael Stich, Alex Cheong
Summary: Ageing research aims to identify factors that affect lifespan and understand their effects. This study introduces a bilogistic model to describe the shape of lifespan curves in Caenorhabditis elegans. The model provides a better fit to experimental data than other models, and can identify and confirm biphasic lifespan data.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Microbiology
Fang Zhang, Liying Wang, Jiayu Jin, Yulu Pang, Hao Shi, Ziyi Fang, Han Wang, Yujie Du, Yufan Hu, Yingchun Zhang, Xiaoyue Ding, Zuobin Zhu
Summary: This study investigated the impact of Escherichia coli mutant strains on fruit fly lifespan and found that feeding E. coli purE strain resulted in the longest lifespan in fruit flies, which was also validated in Caenorhabditis elegans. RNA sequencing and analysis revealed that E. coli mutant strains affect lifespan by regulating protein synthesis rate and ATP levels. This research provides new insights into the genetic influences of gut microbiota on host lifespan and offers a foundation for developing anti-aging probiotics and drugs.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Siqi Jiang, Na Deng, Bisheng Zheng, Tong Li, Rui Hai Liu
Summary: Rhodiola extract was found to significantly extend the lifespan of C. elegans and enhance its stress resistance by regulating gene expression and promoting protein translocation.
Review
Nutrition & Dietetics
Xinlu Guo, Junjie Luo, Jingyi Qi, Xiya Zhao, Peng An, Yongting Luo, Guisheng Wang
Summary: The increasing elderly proportion of the population poses burdens on society, the economy, and the medical field. Polysaccharides have gained attention for their potential use in anti-aging therapies due to their natural and efficient biological properties, including antioxidant, anti-inflammatory, and immune regulatory activities.
Article
Multidisciplinary Sciences
Mikiko Oka, Emiko Suzuki, Akiko Asada, Taro Saito, Koichi M. Iijima, Kanae Ando
Summary: Brain neurons play a significant role in organismal aging, with decreased ATP concentration, glucose content, and mitochondrial quality found in aged flies. By increasing neuronal glucose uptake, ATP levels can be maintained, locomotor deficits can be suppressed, and life span can be extended, especially during dietary restriction.
Article
Biochemistry & Molecular Biology
Shiling Feng, Chunyan Zhang, Tao Chen, Lijun Zhou, Yan Huang, Ming Yuan, Tian Li, Chunbang Ding
Summary: The study found that OLE significantly prolongs the lifespan of Caenorhabditis elegans and increases their resistance to lethal heat shock and oxidative stress. OLE regulates stress resistance and lifespan extension in nematodes through the activation of the IIS and SKN-1/Nrf2 signaling pathways.
Review
Cell Biology
Anja Wagner, Markus Schosserer
Summary: RNA modifications play a regulatory role in gene expression, but the underlying molecular mechanisms and physiological consequences are still poorly understood. This review systematically examines different types of RNA modifications, analysis methods, challenges in the field, and associations with human diseases. Furthermore, evidence is compiled for the connection between RNA modification enzymes and lifespan in yeast, worms, and flies.
AGEING RESEARCH REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Brecht Driesschaert, Lucas Mergan, Liesbet Temmerman
Summary: A mechanistic understanding of biology involves appreciating the spatiotemporal aspects of gene expression and its functional implications. Conditional gene expression allows reversible or irreversible switching of genes on or off, providing spatial and/or temporal control for a wider range of research questions across biological disciplines. The use of specific promoters, temperature regimens, compound addition, or illumination grants spatial and/or temporal control, particularly in invertebrate animal models, facilitating the study of biological processes on large scales in short time frames. Recent years have seen exciting expansion and optimization of genetic tool kits in these models, highlighting their mechanisms, applicability, benefits, drawbacks, and future developments.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Multidisciplinary Sciences
Jose Miguel Simoes, Joshua I. Levy, Emanuela E. Zaharieva, Leah T. Vinson, Peixiong Zhao, Michael H. Alpert, William L. Kath, Alessia Para, Marco Gallio
Summary: The study demonstrates that the avoidance of heat in fruit flies is not as hard-wired as previously believed, and actually exhibits unexpected plasticity. Fruit flies use small temperature differences between their antennae to steer away from thermal danger, suggesting that their heat avoidance behavior involves decision-making, rapid learning, and is robust to new conditions.
NATURE COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Leon Avery, Brian Ingalls, Catherine Dumur, Alexander Artyukhin
Summary: Collective behaviors in Starved first-stage larvae of the nematode Caenorhabditis elegans are known to produce large-scale organization. A mathematical model was developed to explain how and why the larvae aggregate, focusing on chemotaxis and the role of two chemical signals. Knocking out the sensory receptor gene srh-2 resulted in irregularly shaped aggregates, suggesting that mutant worms moved slower than wild type.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Ecology
Carola Petersen, Alexandra Krahn, Matthias Leippe
Summary: Some small animals use other, more mobile animals to migrate from short-lived and resource-poor habitats. A study was conducted to determine if the nematode Caenorhabditis elegans is attracted to invertebrates. It was found that C. elegans is attracted to the odor of Drosophila melanogaster fruit flies.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Biochemistry & Molecular Biology
Monica Filaferro, Alessandro Codeluppi, Virginia Brighenti, Francesca Cimurri, Ana Maria Gonzalez-Paramas, Celestino Santos-Buelga, Davide Bertelli, Federica Pellati, Giovanni Vitale
Summary: In this study, an autochthonous variety of sweet cherry was processed to prepare polyphenol-rich extracts, which showed protective effects against Parkinson's disease and oxidative stress. The findings suggest that these extracts could be potential candidates for the formulation of nutraceutical products to prevent oxidative stress-induced disorders.
Article
Chemistry, Multidisciplinary
Nariani Rocha Saraiva, Juliana Foletto Fredo Roncato, Monica Pascoli, Joao Marcos Fonseca Macedo e Sousa, Luiz Felipe Windberg, Fernanda Cristina Possamai Rossatto, Jefferson de Jesus Soares, Elton Luis Gasparotto Denardin, Robson Luiz Puntel, Karine Rigon Zimmer, Leonardo Fernandes Fraceto, Daiana Silva Avila
Summary: The biodegradable zein nanoparticles loaded with clove oil or eugenol displayed low toxicity to nematodes and significant insecticidal activity against fruit flies, showing promise for eco-friendly botanical insecticide production.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Chemistry, Medicinal
Jing-Shan Wu, Chun-Guo Lin, Chang-Long Jin, Yan-Xia Zhou, Ying-Xiu Li
Summary: The marine bacterium Planococcus maritimu ML1206 was found to have antioxidant properties and could enhance the ability of nematodes to resist oxidative stress and extend their lifespan. These findings suggest that ML1206 has potential anti-aging and antioxidant functions and could be used in aquaculture and as a dietary supplement.
