Article
Biochemistry & Molecular Biology
Xiaojie Sun, Jing Li, Kai Shao, Chang Su, Shichao Bi, Yuzhi Mu, Kaichao Zhang, Zheng Cao, Xiaoye Wang, Xiguang Chen, Chao Feng
Summary: The AC-DB sponge demonstrated rapid hemostatic ability and good biocompatibility, activating intrinsic coagulation pathway to accelerate clotting process, with shortest clotting time and minimal blood loss in vivo assessments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Multidisciplinary
Jiaxi Liu, Xiang Zhou, Yin Zhang, Wei Zhu, Anping Wang, Meijia Xu, Shuxian Zhuang
Summary: In this study, a composite hemostatic sponge composed of cerium-containing mesoporous bioactive glass and chitosan was prepared and compared with a commercially available gelatin sponge. The results showed that the composite sponge had superior hemostatic performance and validated its thrombosis, platelet adhesion, and blood compatibility. Additionally, the composite sponge exhibited strong antibacterial effects against common bacteria.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Chemistry, Applied
Zheng Cao, Chang Su, Xiaojie Sun, Kai Shao, Xiaoye Wang, Yuzhi Mu, Xiguang Chen, Chao Feng
Summary: The temperature-sensitive hydrogel composed of diatom biosilica and hydroxybutyl chitosan shows significantly enhanced mechanical strength and favorable blood compatibility and biocompatibility. By adjusting the ratio of diatom biosilica and hydroxybutyl chitosan, the properties of the hydrogel can be flexibly controlled.
CARBOHYDRATE POLYMERS
(2022)
Article
Biophysics
Hussein E. Rozan, Guangsheng Wu, Zhongzheng Zhou, Qinfeng Li, Mohamed Sharaf, Xiguang Chen
Summary: In this study, a hydroxybutyl chitosan/diatom biosilica/doxycycline composite hydrogel was developed, which exhibited significant antibacterial activity and biocompatibility. It could promote wound healing and show potential for clinical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Fuyu Song, Yue Kong, Changyou Shao, Yi Cheng, Jie Lu, Yehan Tao, Jian Du, Haisong Wang
Summary: A flexible chitosan-based hemostatic bio-hydrogel with self-adhesive, self-healing, stretchability, biocompatibility, antibacterial, and antioxidant properties was successfully developed. The hydrogel demonstrated excellent adhesion and hemostasis capabilities in humid conditions, making it a promising candidate for emergency hemostasis applications, particularly in joints and extremities.
ACTA BIOMATERIALIA
(2021)
Review
Pharmacology & Pharmacy
Hayeon Lim, Yoseph Seo, Daeryul Kwon, Sunggu Kang, Jiyun Yu, Hyunjun Park, Sang Deuk Lee, Taek Lee
Summary: A drug delivery system (DDS) is a technology that efficiently delivers target drugs to specific diseased tissues. Among them, mesoporous silica DDS (MS-DDS) is a commonly used drug carrier, but complications caused by synthesis methods have led to the emergence of natural biosilica as an alternative.
Article
Materials Science, Biomaterials
V Deineka, O. Sulaieva, N. Pernakov, J. Radwan-Praglowska, L. Janus, V Korniienko, Ye Husak, A. Yanovska, I Liubchak, A. Yusupova, M. Piatkowski, A. Zlatska, M. Pogorielov
Summary: Research has shown that new hemostatic materials based on chitosan have high hemostatic performance and biocompatibility, with electrospinning-made chitosan copolymers significantly improving in vivo biocompatibility and degradation. Chitosan aerogel has high antibacterial activity and is suitable for hemostatic patch development, but is not recommended for visceral application.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Physical
Yuqi Ding, Yuzhi Mu, Yi Hu, Jiahao Liu, Chang Su, Xiaojie Sun, Xiguang Chen, Nan Jia, Chao Feng
Summary: A temperature-sensitive composite hydrogel was developed to improve the diabetic wound microenvironment by promoting inflammatory processes, tissue cell proliferation, and collagen deposition, leading to accelerated wound healing.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Article
Biophysics
Rong-Rong Yan, Dai Xue, Chang Su, Yan Xu, Jin-Song Gong, Yan-Ling Liu, Min Jiang, Yan Geng, Guo-Zhong Lv, Zheng-Hong Xu, Jin-Song Shi
Summary: Keratin/chitosan sponge has rapid hemostatic effect, good biocompatibility and biodegradability. It functions in hemostasis through the endogenous coagulation pathway, demonstrating better performance than traditional hemostatic materials.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Xiaojie Sun, Mengxue Zhang, Jinfeng Liu, Guangyan Hui, Xiguang Chen, Chao Feng
Summary: Diatom biosilica is a natural inorganic material with a micro-nanoporous structure and has great application potential in drug delivery, hemostat materials, and biosensors. Manipulating the micro-nanostructure of diatom biosilica through biological regulation methods can transform the screening mode of its structural features and maximize its possibility as a biological material.
Article
Polymer Science
Yingfeng Wang, Maoli Yin, Xianhong Zheng, Wei Li, Xuehong Ren
Summary: In this study, a novel N-halamine-based aerogel was developed by attaching N-halamine precursor monomer onto mesoporous silica and cross-linking with gamma-chloropropyl-triethoxysilane. The aerogel demonstrated potent bactericidal and hemostatic properties, showing potential for application in wound dressings.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Xiaomei Wang, Bin Mu, Hong Zhang, Yan Du, Fangfang Yang, Aiqin Wang
Summary: This study successfully prepared high-performance hemostatic nanocomposite films containing natural mixed-dimensional clay. Compared with the control group, the nanocomposite films exhibited higher tensile strength, lower water contact angle, better degradation, thermal stability, and biocompatibility after the addition of O-MDPal. Furthermore, the nanocomposite films showed excellent hemostatic performance in a mouse tail amputation model, which could be attributed to the enriched functional sites and hydrophilic surface of the nanocomposite films. Therefore, this nanocomposite film holds great potential for practical application in wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Ceramics
Ali Can Ozarslan, Yeliz Basaran Elalmis, Sevil Yucel
Summary: This study compared the rheological features, bioactivity behavior, and effect on cell viability of composite putties containing biosilica and commercial silica based bioactive glasses. The results showed differences between the two types of materials in rheological and bioactivity properties, but both did not have adverse effects on cell viability.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2021)
Article
Engineering, Biomedical
Junxia Deng, Zhen Wang, Jinfeng Xing
Summary: In this study, an antibacterial hemostatic hydrogel was created by combining SBMA and QCCS and using green LED irradiation. The resulting PSBMA/QCCS powder exhibited quick hemostasis, strong wet adhesion, significant antibacterial properties, and adaptability to irregularly shaped wounds.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Chemistry, Physical
Mikkel Bregnhoj, Helmut Lutz, Steven J. Roeters, Ingo Lieberwirth, Rolf Mertig, Tobias Weidner
Summary: Diatoms use silaffin peptides to synthesize titanium dioxide nanoparticles, providing an environmentally friendly approach for the production of nanomaterials with potential applications in water splitting and biocompatible materials design. The study demonstrates that the silaffin peptide R5 can precipitate stable titanium dioxide sheets.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Guiyang Xia, Lingyan Wang, Huan Xia, Yuzhuo Wu, Yanan Wang, Haiyu Hu, Sheng Lin
Summary: A new family of circularly polarized luminescence-active small organic molecules (CPL-SOMs) with high fluorescence efficiency and fascinating CPL properties was discovered and characterized. The usefulness of CPL-calculation as a unique method for stereochemical assignment was demonstrated. This study may open up a new perspective for the future development of stereochemical studies and CPL materials.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Medicinal
Rongfei Qin, Pengxu Wang, Bin Wang, Lei Fu, Sarah M. Batt, Gurdyal S. Besra, Chengwei Wu, Yanan Wang, Haihong Huang, Yu Lu, Gang Li
Summary: A series of thiophene-benzenesulfonamide derivatives were designed and synthesized to explore their structure-activity relationship as antituberculosis agents. Compound 17b showed improved activity compared to the lead compounds, displaying good intracellular antimycobacterial activity and favorable drug properties.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Zhiguo Liu, Li Liu, Anqi Wang, Li Li, Sinan Zhao, Yanan Wang, Yi Sun
Summary: Five novel tyrosine-decahydrofluorene analogues were isolated from the endophytic fungus Xenoacremonium sinensis. These compounds displayed anti-inflammatory and antiproliferative activities.
Article
Biochemical Research Methods
Mengyin Tian, Yanan Wang, Anqi Lu, Qianru Zhang, Xin Li, Ning Zhang, Jianjun Zhang, Sujuan Wang
Summary: The study aims to reveal the chemical differences between Ramulus Mori (RM) and Cortex Mori (CM) and evaluate their quality. It concludes that CM exhibits chemical diversity, while RM has good homogeniety. In addition, content limits for four quality markers with anti-inflammatory or analgesic activities were proposed for RM, and a possible biosynthetic relationship between kuwanon C, kuwanon G, and morusin was hypothesized.
PHYTOCHEMICAL ANALYSIS
(2022)
Article
Plant Sciences
Ling-Yan Wang, Gui-Yang Xia, Min Wang, Yu-Zhuo Wu, Ya-Nan Wang, Li-Min Chai, Sheng Lin
Summary: A new polyketide derivative penicipurate A (1) containing a 3-hydroxydecanoic acid ester moiety was isolated from the solid cultures of the endophytic fungal strain Penicillium purpurogenum in the leaves of Edgeworthia chrysantha. The structure of 1 was determined using various spectroscopic methods and chemical degradation. Compound 1 exhibited moderate inhibitory activity against pancreatic lipase.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2022)
Article
Chemistry, Analytical
Yan Wu, Jia-Qi Wang, Ya-Nan Wang, Xiao-Xia Pang, Jie Bao, Xiao-Bing Guan, Su-Juan Wang
Summary: This study analyzed the serum metabolites in hamsters with ZSP-induced liver damage using metabolomics methods and identified 12 metabolites associated with ZSP-induced hepatotoxicity. Amino acid metabolism and the urea cycle were significantly altered, and the role of three amino acid metabolic enzymes was validated. The major hepatotoxic constituents in ZSP were identified as furanoids from two herbs, and a preparation method with low hepatotoxicity was proposed.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2022)
Letter
Medicine, General & Internal
Xiaodong Li, Xiaomeng Zheng, Yanxia Cao, Yanan Wang, Xiangyu Fan, Wengui Xu
Article
Engineering, Multidisciplinary
Di Qin, Xinguo You, Haonan Wang, Yixuan Liu, Yan Shi, Na Wang, Xin Zhang, Chao Feng, Ya Liu, Ming Kong, Xiaojie Cheng, Shichao Bi, Xiguang Chen
Summary: Surface topography of fish scales promotes bone regeneration by directing cell behavior and modulating the osteoimmune microenvironment. The anisotropic ridged micropatterns and mineralized collagen on the scales induce macrophage polarization and stimulate anti-inflammatory cytokine secretion. In addition, they enhance osteogenic differentiation of mesenchymal stem cells and increase bone formation. The findings suggest that fish scales can be a potential implant material for bone repair.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Engineering, Biomedical
Xu Qiu, Chao Feng, Wenxuan Wang, Guangsheng Wu, Yingzhe Hu, Shuhan Li, Xiangru Gao, Xiguang Chen, Qiuxia Ji
Summary: This study demonstrated that copper-deposited Diatom-biosilica (Cu-DBs) have the potential to repair bone defects caused by inflammation. Cu-DBs promoted osteogenesis and angiogenesis, as well as inhibited inflammatory responses and reduced immune cell infiltration. In vitro and in vivo experiments confirmed the osteogenic properties of Cu-DBs. The unique chemical characteristics of Cu2+ and Si4+ ions enhanced the osteogenic differentiation of periodontal ligament stem cells and stimulated osteogenesis in rats.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Chenfei Yang, Chao Feng, Yuhang Li, Zheng Cao, Yan Sun, Xiaohui Li, Lin Zhang, Chengxu Zhou, Jichang Han
Summary: Diatoms, with their silicified cell wall known as frustule, are crucial to marine primary production. The frustule provides various benefits to diatoms, including nutrient uptake, UV protection, predator deterrent, parasite resistance, light harvesting, CO2 capture, and position control. Moreover, as an exquisite biosilica, the frustule holds great potential as bionanomaterials in the biomedical field. This review explores the morphological and physicochemical characteristics of the frustule, as well as its biological functions and biomedical applications.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Chemistry, Multidisciplinary
Xiaojie Sun, Na Li, Chang Su, Yuzhi Mu, Xin Cong, Zheng Cao, Xiaoye Wang, Xiaoyan Yang, Xiguang Chen, Chao Feng
Summary: In this study, a diatom-inspired bionic hydrophilic polysaccharide adhesive was developed for rapid hemostasis. The adhesive exhibited strong mechanical strength and viscosity, and maintained adhesion ability in wet environments. The dry adhesive prepared by lyophilization also showed excellent clotting ability for anticoagulant whole blood.
Article
Chemistry, Physical
Chang Su, Zheng Cao, Jiahao Liu, Xiaojie Sun, Kaijin Qiu, Yuzhi Mu, Xin Cong, Xiaoye Wang, Xiguang Chen, Nan Jia, Chao Feng
Summary: We developed a Ca2+ modified diatom biosilica-based hemostat (DBp-Ca2+) with a hierarchical porous structure. The unique porous size arrangement of DBp-Ca2+ allows for selective adsorption during coagulation process, resulting in rapid hemorrhage control. In vitro and in vivo studies confirmed that DBp-Ca2+ has high porosity, water absorption, protein absorption, and can accelerate blood exchange and reduce thrombosis time.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Marine & Freshwater Biology
Qinfeng Li, Zheng He, Hussein. E. Rozan, Chao Feng, Xiaojie Cheng, Xiguang Chen
Summary: The influence of Ca2+ biomineralization on diatom biosilica (DBs) was explored to develop fast hemostatic materials with a low hemolysis rate. Ca-DBs-3 exhibited good biocompatibility, rapid hemostatic effect, and non-hemolysis, making it a potential candidate for diatom biosilica hemostatic materials.
MARINE LIFE SCIENCE & TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Xiaojie Sun, Mengxue Zhang, Jinfeng Liu, Guangyan Hui, Xiguang Chen, Chao Feng
Summary: Diatom biosilica is a natural inorganic material with a micro-nanoporous structure and has great application potential in drug delivery, hemostat materials, and biosensors. Manipulating the micro-nanostructure of diatom biosilica through biological regulation methods can transform the screening mode of its structural features and maximize its possibility as a biological material.
Article
Materials Science, Biomaterials
Xiaojie Sun, Na Li, Xiaolei Wang, Yuzhi Mu, Chang Su, Xin Cong, Xiaoye Wang, Feifei Wu, Guangsheng Wu, Xiguang Chen, Chao Feng
Summary: In this study, a hybrid hemostatic gauze (MG-PEG) was prepared by template method for hemorrhage control. It exhibited superior hemostatic performance and wider indications range for practical application.
BIOMATERIALS ADVANCES
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
