Review
Food Science & Technology
Musthafa Mohamed Essa, Muhammed Bishir, Abid Bhat, Saravana Babu Chidambaram, Buthaina Al-Balushi, Hamdan Hamdan, Nagamaniammai Govindarajan, Robert P. Freidland, M. Walid Qoronfleh
Summary: Functional foods play a crucial role in maintaining a healthy lifestyle and reducing the risk of diseases. These foods contain functional ingredients that have potential health benefits. The market for functional foods is expanding and more research is needed to determine their potential health benefits.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Food Science & Technology
Priscilla Magro Reque, Adriano Brandelli
Summary: This study discusses the recent developments in probiotics encapsulation for application in nutraceutical and food industries, covering topics such as encapsulation systems, concepts of nutraceuticals and probiotics, current market situation, microbial microencapsulation, and food applications. Studies on the viability and stability of encapsulated probiotics in food matrices are presented, with emphasis on the importance of in vivo human studies to prove the effectiveness of such formulations.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Willem M. de Vos, Herbert Tilg, Matthias Van Hul, Patrice D. Cani
Summary: The gut microbiota plays a crucial role in regulating host health and its deviations are linked with various diseases. Understanding the molecular aspects of the gut microbiota's influence on health can lead to the development of novel therapies.
Review
Food Science & Technology
Chanez Bennacef, Stephane Desobry, Laurent Probst, Sylvie Desobry-Banon
Summary: Encapsulation is a technology used in various industries to protect active molecules and control their release. Coextrusion encapsulation methods can produce core-shell capsules. This review focuses on the applications of coextrusion encapsulation for preserving oils, essential oils, probiotics, and other bioactives. This technology isolates the active molecules, enhances their stability, and allows controlled release. Coextrusion offers valuable opportunities for preserving active molecules in pharmaceutical, food, and agriculture sectors.
Article
Food Science & Technology
Alessandra De Giani, Federica Bovio, Matilde Emma Forcella, Marina Lasagni, Paola Fusi, Patrizia Di Gennaro
Summary: Maitake extract showed promising prebiotic potential by stimulating the growth of probiotic strains and producing SCFAs, which exerted positive effects on colorectal cell lines, particularly in protection from reactive oxygen species.
Review
Medicine, General & Internal
Jiezhong Chen, Luis Vitetta
Summary: The gut microbiota plays a crucial role in the prevention and treatment of COVID-19, with modulation of gut microbiota and supplementation of commensal bacterial metabolites being able to reduce severity of the disease. Various approaches such as probiotics and bacterial metabolites have been studied to improve gut microbiota in COVID-19. Clinical trials testing the efficacy of probiotics and synbiotics in COVID-19 prevention and treatment are currently ongoing, showing promising results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Health Care Sciences & Services
Marco Matteo Ciccone, Mario Erminio Lepera, Andrea Igoren Guaricci, Cinzia Forleo, Concetta Cafiero, Marica Colella, Raffele Palmirotta, Luigi Santacroce
Summary: In recent years, there has been a growing number of studies on the relationship between the gut microbiota and atherosclerosis, generating significant interest. The gut microbiota, its metabolites, and gut dysbiosis have been found to play a crucial role in the development of atherosclerosis. Inflammation originating from the intestinal tract further disrupts the human ecosystem, leading to metabolic diseases and cardiovascular diseases. Understanding these mechanisms is essential for developing new therapeutic targets in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Microbiology
Kunling Teng, Fuqing Huang, Yayong Liu, Yudong Wang, Tianqi Xia, Fangfei Yun, Jin Zhong
Summary: Gut microbes and their interactions with the host have an impact on human health and diseases. Bacteriocins, produced by gut commensals and food-originated bacteria, can inhibit pathogens and modulate gut microbiota. They are potential candidates for precision therapy of gut disorders. Lactic acid bacteria, including many probiotics, are the main producers of bacteriocins. Bacteriocin production is considered a probiotic trait that provides a competitive advantage to bacteria in colonizing the human gut and mediating interactions with the host ecosystem.
CRITICAL REVIEWS IN MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Divakar Dahiya, Poonam Singh Nigam
Summary: Antibiotic therapy can harm the normal microbiota of the gastrointestinal tract, resulting in decreased diversity, changed metabolic activity, and the emergence of antibiotic-resistant strains. This can lead to antibiotic-associated diarrhoea and recurrent infections. Different classes of antibiotics can also cause gastrointestinal, immunologic, and neurocognitive conditions. Restoring the imbalanced gut microbiota to a healthy state is crucial for overall well-being. Probiotic strains, consumed through food, beverages, or supplements, can help establish a beneficial gut-brain relationship.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Food Science & Technology
Elena Hadjimbei, George Botsaris, Stavrie Chrysostomou
Summary: Probiotic fermented milks and yoghurts are nutrition-dense foods that provide numerous health benefits, including the prevention of diseases and promotion of overall well-being. They are acidified and fermented by viable bacteria, resulting in a thicker product with a longer shelf life.
Review
Food Science & Technology
Miao Zhang, Robert W. Li, Haiyan Yang, Zhongfang Tan, Fang Liu
Summary: Butyrate, one of the major short-chain fatty acids produced by microbial fermentation, acts as both a preferred energy substrate and an important signaling molecule. However, aging and various disorders can compromise the genetic capacity of butyrate biosynthesis by the gut microbiota. Efforts have been made to identify butyrogenic substrates and butyrate-hyperproducing bacteria to address butyrate deficiency. Interindividual variations in butyrogenic responses are more strongly associated with gut microbiota composition than ingested prebiotic substrates. This review discusses major food types rich in butyrogenic substrates and explores the potential of butyrogenic foods for promoting gut health and disease management based on clinical trial findings.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Microbiology
Morayma Ramirez Damian, Naima G. Cortes-Perez, Erika T. Quintana, Alicia Ortiz-Moreno, Cynthia Garfias Noguez, Carlos Eugenio Cruceno-Casarrubias, Maria Elena Sanchez Pardo, Luis G. Bermudez-Humaran
Summary: This chapter reviews the recent research and advancements in the field of functional foods, and discusses the future outlook in this area.
Review
Food Science & Technology
Kandathil Ashwin, Ashok Kumar Pattanaik, Gordon S. Howarth
Summary: Polyphenols, although not nutrients, provide health benefits in humans and animals, particularly in the gut. Microbial modifications of polyphenols affect gut ecology and promote beneficial bacterial growth.
Article
Biochemistry & Molecular Biology
Alessandra De Giani, Monica Oldani, Matilde Forcella, Marina Lasagni, Paola Fusi, Patrizia Di Gennaro
Summary: Oxidative stress affects aging and disease development. Functional foods with specific probiotics and natural extracts as antioxidants are being explored as a preventive measure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Agriculture, Dairy & Animal Science
Domingo Ruiz-Cano, Gines Sanchez-Carrasco, Amina El-Mihyaoui, Marino B. Arnao
Summary: This article reviews the applications of plant-based compounds in the nutrition and health of dogs, with a focus on the use of essential oils and melatonin. The combination of essential oils and melatonin is considered an innovative product that shows great potential in addressing issues such as stress, anxiety, sleep disorders, alopecia, and hair growth problems in pets.
Article
Energy & Fuels
Khamila Nurul Khaqqi, Janusz J. Sikorski, Kunn Hadinoto, Markus Kraft
Article
Chemistry, Medicinal
Hong Yu, Li Ming Lim, Bingxue Dong, Kunn Hadinoto
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2019)
Article
Pharmacology & Pharmacy
The-Thien Tran, Hong Yu, Celine Vidaillac, Albert Y. H. Lim, John A. Abisheganaden, Sanjay H. Chotirmall, Kunn Hadinoto
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2019)
Article
Materials Science, Biomaterials
Minh-Hiep Nguyen, Suen Ern Lee, The-Thien Tran, Chi-Bao Bui, Thi-Huynh-Nga Nguyen, Ngoc-Bich-Dao Vu, Thi-Thuy Tran, Trong-Hoanh-Phong Nguyen, Thi-Thu Nguyen, Kunn Hadinoto
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Engineering, Chemical
Bingxue Dong, Wean Sin Cheow, Kunn Hadinoto
Article
Pharmacology & Pharmacy
Bingxue Dong, Li Ming Lim, Kunn Hadinoto
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Bingxue Dong, Kunn Hadinoto
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Pharmacology & Pharmacy
Li Ming Lim, Kunn Hadinoto
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Review
Engineering, Chemical
Siyu Pu, Kunn Hadinoto
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2020)
Article
Engineering, Chemical
Bingxue Dong, Wean Sin Cheow, Kunn Hadinoto
ADVANCED POWDER TECHNOLOGY
(2020)
Article
Biophysics
The-Thien Tran, Kunn Hadinoto
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
Article
Pharmacology & Pharmacy
The-Thien Tran, Nur Amalina, Wean Sin Cheow, Kunn Hadinoto
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Green & Sustainable Science & Technology
Danping Wang, Wean Sin Cheow, Nur Amalina, Muhammad Faiezin, Kunn Hadinoto
Summary: The study conducted a life cycle assessment of API tablet production with two different excipient formulations. The results showed that excipient selection plays a significant role in the environmental impacts of API tablet production.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Engineering, Chemical
Siyu Pu, Kunn Hadinoto
Summary: The development of a segmented slug flow crystallizer (SFC) design improved the reproducibility of crystal size distribution by limiting the formation of small crystals and large agglomerates, resulting in the production of lysozyme crystals with well-preserved bioactivity.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
The-Thien Tran, Kunn Hadinoto
Summary: The study developed a chitosan nanoplex to enhance the solubility of quercetin in physiological fluids, while preserving its bioactivity, showing significant inhibitory effects on Pseudomonas aeruginosa biofilm formation and swimming motility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
