Article
Food Science & Technology
Feng Lu, Rongrong Zhai, Siyu Ruan, Xue Yang, Evans A. Alenyorege, Yucheng Wang, Yanhua Ding, Haile Ma
Summary: The study found that ultrasound can improve the decoloration process of Lycium barbarum polysaccharides on resins and enhance their dynamic desorption effect. By optimizing conditions, a better desorption effect can be achieved.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Ruixue Ma, Meng Zhang, Xiaohua Yang, Jia Guo, Yanli Fan
Summary: This study analyzed the cell wall polysaccharide composition and gene analysis of goji berries from Zhongning, Qinghai, and Gansu in China. The results revealed that cellulose, fructose, and arabinose are the main components of the cell wall, and gene expression plays a significant role in polysaccharide synthesis and metabolism.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Ze Liang, Zisheng Luo, Wenxuan Li, Mingyi Yang, Lei Wang, Xingyu Lin, Li Li
Summary: This study investigated the effects of elevated CO2 on the quality attributes and cell wall degradation of wolfberry fruit during storage. The results showed that 10% CO2 better maintained the physiological quality of the fruit and reduced weight loss, decay index, and color change.
Article
Food Science & Technology
Letizia Poggioni, Marco Romi, Massimo Guarnieri, Giampiero Cai, Claudio Cantini
Summary: This study investigated the relationship between the functional constituents and environmental factors in goji berries grown in central Italy. The results showed that goji berries harvested at the beginning of the fruiting season had the highest flavonoids content and antioxidant power, while those harvested in September had the highest total polyphenols and zeaxanthin contents.
Article
Agriculture, Multidisciplinary
Peng Wang, Junjie Wang, Huaiyu Zhang, Cong Wang, Lunaike Zhao, Ting Huang, Ken Qing
Summary: This study investigated the cuticular wax of six goji berry cultivars, revealing that fatty acids, alkanes, and primary alcohols are major components related to the formation of irregular lamellar crystal structures. The terpenoid compounds in goji berries' cuticular wax showed high resistance to Alternaria rot. Genes such as CER1, CER6, LACS1, MAH1, LTP4, ABC11, MYB96, and WIN1 were found to be closely related to wax synthesis in goji berries.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Applied
Wenqi Huang, Mengwei Zhao, Xinyi Wang, Yang Tian, Chengjian Wang, Jing Sun, Zhongfu Wang, Guiping Gong, Linjuan Huang
Summary: In this study, LBGP70, LBGP70-OL, and LBGP70-OL-I were obtained from crude Lycium barbarum polysaccharides (LBP) by stepwise precipitation, and the structural features of LBGP70-OL were investigated. The results showed that LBGP70-OL exhibited high anti-ageing activity, with its side chain and backbone synergistically contributing to the activity.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Huan Liu, Xiong Zhou, Shaowen Huang, Jie Yang, Ruijing Liu, Chunhong Liu
Summary: This study demonstrated that Lycium barbarum polysaccharides and wolfberry juice have significant detoxification effects against DEHP-induced hepatotoxicity by activating key detoxifying enzymes. Moreover, the intervention effect of wolfberry juice was more pronounced compared to Lycium barbarum polysaccharides.
Article
Agriculture, Dairy & Animal Science
Paola Cremonesi, Giulio Curone, Filippo Biscarini, Elisa Cotozzolo, Laura Menchetti, Federica Riva, Maria Laura Marongiu, Bianca Castiglioni, Olimpia Barbato, Albana Munga, Marta Castrica, Daniele Vigo, Majlind Sulce, Alda Quattrone, Stella Agradi, Gabriele Brecchia
Summary: This study evaluated the effects of Goji berry supplementation on the microbiota of a rabbit's digestive tract. The results showed that Goji berries could modulate the microbiota composition, increasing the growth of beneficial bacteria and stimulating lactic acid fermentation in the caecum.
Article
Chemistry, Applied
Jiayi Huang, Ka H. Wong, Wei Liang Tan, Stephanie V. Tay, Shujing Wang, James P. Tam
Summary: The discovery of a novel hyperstable beta-lybatide from wolfberry plant as a carboxypeptidase inhibitor is reported. This peptide, belonging to a different CRP family, displayed a knottin-like structure and showed potent inhibitory activity against carboxypeptidase, contributing to wolfberry biological activities. Bioinformatics analysis revealed additional similar plant carboxypeptidase inhibitors, indicating beta-lybatide as the first and smallest plant-derived hyperstable carboxypeptidase inhibitor from functional foods.
Article
Chemistry, Applied
Jiepeng Liu, Xin Shi, Haifeng Lin, Chengcheng He, Quanquan Li, Guiping Shen, Jianghua Feng
Summary: In this study, NMR-based analysis was used to identify the nutritional composition and geographical indication markers of Goji berry in Ningxia. The results showed that Goji berry from Zhongning had exceptional nutritional characteristics, and Ningqi No. 9 could be considered as a better choice among the varieties. These findings are meaningful for establishing quality control system and combating illegal labeling.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Plant Sciences
Ruixue Ma, Xiazhi Sun, Chao Yang, Yanli Fan
Summary: This study investigated the flavonoid metabolites and gene expression levels of goji berries from three major production areas in China. The findings showed variations in flavonoid content among the different regions, with Ningxia having the highest levels. The study also identified specific genes and transcription factors involved in the regulation of flavonoid synthesis in goji berries.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Cristina Juan, Domenico Montesano, Jordi Manes, Ana Juan-Garcia
Summary: This study investigated the bioavailability of carotenoids in goji berries using a Caco-2 cell model, and evaluated the cytoprotective effect of one carotenoid against a fungal toxin. The results showed that the bioavailability of carotenoids from goji berries varied depending on their compound structure, with ZDP being the most bioavailable. Additionally, goji berry carotenoids exhibited a certain level of cytoprotection against the fungal toxin.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Review
Horticulture
Nurul Izzati Osman, Asmah Awal
Summary: Plant tissue culture is a powerful alternative approach in breeding and conserving plant species. It allows overcoming growth limitations and enables mass propagation of plants all year round, thus improving plant production and conserving endangered species.
HORTICULTURE ENVIRONMENT AND BIOTECHNOLOGY
(2023)
Article
Plant Sciences
Li Tan, Jianfeng Xu, Michael Held, Derek T. A. Lamport, Marcia Kieliszewski
Summary: This study found that Hyp-O-polysaccharides isolated from transgenic Arabidopsis suspension culture have similar structural features to AGPs isolated from tobacco. It also confirmed the presence of a previously identified β-1,6-linkage on the galactan backbone in AGP fusion glycoproteins expressed in tobacco. Furthermore, AGPs expressed in Arabidopsis suspension culture have differences in terminal-rhamnosyl residues and glucuronosylation compared to those expressed in tobacco suspension culture, suggesting the presence of distinct glycosyl transferases and minimum AG structures for type II AG functional features.
Article
Agronomy
Danial Fatchurrahman, Maria Luisa Amodio, Maria Lucia Valeria De Chiara, Leonarda Mastrandrea, Giancarlo Colelli
Summary: This study characterized goji berry fruit in terms of color, firmness, phytochemicals, and metabolic behavior at different stages of maturity and ripening. The results showed changes in size, soluble solids, titratable acidity, and other attributes as the fruit matured. Goji berries were found to have high nutritional value and antioxidant content.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Maria Angeles Bermudez Alcantara, Justyna Dobruchowska, Parastoo Azadi, Bruno Diez Garcia, Fernando P. Molina-Heredia, Francisco Manuel Reyes-Sosa
BIOTECHNOLOGY FOR BIOFUELS
(2016)
Article
Chemistry, Applied
Yuxiang Bai, Justyna M. Dobruchowska, Rachel M. van der Kaaij, Gerrit J. Gerwig, Lubbert Dijkhuizen
CARBOHYDRATE POLYMERS
(2016)
Article
Biochemistry & Molecular Biology
Justyna M. Dobruchowska, Jon O. Jonsson, Olafur H. Fridjonsson, Arnthor Aevarsson, Jakob K. Kristjansson, Josef Altenbuchner, Hildegard Watzlawick, Gerrit J. Gerwig, Lubbert Dijkhuizen, Johannis P. Kamerling, Gudmundur O. Hreggvidsson
Article
Chemistry, Applied
Xiangfeng Meng, Tjaard Pijning, Martin Tietema, Justyna M. Dobruchowska, Huifang Yin, Gerrit J. Gerwig, Slavko Kralj, Lubbert Dijkhuizen
Article
Multidisciplinary Sciences
Evelien M. te Poele, Tim Devlamynck, Manuel Jager, Gerrit J. Gerwig, Davy Van de Walle, Koen Dewettinck, Anna K. H. Hirsch, Johannis P. Kamerling, Wim Soetaert, Lubbert Dijkhuizen
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Joana Gangoiti, Sander S. van Leeuwen, Gerrit J. Gerwig, Stephane Duboux, Christina Vafiadi, Tjaard Pijning, Lubbert Dijkhuizen
SCIENTIFIC REPORTS
(2017)
Article
Chemistry, Applied
Tim Devlamynck, Evelien M. te Poele, Koen Quataert, Gerrit J. Gerwig, Davy Van de Walle, Koen Dewettinck, Johannis P. Kamerling, Wim Soetaert, Lubbert Dijkhuizen
Article
Biochemistry & Molecular Biology
Bernadeth F. Ticar, Zuliyati Rohmah, Therese Ariane N. Neri, Ida G. Pahila, Ariana Vasconcelos, Stephanie A. Archer-Hartmann, Chad E. N. Reiter, Justyna M. Dobruchowska, Byeong-Dae Choi, Christian Heiss, Parastoo Azadi, Vitor H. Pomin
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Biochemistry & Molecular Biology
Cory Q. Wenzel, Dominic C. Mills, Justyna M. Dobruchowska, Jiri Vlach, Harald Nothaft, Patrick Nation, Parastoo Azadi, Stephen B. Melville, Russell W. Carlson, Mario F. Feldman, Christine M. Szymanski
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Agriculture, Multidisciplinary
Evelien M. te Poele, Stevan E. van der Hoek, Anastasia C. Chatziioannou, Gerrit J. Gerwig, Wouter J. Duisterwinkel, Lizette A. A. C. M. Oudhuis, Joana Gangoiti, Lubbert Dijkhuizen, Hans Leemhuis
Summary: The study reports a novel thermostable starch-acting enzyme Geobacillus sp. 12AMOR1 GtfC, which has the ability to synthesize starch at high temperatures and shows anti-staling effects in bread bakery products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Adrian H. Kopf, Odette Lijding, Barend O. W. Elenbaas, Martijn C. Koorengevel, Justyna M. Dobruchowska, Cornelis A. van Walree, J. Antoinette Killian
Summary: In this study, a library of well-defined alternating copolymers of SMA analogues was designed and synthesized, revealing important polymer properties for membrane protein solubilization and stability. Remarkably, halogenation of the SMA copolymers significantly improved solubilization efficiency, while substituents on the copolymer backbone enhanced resistance to Ca2+.
Article
Plant Sciences
Justyna M. Dobruchowska, Bryndis Bjornsdottir, Olafur H. Fridjonsson, Josef Altenbuchner, Hildegard Watzlawick, Gerrit J. Gerwig, Lubbert Dijkhuizen, Johannis P. Kamerling, Gudmundur O. Hreggvidsson
Summary: Alginate lyases are enzymes that catalyze the depolymerization of alginate, a linear polysaccharide. In this study, two alginate lyase genes were cloned and expressed from a marine thermophilic bacterium. The recombinant enzymes showed high thermostability and activity at elevated temperatures. The NMR analysis revealed that one of the enzymes is an endolytic lyase, while the other is an exolytic lyase.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Gerrit J. Gerwig, Evelien M. te Poele, Lubbert Dijkhuizen, Johannis P. Kamerling
CARBOHYDRATE RESEARCH
(2017)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)