Article
Chemistry, Multidisciplinary
Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang, Heyou Han
Summary: This study presents the design of a novel nanocarrier DNAH for the treatment of bladder cancer, utilizing photothermal therapy to overcome the bladder mucosal barrier and enhance drug penetration. The results demonstrate the potential inhibition of bladder tumor growth by DNAH, leading to improved survival time in mice.
Article
Pharmacology & Pharmacy
Guoliang Liu, Min Wang, Hongyu He, Jiannan Li
Summary: This study developed tumor-targeting nanoparticles loaded with doxorubicin for the treatment of colorectal cancer. The nanoparticles utilize a peptide, VATANST (STP), to achieve tumor-targeting effects, have a core-shell structure, and are sensitive to the tumor microenvironment. In vivo experiments in mice demonstrated the nanoparticles' properties as drug delivery systems and their good antitumor effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Vijay Sagar Madamsetty, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, John D. Schneible, Iman Fatemi, Abdolsamad Shirvani, Ali Zarrabi, Fereshteh Azedi, Ali Dehshahri, Abbas Aghaei Afshar, Kian Aghaabbasi, Abbas Pardakhty, Reza Mohammadinejad, Prashant Kesharwani
Summary: Breast cancer is a highly deadly neoplastic disease with limited efficacy in existing treatment methods, prompting a search for new remedies. Nanotechnology has shown promise in the field, particularly with chitosan as a potential carrier for anticancer drugs. Further research is ongoing to explore the therapeutic and diagnostic applications of chitosan in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Pharmacology & Pharmacy
Mallesh Kurakula, Shashank Gorityala, Keshav Moharir
Summary: Colon-targeted drug delivery systems focus on selectively releasing drugs in the colonic environment to enhance oral delivery of active drug moieties sensitive to the upper gastrointestinal tract's acidic conditions. Chitosan is a key biopolymer widely used for drug delivery to the colon. Current research emphasizes the role of chitosan in designing colon-targeted drugs and highlights recent developments in colon-specific formulations based on chitosan.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Zongheng Wang, Miaomiao Xiao, Fangliang Guo, Yue Yan, Hong Tian, Qianshi Zhang, Shuangyi Ren, Liqun Yang
Summary: Cancer poses a serious threat to human health, with few cases having a complete cure. Nano-drug delivery systems based on biodegradable polyesters have gained widespread attention for their potential in offering high bioavailability, effective encapsulation, controlled release, and minimal toxicity. Poly (epsilon-caprolactone) (PCL), poly (lactic-co-glycolic acid) (PLGA), and polylactic acid (PLA) are commonly used carriers in these systems. This paper comprehensively reviews the recent advancements and limitations of these materials as nano-carriers for delivering chemotherapeutic drugs and suggests future research directions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
P. Tiago Ribeiro, J. Agostinho Moreira, J. Fernando Monterio, S. Marta Laranjeira
Summary: Nanoparticle mediated hyperthermia is a method of increasing cancer treatment efficacy by heating tumors from the inside out. This method utilizes nanoparticles that respond to external stimuli and convert energy into heat, causing damage to tumor cells. Combining hyperthermia with chemotherapy has been shown to be more effective, with the high temperature and drug effects working synergistically and allowing for remote controlled drug release.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
S. Panda, S. Hajra, A. Kaushik, H. G. Rubahn, Y. K. Mishra, H. J. Kim
Summary: This comprehensive review explores the potential of smart nanomaterials in cancer management, focusing on various types of nanomaterials and their applications in diagnostics, targeted drug delivery, and therapy. It critically analyzes recent studies and discusses challenges and prospects in the field, proposing a novel multidisciplinary and combinational approach for personalized cancer management.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Wipada Samprasit, Praneet Opanasopit, Benchawan Chamsai
Summary: Alpha-Mangostin-loaded mucoadhesive nanoparticles were prepared using pH-dependent composite mucoadhesive nanoparticles. Different components and processing methods were found to affect the properties of the particles. In vitro experiments and anti-tumor activity tests confirmed the potential of these nanoparticles for colon-targeted drug delivery.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Summary: Evasion of apoptosis is a characteristic of cancer, and overexpression of Bcl-2 is a contributing factor. Therapeutic targeting of Bcl-2 has shown efficacy in the clinic and is being extensively tested in combination with chemotherapy. Therefore, developing co-delivery systems for Bcl-2 targeting agents and chemotherapeutics, such as LNPs, holds promise for combination cancer therapies.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Biochemistry & Molecular Biology
Xudong Li, Yuran Wang, Chenyun Feng, Haijun Chen, Yu Gao
Summary: This review discusses the application of chitosan in cancer theranostics, including its chemical functionalities, synthesis methods, and the improvement of treatment efficiency through functionalization. Several case studies of chitosan-based nanotheranostics are also reported.
Review
Pharmacology & Pharmacy
Mengru Yang, Ying Zhang, Zheming Hu, Haonan Xie, Wenli Tian, Zhidong Liu
Summary: This article summarizes the application of hyaluronic acid-based nanoparticles in combination therapy for cancer treatment. These nanoparticles have exceptional biocompatibility and targeting capabilities, offering a new approach for precise drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Asghar Narmani, Saeid Ganji, Maryam Amirishoar, Roghayyeh Jahedi, Mohammad Saeed Kharazmi, Seid Mahdi Jafari
Summary: A novel targeted chitosan-based nanocarrier was developed for delivering sorafenib to lung cancer cells, showing controlled and pH-sensitive drug release. MTT assay demonstrated high cytotoxicity in cancer cells but low toxicity in normal cells. qRT-PCR revealed upregulation of Caspase9 and P53 genes and downregulation of Bcl2 gene after treatment with the nanocarrier. Cell cycle arrest and apoptosis assays confirmed the effectiveness of the nanocarrier in inducing apoptosis in cancer cells. Evaluation of internalization showed high uptake of the nanocarrier in cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Chemistry, Applied
Guiqiu Wang, Rilun Li, Benyamin Parseh, Gang Du
Summary: Chitosan, with its advantages of being non-toxic, non-immunogenic, and biocompatible, holds great potential as a drug delivery system for treating breast cancer.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Yonggang Lv, Xi Chen, Yaping Shen
Summary: A new drug delivery system was developed using intracellular Ca2+ production for the treatment of breast cancer, combined with the inhibitory effect of curcumin. The system showed good biocompatibility and stability, and could specifically target tumor tissues and enter tumor cells to achieve anti-tumor effects. This study provides a new strategy for cancer therapy.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Asghar Narmani, Seid Mahdi Jafari
Summary: Cancer is a major global health issue, with traditional therapeutic methods showing limited efficacy. Developing novel nanoparticle-based drug delivery systems, such as chitosan nanoparticles, can be highly beneficial for cancer suppression.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Ahmed O. Rashed, Chi Huynh, Andrea Merenda, Si Qin, Ken Aldren S. Usman, Abu Sadek, Lingxue Kong, Takeshi Kondo, Ludovic F. Dumee, Joselito M. Razal
Summary: This study presents a stimuli-responsive membrane reactor for simultaneous separation and degradation of organic contaminants through photo or electro stimuli. By assembling carbon nanotubes (CNT) with conformal nanoscale SnO2 coatings, ultrathin and flexible ultrafiltration membranes were fabricated. The membranes exhibited high water permeance and faster reaction kinetics, making them suitable for cost-effective water purification.
Article
Engineering, Environmental
Priyanka Kumari, Nupur Bahadur, Xavier A. Conlan, Xiangkang Zeng, Lingxue Kong, Luke A. O'Dell, Abu Sadek, Andrea Merenda, Ludovic F. Dumee
Summary: The design of semiconducting metal oxide heterojunctions can overcome the limitations of conventional photocatalysis or electrocatalysis. This study focuses on the formation of nanoscale heterojunctions between TiO2 and ZnO, resulting in enhanced photocurrent efficiency and electrochemical reactions. By controlling the nanoscale dimensions and stacking of metal oxide nano-sheets, multi-heterojunctions with improved catalytic efficiency and stability are developed. The coupling of photo-electrocatalysis and pressure driven membrane processes in a novel cross-flow filtration module leads to highly enhanced degradation of persistent organic pollutants.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Environmental
Ahmed O. Rashed, Chi Huynh, Andrea Merenda, Si Qin, Maxime Maghe, Lingxue Kong, Takeshi Kondo, Joselito M. Razal, Ludovic F. Dumee
Summary: The development of electrochemically active ultrafiltration membrane reactors has led to the synthesis of electrically conductive and flexible ultrafiltration membranes using drawable carbon nanotubes (CNT). These membranes show fine-tuned selectivity and high water permeance, as well as remarkable electrocatalytic properties for efficient water treatment. The results demonstrate the potential of CNT dry spinning technology for the scalable fabrication of highly permeable, selective membranes at an exceptional reaction rate.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Baoqi Dong, Tingping Hou, Kaiming Wu, Bernie Rolfe, Lingxue Kong, Minghui Cai, Peter Hodgson
Summary: The effect of a 12 Tesla magnetic field on the microstructure and carbon partitioning in a low temperature bainitic steel was studied. The high magnetic field accelerated the formation of bainitic ferrite, resulting in refined laths and uniform distribution. It also promoted carbon partitioning to retained austenite and increased the carbon accommodation of the retained austenite.
MATERIALS CHARACTERIZATION
(2023)
Article
Chemistry, Multidisciplinary
Xiangyang Guo, Chung Kim Nguyen, Aishani Mazumder, Yichao Wang, Nitu Syed, Enrico Della Gaspera, Torben Daeneke, Sumeet Walia, Samuel J. Ippolito, Ylias Sabri, Yongxiang Li, Ali Zavabeti
Summary: Various non-stratified two-dimensional (2D) materials can be obtained from liquid metal surfaces that are not naturally accessible. These materials have high-quality oxide layers that can be transferred onto desired substrates. The liquid metal-derived 2D oxides have versatile applications, but their gas-sensing properties remain underexplored.
Review
Biochemistry & Molecular Biology
Senlin Gu, Liangliang Zhang, Liliana de Campo, Luke A. O'Dell, Dong Wang, Guang Wang, Lingxue Kong
Summary: Mesoporous materials based on lyotropic liquid crystal templates offer a solution to water scarcity, while polyamide-based thin-film composite membranes have trade-offs between permeability and selectivity. This review explores the advancements in fabricating active layers using liquid crystal templates, analyzes membrane performance, and compares the effects of different substrates on TFC membranes. It also discusses strategies for surface modification and interlayer introduction, and techniques for detecting interfacial structures.
Article
Chemistry, Analytical
Xiaodi Wu, Zheng Li, Jin Hu, Shumin Wang, Yichao Wang, Peng Lin, Hong Zhou, Wei-Wei Zhao
Summary: Scientists have been seeking a solution for developing an organic photoelectrochemical transistor (OPECT) biosensor with a removed background, but this challenge remains. However, by tailoring a unique heterogeneous light antenna as the functional gating module and its cascade interaction with a proper channel, we have successfully addressed this issue. This achievement resulted in an OPECT with minimal background and the highest current gain of 19,000.
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Chemical
Riyadh Al-Attabi, Fenghua She, Shuaifei Zhao, Ludovic F. Dumee, Jurg A. Schutz, Weihong Xing, Zhaoxiang Zhong, Lingxue Kong
Summary: Electrospinning was used to synthesize nanofiber membranes from polyvinylidene fluoride (PVDF) for separating airborne contaminants. By optimizing the electrospinning process, scalable and comfortable PVDF nanofiber membranes with high filtration efficiency were achieved. Compared to commercial surgical face masks, the PVDF nanofiber membranes had smaller fiber diameter, higher mechanical strength, and better filtration efficiency.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Albert Guirguis, Wenrong Yang, Xavier A. Conlan, Lingxue Kong, David M. Cahill, Yichao Wang
Summary: Artificially augmented photosynthesis in nano-bionic plants requires tunable nano-antenna structures with specific properties, such as physiochemical and optoelectronic properties, as well as unique light conversion capabilities. The use of carbon dots as nanomaterials has shown promising results in enhancing photosynthesis through tunable uptake, translocation, and biocompatibility. This review discusses the recent progress in fabricating nano-antennas based on carbon dots and their performance in artificially boosted photosynthesis.
Article
Engineering, Environmental
Ahmed O. Rashed, Chi Huynh, Andrea Merenda, Julio Rodriguez-Andres, Lingxue Kong, Takeshi Kondo, Joselito M. Razal, Ludovic F. Dumee
Summary: By engineering dry-spun ultrafiltration carbon nanotube (CNT) membranes coated with anti-viral SnO2 thin films, an efficient approach for simultaneous filtration and disinfection of waterborne Human Coronavirus 229E (HCoV-229E) is proposed.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Review
Chemistry, Physical
Milad Laghaei, Mohsen Ghasemian, Weiwei Lei, Lingxue Kong, Qi Chao
Summary: The conversion of carbon dioxide into valuable chemicals by photoreduction using two-dimensional nanomaterials, such as boron nitride, shows promising potential. However, modification strategies are needed to enhance their efficiency in CO2 reduction due to their large band gaps and inert surface chemistry. Various modification techniques, including doping, fabricating composite heterojunctions, and engineering defects, have been developed to tailor CO2 adsorption/conversion. Challenges regarding large-scale production, stability, and product selectivity are discussed, along with suggestions for future studies.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Plant Sciences
Thi Linh Chi Tran, Albert Guirguis, Thanojan Jeyachandran, Yichao Wang, David M. Cahill
Summary: Nanoparticles have been shown to enhance plant growth and development, and improve crop production, especially under adverse environmental conditions like drought. Silicon dioxide nanoparticles have been found to be taken up by plants and have the potential to improve tolerance to abiotic stress.
FUNCTIONAL PLANT BIOLOGY
(2023)
Review
Engineering, Environmental
Akbar Samadi, Zhuan Wang, Shaobin Wang, S. K. Nataraj, Lingxue Kong, Shuaifei Zhao
Summary: This review critically assesses PANI-based adsorbents in terms of their advantages, disadvantages, and separation mechanisms in pollutant removal. It highlights the significant roles of low-cost materials as well as emerging 2D nanosheets in enhancing the performance of PANI-based adsorbents.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Yayun Zheng, Yuefo Yi, Ziyi Yang, Wenbin Zhou, Yichao Wang, Zhengfei Chen
Summary: A crystalline Ti2O1.3(PO4)(1.6)/TiO2 carbon-coated composite was successfully synthesized using a glucose-modified hydrothermal method. Compared to the counterpart prepared without glucose modification, this composite exhibits the highest reversible capacities, excellent rate properties, and remarkable cycling performances, with a capacity of 233.9 mA h g(-1) maintained after 200 cycles at 1000 mA g(-1).
CHEMICAL COMMUNICATIONS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)