Review
Chemistry, Multidisciplinary
Vijay Sagar Madamsetty, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, John D. Schneible, Iman Fatemi, Abdolsamad Shirvani, Ali Zarrabi, Fereshteh Azedi, Ali Dehshahri, Abbas Aghaei Afshar, Kian Aghaabbasi, Abbas Pardakhty, Reza Mohammadinejad, Prashant Kesharwani
Summary: Breast cancer is a highly deadly neoplastic disease with limited efficacy in existing treatment methods, prompting a search for new remedies. Nanotechnology has shown promise in the field, particularly with chitosan as a potential carrier for anticancer drugs. Further research is ongoing to explore the therapeutic and diagnostic applications of chitosan in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Nanoscience & Nanotechnology
Siyan Liu, Jing Li, Lin Gu, Kunzhe Wu, Hua Xing
Summary: Chemoimmunotherapy shows promise for treating TNBC, but challenges remain in improving efficacy and reducing side effects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Engineering, Biomedical
Bijay Singh, Sushila Maharjan, Daniel C. Pan, Zongmin Zhao, Yongsheng Gao, Yu Shrike Zhang, Samir Mitragotri
Summary: Monotherapy with a single chemotherapeutic regimen has faced challenges in terms of clinical efficacy, leading to the need for combination therapy. This study demonstrates the potential of a hyaluronic acid-based drug combination of gemcitabine with imiquimod to stimulate immune cells and suppress breast cancer growth.
Review
Pharmacology & Pharmacy
Jingxian Ding, Yonghong Guo
Summary: Cancer is a major public health issue globally. Chemotherapy is one of the most important treatments for cancer patients, but it has many adverse effects and limitations. To improve treatment effectiveness and reduce side effects, more targeted treatments are needed. Chitosan, a natural polysaccharide with notable antitumor activity, is widely used in pharmacology, especially in oncotherapy. However, commercialization of chitosan copolymers is still a challenge.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Polymer Science
Yedi Herdiana, Patihul Husni, Siti Nurhasanah, Shaharum Shamsuddin, Nasrul Wathoni
Summary: Breast cancer is a significant global cause of death, accounting for 13% of all deaths. Chemotherapy can generate reactive oxygen species (ROS) and oxidative stress, which can have adverse effects on the body. Antioxidants are crucial for cell health and immune system functionality, but their effectiveness when taken orally is limited due to poor solubility. Chitosan-based nanoparticle (CSNP) systems have been explored as a strategy to enhance oral bioavailability of natural antioxidants. This review focuses on the development of effective oral dosage forms for natural antioxidants using chitosan-based nanoformulation.
Article
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Nazim Nasir, Shadma Wahab, Mallikarjuna Rao Pichika, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Breast cancer is a common type of cancer with significant side effects after therapy. Nanoparticle-based drug delivery systems, particularly natural polysaccharide-based nanoparticles, have gained attention for their ability to achieve targeted drug delivery. Dextran and its derivatives have shown potential in breast cancer therapy. This review provides insights into dextran and its modification, discusses the role of dextran-based nanoparticles in breast cancer treatment and imaging, and presents clinical trials and future perspectives.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Mariyeh Rajaei, Hamid Rashedi, Fatemeh Yazdian, Mona Navaei-Nigjeh, Abbas Rahdar, Ana M. Diez-Pascual
Summary: A promising methodology has been developed to improve drug loading performance and achieve sustained release of 5-fluorouracil (5-FU) for breast cancer treatment. A pH-sensitive and biocompatible hydrogel of chitosan/agarose/graphene oxide (CS/AG/GO) was synthesized with glyoxal as cross-linker, and 5-FU-loaded nanocomposites (NCs) of CS/AG/GO were prepared. The NCs showed high drug loading and encapsulation efficiency, and exhibited effective sustained drug release and cytotoxicity against breast cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Parnian Baharlouei, Azizur Rahman
Summary: Chitin and chitosan, abundant polymers in nature, have gained attention for their favorable properties and enormous potential biomedical applications. They can be used in drug delivery systems, cancer treatment, wound dressings, and more, making them important in the medical field.
Review
Pharmacology & Pharmacy
Pankaj Kumar, Bharti Mangla, Shamama Javed, Waquar Ahsan, Pankaj Musyuni, Durgaramani Sivadasan, Saad S. Alqahtani, Geeta Aggarwal
Summary: Breast cancer is a common cancer in women, accounting for a quarter of all cancer cases. Current therapy for breast cancer faces challenges such as drug resistance and limited bioavailability. Nanocarriers-assisted delivery of anticancer drugs has been introduced as a promising approach. Nanotechnology has shown significant progress in combating drug resistance and has been successfully applied to different forms of breast cancer. This review provides a comprehensive overview of nanoformulations for improved drug delivery and summarizes clinical studies and patents related to nanotechnology-based breast cancer drug delivery.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang, Heyou Han
Summary: This study presents the design of a novel nanocarrier DNAH for the treatment of bladder cancer, utilizing photothermal therapy to overcome the bladder mucosal barrier and enhance drug penetration. The results demonstrate the potential inhibition of bladder tumor growth by DNAH, leading to improved survival time in mice.
Article
Chemistry, Multidisciplinary
Yifan Zhang, Shujing Yue, Rainer Haag, Huanli Sun, Zhiyuan Zhong
Summary: Antibody-drug conjugates (ADCs) have made significant advancements in clinical cancer treatments, but are plagued by issues like low drug/antibody ratio and the need for large amounts of antibody. Researchers have developed an intelligent cell-selective nanotoxin with high specificity and cytotoxicity towards various cancer cells, showing significant inhibition effects. This nanotoxin appears to be a better platform than ADCs for targeted cancer therapy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Irina Le-Deygen, Anastasia Safronova, Polina Mamaeva, Yana Khristidis, Ilya Kolmogorov, Anna Skuredina, Peter Timashev, Elena Kudryashova
Summary: The severe course of COVID-19 can lead to long-term pulmonary diseases, and developing new effective drug formulations, including inhalation administration, is crucial. This study proposes a method for creating lipid-polymer delivery systems using liposomes decorated with mucoadhesive mannosylated chitosan for fluoroquinolones and pirfenidone. The interactions between drugs and liposomes of different compositions are studied, and the role of the polymer shell in stabilizing vesicles and delaying the drug release is demonstrated. Results show prolonged accumulation of moxifloxacin in lung tissues after a single endotracheal administration in mice.
Article
Pharmacology & Pharmacy
Hui Zhang, Qingwen Xue, Zihan Zhou, Ningning He, Shangyong Li, Cheng Zhao
Summary: Breast cancer is the most common malignancy in women, and chemotherapy or radiotherapy is the standard treatment. Researchers have designed and synthesized a co-delivery nanodelivery drug system that can accurately release drugs into cells by changing pH, effectively inhibiting tumor cell autophagy, and significantly enhancing the cytotoxicity of co-administered drugs in vitro. This study provides a promising strategy for the treatment of breast cancer.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Kheireddine El-Boubbou, Rizwan Ali, Sulaiman Al-Humaid, Alshaimaa Alhallaj, O. M. Lemine, Mohamed Boudjelal, Abdulmohsen AlKushi
Summary: This work focuses on the fabrication and characterization of iron oxide mesoporous magnetic nanostructures (IO-MMNs), which showed high surface areas, large pore volumes, small sizes, good crystallinity, and biocompatibility. The drug-loaded IO-MMNs demonstrated significant inhibition of breast and colon cancer cells with minimal toxicity towards normal cells. These results suggest the potential use of IO-MMNs as effective drug delivery agents in cancer theranostics.
Review
Biochemistry & Molecular Biology
Victor Marin, Viviana Burgos, Rebeca Perez, Durvanei Augusto Maria, Paulo Pardi, Cristian Paz
Summary: Breast cancer is a highly prevalent cancer worldwide, with a high mortality rate despite treatment options such as surgery, radiotherapy, chemotherapy, and antibodies. Epigallocatechin-3-gallate (EGCG), found in green tea, has shown promising effects in controlling breast cancer by targeting various cellular processes. It has been proven to have synergistic effects when combined with traditional chemotherapy, increasing treatment efficacy. This review focuses on the impact of EGCG on breast tumor cells, the signaling pathways involved, the potential synergistic effects with current drugs, and the use of nanomaterials to enhance EGCG's bioavailability in breast cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)