Article
Food Science & Technology
Farzaneh Tajfiroozeh, Ali Moradi, Fakhri Shahidi, Jebrail Movaffagh, Hossein Kamali, Sahar Roshanak, Azadeh Shahroodi
Summary: This study aimed to develop biodegradable electrospun chitosan/polyethylene oxide membranes loaded with gallic acid and nisin for antioxidant and antibacterial properties. The core-shell chitosan/polyethylene oxide nanofiberous membranes loaded with gallic acid and nisin were successfully fabricated through electrospinning and characterized using various techniques. The loaded membranes exhibited maximum tensile strength, antioxidant, and antimicrobial effects for different durations, suggesting their potential use as food packaging membranes.
Article
Nanoscience & Nanotechnology
Hatai Jongprasitkul, Vijay Singh Parihar, Sanna Turunen, Minna Kellomaki
Summary: The challenges of poor printability and low printing accuracy in hyaluronic acid-based bioinks for extrusion-based 3D bioprinting are tackled by developing a bioink consisting of gallic acid-functionalized hyaluronic acid (HAGA) and hyaluronic acid methacrylate (HAMA). The blend's HAGA component enables viscosity modulation, resulting in improved injectability and printability. Postprinting, the HAMA component is photocrosslinked to create a hydrogel with both HAGA and HAMA networks, showing sufficient printing quality and accuracy. The bioink also has enhanced viscoelastic properties, tissue adhesion, and antioxidant activity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Omer Isildak, Ilyas Yildiz, Nusret Genc
Summary: In this study, a new type of solid-state-contact potentiometric PVC membrane sensor was developed for the evaluation of 1,1-diphenyl-1-picrylhydrazil (DPPH) radical scavenging activity. The sensor demonstrated simple, fast, stable, and low-cost characteristics, and could measure at low volumes. The results obtained were in accordance with the spectroscopic method.
Article
Biochemistry & Molecular Biology
Gyu Ri Park, Min A. Gwak, Yun Hyeok Choi, Won Ho Park
Summary: Malignant tumors are a significant health issue, therefore, there is increasing interest in developing pH-sensitive polymers for targeted drug delivery. In this study, gallic acid (GA) was used to enhance the pH-sensitivity of chitosan (CS) hydrogel beads, which showed excellent swelling/deswelling abilities at different pH values. The reversible breakage/recovery of imine crosslinks in the CS-GA hydrogel beads was confirmed, and the beads demonstrated potential as a drug delivery system sensitive to acidic tumor sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Mohamed A. Mohamady Hussein, Jose Manuel Olmos, Michal K. Pieranski, Mariusz Grinholc, Eva Miriam Buhl, Oguzhan Gunduz, Ahmed M. Youssef, Carlos M. Pereira, Ibrahim M. El-Sherbiny, Mosaad Megahed
Summary: The present study proposes two unique systems for combining Ag, chitosan (CS), and gallic acid (GA) into a single particulate nanostructure using free radical-induced grafting reactions. The grafting of GA into CS-AgNPs was confirmed, and the obtained hybrid NPs II showed lower toxicity, higher antioxidant, and antibacterial activity compared to other samples. The results suggest that grafting GA to CS-AgNPs is a unique process with potential future applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Marcin Molski
Summary: The global descriptors of the chemical activity of gallic acid were determined using various computational methods and solvation models. The calculations revealed the scavenging mechanisms of gallic acid in vacuum and water medium and the thermodynamic parameters characterizing its antioxidant activity. Among the parameters of chemical activity, the indexes Ra and Rd are the most independent of the computational method and the solvation model used, making them reliable sources of information.
Article
Chemistry, Applied
Yuda Liu, Dongmei Chen, Aoxue Zhang, Man Xiao, Zhenxia Li, Wanhe Luo, Yuanhu Pan, Wei Qu, Shuyu Xie
Summary: This study explores a pH/hyaluronidase dual-responsive nano-system for targeted treatment of Staphylococcus aureus infections. The nano-system shows excellent stability and responsive release, displaying strong surface adsorption on S. aureus and enhanced activity against it.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Maria Marzano, Nicola Borbone, Felice Amato, Giorgia Oliviero, Pierpaolo Fucile, Teresa Russo, Filomena Sannino
Summary: Three-dimensional chitosan-gallic acid complexes were prepared by adsorbing gallic acid on three-dimensional chitosan structures. The complexes exhibited high antioxidant activity and antimicrobial capacity, making them suitable for nutraceutical, cosmeceutical, and pharmaceutical applications.
Article
Engineering, Chemical
Qingqing Guo, Xin Wu, Yanhong Ji, Yufan Hao, Shuyu Liao, Zhenyu Cui, Jianxin Li, Mohammad Younas, Benqiao He
Summary: A novel pH-responsive NF membrane was synthesized via interfacial polymerization with a mixture of piperazine and chitosan as the aqueous phase and trimesoyl chloride in n-hexane as the organic phase. This NF membrane exhibited excellent separation performance at pH 12 and could be adjusted for different applications by changing the pH values.
JOURNAL OF MEMBRANE SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Fariha Chowdhury, Sakiba Ahmed, Muntasir Rahman, Md Alomgir Ahmed, Md Delower Hossain, Hasan Mahmud Reza, Sung Young Park, Shazid Md Sharker
Summary: Natural or synthetic polymeric films have gained interest in biomedical research due to their biocompatibility. A nanocomposite film using the chitosan-tannic acid (CT) crosslinking process has been developed, showing antibacterial activity and pH-responsive drug release both in vitro and in vivo.
MATERIALS TODAY COMMUNICATIONS
(2022)
Review
Biotechnology & Applied Microbiology
Hamidreza Garshasbi, Saba Salehi, Seyed Morteza Naghib, Sadegh Ghorbanzadeh, Wei Zhang
Summary: Injectable hydrogels have gained significant attention in the past decade for their functional properties in drug delivery, particularly in precise, non-invasive, and targeted tissue locations. The development of drug delivery systems that are responsive to hydrogel stimuli to release drugs under various external stimuli is a challenging task. Chitosan-based hydrogels, known for their biocompatibility, mucosal adhesion, and hemostatic activity, hold great potential for tissue engineering and drug delivery. However, managing the structure of stimuli-responsive chitosan hydrogels or incorporating additional crosslinking agents, such as those with dual pH and thermo-responsiveness, can be difficult. Therefore, it is crucial to create these hydrogels for medicinal applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Applied
Hessam Jafari, Gholam Reza Mahdavinia, Bagher Kazemi, Hermann Ehrlich, Yvonne Joseph, Mehdi Rahimi-Nasrabadi
Summary: This study developed novel smart drug delivery systems using magnetic hydroxypropyl methylcellulose and chitosan to create core-shell nano-carriers with high loading capacity and pH-sensitive drug release properties.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Shuangshuang Zhao, Ruoyu Jia, Jie Yang, Lei Dai, Na Ji, Liu Xiong, Qingjie Sun
Summary: The study developed a new type of intelligent and multifunctional bilayer films using natural biopolymers, which can act as pH-responsive actuators and preserve fruits. The bilayer films showed improved physical and antimicrobial properties compared to single-layer films. They also demonstrated excellent pH-responsive behavior and prolonged the storage time of bananas.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Min Mu, Xiaoyan Liang, Di Chuan, Shasha Zhao, Wei Yu, Rangrang Fan, Aiping Tong, Na Zhao, Bo Han, Gang Guo
Summary: The study successfully constructed a Cabazitaxel@MPN/CS delivery system, with good drug release and cellular internalization effects in melanoma therapy, providing a promising strategy for cancer treatment.
CARBOHYDRATE POLYMERS
(2021)
Article
Polymer Science
Suyoung Lee, Dong Soo Hwang
Summary: By comparing the interaction energies of chitosan-catechol and chitosan-pyrogallol, this study reveals the impact of phenolic moieties on chitosan adhesives. The phenolic moieties can decrease the rigidity of the chitosan chain and increase solubility, thereby enhancing adhesion and cohesion.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Kun-Ying Lu, Pei-Ru Jheng, Long-Sheng Lu, Lekshmi Rethi, Fwu-Long Mi, Er-Yuan Chuang
Summary: A bioinspired nanoplatform was developed for enhanced cancer cell/tumor specific accumulation and oxidative stress levels, showing potent photothermal therapeutic effects. Additionally, the platform may suppress tumor vascular endothelial growth factor expression, indicating promising potential for future medical translation in tumor eradication.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Biomaterials
Tzu-Wen Huang, Hsien-Tsung Lu, Yi-Cheng Ho, Kun-Ying Lu, Pan Wang, Fwu-Long Mi
Summary: This study successfully developed smart, stimuli responsive self-assembled multilayer and complex film by reducing the hydrophilicity of HPMC and enhancing mechanical strength, free radical scavenging capability, and water vapor and light barrier properties. The complex film can control EGCG release by tuning pH or temperature and trigger EGCG release in an on-demand fashion under near-infrared exposure.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Review
Engineering, Biomedical
Chiranjeevi Korupalli, Hui Li, Nhien Nguyen, Fwu-Long Mi, Yen Chang, Yu-Jung Lin, Hsing-Wen Sung
Summary: The use of conductive materials to promote the activity of electrically responsive cells is an effective means of accelerating wound healing. Recent advancements in conductive materials, particularly in their incorporation with non-conducting polymers to fabricate electroactive wound dressings, have been deliberated for their potential in monitoring the course of wound healing in vivo while simultaneously accelerating the healing process.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Lee-Hsin Chang, Er-Yuan Chuang, Tsai-Mu Cheng, Chi Lin, Chun-Ming Shih, Alexander T. H. Wu, Pei-Ru Jheng, Hsin-Ying Lu, Chun-Che Shih, Fwu-Long Mi
Summary: A novel photothermal theranostic nanocomposite for thrombus-targeted delivery of urokinase and near-infrared fluorescence contrast agent indocyanine green (ICG) was developed, showing potential for precise thrombus imaging and enzyme/hyperthermia combined thrombolytic therapy. The nanocomposite has multiple functions including thrombus targeting, imaging, and photothermal thrombolysis, making it an advanced platform for targeted thrombolytic therapy.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Yang-Bao Miao, Kuan-Hung Chen, Chiung-Tong Chen, Fwu-Long Mi, Yu-Jung Lin, Yen Chang, Chi-Shiun Chiang, Jui-To Wang, Kun-Ju Lin, Hsing-Wen Sung
Summary: An oral prodrug delivery system has been developed to target gliomas by overcoming the intestinal epithelial barrier and the blood-brain barrier. The prodrug specifically targets intestinal M cells, crosses the barriers, and releases the active drug at the tumor site for improved therapeutic efficacy.
ADVANCED MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Stephen Wan Leung, Po-Ching Cheng, Chih-Ming Chou, Chi Lin, Yu-Chieh Kuo, Yu-Lin Amy Lee, Cheng-Yang Liu, Fwu-Long Mi, Chia-Hsiung Cheng
Summary: This study demonstrated that low-molecular-weight chitosan could be utilized for gene delivery into zebrafish larvae, enhancing ISG expression, with potential implications for aquaculture applications. The delivery efficiency of LMWCSrNPs was highest at a weight ratio of 20:8:1.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Hsien-Tsung Lu, Guan-Yu Huang, Wong-Jin Chang, Tzu-Wei Lu, Tzu-Wen Huang, Ming-Hua Ho, Fwu-Long Mi
Summary: In this study, chitosan electrospun nanofiber membranes were modified with fucoidan and CuS nanoparticles, enhancing acid resistance and reducing swelling rate. The composite material exhibited durable Fenton-like catalytic activity and was effective in killing bacteria through photothermal and photocatalytic effects. Additionally, the release of fucoidan and copper ions promoted the activity of osteoblast cells and capillary tube formation of endothelial cells.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Environmental
Guan-Yu Huang, Wong-Jin Chang, Tzu-Wei Lu, I-Lin Tsai, Shao-Jung Wu, Ming-Hua Ho, Fwu-Long Mi
Summary: The study developed CuS NPs/chitosan nanofiber composites with photo-Fenton catalytic and photothermal activities for enhanced removal of recalcitrant biomedical pollutants. The complementary performances between adsorption of pollutants by chitosan nanofibers and Fenton-like reaction of pollutants with CuS NPs were investigated, showing potential for chemical engineering, biomedical, and environmental applications.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Putry Yosefa Siboro, Van Khanh Thi Nguyen, Yang-Bao Miao, Amit Kumar Sharma, Fwu-Long Mi, Hsin-Lung Chen, Kuan-Hung Chen, Yu-Tzu Yu, Yen Chang, Hsing-Wen Sung
Summary: In this study, a zinc-based zeolitic imidazolate framework as a nanoreactor system was prepared for the localized synthesis of an antitumor drug. Ultrasonic irradiation was used to promote the penetration of the drug into the tumor tissue, effectively inhibiting tumor development. The tumor-specific in situ synthesis method demonstrated good biocompatibility and minimal in vivo toxicity.
Article
Polymer Science
Chi Lin, Fang-Yu Hsu, Wei-Ting Lin, Chia-Yun Cha, Yi-Cheng Ho, Fwu-Long Mi
Summary: In this study, bioactive polysaccharides from Ophiopogon japonicus were combined with chitosan and casein hydrolysate to prepare biodegradable nanoparticles for oral delivery. The nanoparticles demonstrated pH-dependent properties and were easily internalized by macrophages, enhancing the anti-inflammatory effects of the polysaccharides.
Article
Chemistry, Physical
Nhien Nguyen, Zong-Hong Lin, Snigdha Roy Barman, Chiranjeevi Korupalli, Ji-Yen Cheng, Ni-Xuan Song, Yen Chang, Fwu-Long Mi, Hsiang-Lin Song, Hsing-Wen Sung, Yu-Jung Lin
Summary: This study developed an engineered electroactive dressing that promotes wound healing and monitors the progress in real-time. The dressing transmits bioelectrical signals to stimulate cells and accelerate tissue restoration, while an electrode detects electrical resistance or output current to monitor the overall healing process. The system can be connected to a smartphone for wireless data transmission to medical staff and provide early warnings of potential infections.
Article
Biochemistry & Molecular Biology
Xin-Yu Wang, Chi Lin, Wong-Jin Chang, Yen-Hua Huang, Fwu-Long Mi
Summary: The synthesis of a novel nanocomposite consisting of thiolated hyaluronic acid (THA), catalase (CAT), and chlorin e6 (Ce6)-adsorbed small gold nanorods (Ce6@sAuNRs) is reported. This nanocomposite exhibits efficient photothermal and photodynamic effects activated by near-infrared/visible light. The internalization of the nanocomposite into multidrug-resistant (MDR) breast cancer cells increases the intracellular accumulation of the photosensitizer Ce6, while the self-supporting oxygen production of CAT enhances the photodynamic effect against hypoxic breast cancer cells. This study demonstrates the potential of this multi-functional nanoplatform for the treatment of hypoxic MDR breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Cheng-Yu Wang, Chih-Ming Chou, Cheng-Ying Chu, Amy Chen, En-Hsin Liu, Cheng-Yang Liu, Yu-Lin Amy Lee, Fwu-Long Mi, Chia-Hsiung Cheng
Summary: In this study, low-molecular-weight chitosan (LMWCS) was used to release reporter proteins in zebrafish, providing potential for detection. A simple fluorometric-based assay using LMWCS and transgenic zebrafish was developed to evaluate clinical antiangiogenic drugs. Treatment with the antiangiogenic drug sorafenib significantly reduced angiogenesis in zebrafish, as indicated by the LMWCS fluorometric-based assay. Evaluation of other clinical drugs also showed a significant reduction in angiogenesis. Overall, this study demonstrated the utility of the LMWCS fluorometric-based assay for evaluating angiogenic drugs in zebrafish.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Han-Lun Huang, I-Lin Tsai, Chi Lin, Yu-Hao Hang, Yi-Cheng Ho, Min-Lang Tsai, Fwu-Long Mi
Summary: In this study, biodegradable packaging films inspired by metalloanthocyanins were developed by combining purple cauliflower extracted anthocyanins with alginate and carboxymethyl chitosan. The addition of fucoidan further enhanced the properties of the films. These metal ion/polysaccharide-involved complex films showed improved mechanical strength, water vapor permeability, antibacterial activity, storage stability, and antioxidant capability, making them potential active and intelligent packaging materials for food products.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Hsien-Tsung Lu, Chi Lin, Yi-Ju Wang, Fang-Yu Hsu, Ju-Ting Hsu, Min-Lang Tsai, Fwu-Long Mi
Summary: In this study, a simple and easy method was developed to form deacetylated B-chitin (DAC-B-chitin) gels at room temperature. The DAC-B-chitin scaffolds were functionalized with a BMP-2-binding sulfate polysaccharide, fucoidan (FD). The FD-functionalized DAC-B-chitin scaffolds showed higher BMP-2 loading capacity and more sustainable release, resulting in better osteogenic activity for bone regeneration.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
