Article
Biochemistry & Molecular Biology
Rong Chang, Donghui Zhao, Chen Zhang, Kaiyue Liu, Yuanmeng He, Fangxia Guan, Minghao Yao
Summary: Nanocomposite hydrogels show promise in the postoperative treatment of melanoma and wound healing. They have excellent photothermal effect and antibacterial activity, which can effectively prevent tumor recurrence and promote wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Multidisciplinary
Di Chuan, Huan Hou, Yuelong Wang, Min Mu, Jinglun Li, Yangmei Ren, Na Zhao, Bo Han, Haifeng Chen, Gang Guo
Summary: Due to the hypoxic state of the tumor microenvironment (TME), photodynamic therapy (PDT) suffers from insufficient ROS production. The metal-polyphenol network-mediated Fenton reaction can generate reactive oxygen species (ROS) by consuming H2O2 in TME, improving the inadequate ROS generation problem of PDT. Therefore, synergistic therapy combining PDT and Fenton response-based CDT is a promising approach for cancer treatment.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kai Jiang, Xuesong Zhou, Tong He
Summary: The composite hydrogels composed of partially oxidated bacterial cellulose and chitosan showed good mechanical properties and pH responsive performance, making them potential drug carriers for clinical therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Xiaomin Zhao, Yunfei Zhang, Li Chen, Zhiqing Ma, Bin Zhang
Summary: This study developed a pH-responsive chitosan-thymol nanoparticle for controlling Botrytis cinerea. The nanoparticle showed excellent antifungal activity and higher protective and curative efficacies compared to unencapsulated thymol.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Meng Xu, Haidong Zha, Run Han, Yaxin Cheng, Jiamao Chen, Ludan Yue, Ruibing Wang, Ying Zheng
Summary: In this study, pH-sensitive nanoparticles were used to deliver dihydroartemisinin (DHA) for tumor therapy in multiple ways. The nanoparticles generate lethal oxidants in the tumor microenvironment and induce cancer cell death through ferroptosis. This strategy differs from traditional approaches and exhibits efficient anticancer efficacy.
Article
Chemistry, Applied
Xinyu Meng, Huan Liu, Xinyu Dong, Qiqi Wang, Yongmei Xia, Xueyi Hu
Summary: Polymeric Pickering emulsifiers, such as chitosan-casein hydrophobic peptides nanoparticles (CSCHP NPs), prepared with a non-covalent anti-solvent procedure, exhibit unique emulsifying behaviors and mechanisms. These soft emulsifiers have antioxidant, antibacterial activities, excellent biocompatibility, and efficient encapsulation properties, making them promising candidates for drug delivery in various industries.
CARBOHYDRATE POLYMERS
(2022)
Review
Nanoscience & Nanotechnology
Xuesong Ren, Qi Jiang, Yali Zeng, Lin Wang
Summary: Melanoma is a deadly form of skin cancer that is highly resistant to conventional treatments. Researchers have developed new treatment strategies using polymeric nanoparticles, particularly chitosan-based nanoparticles, to overcome the challenges in melanoma therapy.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Engineering, Environmental
Douxin Xiao, Jingli Cheng, Wenlong Liang, Lianli Sun, Jinhao Zhao
Summary: The pH-responsive delivery system PC@TA/Cu prepared in the study showed effective pesticide release in acidic environments, good control effect against Sclerotinia disease, and significantly reduced toxicity to non-target organisms.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Himabindu Battula, Moromi Nath, Sabyashachi Mishra, Subbalakshmi Jayanty
Summary: This study reports a novel multifunctional active molecular material (RHBIT) that perceives both emission color change and switching between off-on states by linking rhodamine B with 3-amino,5-nitro[2,1]benzoisothiazole (ANB) in a facile synthetic pathway. RHBIT shows acidochromism, photochromism, and pH sensitivity accompanied by unique ethanol responsiveness, with potential applications in anti-counterfeiting and drug delivery.
Review
Biochemistry & Molecular Biology
Parisa Maleki Dana, Jamal Hallajzadeh, Zatollah Asemi, Mohammad Ali Mansournia, Bahman Yousefi
Summary: Melanoma, a less common type of skin cancer, has the highest mortality rate. Although there have been advances in melanoma treatment, it still faces challenges such as systemic toxicity, water insolubility, and inadequate cellular penetration. Chitosan-based delivery platforms have shown significant success in overcoming these challenges.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yihao Wang, Shengkui Yi, Rui Lu, Dur E. Sameen, Saeed Ahmed, Jianwu Dai, Wen Qin, Suqing Li, Yaowen Liu
Summary: In this study, chitosan/halloysite nanotubes/tea polyphenol (CS/HNTs/TP) nanocomposite films were prepared and characterized. The optimal C6H4-TP10 film showed improved water vapor barrier property, decreased swelling degree and water solubility, and exhibited good antioxidant and antibacterial capacities. The study demonstrates a simple approach to construct promising natural antioxidants and antibacterial food packaging.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Duo Kang, Wenhai Wang, Yanmei Li, Yi Ma, Yadong Huang, Jufang Wang
Summary: In this study, a multifunctional biological macromolecule hydrogel was developed to accelerate full-thickness healing of skin wounds. The hydrogel exhibited sufficient mechanical strength, fatigue resistance, and various healing properties. It was constructed with multiple crosslinking networks to enhance its suitability for clinical applications. Additionally, the hydrogel demonstrated potent antibacterial and vascularization capabilities. Animal experiments confirmed that this biological macromolecule hydrogel has great potential as an acute wound-healing dressing.
Article
Materials Science, Multidisciplinary
Bagher Kazemi Heragh, Hakimeh Taherinezhad, Gholam Reza Mahdavinia, Shahrzad Javanshir, Parisa Labib, Sara Ghasemsolb
Summary: Combining natural antioxidants with synthetic anticancer agents is a helpful approach in chemotherapy. This study designed cross-linked chitosan/laponite RD nanoparticles for co-encapsulation of doxorubicin and saffron extract. The nanocarriers showed pH-responsive release behavior and exhibited high cytotoxicity against cancer cells and antibacterial activity.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Weiling Song, Huan Yang, Yujie Sun, Yuanming Yang, Qi Dong, Peng He, Gengjun Liu, Zhen Zhao, Lifeng Qin, Shunxiang Gao, Jing Liu, Hong Zhou, Haiyan Wang
Summary: This study developed a multifunctional nanocomposite for synergistic tumor therapy, combining chemodynamic therapy, chemotherapy, and photothermal therapy. In vitro and in vivo experiments demonstrated its ability to inhibit tumor growth.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Junliang Dong, Ke Ma, Yuxin Pei, Zhichao Pei
Summary: A novel core-shell metal organic framework (MOF), Cu-MOF@SMON/DOX-HA, was developed for combined chemo-chemodynamic therapy with high drug-loading capacity, pH/GSH dual-responsiveness, and good biocompatibility.
CHEMICAL COMMUNICATIONS
(2022)
Review
Chemistry, Applied
Xiaoyan Liang, Min Mu, Rangrang Fan, Bingwen Zou, Gang Guo
Summary: Chitosan, with its biodegradable, biocompatible, nonimmunogenic and nontoxic properties, has shown great potential as a delivery material in cancer immunotherapy, improving drug effectiveness and offering broad application prospects.
CARBOHYDRATE POLYMERS
(2022)
Article
Oncology
Shasha Zhao, Yuelong Wang, Nian Yang, Min Mu, Zhiguo Wu, Hexian Li, Xin Tang, Kunhong Zhong, Zongliang Zhang, Cheng Huang, Ting Cao, Meijun Zheng, Guoqing Wang, Chunlai Nie, Hui Yang, Gang Guo, Liangxue Zhou, Xi Zheng, Aiping Tong
Summary: This study identified the crucial role of transcription factor SP20H in regulating B7-H3 expression and tumor progression, suggesting its potential as a target for improving anti-B7-H3 therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Min Mu, Xiaoyan Liang, Na Zhao, Di Chuan, Bo Chen, Shasha Zhao, Guoqing Wang, Rangrang Fan, Bingwen Zou, Bo Han, Gang Guo
Summary: A supramolecular nanoreactor (DOC@TA-Fe3+) based on tannic acid (TA), iron ion (Fe3+), and docetaxel (DOC) was developed for ferroptosis/apoptosis treatment in colorectal cancer, with microtubule inhibition, reactive oxygen species (ROS) generation, and glutathione peroxidase 4 (GPX4) inhibition.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Engineering, Biomedical
Rangrang Fan, Caili Chen, Junshan Hu, Min Mu, Di Chuan, Zhouyun Chen, Gang Guo, Jianguo Xu
Summary: A multifunctional gold nanorod-based nanosystem was developed in this study by attaching siRNA against B7-H3, glucose oxidase (GOx), and hyaluronic acid (HA), which enables efficient low-temperature photothermal therapy. The nanoplatform can induce tumor ablation without damage to healthy tissues by exhaust glucose to induce starvation therapy and reduce HSP. It also promotes treatment effectiveness by downregulating B7-H3 with siRNA.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Multidisciplinary
Bo Chen, Linrui Cai, Rangrang Fan, Min Mu, Di Chuan, Yangmei Ren, Haifeng Chen, Gang Guo
Summary: This study introduces a novel nanoplatform (CBDM) for cancer therapy that can ameliorate tumor hypoxia and promote oxygen production, thus enhancing the therapeutic effect of photodynamic therapy.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Cheng Huang, Xing Duan, Jichao Wang, Qingqing Tian, Yangmei Ren, Kepan Chen, Zongliang Zhang, Yuanyou Li, Yunyu Feng, Kunhong Zhong, Yuelong Wang, Liangxue Zhou, Gang Guo, Xiangrong Song, Aiping Tong
Summary: The study developed a treatment strategy based on mRNA expression, utilizing LNPs to achieve high transfection efficiency and a potent antitumor effect.
Article
Pharmacology & Pharmacy
Bo Chena, Lan Mei, Rangrang Fan, Di Chuan, Yangmei Ren, Min Mua, Haifeng Chen, Bingwen Zou, Gang Guo
Summary: The combination of photothermal therapy with chemotherapy using a nanoplatform based on polydopamine-coated gold nanoparticles has shown promising potential in cancer treatment. The nanoplatform exhibited enhanced photothermal conversion efficiency and colloidal stability. By assembling an i-motif DNA nanostructure on the nanoplatform, pH-responsive characteristics were achieved. The addition of a targeting ligand, AS1411 aptamer, enhanced specific cellular uptake. The nanoplatform also showed excellent photothermal performance and efficient cancer cell inhibition under near-infrared irradiation. Overall, this nanoplatform has great potential in synergistic photothermal-chemotherapy.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Xiaoyan Liang, Min Mu, Bo Chen, Di Chuan, Na Zhao, Rangrang Fan, Xin Tang, Haifeng Chen, Bo Han, Gang Guo
Summary: Colorectal cancer is one of the most common and deadliest cancers globally. In this study, a metal polyphenol network based on EGCG was used for the co-delivery of targeted photosensitizers to achieve comprehensive treatment for colorectal cancer.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Rangrang Fan, Caili Chen, Min Mu, Di Chuan, Hao Liu, Huan Hou, Jianhan Huang, Aiping Tong, Gang Guo, Jianguo Xu
Summary: Recombinant anti-B7-H3xCD3 bispecific antibodies (biAbs) were prepared and MMP-2-sensitive S-biAb/dEGCG@NPs were constructed for efficient and systemic glioblastoma (GBM) elimination. S-biAb/dEGCG@NPs showed enhanced intracranial accumulation compared to biAb/dEGCG@NPs, biAb/dEGCG complexes, and free biAbs. Furthermore, S-biAb/dEGCG@NPs induced GBM elimination by boosting the ferroptosis effect and enhancing immune checkpoint blockade (ICB) immunotherapy, making them promising antibody nanocarriers for enhanced cancer therapy.
Review
Biochemistry & Molecular Biology
Chenqian Feng, Bo Chen, Rangrang Fan, Bingwen Zou, Bo Han, Gang Guo
Summary: With the advancement of cancer treatment and precision medicine, there is a growing demand for advanced and versatile drug delivery systems. Polyphenols, which can act as both active ingredients and building blocks, are being explored as potential multifunctional carriers for efficient and safe cancer therapy. This review discusses the recent advances in the design, synthesis, and application of polyphenol-based nanosystems and highlights the challenges and optimization needed for their clinical translation.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Polymer Science
Youping Li, Gaixia Liu, Mengting Wang, Yuling Zhang, Shiwan You, Jing Zhang, Gang Guo, Bo Han, Le Li, Na Zhao
Summary: In this study, a thermosensitive hydrogel (PPH hydrogel) was developed using poloxamer 407, poloxamer 188, and hydroxypropyl methylcellulose. The hydrogel loaded with tannic acid and mitomycin C showed excellent controlled drug release and anti-adhesive effects, making it a potential solution for preventing postoperative abdominal adhesion.
Review
Biotechnology & Applied Microbiology
Hui Li, Rangrang Fan, Bingwen Zou, Jiazhen Yan, Qiwu Shi, Gang Guo
Summary: With the rapid advancement of nanomedical technology, novel nanomaterials known as MXenes have gained significant attention in the field of biomedicine. MXenes, featuring ultrathin atomic thickness and high specific surface area, have shown great promise in various biomedical applications, including biosensors, diagnosis, therapy, antibacterial agents, implants, wearable devices, and immunotherapy. This review comprehensively summarizes the synthesis methods, surface modification strategies, and research progress of MXene-based materials, while also addressing the challenges associated with their clinical translation in biomedical applications.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Di Chuan, Huan Hou, Yuelong Wang, Min Mu, Jinglun Li, Yangmei Ren, Na Zhao, Bo Han, Haifeng Chen, Gang Guo
Summary: Due to the hypoxic state of the tumor microenvironment (TME), photodynamic therapy (PDT) suffers from insufficient ROS production. The metal-polyphenol network-mediated Fenton reaction can generate reactive oxygen species (ROS) by consuming H2O2 in TME, improving the inadequate ROS generation problem of PDT. Therefore, synergistic therapy combining PDT and Fenton response-based CDT is a promising approach for cancer treatment.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yangmei Ren, Lan Mei, Cheng Huang, Rangrang Fan, Bo Chen, Aiping Tong, Chao Wang, Haifeng Chen, Gang Guo
Summary: The researchers synthesized a photosensitive material based on nano-crystalline cellulose and further obtained stereocomplex crystallite (SC)-based micelle with folic acid for improved type I PDT. The SC-based micelle co-delivering DOX and MTH1 inhibitor could enhance ROS-induced oxidative stress injury and disrupt the ROS defense system of tumor tissues. The designed system combining PDT and chemotherapy displays an enhanced cell apoptosis process, inhibiting or eliminating tumors without toxic side effects.
ACS MATERIALS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Yunyun Qi, Jinxiang Yang, Yaping Chi, Peng Wen, Zhongying Wang, Shiyi Yu, Rui Xue, Jingmin Fan, Hong Li, Wen Chen, Xinjun Wang, Yan Zhang, Gang Guo, Bo Han
Summary: Periodontitis is a common chronic inflammatory disease. Polyphenols from Turkish gall have significant antibacterial, anti-inflammatory, and antioxidant activities. This study developed a simple method to prepare nanoparticles encapsulated in a hydrogel for sustained release of effective constituents, demonstrating strong antibacterial activity against oral pathogens.
MOLECULAR BIOMEDICINE
(2022)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
