Article
Materials Science, Multidisciplinary
Lei Chen, Yufei Tang, Kang Zhao, Xiaojiao Yu, Binghua Yao, Xianghui Li, Xiang Zha, Bo Zhang, Quanchang Tan, Zhao Yang, Zixiang Wu
Summary: In this study, drug-loaded nanoparticles with anti-osteoporosis function were synthesized and introduced into PMMA bone cement. The water absorption pathways in the cement were constructed by adjusting the particle size of the nanoparticles, allowing for sustained release of the drugs. The results showed high cumulative release ratios of the drugs and extended release cycles, effectively preventing infection and matching bone healing cycle.
MATERIALS & DESIGN
(2022)
Article
Polymer Science
Sofia Treccani, Jenny Alongi, Amedea Manfredi, Paolo Ferruti, Roberta Cavalli, Giuseppina Raffaini, Elisabetta Ranucci
Summary: The aza-Michael polyaddition of L-arginine and N,N'-methylene-bis-acrylamide yields the biocompatible and easily cell-internalized polyamidoamine ARGO7. Encapsulation of curcumin using ARGO7 precursors can significantly enhance solubility, stability, and controlled release of the drug, with release rate depending on pH values.
Article
Biochemistry & Molecular Biology
Nagi M. El-Shafai, Mamdouh S. Masoud, Mohamed M. Ibrahim, Mohamed S. Ramadan, Gaber A. M. Mersal, Ibrahim M. El-Mehasseb
Summary: This study focuses on improving the loading and release efficiency of sofosbuvir drug (SOF) for anti-hepatitis C virus (HCV) by combining it with beta-cyclodextrin (beta CD) basket to form a novel self-assembly beta CD-SOF. The drug is then loaded onto chitosan nanoparticles (Cs NPs) to create a hybrid composite named Cs@beta CD-SOF. Through various characterization methods, it is confirmed that Cs@beta CD-SOF has a loading efficiency of 94.54% and exhibits high release efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Multidisciplinary
Roberto Vittorio Pivato, Filippo Rossi, Monica Ferro, Franca Castiglione, Francesco Trotta, Andrea Mele
Summary: Cyclodextrin nanosponges (CDNS) are 3D nanoporous polymers formed by reacting beta-cyclodextrin with suitable bifunctional cross-linkers, which can be used as biomaterials for controlled drug delivery due to their nontoxicity, biocompatibility, and biodegradability. The release kinetics of a drug carrier in CDNS hydrogels are influenced by the nanoarchitectonics of the hydrogel and the interactions between drug and polymer across the 3D network.
ACS APPLIED POLYMER MATERIALS
(2021)
Review
Medicine, Research & Experimental
Melika Hosseini, Mahnaz Amiri, Mojgan Ghanbari, Makarim A. Mahdi, Waleed K. Abdulsahib, Masoud Salavati-Niasari
Summary: Medicine/nanotechnology is gaining great attention as a new and applicable technique for cancer treatment through drug delivery systems. Polysaccharides, such as cellulose, beta-cyclodextrin, sodium carboxymethyl cellulose, and chitosan, are natural bio-materials that are suitable for designing and formulating nanosystems due to their exceptional advantages. An intelligent drug delivery platform based on these hybrids has been developed for dual-responsive dual-drug delivery. The combination of nanotechnology and biological molecules has been actively explored to overcome the limitations of conventional cancer treatments. This review discusses and investigates the latest developments in the field of biomedical therapeutics and cancer therapy using hybrid platforms of anticancer drugs/nanoparticles/Polysaccharides, highlighting their biocompatibility, large surface area, and promising future prospects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Samaneh Tayebi-Moghaddam, Razieh Khatibi, Sevil Taklavi, Mona Hosseini-Isfahani, Hassan Rezaeinia
Summary: In this study, the sustained-release of clove essential oil (CEO) loaded into electrospun nanofibers of zein was used as a biopreservative to extend the shelf life of Iranian white cheese. Different loading levels of CEO affected the fiber structure and mechanical properties, while the gentle release of CEO effectively suppressed bacterial growth in the cheese.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mostafa R. Abukhadra, Alyaa Adlii, Jong Seong Khim, Jamaan S. Ajarem, Ahmed A. Allam
Summary: The study demonstrated that the CaO(NP)/Clino composite as a carrier for the 5-FL drug has high loading capacity and release properties, showing significant cytotoxic effects on colon cancer cells. Additionally, the composite material exhibits safe and biocompatible effects on normal colon cells.
Article
Physics, Applied
Andressa Novatski, Mauricio Ap. Ribeiro, Alexandre Camilo Jr, Ervin Kaminski Lenzi, Amanda M. Urban, Amanda Schoeffel, Vanessa M. Urban, Karin H. Neppelenbroek, Carlos Jacinto, Francielle Sato, Nelson G. C. Astrath, Loanda A. C. Rudnik, Carla C. Kanunfre, Jessica Mendes Nadal, Paulo V. Farago
Summary: Freeze- and spray-dried inclusion complexes (ICs) of chlorhexidine (CHX) in beta-cyclodextrin were characterized using Fourier transform (FT)-Raman, 1H nuclear magnetic resonance (NMR), and photoacoustic spectroscopy. The drying method influenced the conformational adjustment of CHX:beta-cyclodextrin, with freeze-drying providing a better inclusion. Freeze-dried ICs showed faster dissolution patterns and provided immediate drug dissolution profiles in an aqueous medium better than pure CHX.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Polymer Science
Muhammad Suhail, Yu-Fang Shao, Quoc Lam Vu, Pao-Chu Wu
Summary: pH-sensitive hydrogels were prepared for targeted drug delivery to the colon. The hydrogels showed high thermal stability, swelling capacity, and drug release in both acidic and basic environments.
Article
Chemistry, Physical
Weiwei Zhu, Jiajie Long, Meiwu Shi
Summary: This study investigated the release kinetics of drug-loaded viscose fabrics using supercritical CO2 fluid. The best-fitting model for all the drugs was the Korsmeyer-Peppas model. It was found that viscose fabric swells and has slower release rate when a drug with a higher solubility parameter is loaded onto it using supercritical CO2 fluid.
Article
Mechanics
Jun Li, Chunpei Cai, Zhi-Hui Li
Summary: The Knudsen diffusion model is accurate for long nanotubes with completely diffusive reflections, but invalid for smooth nanotubes with partly specular reflections, leading to discrepancies between measurement and theory. The implementation of Fick's first law can lead to inaccurate predictions and interpretations of gas diffusion through nanotubes, which can be avoided by using the molecular transmission probability obtained by the kinetic theory.
Article
Polymer Science
Ayesha Siddiqua, Nazar Muhammad Ranjha, Sadia Rehman, Hina Shoukat, Nasreen Ramzan, Humaira Sultana
Summary: By manufacturing a pH-sensitive and biocompatible interpenetrating polymer network device, the targeting and absorption enhancement of BCS III drugs in the colon can be achieved. The porosity and gel fraction of the hydrogel were related to the content of pectin and acrylamide, and the drug release mechanism was mainly Fickian diffusion.
Article
Chemistry, Multidisciplinary
Ashok Kumar Jangid, Raghu Solanki, Sunita Patel, Kanakaraju Medicherla, Deep Pooja, Hitesh Kulhari
Summary: In this study, poly(ethylene) glycol (PEG4000) conjugated chrysin nanoparticles were prepared to achieve tumor microenvironment-specific drug release. The conjugated nanoparticles showed better drug release profile and higher anticancer activity against human breast cancer cells.
Article
Polymer Science
Betul Ari, Sahin Demirci, Ramesh S. Ayyala, Bekir Salih, Nurettin Sahiner
Summary: One-step, simple preparation of superporous p(beta-cyclodextrin) (p(beta-CD)) cryogels under cryogenic conditions was reported for the first time. The prepared cryogels exhibited excellent swelling properties and showed potential as drug delivery systems for both hydrophilic and hydrophobic drugs.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Physical
Shan Du, Yunhang Wei, Yuhao Tan, Yong Li, Jingliang Li, Ting Wu, Lu Han, Ming Wang, Shaharia Ahmed, Weitao Zhou, Linqian Wu, Tianhui Zhang
Summary: Silk fibroin from Antheraea pernyi (A. pernyi), rich in Arg-Gly-Asp (RGD) moiety, can self-assemble into mesoporous particles without organic solvents, showing potential for sustained drug release.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Engineering, Chemical
Asghar Bakravi, Yashar Ahamadian, Hamed Hashemi, Hassan Namazi
ADVANCES IN POLYMER TECHNOLOGY
(2018)
Article
Materials Science, Multidisciplinary
Hamed Hashemi, Hassan Namazi
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2018)
Article
Chemistry, Applied
Siamak Javanbakht, Naser Nazari, Rasul Rakhshaei, Hassan Namazi
CARBOHYDRATE POLYMERS
(2018)
Article
Electrochemistry
Amin Goljanian Tabrizi, Nasser Arsalani, Abdolkhaled Mohammadi, Laleh Saleh Ghadimi, Iraj Ahadzadeh, Hassan Namazi
ELECTROCHIMICA ACTA
(2018)
Article
Biochemistry & Molecular Biology
Monireh Rasoulzadehzali, Hassan Namazi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Environmental Sciences
N. Alipour, H. Namazi
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2019)
Article
Materials Science, Multidisciplinary
Alireza Banaei, Mojtaba Farokhi Yaychi, Soheyla Karimi, Hossein Vojoudi, Hassan Namazi, Alireza Badiei, Eslam Pourbasheer
MATERIALS CHEMISTRY AND PHYSICS
(2018)
Article
Materials Science, Biomaterials
Siamak Javanbakht, Hassan Namazi
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2018)
Article
Acoustics
Hamed Hashemi, Hassan Namazi
ULTRASONICS SONOCHEMISTRY
(2018)
Article
Biophysics
Malihe Pooresmaeil, Hassan Namazi
COLLOIDS AND SURFACES B-BIOINTERFACES
(2018)
Article
Biochemistry & Molecular Biology
Siamak Javanbakht, Malihe Pooresmaeil, Hamed Hashemi, Hassan Namazi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
Article
Polymer Science
Yashar Ahmadian, Asghar Bakravi, Hamed Hashemi, Hassan Namazi
Article
Pharmacology & Pharmacy
Hamed Hashemi, Hassan Namazi
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2018)
Article
Pharmacology & Pharmacy
Hassan Namazi, Elnaz Abdollahzadeh
Article
Chemistry, Applied
Rahim Ghadari, Hassan Namazi, Mohammad Aghazadeh
APPLIED ORGANOMETALLIC CHEMISTRY
(2018)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
