Positive feedback loop and synergistic effects between hypoxia-inducible factor-2α and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma

SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids

(2012) Paul Mason et al.   PLoS One

Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element

(2011) J Xu et al.   ONCOGENE

Role of VHL gene mutation in human renal cell carcinoma

(2011) Wani Arjumand et al.   TUMOR BIOLOGY

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

Feedback regulators of hypoxia-inducible factors and their role in cancer biology

(2010) Anne-Theres Henze et al.   CELL CYCLE

The fatty acid desaturation index of blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase expression, is a predictive factor of breast cancer risk

(2010) Véronique Chajès et al.   CURRENT OPINION IN LIPIDOLOGY

Abrogation of De novo Lipogenesis by Stearoyl-CoA Desaturase 1 Inhibition Interferes with Oncogenic Signaling and Blocks Prostate Cancer Progression in Mice

(2010) V. Fritz et al.   MOLECULAR CANCER THERAPEUTICS

Hypoxia-Inducible Factors and the Response to Hypoxic Stress

(2010) Amar J. Majmundar et al.   MOLECULAR CELL

Inhibition of StearoylCoA Desaturase Activity Blocks Cell Cycle Progression and Induces Programmed Cell Death in Lung Cancer Cells

(2010) Daniel Hess et al.   PLoS One

Inhibition of Stearoyl-CoA Desaturase 1 Expression Induces CHOP-Dependent Cell Death in Human Cancer Cells

(2010) Mélaine Minville-Walz et al.   PLoS One

Effects of HIF-1 and HIF2 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

(2010) Swethajit Biswas et al.   Journal of Oncology

Hypoxic transcription gene profiles under the modulation of nitric oxide in nuclear run on-microarray and proteomics

(2009) Emeka I Igwe et al.   BMC GENOMICS

Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy

(2009) Jaya Krishnan et al.   Cell Metabolism

Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism

(2009) E. B. Rankin et al.   MOLECULAR AND CELLULAR BIOLOGY

Inhibition of StearoylCoA Desaturase-1 Inactivates Acetyl-CoA Carboxylase and Impairs Proliferation in Cancer Cells: Role of AMPK

(2009) Natalia Scaglia et al.   PLoS One

HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma

(2008) John D. Gordan et al.   CANCER CELL

Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

(2008) Alfredo Toschi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY