Article
Chemistry, Multidisciplinary
Xiao Fang, Shuxian Cai, Min Wang, Zhaowei Chen, Chunhua Lu, Huanghao Yang
Summary: The study introduces a NO-based phototherapeutic strategy for hypoxic tumors using photogenerated holes to oxidize water into H2O2, subsequently producing NO. In vitro and in vivo experiments demonstrated that this strategy induced cancer cell apoptosis, paving the way for the development of NO therapeutic strategies.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Laura Puente-Santamaria, Lucia Sanchez-Gonzalez, Nuria Pescador, Oscar Martinez-Costa, Ricardo Ramos-Ruiz, Luis del Peso
Summary: This study utilized meta-analysis techniques to integrate multiple transcription datasets from different experimental conditions, revealing the impact of hypoxia on gene expression and identifying a set of robust hypoxia-regulated gene signatures.
Article
Agricultural Engineering
Zhenyi Wang, Jun Cheng, Xiangdong Zhang, Lechong Chen, Jianzhong Liu
Summary: Adding exogenous spermidine significantly enhanced the resistance of Chlorella to high NO concentrations by inducing NO fixation in amino acids, improving antioxidant enzyme activity, and protecting the photosynthetic system.
BIORESOURCE TECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Jing Chen, Qingshuang Tang, Yuan Wang, Menghong Xu, Suhui Sun, Jinxia Zhang, Ruiqi Wu, Xiuli Yue, Xiaoda Li, Qingfeng Chen, Xiaolong Liang
Summary: A novel nanoplatform was developed for efficient NO production based on ultrasound-induced piezocatalysis. The nanoplatform was fabricated by coating amphiphilic poly-L-arginine (DSPE-PEG2000-Arg, DPA) on the piezoelectric material of barium titanate (BTO). The resulting BTO@DPA nanoparticles can generate H2O2, 1O2, and O2 via ultrasound-induced piezocatalysis based on BTO, and oxidize surface arginine to produce NO, inducing tumor cell apoptosis in hypoxia and normoxia.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Cuihong Yang, Ganen Mu, Ying Zhang, Yang Gao, Wenxue Zhang, Jinjian Liu, Wenwen Zhang, Paiyun Li, Lijun Yang, Zhimou Yang, Jie Gao, Jianfeng Liu
Summary: Nitric oxide (NO) acts as a radiosensitizer by directly reacting with DNA and increasing oxygen supply through normalizing tumor vessels. A NO depot system is designed to control the release of NO and reverse tumor radioresistance.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Benjamin Lau, Hossein Fazelinia, Ipsita Mohanty, Serena Raimo, Margarita Tenopoulou, Paschalis-Thomas Doulias, Harry Ischiropoulos
Summary: This study identified and analyzed S-nitrosocysteine residues in mouse heart proteins, with a significant enrichment of these modifications in mitochondrial proteins participating in metabolism. The major functional pathways impacted by protein S-nitrosylation include regulatory proteins in glycolysis, TCA cycle, oxidative phosphorylation, and ATP production. The meta-analysis of the proteomic data supports the hypothesis that nitric oxide signaling via protein S-nitrosylation is a regulator of cardiomyocyte metabolism to ensure optimal cardiac function.
Review
Chemistry, Multidisciplinary
Jingtao Zheng, Yanyan Pan, Yubin Chen, Junyan Li, Weishuo Li
Summary: Hypoxia is a key factor in tumor progression, metastasis, and resistance to standard therapies. Free radical-mediated treatments, which efficiently damage tumor cells, are of great interest for hypoxic tumors. This review discusses the physicochemical and biological characteristics of hypoxic tumor tissues, as well as the principles and application examples of oxygen-centered, carbon-centered, and other atom-centered free-radical based therapies. Current limitations and future prospects of free radical-mediated hypoxic tumor therapy are also addressed. This review provides an up-to-date compilation to advance the development of hypoxic tumor therapy.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Biochemistry & Molecular Biology
Wajeha Hamoudi, Manish Kumar Tripathi, Shashank Kumar Ojha, Haitham Amal
Summary: This study identifies novel SNO of key glutamatergic proteins in Shank3 mutant mice and reveals a cross-talk between nitric oxide and the glutamatergic system.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Engineering, Biomedical
Xinyi Lv, Jingai Jiang, Jie Ren, Hui Li, Dongliang Yang, Xuejiao Song, Yanling Hu, Wenjun Wang, Xiaochen Dong
Summary: A phototherapeutic nanoagent that releases nitric oxide (NO) has been developed to overcome biofilm-associated infections. Under laser irradiation, the nanoagent releases NO, enhances biofilm permeability, and generates reactive oxygen species (ROS) to effectively eliminate biofilm infections. It also stimulates collagen deposition and promotes angiogenesis in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Chuanlong Cui, Changgong Wu, Ping Shu, Tong Liu, Hong Li, Annie Beuve
Summary: Soluble guanylyl cyclase (GC1) is an essential protein that produces cGMP when stimulated by nitric oxide (NO). Under oxidative stress, GC1 can increase cellular S-nitrosation via transnitrosation. One of the S- nitrosation targets of GC1 is the oxidized form of Thioredoxin1 (oTrx1). Further studies revealed that SNO-GC1 inhibits the RhoA signaling pathway through transnitrosation, in contrast to the canonical NO-cGMP pathway.
Editorial Material
Biochemistry & Molecular Biology
Tiffany M. Russell, Des R. Richardson
Summary: GSTs are versatile proteins that play important roles in detoxification and cellular nitric oxide metabolism. They have the ability to convert organic nitrates into nitric oxide, thereby regulating vasodilation. GSTs are also considered suitable targets for pharmaceutical development, particularly in the field of anti-cancer drugs.
Article
Pharmacology & Pharmacy
Tomoyasu Yamanaka, Takatoshi Ueki, Mitsuhito Mase, Koichi Inoue
Summary: Modern western dietary habits and low physical activity can lead to metabolic abnormalities and atherosclerosis. This study investigates the potential therapeutic use of a designed optogenetic approach to regulate vascular inflammatory responses. Using a blue light-activated Ca2+ channel switch, the researchers observed an increase in intracellular Ca2+ in vascular endothelial cells, as well as activation of immune cells and production of anti-inflammatory molecules. These findings suggest that regulating cellular Ca2+ could be a novel approach against vascular inflammation.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
C. Dias, C. F. Lourenco, J. Laranjinha, A. Ledo
Summary: Nitrite can serve as an alternative source of nitric oxide production, independent of nitric oxide synthase activity, particularly in conditions of low oxygen availability. Increasing nitrite concentration through diet may provide a therapeutic intervention for brain ischemia. Nitrite has been found to modulate mitochondrial function and decrease oxidative burst in in vitro and in vivo models of ischemia/reperfusion.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Agronomy
Shuang Zhang, Lingling Liu, Zhengbao Wu, Luyin Wang, Zhaojun Ban
Summary: Chilling stress poses a threat to the quality of postharvest fruit and vegetables. This study investigated the quality attributes of jujube fruit and analyzed differentially abundant proteins and S-nitrosylated proteins in response to chilling stress and exogenous nitric oxide (NO) signaling. The results showed that there were 5836 differentially expressed proteins, 1045 S-nitrosylated proteins, and 1653 S-nitrosylated sites in response to chilling stress. Moreover, the function annotation and protein-protein interaction network analysis were conducted, demonstrating the important role of S-nitrosylated proteins in resistance to environmental stress.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Plant Sciences
Yihua Zhang, Pengfei Cheng, Jun Wang, Dyaaaldin Abdalmegeed, Ying Li, Mangteng Wu, Chen Dai, Shubei Wan, Rongzhan Guan, Huiming Pu, Wenbiao Shen
Summary: Heterosis was observed in Brassica napus L. hybrid under salt stress, with better redox and ion balance compared to parental lines. Increased endogenous NO levels and suppressed protein abundance related to metabolic processes were key factors contributing to heterosis in hybrid plants under salt stress conditions. The study suggests that NO-dependent activation of defense responses and metabolic processes may mediate heterosis in F1 hybridization for salt stress tolerance.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Natalie Al-Furoukh, Alessandro Ianni, Hendrik Nolte, Soraya Hoelper, Marcus Krueger, Sjoerd Wanrooij, Thomas Braun
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2015)
Article
Multidisciplinary Sciences
Ruben Torregrosa-Munumer, Josefin M. E. Forslund, Steffi Goffart, Annika Pfeiffer, Gorazd Stojkovic, Gustavo Carvalho, Natalie Al-Furoukh, Luis Blanco, Sjoerd Wanrooij, Jaakko L. O. Pohjoismaki
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biochemistry & Molecular Biology
Juan M. Adrian-Segarra, Natalie Schindler, Praveen Gajawada, Holger Loerchner, Thomas Braun, Jochen Poeling
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Cell Biology
Janica Lea Wiederstein, Hendrik Nolte, Stefan Guenther, Tanja Piller, Martina Baraldo, Sawa Kostin, Wilhelm Bloch, Natalie Schindler, Marco Sandri, Bert Blaauw, Thomas Braun, Soraya Hoelper, Marcus Krueger
Article
Biochemistry & Molecular Biology
Natalie Al-Furoukh, Steffi Goffart, Marten Szibor, Sjoerd Wanrooij, Thomas Braun
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2013)
Article
Biochemistry & Molecular Biology
Juliana Heidler, Natalie Al-Furoukh, Christian Kukat, Isabelle Salwig, Marie-Elisabeth Ingelmann, Peter Seibel, Marcus Krueger, Juergen Holtz, Ilka Wittig, Thomas Braun, Marten Szibor
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Biochemistry & Molecular Biology
Jaakko L. O. Pohjoismaeki, Marcus Krueger, Natalie Al-Furoukh, Anssi Lagerstedt, Pekka J. Karhunen, Thomas Braun
MOLECULAR BIOSYSTEMS
(2013)
Article
Multidisciplinary Sciences
Natalie Al-Furoukh, Julia R. Kardon, Marcus Krueger, Marten Szibor, Tania A. Baker, Thomas Braun
Review
Biochemistry & Molecular Biology
Olga Vydzhak, Brian Luke, Natalie Schindler
JOURNAL OF MOLECULAR BIOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Sriram Aravamudhan, Clara Turk, Theresa Bock, Lena Keufgens, Hendrik Nolte, Franziska Lang, Ramesh Kumar Krishnan, Tim Konig, Philipp Hammerschmidt, Natalie Schindler, Susanne Brodesser, Dieu Hien Rozsivalova, Elena Rugarli, Aleksandra Trifunovic, Jens Bruening, Thomas Langer, Thomas Braun, Marcus Krueger
Summary: This research found that the outer mitochondrial membrane protein PERM1 plays a crucial role in regulating the homeostasis of lipid and amino acid metabolites in mitochondria through analysis of phosphorylation sites during the early stages of cardiac postnatal development in mice. Deficiency of PERM1 results in reduced protein expression of lipin-1, accumulation of specific phospholipid species, and downregulation of mitochondrial transport proteins for amino acids and carnitines.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Vera M. Kissling, Giordano Reginato, Eliana Bianco, Kristina Kasaciunaite, Janny Tilma, Gea Cereghetti, Natalie Schindler, Sung Sik Lee, Raphael Guerois, Brian Luke, Ralf Seidel, Petr Cejka, Matthias Peter
Summary: This study reveals the oligomerization mechanism of the Mre11-Rad50 complex and its functional significance in DNA damage repair. The results show that Rad50 mediates the oligomerization of the Mre11-Rad50 complex, and its mutations may be linked to hereditary cancer predisposition.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Natalie Schindler, Matthias Tonn, Vanessa Kellner, Jia Jun Fung, Arianna Lockhart, Olga Vydzhak, Thomas Juretschke, Stefanie Moeckel, Petra Beli, Anton Khmelinskii, Brian Luke
Summary: The study reveals a genetic network involved in repairing the single ribonucleoside monophosphates (rNMPs) induced lesions and highlights its importance in human pathologies. This could potentially be utilized in the treatment of RNase H2-deficient pathologies.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Annett Reichel, Dirk Schaible, Natalie Al Furoukh, Mati Cohen, Gideon Schreiber, Jacob Piehler
ANALYTICAL CHEMISTRY
(2007)