Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3β/Snail signaling in renal cell carcinoma

Expression of epithelial-mesenchymal transition markers in renal cell carcinoma: impact on prognostic outcomes in patients undergoing radical nephrectomy

(2012) Ken-ichi Harada et al.   BJU INTERNATIONAL

Notch1 activation promotes renal cell carcinoma growth via PI3K/Akt signaling

(2012) Le Xu et al.   CANCER SCIENCE

Hepatitis B virus X protein promotes hepatoma cell invasion and metastasis by stabilizing Snail protein

(2012) Haiou Liu et al.   CANCER SCIENCE

Klotho

(2012) Sharon M. Moe   CIRCULATION

The Genetic Basis of Kidney Cancer: Implications for Management and Use of Targeted Therapeutic Approaches

(2012) W. Marston Linehan   EUROPEAN UROLOGY

Hepatitis B Virus X Protein Confers Resistance of Hepatoma Cells to Anoikis by Up-regulating and Activating p21-Activated Kinase 1

(2012) Jiejie Xu et al.   GASTROENTEROLOGY

Hepatitis B Virus Large Surface Antigen Promotes Liver Carcinogenesis by Activating the Src/PI3K/Akt Pathway

(2011) H. Liu et al.   CANCER RESEARCH

KL1 Internal Repeat Mediates Klotho Tumor Suppressor Activities and Inhibits bFGF and IGF-I Signaling in Pancreatic Cancer

(2011) L. Abramovitz et al.   CLINICAL CANCER RESEARCH

Klotho Inhibits Transforming Growth Factor-β1 (TGF-β1) Signaling and Suppresses Renal Fibrosis and Cancer Metastasis in Mice

(2011) Shigehiro Doi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Snail and Slug in renal cell carcinoma: E-cadherin repressor Snail is associated with cancer invasion and prognosis

(2011) Shuji Mikami et al.   LABORATORY INVESTIGATION

Klotho predicts good clinical outcome in patients with limited-disease small cell lung cancer who received surgery

(2011) Jitsuo Usuda et al.   LUNG CANCER

Klotho suppresses RIG-I-mediated senescence-associated inflammation

(2011) Feng Liu et al.   NATURE CELL BIOLOGY

What can molecular pathology contribute to the management of renal cell carcinoma?

(2011) Grant D. Stewart et al.   Nature Reviews Urology

Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer

(2011) Jie Pan et al.   TUMOR BIOLOGY

Molecular Diagnosis and Therapy of Kidney Cancer

(2010) W. Marston Linehan et al.   Annual Review of Medicine

AACR Special Conference on Epithelial-Mesenchymal Transition and Cancer Progression and Treatment

(2010) E. T. Roussos et al.   CANCER RESEARCH

Hepatitis B virus X protein blunts senescence-like growth arrest of human hepatocellular carcinoma by reducing Notch1 cleavage

(2010) Jiejie Xu et al.   HEPATOLOGY

Klotho inhibits growth and promotes apoptosis in human lung cancer cell line A549

(2010) Bo Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma

(2010) Jaehyouk Lee et al.   Molecular Cancer

Treatment of metastatic renal cell carcinoma

(2010) Maxine Sun et al.   Nature Reviews Urology

Loss of Klotho during melanoma progression leads to increased filamin cleavage, increased Wnt5A expression, and enhanced melanoma cell motility

(2010) Tura C. Camilli et al.   Pigment Cell & Melanoma Research

Relevant use of Klotho in FGF19 subfamily signaling system in vivo

(2010) K.-i. Tomiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Renal cell carcinoma

(2009) Brian I Rini et al.   LANCET

Regulation of Renal Outer Medullary Potassium Channel and Renal K+ Excretion by Klotho

(2009) S.-K. Cha et al.   MOLECULAR PHARMACOLOGY

Klotho

(2009) Makoto Kuro-o   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer

(2008) I Wolf et al.   ONCOGENE

PI3K/Akt: getting it right matters

(2008) T F Franke   ONCOGENE

Removal of sialic acid involving Klotho causes cell-surface retention of TRPV5 channel via binding to galectin-1

(2008) S.-K. Cha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA